D J Conway

Summary

Affiliation: London School of Hygiene and Tropical Medicine
Country: UK

Publications

  1. pmc Scarring trachoma is associated with polymorphism in the tumor necrosis factor alpha (TNF-alpha) gene promoter and with elevated TNF-alpha levels in tear fluid
    D J Conway
    Department of Clinical Sciences, London School of Hygiene and Tropical Medicine, United Kingdom
    Infect Immun 65:1003-6. 1997
  2. pmc High recombination rate in natural populations of Plasmodium falciparum
    D J Conway
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, United Kingdom
    Proc Natl Acad Sci U S A 96:4506-11. 1999
  3. ncbi request reprint Population genetic analysis of the Plasmodium falciparum erythrocyte binding antigen-175 (eba-175) gene
    R H Binks
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, WC1E 7HT, London, UK
    Mol Biochem Parasitol 114:63-70. 2001
  4. ncbi request reprint A principal target of human immunity to malaria identified by molecular population genetic and immunological analyses
    D J Conway
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT
    Nat Med 6:689-92. 2000
  5. ncbi request reprint Extreme geographical fixation of variation in the Plasmodium falciparum gamete surface protein gene Pfs48/45 compared with microsatellite loci
    D J Conway
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, WC1E 7HT, London, UK
    Mol Biochem Parasitol 115:145-56. 2001
  6. ncbi request reprint High-throughput sequence typing of T-cell epitope polymorphisms in Plasmodium falciparum circumsporozoite protein
    A Alloueche
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Mol Biochem Parasitol 106:273-82. 2000
  7. pmc Strong diversifying selection on domains of the Plasmodium falciparum apical membrane antigen 1 gene
    S D Polley
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom
    Genetics 158:1505-12. 2001
  8. pmc Analysis of human antibodies to erythrocyte binding antigen 175 of Plasmodium falciparum
    D M Okenu
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom
    Infect Immun 68:5559-66. 2000
  9. ncbi request reprint Origin of Plasmodium falciparum malaria is traced by mitochondrial DNA
    D J Conway
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK
    Mol Biochem Parasitol 111:163-71. 2000
  10. ncbi request reprint Polymorphisms in candidate genes and risk of scarring trachoma in a Chlamydia trachomatis--endemic population
    N Mozzato-Chamay
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    J Infect Dis 182:1545-8. 2000

Collaborators

Detail Information

Publications18

  1. pmc Scarring trachoma is associated with polymorphism in the tumor necrosis factor alpha (TNF-alpha) gene promoter and with elevated TNF-alpha levels in tear fluid
    D J Conway
    Department of Clinical Sciences, London School of Hygiene and Tropical Medicine, United Kingdom
    Infect Immun 65:1003-6. 1997
    ..001). The results indicate that TNF-alpha plays a major role in the tissue damage and scarring which occurs as a consequence of Chlamydia trachomatis infection...
  2. pmc High recombination rate in natural populations of Plasmodium falciparum
    D J Conway
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, United Kingdom
    Proc Natl Acad Sci U S A 96:4506-11. 1999
    ..falciparum populations. Moreover, the data have major implications for the design and interpretation of population genetic studies of selection on P. falciparum genes...
  3. ncbi request reprint Population genetic analysis of the Plasmodium falciparum erythrocyte binding antigen-175 (eba-175) gene
    R H Binks
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, WC1E 7HT, London, UK
    Mol Biochem Parasitol 114:63-70. 2001
    ..Finally, there was no association between the Cseg/Fseg alleles of eba-175 in parasites and the M/N alleles of the glycophorin A erythrocyte receptor in the human subjects...
  4. ncbi request reprint A principal target of human immunity to malaria identified by molecular population genetic and immunological analyses
    D J Conway
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT
    Nat Med 6:689-92. 2000
    ..This demonstrated that serum IgG antibodies against each of the two most frequent allelic types of block 2 of the protein were strongly associated with protection from P. falciparum malaria...
  5. ncbi request reprint Extreme geographical fixation of variation in the Plasmodium falciparum gamete surface protein gene Pfs48/45 compared with microsatellite loci
    D J Conway
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, WC1E 7HT, London, UK
    Mol Biochem Parasitol 115:145-56. 2001
    ....
  6. ncbi request reprint High-throughput sequence typing of T-cell epitope polymorphisms in Plasmodium falciparum circumsporozoite protein
    A Alloueche
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Mol Biochem Parasitol 106:273-82. 2000
    ..PCR-SSOP could be used to determine the allelic frequencies of other parasite antigens and their geographical distribution...
  7. pmc Strong diversifying selection on domains of the Plasmodium falciparum apical membrane antigen 1 gene
    S D Polley
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom
    Genetics 158:1505-12. 2001
    ..We predict that these domains in particular are targets of naturally acquired protective immune responses in humans...
  8. pmc Analysis of human antibodies to erythrocyte binding antigen 175 of Plasmodium falciparum
    D M Okenu
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom
    Infect Immun 68:5559-66. 2000
    ..However, there was a trend indicating that individuals with high levels of IgG to region II may have some protection...
  9. ncbi request reprint Origin of Plasmodium falciparum malaria is traced by mitochondrial DNA
    D J Conway
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK
    Mol Biochem Parasitol 111:163-71. 2000
    ..This indicates that P. falciparum originated in Africa and colonised Southeast Asia and South America separately...
  10. ncbi request reprint Polymorphisms in candidate genes and risk of scarring trachoma in a Chlamydia trachomatis--endemic population
    N Mozzato-Chamay
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    J Infect Dis 182:1545-8. 2000
    ..2; P=.009). This single association is consistent with data indicating that the IL-10-1082G allele is associated with higher levels of IL-10 transcription and that Th2-type immune responses are associated with risk of chlamydial disease...
  11. pmc Acquisition of antibody isotypes against Plasmodium falciparum blood stage antigens in a birth cohort
    N O Duah
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Parasite Immunol 32:125-34. 2010
    ..This confirms that IgG subclass responses to MSP2 are strongly dependent on age or previous malaria experience, polarized towards IgG1 early in life and to IgG3 in older exposed individuals...
  12. ncbi request reprint Polymorphisms in the IkappaB-alpha promoter region and risk of diseases involving inflammation and fibrosis
    N Mozzato-Chamay
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK
    Genes Immun 2:153-5. 2001
    ....
  13. pmc Naturally acquired antibodies to polymorphic and conserved epitopes of Plasmodium falciparum merozoite surface protein 3
    F H A Osier
    London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Parasite Immunol 29:387-94. 2007
    ..41 with 95% confidence interval 0.20-0.81, P = 0.011). The potential importance of allele-specific immunity to MSP3 should be considered in addition to immunity to conserved epitopes, in the development of an MSP3 malaria vaccine...
  14. ncbi request reprint Micro-evolution and emergence of pathogens
    D J Conway
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, WC1E 7HT, London, UK
    Int J Parasitol 30:1423-30. 2000
    ..Approaches to understanding the recent evolution of eukaryotic pathogens are outlined, with particular reference to current problems of emerging zoonoses, and changes in virulence and drug resistance...
  15. ncbi request reprint Experimental and molecular genetic analysis of the impact of pyrethroid and non-pyrethroid insecticide impregnated bednets for mosquito control in an area of pyrethroid resistance
    J H Kolaczinski
    London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
    Bull Entomol Res 90:125-32. 2000
    ....
  16. ncbi request reprint Measuring immune selection
    D J Conway
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT
    Parasitology 125:S3-16. 2002
    ..Here, methods for identifying these selective signatures are reviewed. Their practical utility for identifying which antigens are targets of protective immune responses is discussed...
  17. ncbi request reprint Strongyloides stercoralis: characterization of immunodiagnostic larval antigens
    D J Conway
    Wellcome Research Centre for Parasitic Infections, Department of Biology, Imperial College, London, United Kingdom
    Exp Parasitol 79:99-105. 1994
    ..A rabbit antiserum raised to a 41-kDa size fraction of S. stercoralis larvae reacted against a doublet of 41-kDa which was distinct from the immunodiagnostic 41-kDa protein...
  18. ncbi request reprint Comparative analysis of molecular variation in Plasmodium falciparum and P. reichenowi maebl gene
    F Verra
    Parassitologia 48:567-72. 2006