David F Goldspink

Summary

Affiliation: Liverpool John Moores University
Country: UK

Publications

  1. ncbi request reprint Ageing and activity: their effects on the functional reserve capacities of the heart and vascular smooth and skeletal muscles
    David F Goldspink
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, 15 21 Webster Street, Liverpool L3 2 ET, UK
    Ergonomics 48:1334-51. 2005
  2. doi request reprint A study of presbycardia, with gender differences favoring ageing women
    David F Goldspink
    Research Institute for Sports and Exercise Sciences, Liverpool John Moores University, Liverpool, L3 2EF, UK
    Int J Cardiol 137:236-45. 2009
  3. ncbi request reprint Relative toxicity of cardiotonic agents: some induce more cardiac and skeletal myocyte apoptosis and necrosis in vivo than others
    Jatin G Burniston
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Webster Street, Liverpool, England
    Cardiovasc Toxicol 5:355-64. 2005
  4. pmc Dose-dependent separation of the hypertrophic and myotoxic effects of the beta(2)-adrenergic receptor agonist clenbuterol in rat striated muscles
    Jatin G Burniston
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Webster Street, Liverpool L3 2ET, UK
    Muscle Nerve 33:655-63. 2006
  5. ncbi request reprint beta2-Adrenergic receptor stimulation in vivo induces apoptosis in the rat heart and soleus muscle
    Jatin G Burniston
    Research Institute for Sports and Exercise Sciences, Liverpool John Moores Univ, Webster St, Liverpool, L3 2ET, United Kingdom
    J Appl Physiol 98:1379-86. 2005
  6. doi request reprint Influence of age, sex, and aerobic capacity on forearm and skin blood flow and vascular conductance
    Gary J Hodges
    Research Institute of Sport and Exercise Sciences, Liverpool John Moores University, Henry Cotton Campus, Webster Street, Liverpool, L3 2ET, UK
    Eur J Appl Physiol 109:1009-15. 2010
  7. ncbi request reprint Catecholamine-induced apoptosis and necrosis in cardiac and skeletal myocytes of the rat in vivo: the same or separate death pathways?
    David F Goldspink
    The Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, 15 21 Webster Street, Liverpool L3 2ET, UK
    Exp Physiol 89:407-16. 2004
  8. ncbi request reprint Characterisation of isoprenaline myotoxicity on slow-twitch skeletal versus cardiac muscle
    YeeLan Ng
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, 15 21 Webster Street, UK
    Int J Cardiol 86:299-309. 2002
  9. pmc Dose-dependent apoptotic and necrotic myocyte death induced by the beta2-adrenergic receptor agonist, clenbuterol
    Jatin G Burniston
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Webster Street, Liverpool L3 2ET, UK
    Muscle Nerve 32:767-74. 2005
  10. pmc Relative myotoxic and haemodynamic effects of the beta-agonists fenoterol and clenbuterol measured in conscious unrestrained rats
    Jatin G Burniston
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Webster Street, Liverpool L3 2ET, UK
    Exp Physiol 91:1041-9. 2006

Detail Information

Publications21

  1. ncbi request reprint Ageing and activity: their effects on the functional reserve capacities of the heart and vascular smooth and skeletal muscles
    David F Goldspink
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, 15 21 Webster Street, Liverpool L3 2 ET, UK
    Ergonomics 48:1334-51. 2005
    ....
  2. doi request reprint A study of presbycardia, with gender differences favoring ageing women
    David F Goldspink
    Research Institute for Sports and Exercise Sciences, Liverpool John Moores University, Liverpool, L3 2EF, UK
    Int J Cardiol 137:236-45. 2009
    ..To rectify this, gender-specific differences in structure and function in the human cardiovascular system were studied in a European population during natural ageing...
  3. ncbi request reprint Relative toxicity of cardiotonic agents: some induce more cardiac and skeletal myocyte apoptosis and necrosis in vivo than others
    Jatin G Burniston
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Webster Street, Liverpool, England
    Cardiovasc Toxicol 5:355-64. 2005
    ..These observations suggest that judicious clinical use of such agents requires careful weighing of potential benefits against the harm via accelerated cumulative loss of myocytes...
  4. pmc Dose-dependent separation of the hypertrophic and myotoxic effects of the beta(2)-adrenergic receptor agonist clenbuterol in rat striated muscles
    Jatin G Burniston
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Webster Street, Liverpool L3 2ET, UK
    Muscle Nerve 33:655-63. 2006
    ..These data show that the low dose of 10 microg.kg(-1).d(-1) can be used in rats to investigate the anabolic effects of clenbuterol in the absence of myocyte death...
  5. ncbi request reprint beta2-Adrenergic receptor stimulation in vivo induces apoptosis in the rat heart and soleus muscle
    Jatin G Burniston
    Research Institute for Sports and Exercise Sciences, Liverpool John Moores Univ, Webster St, Liverpool, L3 2ET, United Kingdom
    J Appl Physiol 98:1379-86. 2005
    ..These data show that, when administered in vivo, beta2-AR stimulation by clenbuterol is detrimental to cardiac and skeletal muscles even at low doses, by inducing apoptosis through beta1- and beta2-AR, respectively...
  6. doi request reprint Influence of age, sex, and aerobic capacity on forearm and skin blood flow and vascular conductance
    Gary J Hodges
    Research Institute of Sport and Exercise Sciences, Liverpool John Moores University, Henry Cotton Campus, Webster Street, Liverpool, L3 2ET, UK
    Eur J Appl Physiol 109:1009-15. 2010
    ..The data indicate that peak FBF is influenced by VO2max but peak CBF is not...
  7. ncbi request reprint Catecholamine-induced apoptosis and necrosis in cardiac and skeletal myocytes of the rat in vivo: the same or separate death pathways?
    David F Goldspink
    The Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, 15 21 Webster Street, Liverpool L3 2ET, UK
    Exp Physiol 89:407-16. 2004
    ....
  8. ncbi request reprint Characterisation of isoprenaline myotoxicity on slow-twitch skeletal versus cardiac muscle
    YeeLan Ng
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, 15 21 Webster Street, UK
    Int J Cardiol 86:299-309. 2002
    ....
  9. pmc Dose-dependent apoptotic and necrotic myocyte death induced by the beta2-adrenergic receptor agonist, clenbuterol
    Jatin G Burniston
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Webster Street, Liverpool L3 2ET, UK
    Muscle Nerve 32:767-74. 2005
    ..Thus, it is important to investigate both apoptotic and necrotic myocyte death, contrary to the current trend of only investigating apoptotic cell death...
  10. pmc Relative myotoxic and haemodynamic effects of the beta-agonists fenoterol and clenbuterol measured in conscious unrestrained rats
    Jatin G Burniston
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Webster Street, Liverpool L3 2ET, UK
    Exp Physiol 91:1041-9. 2006
    ..3 mmol kg(-1) decreased diastolic blood pressure (1.3-fold; P < 0.05). In conclusion, the cardiotoxicity of fenoterol was similar to isoprenaline and greater than clenbuterol, and fenoterol had less desirable haemodynamic effects...
  11. ncbi request reprint Aldosterone induces myocyte apoptosis in the heart and skeletal muscles of rats in vivo
    Jatin G Burniston
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Webster Street, Liverpool L3 2ET, UK
    J Mol Cell Cardiol 39:395-9. 2005
    ..High circulating levels of aldosterone are clearly capable of damaging all types of striated muscle and this may lend support to the concept that heart failure is a generalised, rather than cardiac-specific, myopathy...
  12. ncbi request reprint Angiotensin II induces apoptosis in vivo in skeletal, as well as cardiac, muscle of the rat
    Jatin G Burniston
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, UK
    Exp Physiol 90:755-61. 2005
    ..Depending on the muscle type, angiotensin II induces myocyte apoptosis in skeletal muscle to a similar or greater extent as in cardiac muscle, supporting the hypothesis that angiotensin II is generally toxic to all striated muscles...
  13. pmc Anabolic effects of a non-myotoxic dose of the beta2-adrenergic receptor agonist clenbuterol on rat plantaris muscle
    Jatin G Burniston
    Muscle Physiology and Proteomics Laboratory, Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Webster Street, Liverpool L3 2ET, UK
    Muscle Nerve 35:217-23. 2007
    ..The clenbuterol-induced increase in muscle growth was concomitant with qualitative changes in the muscle's proteome that need to be considered when proposing therapeutic uses for this agent...
  14. ncbi request reprint Cardiomyocyte death and the ageing and failing heart
    David F Goldspink
    The Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, 15 21 Webster Street, UK
    Exp Physiol 88:447-58. 2003
    ....
  15. doi request reprint The effect of 48 weeks of aerobic exercise training on cutaneous vasodilator function in post-menopausal females
    Gary J Hodges
    Research Institute of Sport and Exercise Sciences, Liverpool John Moores University, Henry Cotton Campus, Webster Street, Liverpool L3 2ET, UK
    Eur J Appl Physiol 108:1259-67. 2010
    ..Aerobic capacity was also significantly improved. These adaptations were further enhanced with progressive increases in exercise intensity...
  16. doi request reprint Proteomic investigation of changes in human vastus lateralis muscle in response to interval-exercise training
    Kathryn V Holloway
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, 15 21 Webster Street, Liverpool, UK
    Proteomics 9:5155-74. 2009
    ..Pro-Q Diamond staining revealed these changes in expression were associated with phosphorylated protein species, which provides novel information regarding muscle adaptation to interval training...
  17. ncbi request reprint Myotoxic effects of clenbuterol in the rat heart and soleus muscle
    Jatin G Burniston
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool L3 2ET, United Kingdom
    J Appl Physiol 93:1824-32. 2002
    ..4 +/- 0.8% in the soleus. These data show significant myocyte-specific necrosis in the heart and skeletal muscle of the rat. Such irreversible damage in the heart suggests that clenbuterol may be damaging to long-term health...
  18. ncbi request reprint Characterization of adrenoceptor involvement in skeletal and cardiac myotoxicity Induced by sympathomimetic agents: toward a new bioassay for beta-blockers
    Lip Bun Tan
    Academic Unit of Molecular Vascular Medicine, University of Leeds, England
    J Cardiovasc Pharmacol 41:518-25. 2003
    ..Further research along these lines may deepen understanding of which beta-blockers work best in heart failure therapy...
  19. ncbi request reprint Cardiac stem cell-based myocardial regeneration: towards a translational approach
    Daniele Torella
    Laboratory of Molecular, and Cellular Cardiology, Department of Experimental and Clinical Medicine, Magna Graecia University, Magna Graecia University, Catanaro 88100, Catanzaro 88100, Italy
    Cardiovasc Hematol Agents Med Chem 6:53-9. 2008
    ..The present review highlights current knowledge on the biology of CSCs and the prospects of CSC activation in situ, without the need for cell expansion in vitro and consequent transplantation...
  20. pmc Acute beta-adrenergic overload produces myocyte damage through calcium leakage from the ryanodine receptor 2 but spares cardiac stem cells
    Georgina M Ellison
    Zena and Michael A Wiener Cardiovascular Institute and Marie Josee and Henry R Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 282:11397-409. 2007
    ..The latter could contribute to the ability of the myocardium to rapidly recover from acute hyperadrenergic damage...
  21. ncbi request reprint Mechanical properties of the latissimus dorsi muscle after cyclic training
    Graham N Askew
    School of Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Appl Physiol 93:649-59. 2002
    ..The power output of the trained LD muscle was calculated to be sufficient to deliver a significant level of assistance to a failing heart during cardiomyoplasty...