Gordon M Lowe

Summary

Affiliation: Liverpool John Moores University
Country: UK

Publications

  1. ncbi request reprint Antioxidant properties of aged garlic extract: an in vitro study incorporating human low density lipoprotein
    Stephanie A Dillon
    School of Biomolecular Sciences, Liverpool John Moores University, Byrom Street, L3 3AF, Liverpool, UK
    Life Sci 72:1583-94. 2003
  2. ncbi request reprint Carotenoids as prooxidants?
    Gordon M Lowe
    School of Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, UK
    Mol Aspects Med 24:363-9. 2003
  3. ncbi request reprint Free radical stimulation of tyrosine kinase and phosphatase activity in human peripheral blood mononuclear cells
    G M Lowe
    School of Biomolecular Sciences, School of Biological and Earth Sciences, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, United Kingdom
    Biochem Biophys Res Commun 245:17-22. 1998
  4. ncbi request reprint Lycopene and beta-carotene protect against oxidative damage in HT29 cells at low concentrations but rapidly lose this capacity at higher doses
    G M Lowe
    School of Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK
    Free Radic Res 30:141-51. 1999
  5. doi request reprint (13Z)- and (9Z)-lycopene isomers are major intermediates in the oxidative degradation of lycopene by cigarette smoke and Sin-1
    Daniel L Graham
    School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK
    Free Radic Res 46:891-902. 2012
  6. ncbi request reprint Aged garlic extract may inhibit aggregation in human platelets by suppressing calcium mobilization
    Gillian L Allison
    School of Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, England, UK
    J Nutr 136:789S-792S. 2006
  7. doi request reprint Does lycopene offer human LDL any protection against myeloperoxidase activity?
    Poh Yeong Chew
    School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK
    Mol Cell Biochem 361:181-7. 2012
  8. doi request reprint The degradation of (all-E)-beta-carotene by cigarette smoke
    Gordon M Lowe
    Liverpool John Moores University, UK
    Free Radic Res 43:280-6. 2009
  9. ncbi request reprint Garlic and cardiovascular disease: a critical review
    Khalid Rahman
    School of Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK
    J Nutr 136:736S-740S. 2006
  10. ncbi request reprint Antioxidant and prooxidant properties of carotenoids
    A J Young
    School of Biological and Earth Sciences, Liverpool John Moores University, UK
    Arch Biochem Biophys 385:20-7. 2001

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Antioxidant properties of aged garlic extract: an in vitro study incorporating human low density lipoprotein
    Stephanie A Dillon
    School of Biomolecular Sciences, Liverpool John Moores University, Byrom Street, L3 3AF, Liverpool, UK
    Life Sci 72:1583-94. 2003
    ..AGE was also shown to reduce LDL oxidation by the chelation of Cu(2+). Thus, AGE may have a role to play in preventing the development and progression of atherosclerotic disease...
  2. ncbi request reprint Carotenoids as prooxidants?
    Gordon M Lowe
    School of Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, UK
    Mol Aspects Med 24:363-9. 2003
  3. ncbi request reprint Free radical stimulation of tyrosine kinase and phosphatase activity in human peripheral blood mononuclear cells
    G M Lowe
    School of Biomolecular Sciences, School of Biological and Earth Sciences, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, United Kingdom
    Biochem Biophys Res Commun 245:17-22. 1998
    ..We conclude that unbound metals can interact with ROS and readily influence signalling mechanisms in human lymphocytes...
  4. ncbi request reprint Lycopene and beta-carotene protect against oxidative damage in HT29 cells at low concentrations but rapidly lose this capacity at higher doses
    G M Lowe
    School of Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK
    Free Radic Res 30:141-51. 1999
    ..This in vitro data presented maybe significant in the light of recent intervention trials...
  5. doi request reprint (13Z)- and (9Z)-lycopene isomers are major intermediates in the oxidative degradation of lycopene by cigarette smoke and Sin-1
    Daniel L Graham
    School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK
    Free Radic Res 46:891-902. 2012
    ..In conclusion, (Z)-lycopene production and (5Z)-lycopene stability may help explain elevated (Z)-lycopene in plasma over (Z)-lycopene content in lycopene-containing foods in the diet...
  6. ncbi request reprint Aged garlic extract may inhibit aggregation in human platelets by suppressing calcium mobilization
    Gillian L Allison
    School of Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, England, UK
    J Nutr 136:789S-792S. 2006
    ....
  7. doi request reprint Does lycopene offer human LDL any protection against myeloperoxidase activity?
    Poh Yeong Chew
    School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK
    Mol Cell Biochem 361:181-7. 2012
    ..Lycopene does react with the products of myeloperoxidase in solvent, but played no role in protecting against enzyme derived oxidation of human LDL...
  8. doi request reprint The degradation of (all-E)-beta-carotene by cigarette smoke
    Gordon M Lowe
    Liverpool John Moores University, UK
    Free Radic Res 43:280-6. 2009
    ..These degradation products suggest that the C4 position on the beta-carotene end-group plays a key role in initiating free radical attack...
  9. ncbi request reprint Garlic and cardiovascular disease: a critical review
    Khalid Rahman
    School of Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK
    J Nutr 136:736S-740S. 2006
    ....
  10. ncbi request reprint Antioxidant and prooxidant properties of carotenoids
    A J Young
    School of Biological and Earth Sciences, Liverpool John Moores University, UK
    Arch Biochem Biophys 385:20-7. 2001
    ..It is unlikely that carotenoids actually act as prooxidants in biological systems; rather they exhibit a tendency to lose their effectiveness as antioxidants...
  11. ncbi request reprint Carotenoid composition and antioxidant potential in subfractions of human low-density lipoprotein
    G M Lowe
    School of Biomolecular Sciences, Liverpool John Moores University, UK
    Ann Clin Biochem 36:323-32. 1999
    ..The more dense LDL subfractions, which had lower levels of these antioxidants, were more readily oxidized, highlighting their possible role in atherosclerotic events...
  12. doi request reprint Cigarette smoke and human plasma lycopene depletion
    D L Graham
    School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, UK
    Food Chem Toxicol 48:2413-20. 2010
    ..The effects have been compared with Sin-1 reactions and isomerization of all-(E) lycopene is common to both treatments. The results clearly indicate that low plasma lycopene may be a direct consequence of smoke inhalation...
  13. ncbi request reprint Aged garlic extract and its constituents inhibit platelet aggregation through multiple mechanisms
    Gillian L Allison
    School of Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, England, UK
    J Nutr 136:782S-788S. 2006
    ..This increase in Ca2+ was abolished in the presence of AGE. It is likely that AGE works in a synergistic manner and exerts multiple effects on the biochemical pathways involved in platelet aggregation...
  14. ncbi request reprint Dietary supplementation with aged garlic extract reduces plasma and urine concentrations of 8-iso-prostaglandin F(2 alpha) in smoking and nonsmoking men and women
    Stephanie A Dillon
    School of Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, England, UK
    J Nutr 132:168-71. 2002
    ..Thus, dietary supplementation with AGE may be useful in reducing oxidative stress in humans...
  15. ncbi request reprint Carotenoid radical chemistry and antioxidant/pro-oxidant properties
    Ali El-Agamey
    Lennard Jones Laboratories, School of Chemistry and Physics, Keele University, Keele, Staffs ST5 5BG, UK
    Arch Biochem Biophys 430:37-48. 2004
    ....