Daniel J Green

Summary

Affiliation: Liverpool John Moores University
Country: UK

Publications

  1. pmc Impact of exercise training on arterial wall thickness in humans
    Dick H J Thijssen
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
    Clin Sci (Lond) 122:311-22. 2012
  2. doi request reprint Is flow-mediated dilation nitric oxide mediated?: A meta-analysis
    Daniel J Green
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Tom Reilly Bldg, Byrom St, L3 3AF Liverpool, United Kingdom
    Hypertension 63:376-82. 2014
  3. pmc Ultrasound settings significantly alter arterial lumen and wall thickness measurements
    Kathleen Potter
    School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    Cardiovasc Ultrasound 6:6. 2008
  4. pmc Carotid intima-medial thickness measured on multiple ultrasound frames: evaluation of a DICOM-based software system
    Kathleen Potter
    School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    Cardiovasc Ultrasound 5:29. 2007
  5. pmc The effect of long-term homocysteine-lowering on carotid intima-media thickness and flow-mediated vasodilation in stroke patients: a randomized controlled trial and meta-analysis
    Kathleen Potter
    School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    BMC Cardiovasc Disord 8:24. 2008
  6. ncbi request reprint Impact of age, sex and exercise on brachial and popliteal artery remodelling in humans
    Daniel J Green
    Research Institute for Sport and Exercise Science, Liverpool John Moore s University, Liverpool L3 2ET, United Kingdom
    Atherosclerosis 210:525-30. 2010
  7. ncbi request reprint Exercise and cardiovascular risk reduction: time to update the rationale for exercise?
    Daniel J Green
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Henry Cotton Campus, 15 21 Webster St, Liverpool L3 2ET, UK
    J Appl Physiol 105:766-8. 2008
  8. doi request reprint Point: exercise training does induce vascular adaptations beyond the active muscle beds
    Daniel J Green
    Liverpool John Moores University, UK
    J Appl Physiol 105:1002-4; discussion 1007. 2008
  9. ncbi request reprint Cardiac and vascular adaptations to exercise
    Daniel J Green
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Henry Cotton Building, 15 21 Webster Street, Liverpool, UK
    Curr Opin Clin Nutr Metab Care 9:677-84. 2006
  10. ncbi request reprint Relationship between changes in brachial artery flow-mediated dilation and basal release of nitric oxide in subjects with Type 2 diabetes
    Daniel J Green
    School of Sport and Exercise Science, Henry Cotton Bldg, 15 21 Webster St, Liverpool John Moores University, L32ET, United Kingdom, and Cardiac Transplant Unit, Royal Perth Hospital, Australia
    Am J Physiol Heart Circ Physiol 291:H1193-9. 2006

Detail Information

Publications97

  1. pmc Impact of exercise training on arterial wall thickness in humans
    Dick H J Thijssen
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
    Clin Sci (Lond) 122:311-22. 2012
    ..Finally, we discuss the impact of exercise training in terms of primary prevention of wall thickening in healthy subjects and remodelling of arteries in subjects with existing cardiovascular disease and risk factors...
  2. doi request reprint Is flow-mediated dilation nitric oxide mediated?: A meta-analysis
    Daniel J Green
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Tom Reilly Bldg, Byrom St, L3 3AF Liverpool, United Kingdom
    Hypertension 63:376-82. 2014
    ..9% [95% CI, 6.0%-7.8%]; FMD(L-NMMA), 2.4% [95% CI, 1.1%-3.7%]; P<0.001). This comprehensive analysis demonstrates that FMD of conduit arteries in humans is, at least in part, mediated by NO...
  3. pmc Ultrasound settings significantly alter arterial lumen and wall thickness measurements
    Kathleen Potter
    School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    Cardiovasc Ultrasound 6:6. 2008
    ..We aimed to quantify the effect that commonly adjusted ultrasound settings have on arterial lumen and wall thickness measurements made with CIMT measurement software...
  4. pmc Carotid intima-medial thickness measured on multiple ultrasound frames: evaluation of a DICOM-based software system
    Kathleen Potter
    School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    Cardiovasc Ultrasound 5:29. 2007
    ....
  5. pmc The effect of long-term homocysteine-lowering on carotid intima-media thickness and flow-mediated vasodilation in stroke patients: a randomized controlled trial and meta-analysis
    Kathleen Potter
    School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    BMC Cardiovasc Disord 8:24. 2008
    ..B-vitamin supplements reduce tHcy and improve endothelial function in short term trials, but the long-term effects of the treatment on vascular structure and function are unknown...
  6. ncbi request reprint Impact of age, sex and exercise on brachial and popliteal artery remodelling in humans
    Daniel J Green
    Research Institute for Sport and Exercise Science, Liverpool John Moore s University, Liverpool L3 2ET, United Kingdom
    Atherosclerosis 210:525-30. 2010
    ..To examine the impact of age, sex and exercise on wall thickness and remodelling in the popliteal and brachial arteries...
  7. ncbi request reprint Exercise and cardiovascular risk reduction: time to update the rationale for exercise?
    Daniel J Green
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Henry Cotton Campus, 15 21 Webster St, Liverpool L3 2ET, UK
    J Appl Physiol 105:766-8. 2008
  8. doi request reprint Point: exercise training does induce vascular adaptations beyond the active muscle beds
    Daniel J Green
    Liverpool John Moores University, UK
    J Appl Physiol 105:1002-4; discussion 1007. 2008
  9. ncbi request reprint Cardiac and vascular adaptations to exercise
    Daniel J Green
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Henry Cotton Building, 15 21 Webster Street, Liverpool, UK
    Curr Opin Clin Nutr Metab Care 9:677-84. 2006
    ..To briefly review some recent studies of cardiac and vascular adaptation to acute exercise and exercise training...
  10. ncbi request reprint Relationship between changes in brachial artery flow-mediated dilation and basal release of nitric oxide in subjects with Type 2 diabetes
    Daniel J Green
    School of Sport and Exercise Science, Henry Cotton Bldg, 15 21 Webster St, Liverpool John Moores University, L32ET, United Kingdom, and Cardiac Transplant Unit, Royal Perth Hospital, Australia
    Am J Physiol Heart Circ Physiol 291:H1193-9. 2006
    ..04, P=0.9). We conclude that conduit artery-stimulated endothelial NO function (FMD) does not reflect basal resistance vessel endothelial NO function in subjects with Type 2 diabetes...
  11. ncbi request reprint Exercise training as vascular medicine: direct impacts on the vasculature in humans
    Daniel J Green
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, UK
    Exerc Sport Sci Rev 37:196-202. 2009
    ..This review considers the impact of exercise training on vascular adaptation in large and small arteries in humans...
  12. pmc Obligatory role of hyperaemia and shear stress in microvascular adaptation to repeated heating in humans
    Daniel J Green
    School of Sport Science, Exercise and Health, The University of Western Australia, Crawley, Western Australia, 6009
    J Physiol 588:1571-7. 2010
    ..We conclude that increased blood flow, and the likely attendant increase in shear stress, is a key physiological stimulus for enhancing microvascular vasodilator function in humans...
  13. doi request reprint Exercise and vascular adaptation in asymptomatic humans
    Daniel J Green
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Henry Cotton Campus, 15 21 Webster Street, Liverpool, UK
    Exp Physiol 96:57-70. 2011
    ....
  14. doi request reprint Flow-mediated dilation and cardiovascular event prediction: does nitric oxide matter?
    Daniel J Green
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Tom Reilly Building, Byrom Street, Liverpool L3 3AF, UK
    Hypertension 57:363-9. 2011
    ..Although this finding should be confirmed with more and larger studies, we suggest that any direct measure of vascular (endothelial) function may provide independent prognostic information in humans...
  15. ncbi request reprint Shear stress mediates endothelial adaptations to exercise training in humans
    Toni M Tinken
    Research Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, United Kingdom
    Hypertension 55:312-8. 2010
    ..These results demonstrate that exercise-induced changes in shear provide the principal physiological stimulus to adaptation in flow-mediated endothelial function and vascular remodeling in response to exercise training in healthy humans...
  16. ncbi request reprint Is the ratio of flow-mediated dilation and shear rate a statistically sound approach to normalization in cross-sectional studies on endothelial function?
    Greg Atkinson
    1Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom
    J Appl Physiol (1985) 107:1893-9. 2009
    ..If the relationship between SR and FMD is generally found to be weak or nonlinear or variable between samples, then ratio normalization should not be applied...
  17. doi request reprint Brachial artery adaptation to lower limb exercise training: role of shear stress
    Gurpreet K Birk
    Research Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, United Kingdom
    J Appl Physiol (1985) 112:1653-8. 2012
    ..05) across the 8-wk intervention period. Our data suggest that lower limb cycle training induces a transient increase in upper limb vascular function in healthy young humans, which is, at least partly, mediated via shear stress...
  18. pmc Heterogeneity in conduit artery function in humans: impact of arterial size
    Dick H J Thijssen
    Research Institute for Sport and Exercise Science, Liverpool John Moore s University, Henry Cotton Campus, 15 21 Webster St, Liverpool L3 2ET, United Kingdom
    Am J Physiol Heart Circ Physiol 295:H1927-34. 2008
    ..This raises the possibility that differences in artery size within or between individuals may influence functional responses...
  19. pmc The impact of baseline diameter on flow-mediated dilation differs in young and older humans
    Dick H J Thijssen
    Research Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, United Kingdom
    Am J Physiol Heart Circ Physiol 295:H1594-8. 2008
    ..This effect was found to be age dependent, which emphasizes the importance of using appropriate methodology to calculate the FMD...
  20. pmc Impact of shear rate modulation on vascular function in humans
    Toni M Tinken
    Research Institute for Sport and Exercise Science, Liverpool John Moores University, 15 21 Webster St, Liverpool L3 2ET, United Kingdom
    Hypertension 54:278-85. 2009
    ....
  21. doi request reprint Retrograde flow and shear rate acutely impair endothelial function in humans
    Dick H J Thijssen
    Research Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, United Kingdom
    Hypertension 53:986-92. 2009
    ..This finding contributes to our understanding regarding the possible detrimental effects of retrograde shear rate in vivo...
  22. doi request reprint Effect of SR manipulation on conduit artery dilation in humans
    Howard H Carter
    School of Sports Science, Exercise, and Health, University of Western Australia, Nedlands, Western Australia, Australia
    Hypertension 61:143-50. 2013
    ..Our findings strongly implicate SR as an important stimulus to increase conduit artery diameter in humans...
  23. pmc A prospective randomized longitudinal study involving 6 months of endurance or resistance exercise. Conduit artery adaptation in humans
    Angela L Spence
    School of Sport Science, Exercise and Health M408, The University of Western Australia, 35 Stirling Highway, Crawley, Perth, WA 6009, Australia
    J Physiol 591:1265-75. 2013
    ..These impacts of both RT and ET would be expected to translate to decreased cardiovascular risk...
  24. doi request reprint Why isn't flow-mediated dilation enhanced in athletes?
    Daniel J Green
    Research Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, United Kingdom
    Med Sci Sports Exerc 45:75-82. 2013
    ..Studies performed in animals and humans strongly suggest that exercise training and physical activity enhance arterial endothelial function. Studies of athletes have, however, been less definitive...
  25. ncbi request reprint Diastolic function in healthy humans: non-invasive assessment and the impact of acute and chronic exercise
    Keith P George
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
    Eur J Appl Physiol 108:1-14. 2010
    ....
  26. ncbi request reprint Exercise training in polycystic ovarian syndrome enhances flow-mediated dilation in the absence of changes in fatness
    Victoria S Sprung
    1Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UNITED KINGDOM 2Department of Diabetes and Endocrinology, University Hospital Aintree, Liverpool, UNITED KINGDOM 3School of Sports Science, Exercise and Health, University of Western Australia, Crawley, Western Australia, AUSTRALIA 4Department of Gynaecology, Liverpool Women s Hospital, Liverpool, United Kingdom and, 5Magnetic Resonance and Image Analysis Research Centre and Department of Musculoskeletal Biology, University of Liverpool, United Kingdom
    Med Sci Sports Exerc 45:2234-42. 2013
    ..Therefore, the aim of the current study was to investigate the impact of exercise on endothelial function, in parallel with body composition, insulin resistance, and cardiopulmonary fitness in PCOS...
  27. ncbi request reprint Local and systemic effects of leg cycling training on arterial wall thickness in healthy humans
    Dick H J Thijssen
    Research Institute for Sport and Exercise Science, Liverpool John Moores University, Tom Reilly Building, Byrom Street, Liverpool L3 3AF, United Kingdom
    Atherosclerosis 229:282-6. 2013
    ..Cross-sectional studies suggest the presence of systemic changes in wall thickness as a result of exercise in healthy subjects, but no previous study has examined this question in humans undertaking exercise training...
  28. ncbi request reprint Comparison of resistance and conduit vessel nitric oxide-mediated vascular function in vivo: effects of exercise training
    Daniel J Green
    School of Human Movement and Exercise Science, The University of Western Australia, Crawley 6009, Western Australia, Australia
    J Appl Physiol (1985) 97:749-55; discussion 748. 2004
    ..211; P = 0.191). We conclude that, although short-term exercise training improves endothelium-dependent nitric oxide-mediated vascular function in both conduit and resistance vessels, the magnitude of these improvements are unrelated...
  29. doi request reprint Effect of unilateral forearm inactivity on endothelium-dependent vasodilator function in humans
    Gurpreet K Birk
    Research Institute for Sport and Exercise Science, Liverpool John Moores University, Tom Reilly Building, Byrom Street, Liverpool L3 3AF, UK
    Eur J Appl Physiol 113:933-40. 2013
    ..However, measures of conduit artery endothelium-dependent vasodilation were not altered across an 8-day period of inactivity, suggesting that initial remodelling occurs at distal ends of the vascular tree...
  30. pmc Relationship between upper and lower limb conduit artery vasodilator function in humans
    Dick H J Thijssen
    Research Institute for Sport and Exercise Science, Tom Reilly Bldg, Liverpool John Moores University, Byrom St, Liverpool L3 3AF, UK
    J Appl Physiol (1985) 111:244-50. 2011
    ..These data do not support the hypothesis that brachial artery FMD in healthy humans represents a systemic index of endothelial function...
  31. pmc Does arterial shear explain the magnitude of flow-mediated dilation?: a comparison between young and older humans
    Dick H J Thijssen
    Research Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, United Kingdom
    Am J Physiol Heart Circ Physiol 296:H57-64. 2009
    ..Therefore, we support presenting SR(AUC) stimuli but not normalizing FMD responses for the SR(AUC) when using this technique...
  32. doi request reprint Repeated increases in blood flow, independent of exercise, enhance conduit artery vasodilator function in humans
    Louise H Naylor
    School of Sports Science, Exercise and Health, The Univ of Western Australia M408, Crawley, 6009 Western Australia
    Am J Physiol Heart Circ Physiol 300:H664-9. 2011
    ..Repeated heating increases blood flow to levels that enhance endothelium-mediated vasodilator function in humans. These findings reinforce the importance of the direct impacts of shear stress on the vascular endothelium in humans...
  33. doi request reprint Endothelial dysfunction in hyperandrogenic polycystic ovary syndrome is not explained by either obesity or ectopic fat deposition
    Victoria S Sprung
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, U K
    Clin Sci (Lond) 126:67-74. 2014
    ..The results suggest that endothelial dysfunction in PCOS is not explained by body fat distribution or volume. FMD might be a useful independent prognostic tool to assess CVD risk in this population. ..
  34. doi request reprint Low-flow mediated constriction is endothelium-dependent: effects of exercise training after radial artery catheterization
    Ellen A Dawson
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom
    Circ Cardiovasc Interv 5:713-9. 2012
    ..A further aim was to examine the effect of local handgrip exercise training on radial artery L-FMC and flow-mediated dilation (FMD) after transradial catheterization...
  35. ncbi request reprint Remote ischemic preconditioning prevents reduction in brachial artery flow-mediated dilation after strenuous exercise
    Tom G Bailey
    Research Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, United Kingdom
    Am J Physiol Heart Circ Physiol 303:H533-8. 2012
    ..4% in healthy men. However, we have shown for the first time that prior RIPC of the lower limbs maintains postexercise brachial artery endothelium-dependent function at preexercise levels...
  36. pmc Impact of age, sex, and exercise on brachial artery flow-mediated dilatation
    Mark A Black
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, L3 2ET, United Kingdom
    Am J Physiol Heart Circ Physiol 297:H1109-16. 2009
    ..In OS men, who had relatively preserved NO dilator function, no training adaptations were observed. This study has potential implications for the prevention of conduit artery endothelial dysfunction in men and women...
  37. doi request reprint Impact of wall thickness on conduit artery function in humans: is there a "Folkow" effect?
    Dick H J Thijssen
    Research Institute for Sport and Exercise Science, Liverpool John Moore s University, Liverpool L3 2ET, United Kingdom
    Atherosclerosis 217:415-9. 2011
    ....
  38. ncbi request reprint Impaired skin blood flow response to environmental heating in chronic heart failure
    Daniel J Green
    School of Human Movement and Exercise Science, The University of Western Australia, Crawley 6009, Nedlands, Western Australia
    Eur Heart J 27:338-43. 2006
    ..We examined the thermoregulatory response to heat exposure in patients with chronic heart failure...
  39. ncbi request reprint Influence of cold-water immersion on limb and cutaneous blood flow after exercise
    Chris Mawhinney
    1Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UNITED KINGDOM 2School of Sport Science, Exercise and Health, The University of Western Australia, Perth, AUSTRALIA and Aspire Academy for Sports Excellence, Doha, Qatar
    Med Sci Sports Exerc 45:2277-85. 2013
    ..This study aimed to determine the influence of cold (8°C) and cool (22°C) water immersion on femoral artery and cutaneous blood flow after exercise...
  40. ncbi request reprint Magnetic resonance imaging-derived right ventricular adaptations to endurance versus resistance training
    Angela L Spence
    School of Sport Science, Exercise and Health, The University of Western Australia, Crawley, Perth, Western Australia, Australia
    Med Sci Sports Exerc 45:534-41. 2013
    ..This is the first prospective, longitudinal randomized study exploring the effect of endurance (E) versus resistance (R) exercise training on RV morphology using magnetic resonance imaging...
  41. doi request reprint Does echocardiography accurately reflect CMR-determined changes in left ventricular parameters following exercise training? A prospective longitudinal study
    Angela L Spence
    School of Sport Science, Exercise and Health, The University of Western Australia, Crawley, Western Australia, Australia
    J Appl Physiol (1985) 114:1052-7. 2013
    ..In summary, echocardiography and CMR imaging modalities produce findings that differ with respect to changes in cardiac size and volume following exercise training...
  42. pmc Comparison of forearm blood flow responses to incremental handgrip and cycle ergometer exercise: relative contribution of nitric oxide
    Daniel J Green
    School of Human Movement and Exercise Science, The University of Western Australia, Parkway Entrance No 3, 35 Stirling Highway, Crawley WA 6009, Australia
    J Physiol 562:617-28. 2005
    ..In conclusion, different types of exercise present different haemodynamic stimuli to the endothelium, which may result in differential effects of shear stress on the vasculature...
  43. doi request reprint Exercise-mediated changes in conduit artery wall thickness in humans: role of shear stress
    Dick H J Thijssen
    Research Inst for Sport and Exercise Science, Liverpool John Moores Univ, Byrom St, Liverpool, L3 3AF, UK
    Am J Physiol Heart Circ Physiol 301:H241-6. 2011
    ..These results suggest that exercise-induced changes in shear rate are not obligatory for arterial wall remodeling during a period of 8 wk of exercise training in healthy humans...
  44. doi request reprint The impact of exercise training on conduit artery wall thickness and remodeling in chronic heart failure patients
    Andrew J Maiorana
    Advanced Heart Failure and Cardiac Transplant Service, Royal Perth Hospital, Perth, Western Australia, Australia
    Hypertension 57:56-62. 2011
    ..Our findings suggest that exercise has a systemic impact on remodeling of conduit arteries in humans and that resistance exercise training may be advantageous in subjects with chronic heart failure in this regard...
  45. doi request reprint Changes in vascular and cardiac function after prolonged strenuous exercise in humans
    Ellen A Dawson
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, 15 21 Webster St, Liverpool L3 2ET, UK
    J Appl Physiol (1985) 105:1562-8. 2008
    ..In conclusion, when taken together, these data suggest a transient depression in cardiac and leg vascular function following prolonged intensive exercise...
  46. doi request reprint The effect of exergaming on vascular function in children
    Andrew Mills
    School of Sport Science, Exercise, and Health, The University of Western Australia, Crawley, Western Australia, Australia
    J Pediatr 163:806-10. 2013
    ..To assess whether exergaming can induce measurable changes in heart rate (HR), energy expenditure (EE), and flow-mediated dilation (FMD) arterial function in healthy children...
  47. ncbi request reprint Exercise training normalizes vascular dysfunction and improves central adiposity in obese adolescents
    Katie Watts
    Human Movement and Exercise Science, University of Western Australia, Crawley, Australia
    J Am Coll Cardiol 43:1823-7. 2004
    ..We sought to characterize the impact of obesity on vascular function in adolescents and to determine whether an exercise program reverses abnormalities in endothelial function...
  48. ncbi request reprint Vasomotor responses to hypoxia in type 2 diabetes
    Cara J Weisbrod
    School of Human Movement and Exercise Science, The University of Western Australia, Crawley, Australia
    Diabetes 53:2073-8. 2004
    ..05). These data indicate that diabetic and control subjects exhibit similar responses to hypoxia in the presence of alpha-adrenergic blockade despite evidence of exaggerated alpha-mediated vasoconstriction at rest...
  49. ncbi request reprint Exercise training improves cutaneous microvascular function in nonalcoholic fatty liver disease
    Christopher J A Pugh
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom
    Am J Physiol Endocrinol Metab 305:E50-8. 2013
    ..02). Exercise training improves cutaneous microvascular NO function in NAFLD patients. The benefit of exercise training compared with conventional care strongly supports a role for exercise in the prevention of CVD in NAFLD...
  50. pmc Impact of inactivity and exercise on the vasculature in humans
    Dick H J Thijssen
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Henry Cotton Campus, 15 21 Webster Street, Liverpool, L3 2ET, UK
    Eur J Appl Physiol 108:845-75. 2010
    ..Inactivity and exercise have direct "vascular deconditioning and conditioning" effects which likely modify cardiovascular risk...
  51. ncbi request reprint Intermittent exercise abolishes the diurnal variation in endothelial-dependent flow-mediated dilation in humans
    Helen Jones
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores Univ, Henry Cotton Campus, Webster St, Liverpool L3 2ET, UK
    Am J Physiol Regul Integr Comp Physiol 298:R427-32. 2010
    ..This infers a reduced function of the intrinsic endothelial NO-vasodilator system in the morning. We also report, for the first time, that a bout of intermittent exercise abolishes this diurnal variation in endothelium-dependent FMD...
  52. doi request reprint Influence of cold water immersion on limb and cutaneous blood flow at rest
    Warren Gregson
    Warren Gregson, Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool L3 3AF UK
    Am J Sports Med 39:1316-23. 2011
    ..Benefits may partly arise from a decline in limb blood flow; however, no study has comprehensively investigated the influence of different degrees of cooling undertaken via cold water immersion on limb blood flow responses...
  53. ncbi request reprint Effects of exercise training on conduit and resistance vessel function in treated and untreated hypercholesterolaemic subjects
    Jennifer H Walsh
    School of Human Movement and Exercise Science, The University of Western Australia, Perth, Australia
    Eur Heart J 24:1681-9. 2003
    ..Despite the importance of both lipid metabolism and physical activity to cardiovascular health, few studies have examined the effect of exercise training on vascular function in hypercholesterolaemic humans...
  54. ncbi request reprint Importance of measuring the time course of flow-mediated dilatation in humans
    Mark A Black
    Research Institute for Sport and Exercise Science, Liverpool John Moores University, 15 21 Webster Street, Liverpool, UK
    Hypertension 51:203-10. 2008
    ..More sophisticated approaches to measurement of FMD are required if it is to be considered a valid biomarker of vascular disease...
  55. ncbi request reprint Exercise-induced improvement in endothelial dysfunction is not mediated by changes in CV risk factors: pooled analysis of diverse patient populations
    Daniel J Green
    School of Human Movement and Exercise Science, The University of Western Australia, and Department of Cardiology, Royal Perth Hospital, Crawley, Western Australia 6009, Australia
    Am J Physiol Heart Circ Physiol 285:H2679-87. 2003
    ..We conclude that, in these subjects with antecedent vascular dysfunction, the beneficial effects of relatively short-term exercise training on vascular function are not solely mediated by the effects of exercise on CV risk factors...
  56. ncbi request reprint Exercise alone reduces insulin resistance in obese children independently of changes in body composition
    Lana M Bell
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Crawley, Western Australia 6009, Australia
    J Clin Endocrinol Metab 92:4230-5. 2007
    ..The number of obese children with insulin resistance and type 2 diabetes is increasing, but the best management strategy is not clear...
  57. doi request reprint Peripheral vascular structure and function in hypertrophic cardiomyopathy
    Nicola Jayne Rowley
    Research Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, UK
    Br J Sports Med 46:i98-103. 2012
    ..We hypothesised that, while HCM patients and athletes would exhibit similar cardiac characteristics, differences would be apparent in their brachial and carotid arteries...
  58. doi request reprint Evidence for a greater elevation in vascular shear stress after morning exercise
    Helen Jones
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
    Med Sci Sports Exerc 41:1188-93. 2009
    ..The aim of this study was to assess vascular responses after exercise at different times of day...
  59. pmc Time course of change in vasodilator function and capacity in response to exercise training in humans
    Toni M Tinken
    Research Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, UK
    J Physiol 586:5003-12. 2008
    ....
  60. doi request reprint Impact of introducer sheath coating on endothelial function in humans after transradial coronary procedures
    Ellen A Dawson
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, and Liverpool Heart and Chest Hospital, Liverpool, England, UK
    Circ Cardiovasc Interv 3:148-56. 2010
    ..The aim of this study was to compare the impact of transradial catheterization with hydrophilic-coated catheter sheaths versus uncoated sheaths on NO-mediated endothelial-dependent and -independent vasodilator function...
  61. doi request reprint Anabolic steroid use and longitudinal, radial, and circumferential cardiac motion
    Peter J Angell
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom
    Med Sci Sports Exerc 44:583-90. 2012
    ..The purpose of this study was to investigate the effect of anabolic steroid (AS) use on cardiac structure and function and cardiovascular risk factors...
  62. doi request reprint Vascular adaptation in athletes: is there an 'athlete's artery'?
    Daniel J Green
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
    Exp Physiol 97:295-304. 2012
    ..Arterial adaptation may, to some extent, emulate that evident in the hearts of endurance athletes, and it is tempting to speculate that similar mechanisms may be at play...
  63. doi request reprint Diurnal variation in vascular function: role of sleep
    Helen Jones
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom
    Chronobiol Int 29:271-7. 2012
    ..These findings also raise the possibility of a lower homeostatic "set point" for vascular function following a period of sleep and in the absence of perturbing hemodynamic fluctuation...
  64. pmc Exercise prevents age-related decline in nitric-oxide-mediated vasodilator function in cutaneous microvessels
    Mark A Black
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, 12 21 Webster Street, Liverpool L3 2ET, UK
    J Physiol 586:3511-24. 2008
    ..Since higher levels of NO confer anti-atherogenic benefit, this study has potential implications for the prevention of microvascular dysfunction in humans...
  65. doi request reprint α1-Adrenoreceptor activity does not explain lower morning endothelial-dependent, flow-mediated dilation in humans
    Helen Jones
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, United Kingdom
    Am J Physiol Regul Integr Comp Physiol 300:R1437-42. 2011
    ..34). Heart rate and norepinephrine levels were higher in the afternoon following prazosin. These data indicate that α(1)-adrenoreceptor activity does not explain lower morning endothelium-dependent FMD...
  66. doi request reprint Exercise and arterial adaptation in humans: uncoupling localized and systemic effects
    Nicola J Rowley
    Research Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, United Kingdom
    J Appl Physiol (1985) 110:1190-5. 2011
    ..These data suggest that localized effects of exercise are evident in the remodeling of arterial size, whereas arterial wall thickness appears to be affected by systemic factors...
  67. doi request reprint Impact of catheter insertion using the radial approach on vasodilatation in humans
    Ellen A Dawson
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool L3 2ET, UK
    Clin Sci (Lond) 118:633-40. 2010
    ..This raises the possibility of an endothelium-independent contribution to the flow-induced vasodilatation in humans...
  68. doi request reprint The impact of exercise on derived measures of central pressure and augmentation index obtained from the SphygmoCor device
    Ellen A Dawson
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, L3 2ET, UK
    J Appl Physiol (1985) 106:1896-901. 2009
    ..Changes in vascular tone with exercise may modify the intrinsic characteristics of the vessel wall and could compromise the assumptions underlying transfer functions used to derive central measures using applanation tonometry...
  69. doi request reprint Seasonal reduction in physical activity and flow-mediated dilation in children
    Nicola Dominique Hopkins
    Research Institute for Sport and Exercise Science, Liverpool John Moore s University, Liverpool, United Kingdom
    Med Sci Sports Exerc 43:232-8. 2011
    ..This study aimed to assess the impact of seasonal changes in physical activity (PA) and body composition on conduit artery endothelial function in children...
  70. ncbi request reprint Do skinfolds accurately assess changes in body fat in obese children and adolescents?
    Katie Watts
    School of Human Movement and Exercise Science, The University of Western Australia, Crawley, Western Australia
    Med Sci Sports Exerc 38:439-44. 2006
    ..This study compared methods of body composition assessment in obese young people to determine whether changes in various measures of body composition as a result of exercise training were correlated...
  71. ncbi request reprint Endothelial nitric oxide synthase gene polymorphism, homocysteine, cholesterol and vascular endothelial function
    William Bilsborough
    Department of Cardiothoracic Surgery, Royal Perth Hospital, GPO Box X2213, Perth 6847, WA, Australia
    Atherosclerosis 169:131-8. 2003
    ..03). In these normal community subjects, plasma homocysteine and HDL-cholesterol were predictors of FMD despite subjects being recruited without regard to these variables and despite normal plasma levels...
  72. ncbi request reprint The 6-minute walk test does not reliably detect changes in functional capacity of patients awaiting cardiac transplantation
    Craig Cheetham
    School of Human Movement and Exercise Science, University of Western Australia, Perth, Western Australia, Australia
    J Heart Lung Transplant 24:848-53. 2005
    ..The purpose of this study was to determine whether changes in 6-minute walk test (6WT) distance, a simple, inexpensive potential alternative measure of functional capacity, can predict changes in Vo(2)peak in patients with severe CHF...
  73. doi request reprint Homocysteine or renal impairment: which is the real cardiovascular risk factor?
    Kathleen Potter
    Department of Cardiology, Level 4, A Block, Royal Perth Hospital, Perth WA6847, Australia
    Arterioscler Thromb Vasc Biol 28:1158-64. 2008
    ....
  74. doi request reprint Effect of functional electrostimulation on impaired skin vasodilator responses to local heating in spinal cord injury
    Noortje T L van Duijnhoven
    Research Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, United Kingdom
    J Appl Physiol (1985) 106:1065-71. 2009
    ..This might relate to the less frequent and smaller magnitude of skin blood flow responses to heat stimuli, compared with controls, than physical inactivity per se...
  75. pmc A prospective randomised longitudinal MRI study of left ventricular adaptation to endurance and resistance exercise training in humans
    Angela L Spence
    School of Sport Science, Exercise and Health M408, The University of Western Australia, 35 Stirling Highway, Crawley Perth, Western Australia, 6009 Australia
    J Physiol 589:5443-52. 2011
    ..Our findings provide some support for the 'Morganroth hypothesis', as it pertains to LV remodelling in response to endurance training, but cast some doubt over the proposal that remodelling occurs in response to resistance training...
  76. doi request reprint Blood vessel remodeling and physical inactivity in humans
    Dick H J Thijssen
    Research Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, United Kingdom
    J Appl Physiol (1985) 111:1836-45. 2011
    ..Moreover, studies should examine the role of (hemodynamic) stimuli that underlie the characteristic vascular adaptations during deconditioning. Our review concludes with some suggestions for future research directions...
  77. doi request reprint Brachial artery blood flow responses to different modalities of lower limb exercise
    Dick H J Thijssen
    Research Institute for Sport and Exercise Science, Henry Cotton Campus, Liverpool John Moores University, Liverpool, United Kingdom
    Med Sci Sports Exerc 41:1072-9. 2009
    ..The purpose of this study was to examine the impact of different types and intensities of lower limb exercise on the BA flow pattern...
  78. ncbi request reprint The athlete's heart: a contemporary appraisal of the 'Morganroth hypothesis'
    Louise H Naylor
    Cardiac Transplant Unit, Royal Perth Hospital, Perth, Western Australia, Australia
    Sports Med 38:69-90. 2008
    ....
  79. ncbi request reprint Arterial prehabilitation: can exercise induce changes in artery size and function that decrease complications of catheterization?
    Amr Alkarmi
    Liverpool Heart and Chest Hospital, Liverpool, UK
    Sports Med 40:481-92. 2010
    ..Future research efforts should focus directly on examination of the 'prehabilitation' hypothesis and the efficacy of different interventions aimed at reducing clinical complications of common interventional procedures...
  80. ncbi request reprint Heritability of arterial function, fitness, and physical activity in youth: a study of monozygotic and dizygotic twins
    Nicola Hopkins
    Research Institute for Sport and Exercise Science, Liverpool John Moore s University, Liverpool, UK
    J Pediatr 157:943-8. 2010
    ..We also determined relationships between physical activity and fitness in each twin subset...
  81. pmc Assessment of flow-mediated dilation in humans: a methodological and physiological guideline
    Dick H J Thijssen
    Research Inst for Sport and Exercise Science, Henry Cotton Campus, Liverpool John Moores Univ, 15 21 Webster St, Liverpool, L3 2ET, UK
    Am J Physiol Heart Circ Physiol 300:H2-12. 2011
    ..The outcome is a series of recommendations on the basis of review and critical appraisal of recent physiological studies, pertaining to the most appropriate methods to assess FMD in humans...
  82. doi request reprint Cardiac adaptation to acute and chronic participation in endurance sports
    Keith George
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Tom Reilly Building, Liverpool, UK
    Heart 97:1999-2004. 2011
    ..Recent commentaries, case reports and case series data have posed the question whether you can 'overdose on exercise', and that is the focus of this brief review...
  83. ncbi request reprint Exercise training improves conduit vessel function in patients with coronary artery disease
    Jennifer H Walsh
    Department of Human Movement and Exercise Science, The University of Western Australia, Crawley 6009, Western Australia, Australia
    J Appl Physiol 95:20-5. 2003
    ..These results provide evidence for the benefit of exercise training, as an adjunct to routine therapy, in patients with a history of CAD...
  84. ncbi request reprint Anti-tumour necrosis factor-alpha therapy over conventional therapy improves endothelial function in adults with rheumatoid arthritis
    William Bilsborough
    Cardiac Transplant Unit, Royal Perth Hospital, GPO Box X2213, Perth, 6847 WA, Australia
    Rheumatol Int 26:1125-31. 2006
    ..The addition of anti-TNFalpha treatment to conventional therapy, in those with severe RA, reduces inflammatory symptoms and improves endothelial function, potentially lowering future atherosclerotic risk...
  85. doi request reprint Endothelial function and carotid intima-medial thickness in adolescents with type 2 diabetes mellitus
    Louise H Naylor
    School of Sport Science, Exercise and Health, The University of Western Australia, Crawley, West Australia, Australia
    J Pediatr 159:971-4. 2011
    ..We assessed the effect of type 2 diabetes mellitus and obesity on flow-mediated dilation (FMD) and endothelial-dependent vasodilation and carotid intima-medial thickness (cIMT) in young people...
  86. ncbi request reprint Effects of exercise training on vascular function in obese children
    Katie Watts
    School of Human Movement and Exercise Science, The University of Western Australia, Crawley, Australia
    J Pediatr 144:620-5. 2004
    ..The aim of this study was to characterize the impact of obesity on vascular function in young children and to determine whether an exercise program improves abnormalities in vascular function...
  87. ncbi request reprint Exercise & Sports Science Australia Position Statement on exercise training and chronic heart failure
    Steve E Selig
    Institute for Sport, Exercise and Active Living, School of Sport and Exercise Science, Victoria University, Melbourne, Australia
    J Sci Med Sport 13:288-94. 2010
    ..The purpose of this statement is to inform and guide exercise practitioners and health professionals in the safe and effective prescription and supervision of exercise for patients with CHF...
  88. ncbi request reprint A comparison of methods for the calculation of peak oxygen uptake in patients with heart failure
    Daniel J Green
    Department of Human Movement and Exercise Science, The University of Western Australia, Crawley
    J Cardiopulm Rehabil 22:85-8. 2002
  89. doi request reprint Last word on point: counterpoint: exercise training does/does not induce vascular adaptations beyond the active muscle beds
    Dick H J Thijssen
    J Appl Physiol 105:1011. 2008
  90. ncbi request reprint Measures of vascular reactivity: prognostic crystal ball or Pandora's box?
    Christopher T Minson
    J Appl Physiol 105:398-9. 2008
  91. pmc Vasomotor responses to decreased venous return: effects of cardiac deafferentation in humans
    Cara J Weisbrod
    School of Human Movement and Exercise Science, University of Western Australia, Perth, Australia 6009
    J Physiol 560:919-27. 2004
    ....
  92. pmc Effect of exercise training on endothelium-derived nitric oxide function in humans
    Daniel J Green
    School of Human Movement and Exercise Science, University of Western Australia, Mailbag Delivery M408, 35 Stirling Highway, Crawley WA 6009, Australia
    J Physiol 561:1-25. 2004
    ....
  93. pmc Reduced ventricular flow propagation velocity in elite athletes is augmented with the resumption of exercise training
    Louise H Naylor
    School of Human Movement and Exercise Science, University of Western Australia, 35 Stirling Highway, Nedlands, Western Australia 6009, Australia
    J Physiol 563:957-63. 2005
    ....
  94. ncbi request reprint Measuring peripheral resistance and conduit arterial structure in humans using Doppler ultrasound
    Louise H Naylor
    School of Human Movement and Exercise Science, The Univ of Western Australia, 35 Stirling Highway, Nedlands 6009, Australia
    J Appl Physiol 98:2311-5. 2005
    ....
  95. ncbi request reprint Effects of training resumption on conduit arterial diameter in elite rowers
    Louise H Naylor
    School of Human Movement and Exercise Science, University of Western Australia, Nedlands, Australia
    Med Sci Sports Exerc 38:86-92. 2006
    ....
  96. ncbi request reprint Lack of effect of oral glucose loading on conduit vessel endothelial function in healthy subjects
    Aris Siafarikas
    Department of Endocrinology and Diabetes, Princess Margaret Hospital, Subiaco, WA 6007, Australia
    Clin Sci (Lond) 107:191-6. 2004
    ....
  97. ncbi request reprint The effect of learning on ventilatory responses to inspiratory threshold loading in COPD
    Gavin A Sturdy
    Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia
    Respir Med 98:1-8. 2004
    ..This study sought to determine whether a similar "learning effect" is evident in patients with COPD, and what the mechanism of any such effect may be...