Isabel dos Santos Silva

Summary

Affiliation: London School of Hygiene and Tropical Medicine
Country: UK

Publications

  1. doi request reprint Cancer incidence in professional flight crew and air traffic control officers: disentangling the effect of occupational versus lifestyle exposures
    Isabel dos Santos Silva
    Departments of Non Communicable Disease Epidemiology and Medical Statistics, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Int J Cancer 132:374-84. 2013
  2. pmc Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre CNIO, Madrid, 28029, Spain
    Breast Cancer Res 12:R110. 2010
  3. pmc Mammographic density and markers of socioeconomic status: a cross-sectional study
    Zoe Aitken
    Cancer Research UK Epidemiology and Genetics Group, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    BMC Cancer 10:35. 2010
  4. pmc Birth size and breast cancer risk: re-analysis of individual participant data from 32 studies
    Isabel Dos Santos Silva
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    PLoS Med 5:e193. 2008
  5. ncbi request reprint The insulin-like growth factor system and mammographic features in premenopausal and postmenopausal women
    Isabel dos Santos Silva
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Cancer Epidemiol Biomarkers Prev 15:449-55. 2006
  6. ncbi request reprint Birthweight and other pregnancy outcomes in a cohort of women with pre-gestational insulin-treated diabetes mellitus, Scotland, 1979-95
    I dos Santos Silva
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Diabet Med 22:440-7. 2005
  7. doi request reprint Overseas sun exposure, nevus counts, and premature skin aging in young English women: a population-based survey
    Isabel Dos Santos Silva
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    J Invest Dermatol 129:50-9. 2009
  8. doi request reprint Reproductive history and adverse pregnancy outcomes in commercial flight crew and air traffic control officers in the United kingdom
    Isabel dos Santos Silva
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, England
    J Occup Environ Med 51:1298-305. 2009
  9. pmc Ovulation-stimulation drugs and cancer risks: a long-term follow-up of a British cohort
    I dos Santos Silva
    Cancer Research UK Epidemiology and Genetics Group, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Br J Cancer 100:1824-31. 2009
  10. ncbi request reprint Phyto-oestrogen intake and breast cancer risk in South Asian women in England: findings from a population-based case-control study
    Isabel dos Santos Silva
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Cancer Causes Control 15:805-18. 2004

Detail Information

Publications47

  1. doi request reprint Cancer incidence in professional flight crew and air traffic control officers: disentangling the effect of occupational versus lifestyle exposures
    Isabel dos Santos Silva
    Departments of Non Communicable Disease Epidemiology and Medical Statistics, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Int J Cancer 132:374-84. 2013
    ..The skin melanoma excess reflects sun-related behaviour rather than cosmic radiation exposure...
  2. pmc Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre CNIO, Madrid, 28029, Spain
    Breast Cancer Res 12:R110. 2010
    ....
  3. pmc Mammographic density and markers of socioeconomic status: a cross-sectional study
    Zoe Aitken
    Cancer Research UK Epidemiology and Genetics Group, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    BMC Cancer 10:35. 2010
    ..This study aims to investigate whether mammographic density varies by SES and to identify the underlying anthropometric, lifestyle and reproductive factors leading to such variation...
  4. pmc Birth size and breast cancer risk: re-analysis of individual participant data from 32 studies
    Isabel Dos Santos Silva
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    PLoS Med 5:e193. 2008
    ..We re-analysed individual participant data from published and unpublished studies to obtain more precise estimates of the magnitude and shape of the birth size-breast cancer association...
  5. ncbi request reprint The insulin-like growth factor system and mammographic features in premenopausal and postmenopausal women
    Isabel dos Santos Silva
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Cancer Epidemiol Biomarkers Prev 15:449-55. 2006
    ....
  6. ncbi request reprint Birthweight and other pregnancy outcomes in a cohort of women with pre-gestational insulin-treated diabetes mellitus, Scotland, 1979-95
    I dos Santos Silva
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Diabet Med 22:440-7. 2005
    ..To assess pregnancy outcomes, in particular birthweight, in a large population-based cohort of women in Scotland with pre-gestational insulin-treated diabetes mellitus...
  7. doi request reprint Overseas sun exposure, nevus counts, and premature skin aging in young English women: a population-based survey
    Isabel Dos Santos Silva
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    J Invest Dermatol 129:50-9. 2009
    ..The findings are of public health relevance given the growing popularity of foreign holidays...
  8. doi request reprint Reproductive history and adverse pregnancy outcomes in commercial flight crew and air traffic control officers in the United kingdom
    Isabel dos Santos Silva
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, England
    J Occup Environ Med 51:1298-305. 2009
    ..To examine reproductive outcomes among flight crew...
  9. pmc Ovulation-stimulation drugs and cancer risks: a long-term follow-up of a British cohort
    I dos Santos Silva
    Cancer Research UK Epidemiology and Genetics Group, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Br J Cancer 100:1824-31. 2009
    ..These findings do not support strong associations between ovulation-stimulation drugs and cancer risks, but they indicate the need for continued monitoring to establish whether risks are elevated in certain subgroups of users...
  10. ncbi request reprint Phyto-oestrogen intake and breast cancer risk in South Asian women in England: findings from a population-based case-control study
    Isabel dos Santos Silva
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Cancer Causes Control 15:805-18. 2004
    ..This study investigates whether intake of phyto-oestrogens is associated with breast cancer risk in South Asian women from the Indian subcontinent, whose diet is rich in pulses and vegetables but poor in soyfoods...
  11. pmc Is the association of birth weight with premenopausal breast cancer risk mediated through childhood growth?
    I Dos Santos Silva
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Br J Cancer 91:519-24. 2004
    ..94 (0.74, 5.14) per 1 kg increase in birth weight). The pathways through which birth weight is associated with premenopausal breast cancer risk seem to be largely independent of those underlying the relation of postnatal growth to risk...
  12. pmc Survival from breast cancer among South Asian and non-South Asian women resident in South East England
    I Dos Santos Silva
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Br J Cancer 89:508-12. 2003
    ..001). These findings indicate that the higher survival from breast cancer in the first 10 years after diagnosis among South Asian was not due to differences in age at diagnosis, socioeconomic deprivation or disease stage at presentation...
  13. ncbi request reprint Prenatal factors, childhood growth trajectories and age at menarche
    Isabel dos Santos Silva
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Int J Epidemiol 31:405-12. 2002
    ..The mechanisms underlying this association are not clear, however, as birthweight is a predictor of body size in childhood, and a large body size is known to be associated with an early onset of menarche...
  14. ncbi request reprint Lifelong vegetarianism and risk of breast cancer: a population-based case-control study among South Asian migrant women living in England
    Isabel dos Santos Silva
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, England
    Int J Cancer 99:238-44. 2002
    ....
  15. doi request reprint Circulating levels of coagulation and inflammation markers and cancer risks: individual participant analysis of data from three long-term cohorts
    Isabel dos Santos Silva
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Int J Epidemiol 39:699-709. 2010
    ..Basic and clinical research support the hypothesis that activation of the coagulation and inflammation pathways may affect cancer onset, but there is limited epidemiological data to support this...
  16. doi request reprint CYP3A variation, premenopausal estrone levels, and breast cancer risk
    Nichola Johnson
    The Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Institute of Cancer Research, London, UK
    J Natl Cancer Inst 104:657-69. 2012
    ..Our aim was to identify common variants in genes involved in sex steroid synthesis or metabolism that are associated with hormone levels and the risk of breast cancer in premenopausal women...
  17. doi request reprint Association of genetic variants at 8q24 with breast cancer risk
    Olivia Fletcher
    Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Cancer Epidemiol Biomarkers Prev 17:702-5. 2008
    ..25-fold increased risk of prostate cancer, with no effect for the two other variants, indicates that the effects of the risk alleles clustered at 8q24 are cancer site specific...
  18. pmc Sex steroids, growth factors and mammographic density: a cross-sectional study of UK postmenopausal Caucasian and Afro-Caribbean women
    Valerie A McCormack
    Cancer Research UK Epidemiology and Genetics Group, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Breast Cancer Res 11:R38. 2009
    ..If such a hormonal basis of mammographic density exists, hormones may underlie ethnic differences in both mammographic density and breast cancer incidence rates...
  19. ncbi request reprint Validation of a food frequency questionnaire to assess macro- and micro-nutrient intake among South Asians in the United Kingdom
    Leena Sevak
    Dept of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Eur J Nutr 43:160-8. 2004
    ..It is useful to investigate the experience of disease and dietary exposures for aetiological clues in South Asians. The FFQ was designed for a population-based case-control study of diet and breast cancer...
  20. doi request reprint Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study
    Olivia Fletcher
    Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    J Natl Cancer Inst 103:425-35. 2011
    ..Genome-wide association studies have identified several common genetic variants associated with breast cancer risk. It is likely, however, that a substantial proportion of such loci have not yet been discovered...
  21. ncbi request reprint Phyto-oestrogen intake and plasma concentrations in South Asian and native British women resident in England
    Dee Bhakta
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Br J Nutr 95:1150-8. 2006
    ..The present study does not support the hypothesis that differences in phytoestrogen intake, or in circulating levels, could explain differences in hormone-related cancer risks between these two populations...
  22. doi request reprint No breast cancer association for transforming growth factor-beta pathway colorectal cancer single nucleotide polymorphisms
    Lorna Gibson
    Non communicable Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Cancer Epidemiol Biomarkers Prev 18:1934-6. 2009
    ..94 or >1.08. One or more of these variants may be associated with a very small OR for breast cancer, but our data suggest that the effects of these alleles are cancer site-specific...
  23. ncbi request reprint A semiquantitative food frequency questionnaire is a valid indicator of the usual intake of phytoestrogens by south Asian women in the UK relative to multiple 24-h dietary recalls and multiple plasma samples
    Dee Bhakta
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    J Nutr 135:116-23. 2005
    ..46 vs. 0.95 and 0.45, respectively) and daidzein (0.67 vs. 0.83 and 0.45, respectively). This FFQ is thus a relatively valid tool with which to estimate phytoestrogen intake among South Asian women in the UK...
  24. pmc Gene-body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients
    James M Flanagan
    CR UK Viral Oncology Group, UCL Cancer Institute, London, UK
    Hum Mol Genet 18:1332-42. 2009
    ..ACCESSION NUMBERS: The microarray data and associated .BED and .WIG files can be accessed through Gene Expression Omnibus accession number: GSE14603...
  25. doi request reprint Cause-specific mortality in professional flight crew and air traffic control officers: findings from two UK population-based cohorts of over 20,000 subjects
    Bianca L de Stavola
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Int Arch Occup Environ Health 85:283-93. 2012
    ..Flight crew are exposed to several potential occupational hazards. This study compares mortality rates in UK flight crew to those in air traffic control officers (ATCOs) and the general population...
  26. pmc Estimating causal effects of genetic risk variants for breast cancer using marker data from bilateral and familial cases
    Frank Dudbridge
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Cancer Epidemiol Biomarkers Prev 21:262-72. 2012
    ..This can be explained by incomplete linkage disequilibrium between the tested marker and the underlying causal variant...
  27. pmc Missense variants in ATM in 26,101 breast cancer cases and 29,842 controls
    Olivia Fletcher
    British Breast Cancer Study, The Breakthrough Breast Cancer Research Centre, London, United Kingdom
    Cancer Epidemiol Biomarkers Prev 19:2143-51. 2010
    ..Truncating mutations in ATM have been shown to increase the risk of breast cancer but the effect of missense variants remains contentious...
  28. ncbi request reprint Mammographic features and subsequent risk of breast cancer: a comparison of qualitative and quantitative evaluations in the Guernsey prospective studies
    Gabriela Torres-Mejia
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, England
    Cancer Epidemiol Biomarkers Prev 14:1052-9. 2005
    ....
  29. doi request reprint Premenopausal mammographic density in relation to cyclic variations in endogenous sex hormone levels, prolactin, and insulin-like growth factors
    Kate Walker
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, and The Academic Department of Biochemistry, The Royal Marsden Hospital, London, UK
    Cancer Res 69:6490-9. 2009
    ..Most of these hormone-density associations were attenuated with further adjustment for BMI...
  30. doi request reprint Cancer incidence in South Asian migrants to England, 1986-2004: unraveling ethnic from socioeconomic differentials
    Camille Maringe
    Cancer Research UK Cancer Survival Group, Department of Non communicable Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Int J Cancer 132:1886-94. 2013
    ..Although these trends vary by cancer, they have important implications for both prevention and anticipating health-care demand...
  31. ncbi request reprint Birth characteristics and adult cancer incidence: Swedish cohort of over 11,000 men and women
    Valerie A McCormack
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Int J Cancer 115:611-7. 2005
    ..These findings provide evidence of a modest association of birth size and adult cancer risk, resulting from positive associations with a few cancer sites and a possible inverse association with endometrial cancer...
  32. ncbi request reprint Statistical issues in life course epidemiology
    Bianca L de Stavola
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Am J Epidemiol 163:84-96. 2006
    ..Examples from two cohorts in the United Kingdom are used to illustrate alternative modeling strategies. The authors conclude that more than one analytical approach should be adopted to gain more insight into the underlying mechanisms...
  33. ncbi request reprint Interaction between CHEK2*1100delC and other low-penetrance breast-cancer susceptibility genes: a familial study
    Nichola Johnson
    Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Lancet 366:1554-7. 2005
    ..Our aim was to measure the risk of breast cancer in relatives of women with bilateral breast cancer who were carriers of this allele...
  34. ncbi request reprint Counting potentially functional variants in BRCA1, BRCA2 and ATM predicts breast cancer susceptibility
    Nichola Johnson
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK
    Hum Mol Genet 16:1051-7. 2007
    ..A risk score incorporating a suitably weighted sum of all potentially functional variants in these and a few other candidate genes may provide clinically useful identification of women at high genetic risk...
  35. pmc Comparison of a new and existing method of mammographic density measurement: intramethod reliability and associations with known risk factors
    Valerie A McCormack
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Wellington, New Zealand
    Cancer Epidemiol Biomarkers Prev 16:1148-54. 2007
    ..It is commonly measured by an interactive threshold method that does not fully use information contained in a mammogram. An alternative fully automated standard mammogram form (SMF) method measures density using a volumetric approach...
  36. pmc The spatial distribution of radiodense breast tissue: a longitudinal study
    Snehal M Pinto Pereira
    Cancer Research UK Epidemiology and Genetics Group, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Breast Cancer Res 11:R33. 2009
    ..This study aims to investigate the spatial distribution of density within the breast using 493 mammographic images from a sample of 165 premenopausal women (~3 medio-lateral oblique views per woman)...
  37. ncbi request reprint Correlates of high-density mammographic parenchymal patterns by menopausal status in a rural population in Northern Greece
    Elena Riza
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Eur J Cancer 41:590-600. 2005
    ..Age at first pregnancy and parity were strong correlates of mammographic density in pre- and post-menopausal women while duration of breast-feeding appeared to be particularly important in pre-menopausal women...
  38. pmc Screen-film mammographic density and breast cancer risk: a comparison of the volumetric standard mammogram form and the interactive threshold measurement methods
    Zoe Aitken
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Cancer Epidemiol Biomarkers Prev 19:418-28. 2010
    ....
  39. ncbi request reprint Breast density and parenchymal patterns as markers of breast cancer risk: a meta-analysis
    Valerie A McCormack
    Non communicable Disease Epidemiology Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Cancer Epidemiol Biomarkers Prev 15:1159-69. 2006
    ..It also refutes the suggestion that the association is an artifact of masking bias or that it is only present in a restricted age range...
  40. pmc Male circumcision and penile cancer: a systematic review and meta-analysis
    Natasha L Larke
    MRC Tropical Epidemiology Group, Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
    Cancer Causes Control 22:1097-110. 2011
    ..We systematically reviewed the evidence of an association between male circumcision and penile cancer...
  41. doi request reprint Sample selection and validity of exposure-disease association estimates in cohort studies
    Costanza Pizzi
    Cancer Epidemiology Unit, CeRMS and CPO Piemonte, University of Turin, Via Santena 7, Turin, Italy
    J Epidemiol Community Health 65:407-11. 2011
    ..Participants in cohort studies are frequently selected from restricted source populations. It has been recognised that such restriction may affect the study validity...
  42. ncbi request reprint Determinants of the availability and accuracy of self-reported birth weight in middle-aged and elderly women
    Diane S Allen
    Department of Academic Oncology, Guy s Hospital, London, England
    Am J Epidemiol 155:379-84. 2002
    ..The most important determinants of accuracy, for those who provided a report, were being younger and the eldest child. Research studies relying on self-reported birth weight should take these factors into account...
  43. doi request reprint Birth size and survival in breast cancer patients from the Uppsala Birth Cohort Study
    Ulla Sovio
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
    Cancer Causes Control 24:1643-51. 2013
    ..This study investigates survival of women after breast cancer diagnosis (n = 437) in the Uppsala Birth Cohort born in 1915-1929...
  44. pmc A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11
    Afshan Siddiq
    Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
    Hum Mol Genet 21:5373-84. 2012
    ..Our results highlight the value of large-scale collaborative studies to identify novel breast cancer risk loci...
  45. ncbi request reprint Lack of evidence on diets for obesity for children: a systematic review
    Lorna J Gibson
    Cancer Research UK Epidemiology and Genetics Group, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Int J Epidemiol 35:1544-52. 2006
    ..A low-fat energy-restricted diet is the conventional therapy for obesity, but alternative dietary interventions have been proposed in recent years...
  46. ncbi request reprint Mortality after radiological investigation with radioactive Thorotrast: a follow-up study of up to fifty years in Portugal
    Isabel dos Santos Silva
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, England
    Radiat Res 159:521-34. 2003
    ..Liver conditions, but not hematological disorders, showed a strong and consistent gradient with cumulative alpha-particle radiation dose...
  47. pmc Localized fibroglandular tissue as a predictor of future tumor location within the breast
    Snehal M Pinto Pereira
    Department of Non communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Cancer Epidemiol Biomarkers Prev 20:1718-25. 2011
    ..Mammographic density (MD) is a strong marker of breast cancer risk, but it is unclear whether tumors arise specifically within dense tissue...