Research Topics
Genomes and Genes | Juan P CasasSummaryAffiliation: London School of Hygiene and Tropical Medicine Country: UK Publications
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Publications
Frequency of eNOS polymorphisms in the Colombian general populationNorma C Serrano
Biomedical Research Centre, Universidad Autonoma de Bucaramanga, Colombia
BMC Genet 11:54. 2010..The objective of the present study was to determine the presence of G894T (rs1799983), intron-4 (27-bp TR) and -T786C (rs2070744) polymorphisms in the eNOS gene among the Colombian general population...
Commentary: Social class, C-reactive protein and coronary heart diseaseJuan P Casas
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, UK
Int J Epidemiol 37:299-300. 2008- PLA2G7 genotype, lipoprotein-associated phospholipase A2 activity, and coronary heart disease risk in 10 494 cases and 15 624 controls of European AncestryJuan P Casas
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, UK
Circulation 121:2284-93. 2010..PLA2G7 variants associated with Lp-PLA2 activity could evaluate whether this relationship is causal... - Effect of inhibitors of the renin-angiotensin system and other antihypertensive drugs on renal outcomes: systematic review and meta-analysisJuan P Casas
Centre for Clinical Pharmacology, Department of Medicine, BHF Laboratories at University College London, London, UK
Lancet 366:2026-33. 2005..Guidelines specify that these are the drugs of choice for the treatment of hypertension in patients with renal disease. We sought to determine to what extent this consensus is supported by the available evidence... - Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphismsReecha Sofat
Centre for Clinical Pharmacology, Department of Medicine, University College London, London, United Kingdom
Circulation 121:52-62. 2010..We hypothesized that common single-nucleotide polymorphisms in the CETP gene could help distinguish mechanism-based from off-target actions of CETP inhibitors to inform on the validity of CETP as a therapeutic target... - Endothelial nitric oxide synthase gene polymorphisms and cardiovascular disease: a HuGE reviewJuan P Casas
Centre for Clinical Pharmacology, Department of Medicine, British Heart Foundation Laboratories at University College London, London, United Kingdom
Am J Epidemiol 164:921-35. 2006..The need for large-scale genetic association studies using tagging polymorphisms is warranted to confirm or refute a role of the NOS3 gene in coronary heart disease... - Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease riskFotios Drenos
Division of Cardiovascular Genetics, Department of Medicine, Royal Free and University College Medical School, 5 University St, London WC1E 6JF, UK
Hum Mol Genet 18:2305-16. 2009..Broader and deeper integrated analyses, linking genomic with transcriptomic, proteomic and metabolomic analysis, as well as clinical events could, in principle, better delineate CHD causing pathways amenable to treatment... 
Inflammation, coagulation and risk of locomotor disability in elderly women: findings from the British Women's Heart and Health StudyEveline Nüesch
London School of Hygiene and Tropical Medicine, London, UK
Eur J Epidemiol 27:633-45. 2012..These results support the role of inflammation and coagulation in the development of locomotor disability in elderly women irrespective of their lifestyle factors and underlying age-related chronic diseases...- Multilocus Bayesian meta-analysis of gene-disease associationsPaul J Newcombe
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, WC1E 7HT London, UK
Am J Hum Genet 84:567-80. 2009..We present results from application of our approach to data on a possible association between PDE4D and ischemic stroke... - Bayesian meta-analysis of genetic association studies with different sets of markersClaudio Verzilli
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
Am J Hum Genet 82:859-72. 2008..The same method could be applied to evidence synthesis of other quantitative traits, whenever the typed SNPs vary among studies, and to assist fine mapping of causal variants... - Homocysteine and stroke: evidence on a causal link from mendelian randomisationJuan P Casas
Centre for Clinical Pharmacology, Department of Medicine, British Heart Foundation Laboratories, Royal Free and University College Medical School, University College London, Rayne Building, 5 University Street, London WC1E 6 JJ, UK
Lancet 365:224-32. 2005.... - Insight into the nature of the CRP-coronary event association using Mendelian randomizationJuan P Casas
Centre for Clinical Pharmacology, Department of Medicine, BHF Laboratories at University College London, UCL, London, UK
Int J Epidemiol 35:922-31. 2006..Since the distribution of this polymorphism occurs at random during gamete formation, its association with coronary events should not be biased or confounded... - Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trialsMichael V Holmes
Research Department of Epidemiology and Public Health, University College London, London, UK
Lancet 378:584-94. 2011..We aimed to reduce the effect of small-study bias and investigate whether folate status modifies the association between MTHFR 677C→T and stroke in a genetic analysis and meta-analysis of randomised controlled trials... - Critical appraisal of CRP measurement for the prediction of coronary heart disease events: new data and systematic review of 31 prospective cohortsTina Shah
Centre for Clinical Pharmacology, University College London, London, UK
Int J Epidemiol 38:217-31. 2009..Non-uniform reporting of relevant relationships and metrics hampers critical appraisal of the clinical utility of C-reactive protein (CRP) measurement for prediction of later coronary events... - Genetic variation in complement factor H and risk of coronary heart disease: eight new studies and a meta-analysis of around 48,000 individualsReecha Sofat
Centre for Clinical Pharmacology, Division of Medicine, University College London, Rayne Building, 5 University Street, London WC1E 6JF, UK
Atherosclerosis 213:184-90. 2010..To investigate the association of polymorphisms in complement factor H (CFH) and coronary heart disease (CHD) using meta-analysis... - Complement factor H genetic variant and age-related macular degeneration: effect size, modifiers and relationship to disease subtypeReecha Sofat
Centre for Clinical Pharmacology, Department of Medicine, University College London, London, UK
Int J Epidemiol 41:250-62. 2012..Previous studies have been case-control studies in populations of European ancestry with little differentiation in AMD subtype, and insufficient power to confirm or refute effect modification by smoking... - Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics CollaborationAspasia Angelakopoulou
Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
Eur Heart J 33:393-407. 2012.... - C-reactive protein and coronary heart disease: predictive test or therapeutic target?Aroon D Hingorani
Division of Population Sciences, Department of Epidemiology and Public Health, University College London, London, UK
Clin Chem 55:239-55. 2009..The research has encompassed observational and genetic epidemiology, basic science studies with cells and tissues, experiments with animal models and humans, and randomized trials (although not of specific CRP-lowering therapies as yet)... - Modelling the association of disability according to the WHO International Classification of Functioning, Disability and Health (ICF) with mortality in the British Women's Heart and Health StudyCaroline Dale
Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, UK
J Epidemiol Community Health 66:170-5. 2012..This paper investigates the association of the different ICF disability domains with mortality... - Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controlsJuan P Casas
Centre for Clinical Pharmacology, British Heart Foundation Laboratories at University College London, London, England
Arch Neurol 61:1652-61. 2004..These findings have important implications for the design of future genetic studies and for predictive genetic testing for stroke and other multifactorial diseases... - Investigating the genetic determinants of cardiovascular disease using candidate genes and meta-analysis of association studiesJuan P Casas
Centre for Clinical Pharmacology, Department of Medicine, BHF Laboratories at UCL, University College London, London, UK
Ann Hum Genet 70:145-69. 2006..This review lays out the framework for the candidate gene approach for CAD and illustrates this with published results from a UK prospective study of 3000 middle-aged men... - Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studiesMichael V Holmes
Centre for Clinical Pharmacology, University College London, London, United Kingdom
PLoS ONE 4:e7960. 2009..Studies of the genetic basis of drug response could help clarify mechanisms of drug action/metabolism, and facilitate development of genotype-based predictive tests of efficacy or toxicity (pharmacogenetics)... - Endothelial nitric oxide synthase genotype and ischemic heart disease: meta-analysis of 26 studies involving 23028 subjectsJuan P Casas
Centre for Clinical Pharmacology, BHF Laboratories at UCL, London, UK
Circulation 109:1359-65. 2004..To evaluate the role of polymorphisms in the eNOS gene in IHD, we considered all available studies in a meta-analysis... - (6R)-5,6,7,8-tetrahydro-L-biopterin and its stereoisomer prevent ischemia reperfusion injury in human forearmLila Mayahi
Centre for Clinical Pharmacology, BHF Laboratories, Department of Medicine, UCL, 5 University Street, London, UK, WC1E 6JJ
Arterioscler Thromb Vasc Biol 27:1334-9. 2007..6R-BH4 corrects ED in animal models of ischemia reperfusion injury (IRI) and in patients with cardiovascular risks. It is uncertain whether the effect of exogenous 6R-BH4 on ED is through its cofactor or antioxidant action... - Tackling non-communicable diseases in low- and middle-income countries: is the evidence from high-income countries all we need?Shah Ebrahim
London School of Hygiene and Tropical Medicine, London, United Kingdom South Asia Network for Chronic Disease, Public Health Foundation of India, New Delhi, India
PLoS Med 10:e1001377. 2013.... - Genetic association studies in pre-eclampsia: systematic meta-analyses and field synopsisEleonora Staines-Urias
Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, UK
Int J Epidemiol 41:1764-75. 2012..Pre-eclampsia is thought to have a polygenic basis, but the identification of susceptibility genes and the quantification of associated risks have been elusive owing to lack of replication from published genetic association studies... - Noncommunicable diseases and injuries in Latin America and the Caribbean: time for actionPablo Perel
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
PLoS Med 3:e344. 2006 - Biomarkers of inflammation predict both vascular and non-vascular mortality in older menRobert Clarke
Clinical Trial Service Unit and Epidemiological Studies Unit, Richard Doll Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7LF, UK
Eur Heart J 29:800-9. 2008..To compare the predictive value of inflammatory biomarkers and lipids for vascular and non-vascular mortality in older men... - Congestive heart failure in Latin America: the next epidemicLuz A Cubillos-Garzón
Heart Failure Council, Colombian Society of Cardiology, Bogota, Colombia
Am Heart J 147:412-7. 2004..Properly conducted clinical and epidemiologic studies are needed to identify, implement, and evaluate preventive strategies that are likely to succeed within the specific context of LAC... - Endothelial NO synthase genotype and risk of preeclampsia: a multicenter case-control studyNorma C Serrano
Genetics and Human Biology Laboratory, Department of Medicine at Universidad Autónoma de Bucaramanga, Colombia, Campus el Bosque, Calle 157 No 19 55 Cañaveral Parque, Colombia
Hypertension 44:702-7. 2004..11 [95% CI, 1.33 to 3.34]) compared with carriers of the "Glu298-786T-4b" haplotype. The eNOS Glu298Asp polymorphism and the Asp298-786C-4b haplotype are risk factors for preeclampsia... - C-reactive protein (+1444C>T) polymorphism influences CRP response following a moderate inflammatory stimulusFrancesco D'Aiuto
Department of Periodontology and Eastman Clinical Investigation Center, Eastman Dental Institute and Hospital, 256 Gray s Inn Road, University College London UCL, London WC1X 8LD, UK
Atherosclerosis 179:413-7. 2005..00 mg/L). This effect was independent of conventional cardiovascular risk factors and inflammatory factors known to affect CRP concentrations. CRP genotype may need to be considered when CRP values are used in coronary risk prediction... - UCHL-1 is not a Parkinson's disease susceptibility geneDaniel G Healy
Department of Molecular Neuroscience, Institute of Neurology, University College London, London, United Kingdom
Ann Neurol 59:627-33. 2006..The strongest evidence comes from a meta-analysis of small studies that reported the S18Y polymorphism as protective against PD, after pooling studies of white and Asian subjects. Here, we present data that challenge this association... - Linking observational and genetic approaches to determine the role of C-reactive protein in heart disease riskAroon D Hingorani
Eur Heart J 27:1261-3. 2006 - Angiotensin-converting enzyme I/D polymorphism and preeclampsia risk: evidence of small-study biasNorma C Serrano
Universidad Autonoma de Bucaramanga, Bucaramanga, Colombia
PLoS Med 3:e520. 2006..However, previous studies of the ACE-I/D variant and preeclampsia have been individually underpowered to detect plausible genotypic risks... - Genetics of ischaemic stroke among persons of non-European descent: a meta-analysis of eight genes involving approximately 32,500 individualsRoshan Ariyaratnam
Imperial College Cerebrovascular Research Unit ICCRU, Department of Clinical Neuroscience, Hammersmith Hospitals and Imperial College, London
PLoS Med 4:e131. 2007..Whether ethnicity itself has a relevant or substantial contribution on those effect estimates is controversial. Comparative analyses between the ethnic groups may allow general conclusions to be drawn about polygenic disorders... - The role of infection in cardiovascular disease: more support but many questions remainLiam Smeeth
Eur Heart J 28:1178-9. 2007 - Using waist circumference as a screening tool to identify Colombian subjects at cardiovascular riskMaritza Perez
Universidad Militar Nueva Granada, Colombia
Eur J Cardiovasc Prev Rehabil 10:328-35. 2003....