Imran Y Saleem
Affiliation: Liverpool John Moores University
Abdelrady H, Hathout R, Osman R, Saleem I, Mortada N. Exploiting gelatin nanocarriers in the pulmonary delivery of methotrexate for lung cancer therapy. Eur J Pharm Sci. 2019;133:115-126 pubmed publisher
..The spray dried gelatin nano-in microparticles demonstrated good aerosolization properties enabling lung deposition in the respirable airways. Thus, providing a promising platform for lung cancer therapy. ..
Mohamed A, Kunda N, Ross K, Hutcheon G, Saleem I. Polymeric nanoparticles for the delivery of miRNA to treat Chronic Obstructive Pulmonary Disease (COPD). Eur J Pharm Biopharm. 2019;136:1-8 pubmed publisher
..Therefore, these results demonstrate the potential of PGA-co-PDL NPs as a delivery system for miR-146a to treat COPD. ..
Kunda N, Alfagih I, Dennison S, Somavarapu S, Merchant Z, Hutcheon G, et al
. Dry powder pulmonary delivery of cationic PGA-co-PDL nanoparticles with surface adsorbed model protein. Int J Pharm. 2015;492:213-22 pubmed publisher
..SDS-PAGE and circular dichroism (CD) confirmed that the primary and secondary structure of the released BSA was maintained. Moreover, the released BSA showed 78.76Â±1.54% relative esterolytic activity compared to standard BSA. ..
Saleem I, Diez F, Jones B, Kayali N, Polo L. Investigation on the aerosol performance of dry powder inhalation hypromellose capsules with different lubricant levels. Int J Pharm. 2015;492:258-63 pubmed publisher
..AFM (atomic force microscopy) data suggest that internal surface roughness may be related with this phenomena. ..
Kunda N, Alfagih I, Miyaji E, Figueiredo D, GonÃ§alves V, Ferreira D, et al
. Pulmonary dry powder vaccine of pneumococcal antigen loaded nanoparticles. Int J Pharm. 2015;495:903-12 pubmed publisher
..Moreover, the released antigen also maintained its antigenicity as determined by ELISA. ..
Alfagih I, Kunda N, Alanazi F, Dennison S, Somavarapu S, Hutcheon G, et al
. Pulmonary Delivery of Proteins Using Nanocomposite Microcarriers. J Pharm Sci. 2015;104:4386-4398 pubmed publisher
..These results indicate the optimal process parameters for the preparation of protein-loaded PGA-co-PDL NCMPs suitable for inhalation. ..
Saleem I, Smyth H. Micronization of a soft material: air-jet and micro-ball milling. AAPS PharmSciTech. 2010;11:1642-9 pubmed publisher
..Micro-ball milling under cold condition was more successful at achieving a lower range particle size reduction of soft materials. ..
Tawfeek H, Abdellatif A, Dennison T, Mohammed A, Sadiq Y, Saleem I. Colonic delivery of indometacin loaded PGA-co-PDL microparticles coated with Eudragit L100-55 from fast disintegrating tablets. Int J Pharm. 2017;531:80-89 pubmed publisher
..95±0.68×10-6cm/s compared to free IND 23.06±3.56×10-6cm/s. These results indicate the possibility of targeting anti-inflammatory drugs to the colon using FDTs containing microparticles coated with Eudragit. ..