M J Burton

Summary

Affiliation: London School of Hygiene and Tropical Medicine
Country: UK

Publications

  1. pmc Post-operative recurrent trachomatous trichiasis is associated with increased conjunctival expression of S100A7 (psoriasin)
    Matthew J Burton
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Negl Trop Dis 6:e1985. 2012
  2. pmc A coding polymorphism in matrix metalloproteinase 9 reduces risk of scarring sequelae of ocular Chlamydia trachomatis infection
    Angels Natividad
    London School of Hygiene and Tropical Medicine, London University, London, UK
    BMC Med Genet 7:40. 2006
  3. pmc Innate immunity in ocular Chlamydia trachomatis infection: contribution of IL8 and CSF2 gene variants to risk of trachomatous scarring in Gambians
    Angels Natividad
    London School of Hygiene and Tropical Medicine, London University, London, UK
    BMC Med Genet 10:138. 2009
  4. pmc Microbial keratitis in East Africa: why are the outcomes so poor?
    Matthew J Burton
    Department of Ophthalmology, Kilimanjaro Christian Medical Centre, Moshi, Tanzania
    Ophthalmic Epidemiol 18:158-63. 2011
  5. pmc What is causing active trachoma? The role of nonchlamydial bacterial pathogens in a low prevalence setting
    Matthew J Burton
    Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 52:6012-7. 2011
  6. pmc Conjunctival transcriptome in scarring trachoma
    Matthew J Burton
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Infect Immun 79:499-511. 2011
  7. pmc Active trachoma is associated with increased conjunctival expression of IL17A and profibrotic cytokines
    Matthew J Burton
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    Infect Immun 79:4977-83. 2011
  8. pmc The global burden of trachoma: a review
    Matthew J Burton
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Negl Trop Dis 3:e460. 2009
  9. doi request reprint Trachoma: an overview
    Matthew J Burton
    International Centre for Eye Health, Department of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Br Med Bull 84:99-116. 2007
  10. pmc Conjunctival expression of matrix metalloproteinase and proinflammatory cytokine genes after trichiasis surgery
    Matthew J Burton
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 51:3583-90. 2010

Detail Information

Publications31

  1. pmc Post-operative recurrent trachomatous trichiasis is associated with increased conjunctival expression of S100A7 (psoriasin)
    Matthew J Burton
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Negl Trop Dis 6:e1985. 2012
    ..In this study we investigated the relationship between recurrent trichiasis and the expression of various cytokines and fibrogenic genes during a two-year follow-up period...
  2. pmc A coding polymorphism in matrix metalloproteinase 9 reduces risk of scarring sequelae of ocular Chlamydia trachomatis infection
    Angels Natividad
    London School of Hygiene and Tropical Medicine, London University, London, UK
    BMC Med Genet 7:40. 2006
    ..Genetic variation within the MMP9 gene affects in vitro MMP9 expression levels, enzymatic activity and susceptibility to various inflammatory and fibrotic conditions...
  3. pmc Innate immunity in ocular Chlamydia trachomatis infection: contribution of IL8 and CSF2 gene variants to risk of trachomatous scarring in Gambians
    Angels Natividad
    London School of Hygiene and Tropical Medicine, London University, London, UK
    BMC Med Genet 10:138. 2009
    ....
  4. pmc Microbial keratitis in East Africa: why are the outcomes so poor?
    Matthew J Burton
    Department of Ophthalmology, Kilimanjaro Christian Medical Centre, Moshi, Tanzania
    Ophthalmic Epidemiol 18:158-63. 2011
    ..This study reports the epidemiology, causative organism, management and outcome of MK in people admitted to a large referral hospital in Northern Tanzania, and explores why the outcomes are so poor for this condition...
  5. pmc What is causing active trachoma? The role of nonchlamydial bacterial pathogens in a low prevalence setting
    Matthew J Burton
    Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 52:6012-7. 2011
    ..This study investigated the relationship between TF, C. trachomatis, and nonchlamydial bacterial infection...
  6. pmc Conjunctival transcriptome in scarring trachoma
    Matthew J Burton
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Infect Immun 79:499-511. 2011
    ....
  7. pmc Active trachoma is associated with increased conjunctival expression of IL17A and profibrotic cytokines
    Matthew J Burton
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    Infect Immun 79:4977-83. 2011
    ..Its activity may be promoted either as part of the cell-mediated response or through innate pathways. It may drive a range of proinflammatory factors leading to excessive tissue damage and repair involving fibrosis...
  8. pmc The global burden of trachoma: a review
    Matthew J Burton
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Negl Trop Dis 3:e460. 2009
    ..3 million Disability-Adjusted Life Years (DALYs). A key issue in producing a reliable estimate of the global burden of trachoma is the limited amount of reliable survey data from endemic regions...
  9. doi request reprint Trachoma: an overview
    Matthew J Burton
    International Centre for Eye Health, Department of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Br Med Bull 84:99-116. 2007
    ..Where this programme has been fully implemented, it has met with some success. However, there are significant gaps in the evidence base and optimal management remains uncertain...
  10. pmc Conjunctival expression of matrix metalloproteinase and proinflammatory cytokine genes after trichiasis surgery
    Matthew J Burton
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 51:3583-90. 2010
    ..Prospective studies are needed to assess the potential importance of these and other factors in progressive disease...
  11. ncbi request reprint Conjunctival chlamydial 16S ribosomal RNA expression in trachoma: is chlamydial metabolic activity required for disease to develop?
    Matthew J Burton
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    Clin Infect Dis 42:463-70. 2006
    ..We measured chlamydial 16S ribosomal RNA (rRNA) expression, a marker of chlamydial metabolic activity, in comparison with the quantitation of a chlamydial DNA target in subjects exposed to trachoma...
  12. pmc Cytokine and fibrogenic gene expression in the conjunctivas of subjects from a Gambian community where trachoma is endemic
    Matthew J Burton
    International Centre for Eye Health, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, United Kingdom
    Infect Immun 72:7352-6. 2004
    ..Markers indicative of T-cell response (gamma interferon, IL-4, IL-12p40, and perforin) were increased when chlamydial infection was present...
  13. pmc A randomised controlled trial of azithromycin following surgery for trachomatous trichiasis in the Gambia
    M J Burton
    International Centre for Eye Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Br J Ophthalmol 89:1282-8. 2005
    ..This study investigates whether enhanced control of infection, both of Chlamydia trachomatis and other bacteria, with azithromycin can improve surgical outcome in a trachoma control programme...
  14. ncbi request reprint Which members of a community need antibiotics to control trachoma? Conjunctival Chlamydia trachomatis infection load in Gambian villages
    Matthew J Burton
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 44:4215-22. 2003
    ....
  15. pmc Long term outcome of trichiasis surgery in the Gambia
    M J Burton
    International Centre for Eye Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Br J Ophthalmol 89:575-9. 2005
    ..There are limited data on the long term outcome of surgery and its effect on vision and corneal opacification. Similarly, the determinants of failure are not well understood...
  16. ncbi request reprint Retinopathy in Gambian children admitted to hospital with malaria
    Matthew Burton
    Medical Research Council Laboratories, Fajara, The Gambia
    Trop Doct 34:214-8. 2004
    ....
  17. ncbi request reprint Re-emergence of Chlamydia trachomatis infection after mass antibiotic treatment of a trachoma-endemic Gambian community: a longitudinal study
    Matthew J Burton
    London School of Hygiene and Tropical Medicine, London, UK
    Lancet 365:1321-8. 2005
    ..We measured the effect of mass treatment on the conjunctival burden of Chlamydia trachomatis in a Gambian community with low to medium trachoma prevalence and investigated the rate, route, and determinants of re-emergent infection...
  18. ncbi request reprint Strategies for control of trachoma: observational study with quantitative PCR
    Anthony W Solomon
    London School of Hygiene and Tropical Medicine, WC1E 7HT, London, UK
    Lancet 362:198-204. 2003
    ..At present, who needs to be treated is unclear. We aimed to establish the burden of ocular Chlamydia trachomatis in three trachoma-endemic communities in Tanzania and The Gambia with real-time quantitative PCR...
  19. pmc Estimating household and community transmission of ocular Chlamydia trachomatis
    Isobel M Blake
    Department of Infectious Disease Epidemiology, Imperial College London, London, UK
    PLoS Negl Trop Dis 3:e401. 2009
    ..The potential impact of more efficient, targeted treatment of infected households depends on the relative contribution of community and household transmission of infection, which have not previously been estimated...
  20. ncbi request reprint Azithromycin for the treatment and control of trachoma
    M J Burton
    International Centre for Eye Health, Institute of Ophthalmology, London, UK
    Expert Opin Pharmacother 3:113-20. 2002
    ..A few countries are beneficiaries of a philanthropic donation by the manufacturer of azithromycin, Pfizer Inc. However, in the absence of a drug donation programme the cost-effectiveness of this measure is unclear...
  21. ncbi request reprint Risk of trachomatous scarring and trichiasis in Gambians varies with SNP haplotypes at the interferon-gamma and interleukin-10 loci
    A Natividad
    London School of Hygiene and Tropical Medicine, London University, London, UK
    Genes Immun 6:332-40. 2005
    ..The promoter IL10-1082G allele, previously associated with high IL10 expression, is in both susceptibility and resistance haplotypes...
  22. pmc The development of an age-structured model for trachoma transmission dynamics, pathogenesis and control
    Manoj Gambhir
    Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
    PLoS Negl Trop Dis 3:e462. 2009
    ..We present an age-structured mathematical model of trachoma transmission and disease to predict the impact of interventions on the prevalence of blinding trachoma...
  23. ncbi request reprint Bacterial infection and trachoma in the gambia: a case control study
    Matthew J Burton
    International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 48:4440-4. 2007
    ..This study was undertaken to investigate whether trachomatous trichiasis or conjunctival scarring are associated with increased prevalence of bacterial infection...
  24. pmc Chlamydia trachomatis ompA variants in trachoma: what do they tell us?
    Aura A Andreasen
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Negl Trop Dis 2:e306. 2008
    ..Sequence-based analysis of the multiple strains typically present in endemic communities may be informative for epidemiology, transmission, response to treatment, and understanding the host response...
  25. pmc Human conjunctival transcriptome analysis reveals the prominence of innate defense in Chlamydia trachomatis infection
    Angels Natividad
    Department of Clinical Research, London School of Hygiene and Tropical Medicine, University of London, London, United Kingdom
    Infect Immun 78:4895-911. 2010
    ..The data suggest that in addition to polymorph and adaptive cellular responses, NK cells may contribute to a significant component of the conjunctival inflammatory response to chlamydial infection...
  26. pmc Trichiasis surgery in The Gambia: a 4-year prospective study
    Saul N Rajak
    London School of Hygiene and Tropical Medicine, London, UK
    Invest Ophthalmol Vis Sci 51:4996-5001. 2010
    ..Although trichiasis surgery can reduce the risk of blindness, retrospective data suggest that long-term recurrence rates may be high. A 4-year prospective investigation of recurrent trichiasis was conducted in The Gambia...
  27. pmc Pathway-focused arrays reveal increased matrix metalloproteinase-7 (matrilysin) transcription in trachomatous trichiasis
    Martin J Holland
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Invest Ophthalmol Vis Sci 51:3893-902. 2010
    ..The purpose was to identify genes that are differentially expressed in the upper tarsal conjunctiva of subjects with TT...
  28. pmc Epidemiology and control of trachoma: systematic review
    Victor H Hu
    London School of Hygiene and Tropical Medicine, UK
    Trop Med Int Health 15:673-91. 2010
    ..This has been associated with significant reductions in the prevalence of active disease over the past 20 years, but there remain a large number of people with trichiasis who are at risk of blindness...
  29. ncbi request reprint The long-term natural history of trachomatous trichiasis in the Gambia
    Matthew J Burton
    International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 47:847-52. 2006
    ..Trachoma is the leading infectious cause of blindness. However, there are few data on the natural history of trachomatous trichiasis to guide program planning or that investigate its pathogenesis...
  30. ncbi request reprint Plummeting lenses in the TB clinic
    M J Burton
    Medical Research Council Laboratories, Fajara, The Gambia
    Lancet 360:138. 2002
  31. ncbi request reprint Chlamydial positivity of nasal discharge at baseline is associated with ocular chlamydial positivity 2 months following azithromycin treatment
    Emily West Gower
    Dana Center for Preventive Ophthalmology, 116 Wilmer Building, Johns Hopkins School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Invest Ophthalmol Vis Sci 47:4767-71. 2006
    ..Routes of transmission remain unclear. In this study, the relationship between Chlamydia trachomatis Amplicor-positive nasal discharge and Amplicor-positive ocular swabs was investigated (Amplicor; Roche, Indianapolis, IN)...