Matthew J Burton

Summary

Affiliation: London School of Hygiene and Tropical Medicine
Country: UK

Publications

  1. ncbi request reprint The long-term natural history of trachomatous trichiasis in the Gambia
    Matthew J Burton
    International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 47:847-52. 2006
  2. pmc Trichiasis surgery in The Gambia: a 4-year prospective study
    Saul N Rajak
    London School of Hygiene and Tropical Medicine, London, UK
    Invest Ophthalmol Vis Sci 51:4996-5001. 2010
  3. pmc Conjunctival expression of matrix metalloproteinase and proinflammatory cytokine genes after trichiasis surgery
    Matthew J Burton
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 51:3583-90. 2010
  4. ncbi request reprint Which members of a community need antibiotics to control trachoma? Conjunctival Chlamydia trachomatis infection load in Gambian villages
    Matthew J Burton
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 44:4215-22. 2003
  5. pmc What is causing active trachoma? The role of nonchlamydial bacterial pathogens in a low prevalence setting
    Matthew J Burton
    Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 52:6012-7. 2011
  6. ncbi request reprint Re-emergence of Chlamydia trachomatis infection after mass antibiotic treatment of a trachoma-endemic Gambian community: a longitudinal study
    Matthew J Burton
    London School of Hygiene and Tropical Medicine, London, UK
    Lancet 365:1321-8. 2005
  7. pmc In vivo confocal microscopy and histopathology of the conjunctiva in trachomatous scarring and normal tissue: a systematic comparison
    Victor H Hu
    Faculty of Infectious and Tropical Diseases, International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, UK
    Br J Ophthalmol 97:1333-7. 2013
  8. pmc Surgery versus epilation for the treatment of minor trichiasis in Ethiopia: a randomised controlled noninferiority trial
    Saul N Rajak
    The London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Med 8:e1001136. 2011
  9. pmc Epilation for trachomatous trichiasis and the risk of corneal opacification
    Saul N Rajak
    The London School of Hygiene and Tropical Medicine, London, United Kingdom
    Ophthalmology 119:84-9. 2012
  10. ncbi request reprint Bacterial infection and trachoma in the gambia: a case control study
    Matthew J Burton
    International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 48:4440-4. 2007

Collaborators

Detail Information

Publications42

  1. ncbi request reprint The long-term natural history of trachomatous trichiasis in the Gambia
    Matthew J Burton
    International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 47:847-52. 2006
    ..Trachoma is the leading infectious cause of blindness. However, there are few data on the natural history of trachomatous trichiasis to guide program planning or that investigate its pathogenesis...
  2. pmc Trichiasis surgery in The Gambia: a 4-year prospective study
    Saul N Rajak
    London School of Hygiene and Tropical Medicine, London, UK
    Invest Ophthalmol Vis Sci 51:4996-5001. 2010
    ..Although trichiasis surgery can reduce the risk of blindness, retrospective data suggest that long-term recurrence rates may be high. A 4-year prospective investigation of recurrent trichiasis was conducted in The Gambia...
  3. pmc Conjunctival expression of matrix metalloproteinase and proinflammatory cytokine genes after trichiasis surgery
    Matthew J Burton
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 51:3583-90. 2010
    ..Prospective studies are needed to assess the potential importance of these and other factors in progressive disease...
  4. ncbi request reprint Which members of a community need antibiotics to control trachoma? Conjunctival Chlamydia trachomatis infection load in Gambian villages
    Matthew J Burton
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 44:4215-22. 2003
    ....
  5. pmc What is causing active trachoma? The role of nonchlamydial bacterial pathogens in a low prevalence setting
    Matthew J Burton
    Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 52:6012-7. 2011
    ..This study investigated the relationship between TF, C. trachomatis, and nonchlamydial bacterial infection...
  6. ncbi request reprint Re-emergence of Chlamydia trachomatis infection after mass antibiotic treatment of a trachoma-endemic Gambian community: a longitudinal study
    Matthew J Burton
    London School of Hygiene and Tropical Medicine, London, UK
    Lancet 365:1321-8. 2005
    ..We measured the effect of mass treatment on the conjunctival burden of Chlamydia trachomatis in a Gambian community with low to medium trachoma prevalence and investigated the rate, route, and determinants of re-emergent infection...
  7. pmc In vivo confocal microscopy and histopathology of the conjunctiva in trachomatous scarring and normal tissue: a systematic comparison
    Victor H Hu
    Faculty of Infectious and Tropical Diseases, International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, UK
    Br J Ophthalmol 97:1333-7. 2013
    ..To compare in vivo confocal microscopy (IVCM) with the histopathological examination of tissue and cellular changes in normal and diseased conjunctiva...
  8. pmc Surgery versus epilation for the treatment of minor trichiasis in Ethiopia: a randomised controlled noninferiority trial
    Saul N Rajak
    The London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Med 8:e1001136. 2011
    ..This trial investigated whether epilation is noninferior to surgery for managing minor trichiasis...
  9. pmc Epilation for trachomatous trichiasis and the risk of corneal opacification
    Saul N Rajak
    The London School of Hygiene and Tropical Medicine, London, United Kingdom
    Ophthalmology 119:84-9. 2012
    ..However, epilation is widely practiced for treating minor TT (1-5 lashes touching the globe). We report the frequency and effectiveness of patient-initiated epilation and its relationship to corneal opacity...
  10. ncbi request reprint Bacterial infection and trachoma in the gambia: a case control study
    Matthew J Burton
    International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 48:4440-4. 2007
    ..This study was undertaken to investigate whether trachomatous trichiasis or conjunctival scarring are associated with increased prevalence of bacterial infection...
  11. pmc Innate immune responses and modified extracellular matrix regulation characterize bacterial infection and cellular/connective tissue changes in scarring trachoma
    Victor H Hu
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, United Kingdom
    Infect Immun 80:121-30. 2012
    ..This study supports the possibility that the immunofibrogenic response in scarring trachoma is partly stimulated by nonchlamydial bacterial infection, which is characterized by the expression of innate factors...
  12. pmc Absorbable versus silk sutures for surgical treatment of trachomatous trichiasis in Ethiopia: a randomised controlled trial
    Saul N Rajak
    The London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Med 8:e1001137. 2011
    ..Trichiasis can recur after corrective surgery. We tested the hypothesis that using absorbable sutures instead of silk sutures might reduce the risk of recurrent disease among patients with major trichiasis in a randomised trial...
  13. pmc Targeting antibiotics to households for trachoma control
    Isobel M Blake
    Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
    PLoS Negl Trop Dis 4:e862. 2010
    ..Here we explore whether alternative, targeted approaches are effective antibiotic-sparing strategies...
  14. pmc The outcome of trachomatous trichiasis surgery in Ethiopia: risk factors for recurrence
    Saul N Rajak
    The London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Negl Trop Dis 7:e2392. 2013
    ..We investigated the outcomes (recurrence rates and other complications) of posterior lamellar tarsal rotation (PLTR) surgery, one of the two most widely practised TT procedures in endemic settings...
  15. pmc The development of an age-structured model for trachoma transmission dynamics, pathogenesis and control
    Manoj Gambhir
    Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
    PLoS Negl Trop Dis 3:e462. 2009
    ..We present an age-structured mathematical model of trachoma transmission and disease to predict the impact of interventions on the prevalence of blinding trachoma...
  16. pmc Conjunctival MicroRNA expression in inflammatory trachomatous scarring
    Tamsyn Derrick
    Department of Clinical Research, Faculty of Infectious Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Negl Trop Dis 7:e2117. 2013
    ..We have investigated host microRNA (miR) expression in health (N) and disease (conjunctival scarring with (TSI) and without (TS) inflammation) to determine if these epigenetic differences are associated with pathology...
  17. ncbi request reprint Conjunctival chlamydial 16S ribosomal RNA expression in trachoma: is chlamydial metabolic activity required for disease to develop?
    Matthew J Burton
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    Clin Infect Dis 42:463-70. 2006
    ..We measured chlamydial 16S ribosomal RNA (rRNA) expression, a marker of chlamydial metabolic activity, in comparison with the quantitation of a chlamydial DNA target in subjects exposed to trachoma...
  18. pmc Human conjunctival transcriptome analysis reveals the prominence of innate defense in Chlamydia trachomatis infection
    Angels Natividad
    Department of Clinical Research, London School of Hygiene and Tropical Medicine, University of London, London, United Kingdom
    Infect Immun 78:4895-911. 2010
    ..The data suggest that in addition to polymorph and adaptive cellular responses, NK cells may contribute to a significant component of the conjunctival inflammatory response to chlamydial infection...
  19. pmc The clinical phenotype of trachomatous trichiasis in Ethiopia: not all trichiasis is due to entropion
    Saul N Rajak
    The London School of Hygiene and Tropical Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 52:7974-80. 2011
    ..This variation in clinical phenotype is potentially important for treatment guidelines. Therefore, this study was conducted to investigate the range of disease type and severity encompassed by TT...
  20. pmc Post-operative recurrent trachomatous trichiasis is associated with increased conjunctival expression of S100A7 (psoriasin)
    Matthew J Burton
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Negl Trop Dis 6:e1985. 2012
    ..In this study we investigated the relationship between recurrent trichiasis and the expression of various cytokines and fibrogenic genes during a two-year follow-up period...
  21. pmc Why do people not attend for treatment for trachomatous trichiasis in Ethiopia? A study of barriers to surgery
    Saul N Rajak
    The London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Negl Trop Dis 6:e1766. 2012
    ..However, only 18-66% of TT patients attend for surgery. This study analyses barriers to attendance among TT patients in Ethiopia, the country with the highest prevalence of TT in the world...
  22. pmc Active trachoma is associated with increased conjunctival expression of IL17A and profibrotic cytokines
    Matthew J Burton
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    Infect Immun 79:4977-83. 2011
    ..Its activity may be promoted either as part of the cell-mediated response or through innate pathways. It may drive a range of proinflammatory factors leading to excessive tissue damage and repair involving fibrosis...
  23. pmc Pathway-focused arrays reveal increased matrix metalloproteinase-7 (matrilysin) transcription in trachomatous trichiasis
    Martin J Holland
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Invest Ophthalmol Vis Sci 51:3893-902. 2010
    ..The purpose was to identify genes that are differentially expressed in the upper tarsal conjunctiva of subjects with TT...
  24. pmc In vivo confocal microscopy in scarring trachoma
    Victor H Hu
    International Centre for Eye Health, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Ophthalmology 118:2138-46. 2011
    ..To characterize the tissue and cellular changes found in trachomatous scarring (TS) and inflammation using in vivo confocal microscopy (IVCM)...
  25. pmc Chlamydia trachomatis ompA variants in trachoma: what do they tell us?
    Aura A Andreasen
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Negl Trop Dis 2:e306. 2008
    ..Sequence-based analysis of the multiple strains typically present in endemic communities may be informative for epidemiology, transmission, response to treatment, and understanding the host response...
  26. pmc Bacterial infection in scarring trachoma
    Victor H Hu
    International Centre for Eye Health, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Invest Ophthalmol Vis Sci 52:2181-6. 2011
    ..To assess whether non-chlamydial bacterial infection is associated with trachomatous scarring in adults...
  27. pmc Conjunctival scarring in trachoma is associated with the HLA-C ligand of KIR and is exacerbated by heterozygosity at KIR2DL2/KIR2DL3
    Chrissy H Roberts
    Clinical Research Department, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Negl Trop Dis 8:e2744. 2014
    ..Certain genetic constellations of KIR and HLA class I polymorphisms are associated with a number of diseases in which modulation of the innate responses to viral and intracellular bacterial pathogens is central...
  28. ncbi request reprint Strategies for control of trachoma: observational study with quantitative PCR
    Anthony W Solomon
    London School of Hygiene and Tropical Medicine, WC1E 7HT, London, UK
    Lancet 362:198-204. 2003
    ..At present, who needs to be treated is unclear. We aimed to establish the burden of ocular Chlamydia trachomatis in three trachoma-endemic communities in Tanzania and The Gambia with real-time quantitative PCR...
  29. pmc Trachomatous trichiasis and its management in endemic countries
    Saul N Rajak
    International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, UK
    Surv Ophthalmol 57:105-35. 2012
    ..We examine the principles of clinical management, treatment options, and the challenging issues of providing the quantity and quality of surgery that is needed in resource-poor settings...
  30. pmc Trachoma: protective and pathogenic ocular immune responses to Chlamydia trachomatis
    Victor H Hu
    Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Negl Trop Dis 7:e2020. 2013
    ..A trachoma vaccine would offer significant advantages. However, limited understanding of the mechanisms of both protective immunity and immunopathology to Ct remain barriers to vaccine development...
  31. pmc In vivo confocal microscopy of trachoma in relation to normal tarsal conjunctiva
    Victor H Hu
    International Centre for Eye Health, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Ophthalmology 118:747-54. 2011
    ....
  32. pmc A coding polymorphism in matrix metalloproteinase 9 reduces risk of scarring sequelae of ocular Chlamydia trachomatis infection
    Angels Natividad
    London School of Hygiene and Tropical Medicine, London University, London, UK
    BMC Med Genet 7:40. 2006
    ..Genetic variation within the MMP9 gene affects in vitro MMP9 expression levels, enzymatic activity and susceptibility to various inflammatory and fibrotic conditions...
  33. pmc Cytokine and fibrogenic gene expression in the conjunctivas of subjects from a Gambian community where trachoma is endemic
    Matthew J Burton
    International Centre for Eye Health, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, United Kingdom
    Infect Immun 72:7352-6. 2004
    ..Markers indicative of T-cell response (gamma interferon, IL-4, IL-12p40, and perforin) were increased when chlamydial infection was present...
  34. pmc Conjunctival transcriptome in scarring trachoma
    Matthew J Burton
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Infect Immun 79:499-511. 2011
    ....
  35. pmc Epidemiology and control of trachoma: systematic review
    Victor H Hu
    London School of Hygiene and Tropical Medicine, UK
    Trop Med Int Health 15:673-91. 2010
    ..This has been associated with significant reductions in the prevalence of active disease over the past 20 years, but there remain a large number of people with trichiasis who are at risk of blindness...
  36. pmc Clearing the backlog: trichiasis surgeon retention and productivity in northern Ethiopia
    Esmael Habtamu
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Negl Trop Dis 5:e1014. 2011
    ..Despite an extensive integrated eye care worker training programme (IECW) and robust support for TT surgical services, productivity has not reached targets. We investigated why surgeon productivity was below target...
  37. doi request reprint Trachoma: an overview
    Matthew J Burton
    International Centre for Eye Health, Department of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Br Med Bull 84:99-116. 2007
    ..Where this programme has been fully implemented, it has met with some success. However, there are significant gaps in the evidence base and optimal management remains uncertain...
  38. pmc The global burden of trachoma: a review
    Matthew J Burton
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Negl Trop Dis 3:e460. 2009
    ..3 million Disability-Adjusted Life Years (DALYs). A key issue in producing a reliable estimate of the global burden of trachoma is the limited amount of reliable survey data from endemic regions...
  39. pmc Posterior segment eye disease in sub-Saharan Africa: review of recent population-based studies
    Andrew Bastawrous
    International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, UK
    Trop Med Int Health 19:600-9. 2014
    ..To assess the burden of posterior segment eye diseases (PSEDs) in sub-Saharan Africa (SSA)...
  40. pmc Doxycycline prevents matrix remodeling and contraction by trichiasis-derived conjunctival fibroblasts
    He Li
    Department of Cell Biology, UCL Institute of Ophthalmology, London, United Kingdom
    Invest Ophthalmol Vis Sci 54:4675-82. 2013
    ..The purpose of this work was to assess the antiscarring properties of doxycycline in an in vitro model of trichiasis fibroblast-mediated tissue contraction...
  41. pmc Cataract surgery in Southern Ethiopia: distribution, rates and determinants of service provision
    Esmael Habtamu
    International Centre for Eye Health, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    BMC Health Serv Res 13:480. 2013
    ..We analyzed the distribution, productivity, cost and determinants of cataract surgery services...
  42. ncbi request reprint Chlamydial positivity of nasal discharge at baseline is associated with ocular chlamydial positivity 2 months following azithromycin treatment
    Emily West Gower
    Dana Center for Preventive Ophthalmology, 116 Wilmer Building, Johns Hopkins School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Invest Ophthalmol Vis Sci 47:4767-71. 2006
    ..Routes of transmission remain unclear. In this study, the relationship between Chlamydia trachomatis Amplicor-positive nasal discharge and Amplicor-positive ocular swabs was investigated (Amplicor; Roche, Indianapolis, IN)...