Teun Bousema

Summary

Affiliation: London School of Hygiene and Tropical Medicine
Country: UK

Publications

  1. ncbi request reprint Identification of hot spots of malaria transmission for targeted malaria control
    Teun Bousema
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom
    J Infect Dis 201:1764-74. 2010
  2. pmc Hitting hotspots: spatial targeting of malaria for control and elimination
    Teun Bousema
    Department of Immunity and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Med 9:e1001165. 2012
  3. pmc Submicroscopic gametocytes and the transmission of antifolate-resistant Plasmodium falciparum in Western Kenya
    Mayke J A M Oesterholt
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 4:e4364. 2009
  4. pmc Serologic markers for detecting malaria in areas of low endemicity, Somalia, 2008
    Teun Bousema
    London School of Hygiene and Tropical Medicine, London, UK
    Emerg Infect Dis 16:392-9. 2010
  5. pmc Residual Plasmodium falciparum parasitemia in Kenyan children after artemisinin-combination therapy is associated with increased transmission to mosquitoes and parasite recurrence
    Khalid B Beshir
    Department of Immunology and Infection
    J Infect Dis 208:2017-24. 2013
  6. pmc Epidemiology of subpatent Plasmodium falciparum infection: implications for detection of hotspots with imperfect diagnostics
    Jacklin F Mosha
    National Institute for Medical Research, NIMR, Mwanza Medical Research Centre, Mwanza, Tanzania
    Malar J 12:221. 2013
  7. pmc Ivermectin to reduce malaria transmission: a research agenda for a promising new tool for elimination
    Carlos J Chaccour
    Internal Medicine Department, Clinica Universidad de Navarra, Av, Pio XII 36, Pamplona 31008, Spain
    Malar J 12:153. 2013
  8. pmc The impact of hotspot-targeted interventions on malaria transmission: study protocol for a cluster-randomized controlled trial
    Teun Bousema
    Department of Immunology and Infection Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Trials 14:36. 2013
  9. doi request reprint Can field-based mosquito feeding assays be used for evaluating transmission-blocking interventions?
    Teun Bousema
    Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, UK
    Trends Parasitol 29:53-9. 2013
  10. pmc Mosquito feeding assays to determine the infectiousness of naturally infected Plasmodium falciparum gametocyte carriers
    Teun Bousema
    Department of Immunity and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 7:e42821. 2012

Detail Information

Publications45

  1. ncbi request reprint Identification of hot spots of malaria transmission for targeted malaria control
    Teun Bousema
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom
    J Infect Dis 201:1764-74. 2010
    ..This heterogeneity creates opportunities for targeted interventions but only if hot spots of malaria transmission can be easily identified...
  2. pmc Hitting hotspots: spatial targeting of malaria for control and elimination
    Teun Bousema
    Department of Immunity and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Med 9:e1001165. 2012
    b>Teun Bousema and colleagues argue that targeting malaria "hotspots" is a highly efficient way to reduce malaria transmission at all levels of transmission intensity.
  3. pmc Submicroscopic gametocytes and the transmission of antifolate-resistant Plasmodium falciparum in Western Kenya
    Mayke J A M Oesterholt
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 4:e4364. 2009
    ..In the present study, we determine the association between parasite mutations, submicroscopic P. falciparum gametocytemia and malaria transmission to mosquitoes...
  4. pmc Serologic markers for detecting malaria in areas of low endemicity, Somalia, 2008
    Teun Bousema
    London School of Hygiene and Tropical Medicine, London, UK
    Emerg Infect Dis 16:392-9. 2010
    ..016). Serologic markers are a promising tool for detecting spatial variation in malaria exposure and evaluating malaria control efforts in areas where transmission has decreased to levels below the detection limit of microscopy...
  5. pmc Residual Plasmodium falciparum parasitemia in Kenyan children after artemisinin-combination therapy is associated with increased transmission to mosquitoes and parasite recurrence
    Khalid B Beshir
    Department of Immunology and Infection
    J Infect Dis 208:2017-24. 2013
    ..Parasite clearance time after artemisinin-based combination therapy (ACT) may be increasing in Asian and African settings. The association between parasite clearance following ACT and transmissibility is currently unknown...
  6. pmc Epidemiology of subpatent Plasmodium falciparum infection: implications for detection of hotspots with imperfect diagnostics
    Jacklin F Mosha
    National Institute for Medical Research, NIMR, Mwanza Medical Research Centre, Mwanza, Tanzania
    Malar J 12:221. 2013
    ..Data from a cross-sectional survey conducted in north-western Tanzania were used to examine the spatial distribution of Plasmodium falciparum and the relationship between household exposure and parasite density...
  7. pmc Ivermectin to reduce malaria transmission: a research agenda for a promising new tool for elimination
    Carlos J Chaccour
    Internal Medicine Department, Clinica Universidad de Navarra, Av, Pio XII 36, Pamplona 31008, Spain
    Malar J 12:153. 2013
    ..Ivermectin effectively targets outdoor transmission, has a novel mechanism of action that could circumvent resistance and might be distributed over the channels already in place for the control of onchocerciasis and lymphatic filariasis...
  8. pmc The impact of hotspot-targeted interventions on malaria transmission: study protocol for a cluster-randomized controlled trial
    Teun Bousema
    Department of Immunology and Infection Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Trials 14:36. 2013
    ..Targeting these hotspots might represent a highly efficacious way of controlling or eliminating malaria if the hotspots fuel malaria transmission to the wider community...
  9. doi request reprint Can field-based mosquito feeding assays be used for evaluating transmission-blocking interventions?
    Teun Bousema
    Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, UK
    Trends Parasitol 29:53-9. 2013
    ..Altogether, we underscore the significant advantages of field-based mosquito feeding assays in basic malaria research and field trials...
  10. pmc Mosquito feeding assays to determine the infectiousness of naturally infected Plasmodium falciparum gametocyte carriers
    Teun Bousema
    Department of Immunity and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 7:e42821. 2012
    ..Such interventions require assays that reliably measure the transmission of Plasmodium from humans to Anopheles mosquitoes...
  11. pmc A cluster-randomized trial of mass drug administration with a gametocytocidal drug combination to interrupt malaria transmission in a low endemic area in Tanzania
    Seif A Shekalaghe
    Kilimanjaro Christian Medical College Kilimanjaro Clinical Research Institute, Moshi, Tanzania
    Malar J 10:247. 2011
    ..75 mg/kg) on malaria transmission was determined in an area of very low and seasonal malaria transmission in northern Tanzania...
  12. pmc The plasticity of Plasmodium falciparum gametocytaemia in relation to age in Burkina Faso
    André Lin Ouédraogo
    Centre National de Recherche et de Formation sur le Paludisme, Burkina Faso
    Malar J 9:281. 2010
    ..Malaria transmission depends on the presence of gametocytes in the peripheral blood. In this study, the age-dependency of gametocytaemia was examined by microscopy and molecular tools...
  13. pmc Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs
    Teun Bousema
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Malar J 9:136. 2010
    ..Simple mathematical models were fitted to data from clinical trials in order to determine the mean gametocyte circulation time and duration of gametocyte carriage in treated malaria patients...
  14. pmc In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals
    Seif A Shekalaghe
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
    Antimicrob Agents Chemother 54:1762-8. 2010
    ..PQ may cause moderate anemia when coadministered with artemisinins, and excluding individuals based on G6PD status alone may not be sufficient to prevent PQ-induced hemolysis...
  15. pmc Primaquine clears submicroscopic Plasmodium falciparum gametocytes that persist after treatment with sulphadoxine-pyrimethamine and artesunate
    Seif Shekalaghe
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 2:e1023. 2007
    ..We determined the efficacy of SP+AS plus a single dose of primaquine (PQ, 0.75 mg/kg) on clearing gametocytaemia measured by molecular methods...
  16. pmc Overuse of artemisinin-combination therapy in Mto wa Mbu (river of mosquitoes), an area misinterpreted as high endemic for malaria
    Charles Mwanziva
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Malar J 7:232. 2008
    ..This study describes diagnostic and treatment practices in Mto wa Mbu, an area that used to be hyperendemic for malaria, but where no recent assessments of transmission intensity have been conducted...
  17. pmc Low density parasitaemia, red blood cell polymorphisms and Plasmodium falciparum specific immune responses in a low endemic area in northern Tanzania
    Seif Shekalaghe
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    BMC Infect Dis 9:69. 2009
    ..falciparum parasite carriage and antibody responses to the asexual stage antigens, G6PD deficiency and alpha+-thalassaemia in 464 subjects from a low endemic area in northern Tanzania...
  18. ncbi request reprint (Sub)microscopic Plasmodium falciparum gametocytaemia in Kenyan children after treatment with sulphadoxine-pyrimethamine monotherapy or in combination with artesunate
    Petra Schneider
    Radboud University Nijmegen Medical Centre, Medical Microbiology 268, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Int J Parasitol 36:403-8. 2006
    ..Our data suggest that the potential of malaria transmission remains high even after treatment with artemisinin combination therapy, although prevalence and density of gametocytes is lower after SP+AS...
  19. pmc Reduction of transmission from malaria patients by artemisinin combination therapies: a pooled analysis of six randomized trials
    Lucy C Okell
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Malar J 7:125. 2008
    ..The size of this effect is estimated in symptomatic P. falciparum infections...
  20. pmc Human immune responses that reduce the transmission of Plasmodium falciparum in African populations
    Teun Bousema
    Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Int J Parasitol 41:293-300. 2011
    ..These results suggest that effective malaria transmission-reducing antibodies do not commonly circulate in African children, and that recent gametocyte carriage is required to initiate and/or boost such responses...
  21. pmc Combined DNA extraction and antibody elution from filter papers for the assessment of malaria transmission intensity in epidemiological studies
    Amrish Baidjoe
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Malar J 12:272. 2013
    ..Filter paper blood spots are commonly used a source of both DNA and antibodies. To enhance the operational practicability of malaria surveys, a method is presented for combined DNA extraction and antibody elution...
  22. pmc Rapid assessment of malaria transmission using age-specific sero-conversion rates
    Laveta Stewart
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    PLoS ONE 4:e6083. 2009
    ..This study evaluated SCR generated from samples collected from health facility attendees as a tool for a rapid assessment of malaria transmission intensity...
  23. ncbi request reprint Single dose primaquine for clearance of Plasmodium falciparum gametocytes in children with uncomplicated malaria in Uganda: a randomised, controlled, double-blind, dose-ranging trial
    Alice C Eziefula
    Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, UK Electronic address
    Lancet Infect Dis 14:130-9. 2014
    ..We assessed the dose-response association of single-dose primaquine for gametocyte clearance and for safety in P falciparum malaria...
  24. pmc IgG responses to Anopheles gambiae salivary antigen gSG6 detect variation in exposure to malaria vectors and disease risk
    Will Stone
    Department of Immunity and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 7:e40170. 2012
    ..While the technique requires further evaluation in a range of malaria endemic settings, our findings suggest that the gSG6 assay may have a role in the evaluation and planning of targeted and preventative anti-malaria interventions...
  25. pmc The potential contribution of mass treatment to the control of Plasmodium falciparum malaria
    Lucy C Okell
    Department of Infectious Disease Epidemiology, MRC Centre for Outbreak Analysis and Modeling, Imperial College London, London, United Kingdom
    PLoS ONE 6:e20179. 2011
    ..The benefits of mass treatment need to be carefully weighed against the risks of increasing drug selection pressure...
  26. pmc Dried blood spots as a source of anti-malarial antibodies for epidemiological studies
    Patrick H Corran
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Malar J 7:195. 2008
    ..Although recommendations for the storage and analysis of small molecule analytes in blood spots exist, there are no published systematic studies of the stability of antibodies under different storage conditions...
  27. doi request reprint The suitability of clay pots for indoor sampling of mosquitoes in an arid area in northern Tanzania
    Wouter van den Bijllaardt
    Department of Medical Microbiology 268, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Acta Trop 111:197-9. 2009
    ..We conclude that clay pots are not a reliable tool to sample mosquitoes in the dry season in an area of low transmission intensity with Anopheles arabiensis as principle vector...
  28. pmc Modelling the impact of artemisinin combination therapy and long-acting treatments on malaria transmission intensity
    Lucy C Okell
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    PLoS Med 5:e226; discussion e226. 2008
    ..This study estimates the reduction in transmission that may be achieved by introducing different types of treatment for symptomatic P. falciparum malaria in endemic areas...
  29. pmc Epidemiology and infectivity of Plasmodium falciparum and Plasmodium vivax gametocytes in relation to malaria control and elimination
    Teun Bousema
    Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Clin Microbiol Rev 24:377-410. 2011
    ..These components are drawn together to show how control measures that aim to reduce malaria transmission, such as mass drug administration and a transmission-blocking vaccine, might better be deployed...
  30. pmc Filter paper collection of Plasmodium falciparum mRNA for detecting low-density gametocytes
    Sophie Jones
    Department of Immunology and Infection Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Malar J 11:266. 2012
    ..Filter papers can be used for collecting RNA samples, but rigorous testing of their capacity to withstand adverse storage conditions has not been fully explored...
  31. pmc Serological markers suggest heterogeneity of effectiveness of malaria control interventions on Bioko Island, equatorial Guinea
    Jackie Cook
    Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 6:e25137. 2011
    ..Bioko Island, Equatorial Guinea, has been subject to comprehensive malaria control interventions since 2004. This has resulted in substantial reductions in the parasite burden, although this drop has not been uniform across the island...
  32. pmc The dynamics of naturally acquired immune responses to Plasmodium falciparum sexual stage antigens Pfs230 & Pfs48/45 in a low endemic area in Tanzania
    Teun Bousema
    Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 5:e14114. 2010
    ..We conducted a longitudinal study on functional sexual stage immune responses...
  33. ncbi request reprint Common genotypic polymorphisms in glutathione S-transferases in mild and severe falciparum malaria in Tanzanian children
    Reginald A Kavishe
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Am J Trop Med Hyg 81:363-5. 2009
    ..0% against 10.3% mild malaria, P = 0.004). We concluded that GSTP1 and possibly GSTM1 may protect against severe falciparum malaria in children...
  34. pmc The polymorphic linker domain of pfmdr1 is associated with resistance-conferring mutations in plasmodium falciparum populations from east and West Africa
    John Okombo
    Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Antimicrob Agents Chemother 57:4595-8. 2013
    ..In Kenya, a specific form of the Asn/Asp-rich domain was significantly linked to the 86Y, 184Y, and 1246Y haplotype of pfmdr1. ..
  35. pmc Glucose-6-Phosphate Dehydrogenase Status and Risk of Hemolysis in Plasmodium falciparum-Infected African Children Receiving Single-Dose Primaquine
    Alice C Eziefula
    Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Antimicrob Agents Chemother 58:4971-3. 2014
    ..G6PD A- heterozygotes and hemizygotes/homozygotes experienced dose-dependent lower hemoglobin concentrations after treatment. No severe anemia was observed. ..
  36. doi request reprint Measuring changes in Plasmodium falciparum transmission: precision, accuracy and costs of metrics
    Lucy S Tusting
    Department of Disease Control, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Adv Parasitol 84:151-208. 2014
    ..Future work should aim to better quantify the precision and accuracy of malaria metrics and to improve methods for their collection. ..
  37. pmc A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains
    Mark D Preston
    Immunology and Infection Department, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Nat Commun 5:4052. 2014
    ..We design a 23-SNP barcode that is highly predictive (~92%) and easily adapted to aid case management in the field and survey parasite migration worldwide. ..
  38. pmc Continuing intense malaria transmission in northern Uganda
    Carla Proietti
    Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom
    Am J Trop Med Hyg 84:830-7. 2011
    ..Malaria control remains a tremendous challenge in areas that have not benefited from large-scale interventions, illustrated here by the district of Apac...
  39. pmc Rationale for short course primaquine in Africa to interrupt malaria transmission
    Alice C Eziefula
    Malaria Centre, London School of Hygiene and Tropical Medicine, London, UK
    Malar J 11:360. 2012
    ..In parallel, efforts need to be made to address issues in drug supply and regulation, to map G6PD deficiency and to support the evaluation of alternative gametocytocidal compounds...
  40. pmc Malaria diagnostic testing and treatment practices in three different Plasmodium falciparum transmission settings in Tanzania: before and after a government policy change
    Guido J H Bastiaens
    Nijmegen Institute for International Health, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Malar J 10:76. 2011
    ....
  41. pmc Reliability of school surveys in estimating geographic variation in malaria transmission in the western Kenyan highlands
    Jennifer C Stevenson
    Department of Disease Control, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 8:e77641. 2013
    ..There is limited evidence on the comparability of prevalence estimates obtained from school and community surveys carried out at the same locality...
  42. pmc Predicting mosquito infection from Plasmodium falciparum gametocyte density and estimating the reservoir of infection
    Thomas S Churcher
    Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
    elife 2:e00626. 2013
    ..DOI:http://dx.doi.org/10.7554/eLife.00626.001...
  43. pmc Plasmodium ovale curtisi and Plasmodium ovale wallikeri circulate simultaneously in African communities
    Mary Chiaka Oguike
    Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, LSHTM, UK
    Int J Parasitol 41:677-83. 2011
    ..Malaria elimination programmes in Africa need to include strategies for control of P. o. curtisi and P. o. wallikeri...
  44. pmc PlasmoView: a web-based resource to visualise global Plasmodium falciparum genomic variation
    Mark D Preston
    Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    J Infect Dis 209:1808-15. 2014
    ..The first release contains over 600,000 high-quality SNPs in 631 Pf isolates from laboratory strains and four malaria-endemic regions (West Africa, East Africa, Southeast Asia and Oceania)...
  45. pmc Scale-up of Malaria Rapid Diagnostic Tests and Artemisinin-Based Combination Therapy: Challenges and Perspectives in Sub-Saharan Africa
    Guido J H Bastiaens
    Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands
    PLoS Med 11:e1001590. 2014
    ..Please see later in the article for the Editors' Summary. ..