Juan P Casas

Summary

Affiliation: London School of Hygiene and Tropical Medicine
Country: UK

Publications

  1. pmc Area-level deprivation and overall and cause-specific mortality: 12 years' observation on British women and systematic review of prospective studies
    Maria T Sánchez-Santos
    Department of Surgery, Medical and Social Sciences, Faculty of Medicine, University of Alcala, Madrid, Spain Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Headington, Oxford, United Kingdom
    PLoS ONE 8:e72656. 2013
  2. pmc Frequency of eNOS polymorphisms in the Colombian general population
    Norma C Serrano
    Biomedical Research Centre, Universidad Autonoma de Bucaramanga, Colombia
    BMC Genet 11:54. 2010
  3. doi request reprint Commentary: Social class, C-reactive protein and coronary heart disease
    Juan P Casas
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, UK
    Int J Epidemiol 37:299-300. 2008
  4. pmc PLA2G7 genotype, lipoprotein-associated phospholipase A2 activity, and coronary heart disease risk in 10 494 cases and 15 624 controls of European Ancestry
    Juan P Casas
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, UK
    Circulation 121:2284-93. 2010
  5. ncbi request reprint Effect of inhibitors of the renin-angiotensin system and other antihypertensive drugs on renal outcomes: systematic review and meta-analysis
    Juan P Casas
    Centre for Clinical Pharmacology, Department of Medicine, BHF Laboratories at University College London, London, UK
    Lancet 366:2026-33. 2005
  6. ncbi request reprint Effect of changes in moderate or vigorous physical activity on changes in health-related quality of life of elderly British women over seven years
    Minkyoung Choi
    Department of Non communicable Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Qual Life Res 22:2011-20. 2013
  7. pmc Inflammation, insulin resistance, and diabetes--Mendelian randomization using CRP haplotypes points upstream
    Eric J Brunner
    Department of Epidemiology and Public Health, Royal Free and University College London Medical School, London, United Kingdom
    PLoS Med 5:e155. 2008
  8. ncbi request reprint Predictors of patterns of change in health-related quality of life in older women over 7 years: evidence from a prospective cohort study
    Caroline E Dale
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Age Ageing 42:312-8. 2013
  9. doi request reprint Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers
    Tina Shah
    Genetic Epidemiology Group, Research Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, London WC1E 6BT, United Kingdom
    Circ Cardiovasc Genet 6:163-70. 2013
  10. pmc Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms
    Reecha Sofat
    Centre for Clinical Pharmacology, Department of Medicine, University College London, London, United Kingdom
    Circulation 121:52-62. 2010

Detail Information

Publications55

  1. pmc Area-level deprivation and overall and cause-specific mortality: 12 years' observation on British women and systematic review of prospective studies
    Maria T Sánchez-Santos
    Department of Surgery, Medical and Social Sciences, Faculty of Medicine, University of Alcala, Madrid, Spain Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Headington, Oxford, United Kingdom
    PLoS ONE 8:e72656. 2013
    ..We investigate the association of area deprivation, using Index of Multiple deprivation (IMD), with overall and cause-specific mortality, contextualising findings within a systematic review...
  2. pmc Frequency of eNOS polymorphisms in the Colombian general population
    Norma C Serrano
    Biomedical Research Centre, Universidad Autonoma de Bucaramanga, Colombia
    BMC Genet 11:54. 2010
    ..The objective of the present study was to determine the presence of G894T (rs1799983), intron-4 (27-bp TR) and -T786C (rs2070744) polymorphisms in the eNOS gene among the Colombian general population...
  3. doi request reprint Commentary: Social class, C-reactive protein and coronary heart disease
    Juan P Casas
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, UK
    Int J Epidemiol 37:299-300. 2008
  4. pmc PLA2G7 genotype, lipoprotein-associated phospholipase A2 activity, and coronary heart disease risk in 10 494 cases and 15 624 controls of European Ancestry
    Juan P Casas
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, UK
    Circulation 121:2284-93. 2010
    ..PLA2G7 variants associated with Lp-PLA2 activity could evaluate whether this relationship is causal...
  5. ncbi request reprint Effect of inhibitors of the renin-angiotensin system and other antihypertensive drugs on renal outcomes: systematic review and meta-analysis
    Juan P Casas
    Centre for Clinical Pharmacology, Department of Medicine, BHF Laboratories at University College London, London, UK
    Lancet 366:2026-33. 2005
    ..Guidelines specify that these are the drugs of choice for the treatment of hypertension in patients with renal disease. We sought to determine to what extent this consensus is supported by the available evidence...
  6. ncbi request reprint Effect of changes in moderate or vigorous physical activity on changes in health-related quality of life of elderly British women over seven years
    Minkyoung Choi
    Department of Non communicable Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Qual Life Res 22:2011-20. 2013
    ..This study investigates the effect of changes in moderate or vigorous physical activity (MVPA) on trajectories in health-related quality of life (HR-QoL) over 7 years in British elderly women...
  7. pmc Inflammation, insulin resistance, and diabetes--Mendelian randomization using CRP haplotypes points upstream
    Eric J Brunner
    Department of Epidemiology and Public Health, Royal Free and University College London Medical School, London, United Kingdom
    PLoS Med 5:e155. 2008
    ..Our objective was to examine the nature of the association between CRP phenotype and diabetes development using CRP haplotypes as instrumental variables...
  8. ncbi request reprint Predictors of patterns of change in health-related quality of life in older women over 7 years: evidence from a prospective cohort study
    Caroline E Dale
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Age Ageing 42:312-8. 2013
    ..This study aims to identify patterns of change in HR-QoL over 7 years and their determinants using data from the British Women's Heart and Health Study, a representative sample of older women (n = 4286)...
  9. doi request reprint Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers
    Tina Shah
    Genetic Epidemiology Group, Research Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, London WC1E 6BT, United Kingdom
    Circ Cardiovasc Genet 6:163-70. 2013
    ..Genetic variants associated with IL-6 provide important tools for probing the causal relevance of IL-6 signaling in a range of cardiometabolic diseases...
  10. pmc Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms
    Reecha Sofat
    Centre for Clinical Pharmacology, Department of Medicine, University College London, London, United Kingdom
    Circulation 121:52-62. 2010
    ..We hypothesized that common single-nucleotide polymorphisms in the CETP gene could help distinguish mechanism-based from off-target actions of CETP inhibitors to inform on the validity of CETP as a therapeutic target...
  11. pmc Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk
    Fotios Drenos
    Division of Cardiovascular Genetics, Department of Medicine, Royal Free and University College Medical School, 5 University St, London WC1E 6JF, UK
    Hum Mol Genet 18:2305-16. 2009
    ..Broader and deeper integrated analyses, linking genomic with transcriptomic, proteomic and metabolomic analysis, as well as clinical events could, in principle, better delineate CHD causing pathways amenable to treatment...
  12. ncbi request reprint Endothelial nitric oxide synthase gene polymorphisms and cardiovascular disease: a HuGE review
    Juan P Casas
    Centre for Clinical Pharmacology, Department of Medicine, British Heart Foundation Laboratories at University College London, London, United Kingdom
    Am J Epidemiol 164:921-35. 2006
    ..The need for large-scale genetic association studies using tagging polymorphisms is warranted to confirm or refute a role of the NOS3 gene in coronary heart disease...
  13. ncbi request reprint Insight into the nature of the CRP-coronary event association using Mendelian randomization
    Juan P Casas
    Centre for Clinical Pharmacology, Department of Medicine, BHF Laboratories at University College London, UCL, London, UK
    Int J Epidemiol 35:922-31. 2006
    ..Since the distribution of this polymorphism occurs at random during gamete formation, its association with coronary events should not be biased or confounded...
  14. doi request reprint Inflammation, coagulation and risk of locomotor disability in elderly women: findings from the British Women's Heart and Health Study
    Eveline Nüesch
    London School of Hygiene and Tropical Medicine, London, UK
    Eur J Epidemiol 27:633-45. 2012
    ..These results support the role of inflammation and coagulation in the development of locomotor disability in elderly women irrespective of their lifestyle factors and underlying age-related chronic diseases...
  15. pmc Multilocus Bayesian meta-analysis of gene-disease associations
    Paul J Newcombe
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, WC1E 7HT London, UK
    Am J Hum Genet 84:567-80. 2009
    ..We present results from application of our approach to data on a possible association between PDE4D and ischemic stroke...
  16. ncbi request reprint Homocysteine and stroke: evidence on a causal link from mendelian randomisation
    Juan P Casas
    Centre for Clinical Pharmacology, Department of Medicine, British Heart Foundation Laboratories, Royal Free and University College Medical School, University College London, Rayne Building, 5 University Street, London WC1E 6 JJ, UK
    Lancet 365:224-32. 2005
    ....
  17. pmc Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals
    Tauseef A Khan
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Int J Epidemiol 42:475-92. 2013
    ..We evaluated the association of APOE genotype with risk of ischaemic stroke and assessed whether the observed effect was consistent with the effects of APOE genotype on LDL-C or other lipids and biomarkers of cardiovascular risk...
  18. pmc Bayesian meta-analysis of genetic association studies with different sets of markers
    Claudio Verzilli
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Am J Hum Genet 82:859-72. 2008
    ..The same method could be applied to evidence synthesis of other quantitative traits, whenever the typed SNPs vary among studies, and to assist fine mapping of causal variants...
  19. doi request reprint Genetic variation in complement factor H and risk of coronary heart disease: eight new studies and a meta-analysis of around 48,000 individuals
    Reecha Sofat
    Centre for Clinical Pharmacology, Division of Medicine, University College London, Rayne Building, 5 University Street, London WC1E 6JF, UK
    Atherosclerosis 213:184-90. 2010
    ..To investigate the association of polymorphisms in complement factor H (CFH) and coronary heart disease (CHD) using meta-analysis...
  20. pmc Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials
    Michael V Holmes
    Research Department of Epidemiology and Public Health, University College London, London, UK
    Lancet 378:584-94. 2011
    ..We aimed to reduce the effect of small-study bias and investigate whether folate status modifies the association between MTHFR 677C→T and stroke in a genetic analysis and meta-analysis of randomised controlled trials...
  21. doi request reprint CYP2C19 genotype, clopidogrel metabolism, platelet function, and cardiovascular events: a systematic review and meta-analysis
    Michael V Holmes
    Genetic Epidemiology Group, Department of Epidemiology and Public Health, University College London, 1 19 Torrington Pl, London, WC1E 6BT, United Kingdom
    JAMA 306:2704-14. 2011
    ....
  22. pmc Does high C-reactive protein concentration increase atherosclerosis? The Whitehall II Study
    Mika Kivimaki
    Department of Epidemiology and Public Health, University College London, London, United Kingdom
    PLoS ONE 3:e3013. 2008
    ....
  23. pmc Causal effects of body mass index on cardiometabolic traits and events: a Mendelian randomization analysis
    Michael V Holmes
    Division of Transplantation, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA Genetic Epidemiology Group, Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, 1 19 Torrington Place, London WC1E 6BT, UK Electronic address
    Am J Hum Genet 94:198-208. 2014
    ..04 (95% CI = 0.97-1.12) per 1 kg/m(2) increase in BMI. In conclusion, we identified causal effects of BMI on several cardiometabolic traits; however, whether BMI causally impacts CHD risk requires further evidence...
  24. pmc Critical appraisal of CRP measurement for the prediction of coronary heart disease events: new data and systematic review of 31 prospective cohorts
    Tina Shah
    Centre for Clinical Pharmacology, University College London, London, UK
    Int J Epidemiol 38:217-31. 2009
    ..Non-uniform reporting of relevant relationships and metrics hampers critical appraisal of the clinical utility of C-reactive protein (CRP) measurement for prediction of later coronary events...
  25. pmc Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration
    Aspasia Angelakopoulou
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Eur Heart J 33:393-407. 2012
    ....
  26. pmc Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke
    Celine Bellenguez
    Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Nat Genet 44:328-33. 2012
    ..28-1.57). All four loci exhibited evidence for heterogeneity of effect across the stroke subtypes, with some and possibly all affecting risk for only one subtype. This suggests distinct genetic architectures for different stroke subtypes...
  27. pmc Secretory phospholipase A(2)-IIA and cardiovascular disease: a mendelian randomization study
    Michael V Holmes
    Faculty of Population Health Sciences, University College London, London, United Kingdom Electronic address
    J Am Coll Cardiol 62:1966-76. 2013
    ..This study sought to investigate the role of secretory phospholipase A2 (sPLA2)-IIA in cardiovascular disease...
  28. pmc Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus
    Zhan Su
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Nat Genet 44:1131-6. 2012
    ..We found evidence that many common variants of small effect contribute to genetic susceptibility to Barrett's esophagus and that SNP alleles predisposing to obesity also increase risk for Barrett's esophagus...
  29. pmc Complement factor H genetic variant and age-related macular degeneration: effect size, modifiers and relationship to disease subtype
    Reecha Sofat
    Centre for Clinical Pharmacology, Department of Medicine, University College London, London, UK
    Int J Epidemiol 41:250-62. 2012
    ..Previous studies have been case-control studies in populations of European ancestry with little differentiation in AMD subtype, and insufficient power to confirm or refute effect modification by smoking...
  30. ncbi request reprint C-reactive protein and coronary heart disease: predictive test or therapeutic target?
    Aroon D Hingorani
    Division of Population Sciences, Department of Epidemiology and Public Health, University College London, London, UK
    Clin Chem 55:239-55. 2009
    ..The research has encompassed observational and genetic epidemiology, basic science studies with cells and tissues, experiments with animal models and humans, and randomized trials (although not of specific CRP-lowering therapies as yet)...
  31. pmc Population genomics of cardiometabolic traits: design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium
    Tina Shah
    Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, London, United Kingdom
    PLoS ONE 8:e71345. 2013
    ....
  32. ncbi request reprint Biomarkers of inflammation predict both vascular and non-vascular mortality in older men
    Robert Clarke
    Clinical Trial Service Unit and Epidemiological Studies Unit, Richard Doll Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7LF, UK
    Eur Heart J 29:800-9. 2008
    ..To compare the predictive value of inflammatory biomarkers and lipids for vascular and non-vascular mortality in older men...
  33. doi request reprint Modelling the association of disability according to the WHO International Classification of Functioning, Disability and Health (ICF) with mortality in the British Women's Heart and Health Study
    Caroline Dale
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, UK
    J Epidemiol Community Health 66:170-5. 2012
    ..This paper investigates the association of the different ICF disability domains with mortality...
  34. ncbi request reprint Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls
    Juan P Casas
    Centre for Clinical Pharmacology, British Heart Foundation Laboratories at University College London, London, England
    Arch Neurol 61:1652-61. 2004
    ..These findings have important implications for the design of future genetic studies and for predictive genetic testing for stroke and other multifactorial diseases...
  35. ncbi request reprint UCHL-1 is not a Parkinson's disease susceptibility gene
    Daniel G Healy
    Department of Molecular Neuroscience, Institute of Neurology, University College London, London, United Kingdom
    Ann Neurol 59:627-33. 2006
    ..The strongest evidence comes from a meta-analysis of small studies that reported the S18Y polymorphism as protective against PD, after pooling studies of white and Asian subjects. Here, we present data that challenge this association...
  36. ncbi request reprint Investigating the genetic determinants of cardiovascular disease using candidate genes and meta-analysis of association studies
    Juan P Casas
    Centre for Clinical Pharmacology, Department of Medicine, BHF Laboratories at UCL, University College London, London, UK
    Ann Hum Genet 70:145-69. 2006
    ..This review lays out the framework for the candidate gene approach for CAD and illustrates this with published results from a UK prospective study of 3000 middle-aged men...
  37. ncbi request reprint Alcohol consumption and cognitive performance: a Mendelian randomization study
    Meena Kumari
    Department of Epidemiology and Public Health, University College London, London, UK ISER, University of Essex, Colchester, UK
    Addiction 109:1462-71. 2014
    ..To use Mendelian randomization to assess whether alcohol intake was causally associated with cognitive function...
  38. doi request reprint Ancestry as a determinant of mean population C-reactive protein values: implications for cardiovascular risk prediction
    Tina Shah
    Centre for Clinical Pharmacology, University College London, United Kingdom
    Circ Cardiovasc Genet 3:436-44. 2010
    ..Most observational studies of CRP and cardiovascular disease have been in Europeans. We evaluated the influence of ancestry on population CRP concentration to assess the implications for statin targeting in non-Europeans...
  39. pmc Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies
    Michael V Holmes
    Centre for Clinical Pharmacology, University College London, London, United Kingdom
    PLoS ONE 4:e7960. 2009
    ..Studies of the genetic basis of drug response could help clarify mechanisms of drug action/metabolism, and facilitate development of genotype-based predictive tests of efficacy or toxicity (pharmacogenetics)...
  40. ncbi request reprint Endothelial nitric oxide synthase genotype and ischemic heart disease: meta-analysis of 26 studies involving 23028 subjects
    Juan P Casas
    Centre for Clinical Pharmacology, BHF Laboratories at UCL, London, UK
    Circulation 109:1359-65. 2004
    ..To evaluate the role of polymorphisms in the eNOS gene in IHD, we considered all available studies in a meta-analysis...
  41. doi request reprint Genetic association studies in pre-eclampsia: systematic meta-analyses and field synopsis
    Eleonora Staines-Urias
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, UK
    Int J Epidemiol 41:1764-75. 2012
    ..Pre-eclampsia is thought to have a polygenic basis, but the identification of susceptibility genes and the quantification of associated risks have been elusive owing to lack of replication from published genetic association studies...
  42. ncbi request reprint (6R)-5,6,7,8-tetrahydro-L-biopterin and its stereoisomer prevent ischemia reperfusion injury in human forearm
    Lila Mayahi
    Centre for Clinical Pharmacology, BHF Laboratories, Department of Medicine, UCL, 5 University Street, London, UK, WC1E 6JJ
    Arterioscler Thromb Vasc Biol 27:1334-9. 2007
    ..6R-BH4 corrects ED in animal models of ischemia reperfusion injury (IRI) and in patients with cardiovascular risks. It is uncertain whether the effect of exogenous 6R-BH4 on ED is through its cofactor or antioxidant action...
  43. pmc A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1
    Amy Strange
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Nat Genet 42:985-90. 2010
    ..Our findings implicate pathways that integrate epidermal barrier dysfunction with innate and adaptive immune dysregulation in psoriasis pathogenesis...
  44. pmc Unintended effects of statins from observational studies in the general population: systematic review and meta-analysis
    Ana Filipa Macedo
    Cochrane Heart Group, London School of Hygiene and Tropical Medicine, London, UK
    BMC Med 12:51. 2014
    ..We aimed to systematically assess unintended effects of statins from observational studies in general populations with comparison of the findings where possible with those derived from randomized trials...
  45. pmc Tackling non-communicable diseases in low- and middle-income countries: is the evidence from high-income countries all we need?
    Shah Ebrahim
    London School of Hygiene and Tropical Medicine, London, United Kingdom South Asia Network for Chronic Disease, Public Health Foundation of India, New Delhi, India
    PLoS Med 10:e1001377. 2013
    ....
  46. pmc Interleukin-6 receptor pathways in abdominal aortic aneurysm
    Seamus C Harrison
    Department of Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, Rayne Building, University Street, London WC1E 6JJ, UK
    Eur Heart J 34:3707-16. 2013
    ..Interleukin-6 (IL-6) signalling through its receptor (IL-6R) is one pathway that could be exploited pharmacologically. We investigated this using a Mendelian randomization approach...
  47. pmc Noncommunicable diseases and injuries in Latin America and the Caribbean: time for action
    Pablo Perel
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Med 3:e344. 2006
  48. pmc Angiotensin-converting enzyme I/D polymorphism and preeclampsia risk: evidence of small-study bias
    Norma C Serrano
    Universidad Autonoma de Bucaramanga, Bucaramanga, Colombia
    PLoS Med 3:e520. 2006
    ..However, previous studies of the ACE-I/D variant and preeclampsia have been individually underpowered to detect plausible genotypic risks...
  49. ncbi request reprint Linking observational and genetic approaches to determine the role of C-reactive protein in heart disease risk
    Aroon D Hingorani
    Eur Heart J 27:1261-3. 2006
  50. ncbi request reprint C-reactive protein (+1444C>T) polymorphism influences CRP response following a moderate inflammatory stimulus
    Francesco D'Aiuto
    Department of Periodontology and Eastman Clinical Investigation Center, Eastman Dental Institute and Hospital, 256 Gray s Inn Road, University College London UCL, London WC1X 8LD, UK
    Atherosclerosis 179:413-7. 2005
    ..00 mg/L). This effect was independent of conventional cardiovascular risk factors and inflammatory factors known to affect CRP concentrations. CRP genotype may need to be considered when CRP values are used in coronary risk prediction...
  51. ncbi request reprint Endothelial NO synthase genotype and risk of preeclampsia: a multicenter case-control study
    Norma C Serrano
    Genetics and Human Biology Laboratory, Department of Medicine at Universidad Autónoma de Bucaramanga, Colombia, Campus el Bosque, Calle 157 No 19 55 Cañaveral Parque, Colombia
    Hypertension 44:702-7. 2004
    ..11 [95% CI, 1.33 to 3.34]) compared with carriers of the "Glu298-786T-4b" haplotype. The eNOS Glu298Asp polymorphism and the Asp298-786C-4b haplotype are risk factors for preeclampsia...
  52. pmc Genetics of ischaemic stroke among persons of non-European descent: a meta-analysis of eight genes involving approximately 32,500 individuals
    Roshan Ariyaratnam
    Imperial College Cerebrovascular Research Unit ICCRU, Department of Clinical Neuroscience, Hammersmith Hospitals and Imperial College, London
    PLoS Med 4:e131. 2007
    ..Whether ethnicity itself has a relevant or substantial contribution on those effect estimates is controversial. Comparative analyses between the ethnic groups may allow general conclusions to be drawn about polygenic disorders...
  53. ncbi request reprint Congestive heart failure in Latin America: the next epidemic
    Luz A Cubillos-Garzón
    Heart Failure Council, Colombian Society of Cardiology, Bogota, Colombia
    Am Heart J 147:412-7. 2004
    ..Properly conducted clinical and epidemiologic studies are needed to identify, implement, and evaluate preventive strategies that are likely to succeed within the specific context of LAC...
  54. ncbi request reprint The role of infection in cardiovascular disease: more support but many questions remain
    Liam Smeeth
    Eur Heart J 28:1178-9. 2007
  55. ncbi request reprint Using waist circumference as a screening tool to identify Colombian subjects at cardiovascular risk
    Maritza Perez
    Universidad Militar Nueva Granada, Colombia
    Eur J Cardiovasc Prev Rehabil 10:328-35. 2003
    ..The present study evaluated a group of Colombian subjects to determine and evaluate the level of WC capable of identifying subjects with CVRF...