D E J Linden

Summary

Country: UK

Publications

  1. ncbi How psychotherapy changes the brain--the contribution of functional neuroimaging
    D E J Linden
    School of Psychology, University of Wales Bangor, Bangor, UK
    Mol Psychiatry 11:528-38. 2006
  2. doi [Auditory hallucinations and functional imaging]
    D E J Linden
    School of Psychology and North Wales Clinical School, University of Wales, Bangor, Wales, UK
    Fortschr Neurol Psychiatr 76:S33-9. 2008
  3. doi Brain imaging and psychotherapy: methodological considerations and practical implications
    David E J Linden
    School of Psychology and North Wales Clinical School, Bangor University, Brigantia Building, Bangor, Wales, UK
    Eur Arch Psychiatry Clin Neurosci 258:71-5. 2008
  4. ncbi What, when, where in the brain? Exploring mental chronometry with brain imaging and electrophysiology
    David E J Linden
    School of Psychology, University of Wales Bangor, Bangor, Wales, UK
    Rev Neurosci 18:159-71. 2007
  5. ncbi The working memory networks of the human brain
    David E J Linden
    Wolfson Centre of Clinical and Cognitive Neuroscience, School of Psychology, University of Wales Bangor, North Wales Clinical School, Bangor, Wales
    Neuroscientist 13:257-67. 2007
  6. ncbi The p300: where in the brain is it produced and what does it tell us?
    David E J Linden
    School of Psychology, Brigantia Building, University of Wales, Bangor LL57 2AS, UK
    Neuroscientist 11:563-76. 2005
  7. doi The brain's voices: comparing nonclinical auditory hallucinations and imagery
    David E J Linden
    Wolfson Centre for Clinical and Cognitive Neuroscience, School of Psychology, UK
    Cereb Cortex 21:330-7. 2011
  8. doi Emotional faces and the default mode network
    S Sreenivas
    North Wales Organisation for Randomised Trials in Health and Social Care, Bangor University, Bangor, UK
    Neurosci Lett 506:229-34. 2012
  9. pmc Dysbindin-1 genotype effects on emotional working memory
    C Wolf
    Wolfson Centre for Cognitive and Clinical Neuroscience, School of Psychology, Bangor University, Bangor, UK
    Mol Psychiatry 16:145-55. 2011
  10. pmc Neural correlates of enhanced visual short-term memory for angry faces: an FMRI study
    Margaret C Jackson
    School of Psychology, Bangor University, Bangor, Gwynedd, United Kingdom
    PLoS ONE 3:e3536. 2008

Collaborators

Detail Information

Publications56

  1. ncbi How psychotherapy changes the brain--the contribution of functional neuroimaging
    D E J Linden
    School of Psychology, University of Wales Bangor, Bangor, UK
    Mol Psychiatry 11:528-38. 2006
    ....
  2. doi [Auditory hallucinations and functional imaging]
    D E J Linden
    School of Psychology and North Wales Clinical School, University of Wales, Bangor, Wales, UK
    Fortschr Neurol Psychiatr 76:S33-9. 2008
    ..Future research with functional and structural imaging should go beyond correlating brain activity and symptoms and also address the functional and structural connectivity patterns in the brain that enable hallucinations...
  3. doi Brain imaging and psychotherapy: methodological considerations and practical implications
    David E J Linden
    School of Psychology and North Wales Clinical School, Bangor University, Brigantia Building, Bangor, Wales, UK
    Eur Arch Psychiatry Clin Neurosci 258:71-5. 2008
    ..I will discuss their initial application in depression and OCD, and suggest potential alternative options based on recent developments in neurofeedback technology...
  4. ncbi What, when, where in the brain? Exploring mental chronometry with brain imaging and electrophysiology
    David E J Linden
    School of Psychology, University of Wales Bangor, Bangor, Wales, UK
    Rev Neurosci 18:159-71. 2007
    ..It will be argued that similar design principles as established for behavioural studies of mental chronometry should apply to neurophysiological investigations as well...
  5. ncbi The working memory networks of the human brain
    David E J Linden
    Wolfson Centre of Clinical and Cognitive Neuroscience, School of Psychology, University of Wales Bangor, North Wales Clinical School, Bangor, Wales
    Neuroscientist 13:257-67. 2007
    ..Finally, the author highlights open questions for cognitive neuroscience research of working memory, such as that of the mechanisms for integrating different types of content (binding) or those providing the link to long-term memory...
  6. ncbi The p300: where in the brain is it produced and what does it tell us?
    David E J Linden
    School of Psychology, Brigantia Building, University of Wales, Bangor LL57 2AS, UK
    Neuroscientist 11:563-76. 2005
    ..Knowledge about the generators of the P300 will be crucial for a better understanding of its cognitive significance and its continuing clinical application...
  7. doi The brain's voices: comparing nonclinical auditory hallucinations and imagery
    David E J Linden
    Wolfson Centre for Clinical and Cognitive Neuroscience, School of Psychology, UK
    Cereb Cortex 21:330-7. 2011
    ..Our results reveal mechanisms of the generation of sensory experience in the absence of external stimulation and suggest new approaches to the investigation of the neurobiology of psychopathology...
  8. doi Emotional faces and the default mode network
    S Sreenivas
    North Wales Organisation for Randomised Trials in Health and Social Care, Bangor University, Bangor, UK
    Neurosci Lett 506:229-34. 2012
    ..The emotion-specific differential pattern of DMN deactivation may be explored further in patients with mood disorder, where the quest for biological markers of emotional biases is still ongoing...
  9. pmc Dysbindin-1 genotype effects on emotional working memory
    C Wolf
    Wolfson Centre for Cognitive and Clinical Neuroscience, School of Psychology, Bangor University, Bangor, UK
    Mol Psychiatry 16:145-55. 2011
    ..The combination of imaging and genetics thus allows us to bridge the gap between the cellular/molecular and systems/behavioral level and extend the cognitive neuroscience approach to a comprehensive biology of cognition...
  10. pmc Neural correlates of enhanced visual short-term memory for angry faces: an FMRI study
    Margaret C Jackson
    School of Psychology, Bangor University, Bangor, Gwynedd, United Kingdom
    PLoS ONE 3:e3536. 2008
    ..This appears to be of particular evolutionary importance when confronted with potentially threatening displays of emotion - previous research has shown better VSTM for angry versus happy or neutral face identities...
  11. doi Cortical oscillatory activity is critical for working memory as revealed by deficits in early-onset schizophrenia
    Corinna Haenschel
    Department of Psychiatry, Johann Wolfgang Goethe University, Frankfurt, Germany
    J Neurosci 29:9481-9. 2009
    ..Inability to maintain oscillatory activity in specific frequency bands could thus result in the information overload that may underlie both cognitive deficits and psychopathological symptoms of schizophrenia...
  12. doi Emotion-cognition interactions in schizophrenia: Implicit and explicit effects of facial expression
    Stefanie C Linden
    Wolfson Centre for Clinical and Cognitive Neuroscience, School of Psychology, Bangor University, United Kingdom
    Neuropsychologia 48:997-1002. 2010
    ....
  13. pmc Neural signatures of stimulus features in visual working memory--a spatiotemporal approach
    Helen M Morgan
    Wolfson Centre for Clinical and Cognitive Neuroscience and Wales Institute of Cognitive Neuroscience, School of Psychology, Bangor University, Penrallt Road, Gwynedd, UK
    Cereb Cortex 20:187-97. 2010
    ....
  14. doi Improving visual short-term memory by sequencing the stimulus array
    Niklas Ihssen
    Wales Institute of Cognitive Neuroscience Wolfson Centre for Clinical and Cognitive Neuroscience, Bangor University, Bangor, Wales
    Psychon Bull Rev 17:680-6. 2010
    ..In contrast, temporal segregation of the stimulus input may help participants maximize their performance and utilize their full VSTM capacity...
  15. doi Enhanced visual short-term memory for angry faces
    Margaret C Jackson
    School of Psychology, Bangor University, Bangor, United Kingdom
    J Exp Psychol Hum Percept Perform 35:363-74. 2009
    ..Perhaps processes activated by the presence of specifically angry expressions enhance VSTM because memory for the identities of angry people has particular behavioral relevance...
  16. doi Random subspace ensembles for FMRI classification
    Ludmila I Kuncheva
    School of Computer Science, Bangor University, LL57 1UT Bangor, U K
    IEEE Trans Med Imaging 29:531-42. 2010
    ..The closest rivals were the single SVM and bagging of SVM classifiers. We use kappa-error diagrams to understand the success of RS...
  17. doi Goal-oriented cognitive rehabilitation for people with early-stage Alzheimer disease: a single-blind randomized controlled trial of clinical efficacy
    Linda Clare
    Bangor University, United Kingdom
    Am J Geriatr Psychiatry 18:928-39. 2010
    ..To provide evidence regarding the clinical efficacy of cognitive rehabilitation (CR) in early-stage Alzheimer disease (AD)...
  18. pmc Working memory load for faces modulates P300, N170, and N250r
    Helen M Morgan
    Bangor University, Bangor, UK
    J Cogn Neurosci 20:989-1002. 2008
    ..Furthermore, we show, for the first time, that WM load affects the N250r and the early visual N170 component. This suggests that higher visual areas play an important role in WM for faces...
  19. doi Goal-oriented cognitive rehabilitation for an individual with Mild Cognitive Impairment: behavioural and neuroimaging outcomes
    Linda Clare
    School of Psychology, Bangor University, Bangor, Gwynedd LL57 2AS, UK
    Neurocase 15:318-31. 2009
    ..Both client-centred measures and fMRI may assist in detecting clinically-meaningful changes resulting from cognitive rehabilitation interventions...
  20. doi Neurofeedback: A promising tool for the self-regulation of emotion networks
    S J Johnston
    Bangor Imaging Unit, Wolfson Centre for Clinical and Cognitive Neuroscience, School of Psychology, Bangor University, Bangor, UK
    Neuroimage 49:1066-72. 2010
    ..These findings demonstrate the feasibility of fMRI-based neurofeedback of emotion networks and suggest a possible development into a therapeutic tool...
  21. doi Can we change brain functioning with cognition-focused interventions in Alzheimer's disease? The role of functional neuroimaging
    Jorien van Paasschen
    School of Psychology, Bangor University, UK
    Restor Neurol Neurosci 27:473-91. 2009
    ..Associative memory function is affected in the early stages of AD and also deteriorates disproportionately in comparison to other types of memory in healthy ageing...
  22. doi Processing conflicting information: facilitation, interference, and functional connectivity
    Roi Cohen Kadosh
    Institute of Cognitive Neuroscience and Department of Psychology, University College London, London, UK
    Neuropsychologia 46:2872-9. 2008
    ..4) These networks were modulated by the two groups that we distinguished based on the ACC activation...
  23. ncbi Decomposition of working memory-related scalp ERPs: crossvalidation of fMRI-constrained source analysis and ICA
    Michael Wibral
    MEG Unit, Brain Imaging Center, Johann Wolfgang Goethe University, Haus 93B, Heinrich Hoffmann Strasse 10, 60528 Frankfurt am Main, Germany
    Int J Psychophysiol 67:200-11. 2008
    ..We conclude that testing at the single-subject level is preferable for crossvalidation purposes if the signal-to-noise ratio of the data allows for this approach...
  24. ncbi Distributed cortical systems in visual short-term memory revealed by event-related functional magnetic resonance imaging
    Matthias H J Munk
    Max Planck Institut für Hirnforschung, Deutschordenstrasse 46, D 60528 Frankfurt, Germany
    Cereb Cortex 12:866-76. 2002
    ..These modulations confirmed a posterior-anterior and right-left dissociation for spatial versus non-spatial memory and revealed that conjunction memory does not rely on a linear addition of the component processes...
  25. ncbi Tracking the mind's image in the brain I: time-resolved fMRI during visuospatial mental imagery
    Elia Formisano
    Department of Cognitive Neuroscience, Faculty of Psychology, Universiteit Maastricht, Postbus 616, The Netherlands
    Neuron 35:185-94. 2002
    ..This is confirmed by a trial-by-trial analysis of correlations between reaction time and onset, width, and amplitude of the hemodynamic response. These findings pose neurophysiological constraints on cognitive models of mental imagery...
  26. ncbi Common neural substrates for visual working memory and attention
    Jutta S Mayer
    Department of Psychiatry, Johann Wolfgang Goethe University, Heinrich Hoffmann Str 10, 60528 Frankfurt, Germany
    Neuroimage 36:441-53. 2007
    ..We propose that competition for resources shared by visual attention and WM encoding can limit processing capabilities in distributed posterior brain regions...
  27. ncbi Imaging the brain activity changes underlying impaired visuospatial judgments: simultaneous FMRI, TMS, and behavioral studies
    Alexander T Sack
    Department of Cognitive Neuroscience, Faculty of Psychology, Maastricht University, 6200 MD Maastricht, The Netherlands
    Cereb Cortex 17:2841-52. 2007
    ....
  28. ncbi Localizing P300 generators in visual target and distractor processing: a combined event-related potential and functional magnetic resonance imaging study
    Christoph Bledowski
    Department of Psychiatry, Johann Wolfgang Goethe University, 60590 Frankfurt, Germany
    J Neurosci 24:9353-60. 2004
    ..The results point to the involvement of distinct attentional subsystems in target and distractor processing...
  29. ncbi Separation of the systems for color and spatial manipulation in working memory revealed by a dual-task procedure
    Harald M Mohr
    Johann Wolfgang Goethe Universitat, Germany
    J Cogn Neurosci 17:355-66. 2005
    ..We speculate that the ventral-dorsal dissociation of visual processing is conserved for manipulation processes and that manipulation differs from maintenance in the extent to which is relies on central executive resources...
  30. ncbi Cortical capacity constraints for visual working memory: dissociation of fMRI load effects in a fronto-parietal network
    David E J Linden
    Max Planck Institut für Himforschung, Deutschordenstrasse 46, D 60528 Frankfurt, Germany
    Neuroimage 20:1518-30. 2003
    ..These results indicate that at least two distinct cortical subsystems are recruited for visual WM, and that their interplay changes when the capacity limit is reached...
  31. ncbi Are numbers special? The comparison systems of the human brain investigated by fMRI
    Roi Cohen Kadosh
    Department of Behavioral Sciences and Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel
    Neuropsychologia 43:1238-48. 2005
    ....
  32. ncbi The spatiotemporal pattern of auditory cortical responses during verbal hallucinations
    Vincent G van de Ven
    Department of Cognitive Neuroscience, Faculty of Psychology, University Maastricht, The Netherlands
    Neuroimage 27:644-55. 2005
    ..We suggest that detection of this activity may be facilitated by examining hallucination epochs of sufficient length, in combination with a data-driven approach...
  33. ncbi When blue is larger than red: colors influence numerical cognition in synesthesia
    Roi Cohen Kadosh
    Ben Gurion University of the Negev, Israel
    J Cogn Neurosci 17:1766-73. 2005
    ..It is proposed that bidirectional coactivation of brain areas is responsible for the links between color and magnitude processing in color-grapheme synesthesia and that unidirectional models of synesthesia might have to be revised...
  34. ncbi Mental chronometry of working memory retrieval: a combined functional magnetic resonance imaging and event-related potentials approach
    Christoph Bledowski
    Department of Psychiatry, Johann Wolfgang Goethe University, 60590 Frankfurt, Germany
    J Neurosci 26:821-9. 2006
    ..This is also supported by their differential temporal contribution to specific subcomponents of the P300 cognitive potential...
  35. ncbi Tracking the mind's image in the brain II: transcranial magnetic stimulation reveals parietal asymmetry in visuospatial imagery
    Alexander T Sack
    Department of Psychiatry, Laboratory for Neurophysiology and Neuroimaging, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, DE 60590 Frankfurt, Germany
    Neuron 35:195-204. 2002
    ..This is compatible with current theories of spatial hemineglect and constitutes a constraint for models of distributed information processing in the parietal lobes...
  36. ncbi The brain locus of interaction between number and size: a combined functional magnetic resonance imaging and event-related potential study
    Roi Cohen Kadosh
    Ben Gurion University of the Negev, Beer Sheva, Israel
    J Cogn Neurosci 19:957-70. 2007
    ..We concluded that the processing of magnitude can be subserved by shared or distinct neural substrates, depending on task requirements...
  37. ncbi Dysfunctional long-range coordination of neural activity during Gestalt perception in schizophrenia
    Peter J Uhlhaas
    Department of Neurophysiology, Max Planck Institute for Brain Research, Frankfurt am Main, 60528, Germany
    J Neurosci 26:8168-75. 2006
    ....
  38. ncbi Attentional systems in target and distractor processing: a combined ERP and fMRI study
    Christoph Bledowski
    Department of Psychiatry, Johann Wolfgang Goethe Universitat, Frankfurt, Germany
    Neuroimage 22:530-40. 2004
    ..Our results thus demonstrate that distractor and target processing engage a common neuronal system for the detection of rare events, but also task-specific subsystems related to attention and memory processes...
  39. ncbi Five hundred years of brain images
    David E J Linden
    Laboratory for Neurophysiology and Neuroimaging, Department of Psychiatry, Johann Wolfgang Goethe Universitat, Heinrich Hoffmann Str 10, D 60528 Frankfurt am Main, Germany
    Arch Neurol 59:308-13. 2002
  40. doi Visual perceptual organization deficits in Alzheimer's dementia
    Peter J Uhlhaas
    Department of Neurophysiology, Max Planck Institute for Brain Research, Department of Psychiatry, Frankfurt am Main, Germany
    Dement Geriatr Cogn Disord 25:465-75. 2008
    ..In the current study, we examined the hypothesis that perceptual organization is specifically impaired in AD compared to other dementias...
  41. ncbi Combining transcranial magnetic stimulation and functional imaging in cognitive brain research: possibilities and limitations
    Alexander T Sack
    Laboratory for Neurophysiology and Neuroimaging, Department of Psychiatry, Johann Wolfgang Goethe Universitat, Heinrich Hoffmann Str 10, 60528, Frankfurt am Main, Germany
    Brain Res Brain Res Rev 43:41-56. 2003
    ..We argue that while some of the methodological limitations of TMS applied alone can be overcome by combination with functional neuroimaging, others will persist until its physical and physiological effects can be controlled...
  42. ncbi Functional connectivity as revealed by spatial independent component analysis of fMRI measurements during rest
    Vincent G van de Ven
    Laboratory for Neurophysiology and Neuroimaging, Department of Psychiatry, Johann Wolfgang Goethe University, Frankfurt, Germany
    Hum Brain Mapp 22:165-78. 2004
    ..These results are discussed in the context of the recent debate on the functional relevance of fluctuations of neural activity in the resting state...
  43. ncbi Enhanced vividness of mental imagery as a trait marker of schizophrenia?
    Alexander T Sack
    Department of Cognitive Neuroscience, Faculty of Psychology, University of Maastricht, The Netherlands
    Schizophr Bull 31:97-104. 2005
    ..g., frequency of hallucinations). Vividness of mental imagery might thus prove to be an independent trait marker of schizophrenia...
  44. ncbi The temporal characteristics of motion processing in hMT/V5+: combining fMRI and neuronavigated TMS
    Alexander T Sack
    Department of Neurocognition, Faculty of Psychology, Maastricht University, PO Box 616, Postbus 616, 6200 MD Maastricht, The Netherlands
    Neuroimage 29:1326-35. 2006
    ....
  45. ncbi Treating auditory hallucinations by transcranial magnetic stimulation: a randomized controlled cross-over trial
    Martin Jandl
    Department of Psychiatry I, University of Ulm, Ulm, Germany
    Neuropsychobiology 53:63-9. 2006
    ..In a previous functional magnetic resonance imaging study, the authors succeeded in demonstrating the activation of Heschl's gyrus during auditory hallucinations (AH)...
  46. ncbi Content- and task-specific dissociations of frontal activity during maintenance and manipulation in visual working memory
    Harald M Mohr
    Department of Psychiatry, Johann Wolfgang Goethe Universitat, D 60590 Frankfurt am Main, Germany
    J Neurosci 26:4465-71. 2006
    ..We suggest that the enhanced demand on cognitive resources in manipulation compared with maintenance was met by interplay of content- and task-specific modules in a frontoparietal network...
  47. ncbi Acquisition of affective dispositions in dementia patients
    Andreas Blessing
    Department of Psychology, University of Konstanz, D 78457 Konstanz, Germany
    Neuropsychologia 44:2366-73. 2006
    ..The results suggest that acquisition and maintenance of implicit affective dispositions are preserved in dementia even when explicit memory is impaired...
  48. ncbi Pain response in depersonalization: a functional imaging study using hypnosis in healthy subjects
    Christian H Röder
    Department of Psychosomatic Medicine and Psychotherapy, Johann Wolfgang Goethe University, Frankfurt, Germany
    Psychother Psychosom 76:115-21. 2007
    ..In this study we used hypnosis to induce DP in healthy subjects and to examine neural patterns of pain perception in the state of DP by means of functional magnetic resonance imaging (fMRI)...
  49. ncbi Neuronal correlates of colour-graphemic synaesthesia: a fMRI study
    Julia M Sperling
    Department of Psychiatry, Johann Wolfgang Goethe University, Frankfurt Main, Germany
    Cortex 42:295-303. 2006
    ..These findings support the hypothesis that the grapheme-induced colour perception in synaesthesia is caused by an activation of the colour areas of the human visual cortex...
  50. ncbi The independent components of auditory P300 and CNV evoked potentials derived from single-trial recordings
    Barrie Jervis
    SoCCE, University of Plymouth, Plymouth PL4 8AA, UK
    Physiol Meas 28:745-71. 2007
    ..For the CNV, BICs corresponding to both the orienting and the expectancy components were found...
  51. ncbi Visual hallucinations in schizophrenia investigated with functional magnetic resonance imaging
    Viola Oertel
    Neurophysiology and Neuroimaging Laboratory, Deparment of Psychiatry, Goethe University, Frankfurt Main, Germany
    Psychiatry Res 156:269-73. 2007
    ..We assume that the hippocampal activity is related to the retrieval of visual images from memory and that sensory cortex activity is related to the vividness of the perceptual experience...
  52. ncbi Contribution of impaired early-stage visual processing to working memory dysfunction in adolescents with schizophrenia: a study with event-related potentials and functional magnetic resonance imaging
    Corinna Haenschel
    Laboratory for Neurophysiology and Neuroimaging, Department of Psychiatry, Johann Wolfgang Goethe University, and Max Planck Institute for Brain Research, Frankfurt, Germany
    Arch Gen Psychiatry 64:1229-40. 2007
    ....
  53. ncbi Combining electrophysiology and functional imaging - different methods for different questions
    Christoph Bledowski
    Trends Cogn Sci 11:500-2. 2007
  54. ncbi Object- and direction-specific interference between manual and mental rotation
    Alexander T Sack
    Faculty of Psychology, Department of Cognitive Neuroscience, Maastricht University, Maastricht, The Netherlands
    Percept Psychophys 69:1435-49. 2007
    ..This object- and direction-specific interference between manual and mental rotation proved to be independent of task difficulty. We furthermore found an angular distance effect across different stimulus types...
  55. ncbi The corpus callosum in schizophrenia-volume and connectivity changes affect specific regions
    Anna Rotarska-Jagiela
    Department of Psychiatry, Neurophysiology and Neuroimaging Lab, Johann Wolfgang Goethe University, Frankfurt Main, Germany
    Neuroimage 39:1522-32. 2008
    ....
  56. ncbi Coordinate and categorical judgements in spatial imagery. An fMRI study
    Luigi Trojano
    Salvatore Maugeri Foundation, IRCCS, Institute of Telese, Loc S Stefano in Lanterria, Telese Terme, BN, Italy
    Neuropsychologia 40:1666-74. 2002
    ....