Alasdair Leslie

Summary

Country: UK

Publications

  1. ncbi Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype
    Alasdair Leslie
    Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, United Kingdom
    J Immunol 177:4699-708. 2006
  2. ncbi Central role of reverting mutations in HLA associations with human immunodeficiency virus set point
    Philippa C Matthews
    Department of Paediatrics, Peter Medawar Building for Pathogen Research, United Kingdom
    J Virol 82:8548-59. 2008
  3. ncbi HLA-Cw*03-restricted CD8+ T-cell responses targeting the HIV-1 gag major homology region drive virus immune escape and fitness constraints compensated for by intracodon variation
    Isobella Honeyborne
    Department of Paediatrics, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, United Kingdom
    J Virol 84:11279-88. 2010
  4. ncbi Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection
    Hayley Crawford
    Department of Pediatrics, University of Oxford, Peter Medawar Building for Pathogen Research, South Parks Rd, Oxford OX1 3SY, United Kingdom
    J Virol 81:8346-51. 2007
  5. ncbi The hypervariable HIV-1 capsid protein residues comprise HLA-driven CD8+ T-cell escape mutations and covarying HLA-independent polymorphisms
    Hayley Crawford
    Department of Paediatrics, University of Oxford, Peter Medawar Building for Pathogen Research, South Parks Rd, Oxford OX1 3SY, United Kingdom
    J Virol 85:1384-90. 2011
  6. ncbi HLA-A*7401-mediated control of HIV viremia is independent of its linkage disequilibrium with HLA-B*5703
    Philippa C Matthews
    Department of Paediatrics, University of Oxford, Oxford OX1 3SY, United Kingdom
    J Immunol 186:5675-86. 2011
  7. ncbi Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes
    Isobella Honeyborne
    Department of Paediatrics, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, United Kingdom
    J Virol 81:3667-72. 2007
  8. ncbi Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1
    Javier Martinez-Picado
    IrsiCaixa Foundation, University Hospital Germans Trias i Pujol, Barcelona, Spain
    J Virol 80:3617-23. 2006
  9. ncbi Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA
    Alasdair Leslie
    Peter Medawar Building, University of Oxford, Oxford OX13SY, UK
    J Exp Med 201:891-902. 2005
  10. ncbi CD8+ T-cell responses to different HIV proteins have discordant associations with viral load
    Photini Kiepiela
    HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu Natal, Durban 4013, South Africa
    Nat Med 13:46-53. 2007

Collaborators

Detail Information

Publications10

  1. ncbi Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype
    Alasdair Leslie
    Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, United Kingdom
    J Immunol 177:4699-708. 2006
    ..These findings are of relevance to vaccine approaches that seek to exploit HLA supertypes to overcome the problem of HLA diversity...
  2. ncbi Central role of reverting mutations in HLA associations with human immunodeficiency virus set point
    Philippa C Matthews
    Department of Paediatrics, Peter Medawar Building for Pathogen Research, United Kingdom
    J Virol 82:8548-59. 2008
    ..The significance of these results is in highlighting the rationale for an HIV vaccine that can induce these broad responses...
  3. ncbi HLA-Cw*03-restricted CD8+ T-cell responses targeting the HIV-1 gag major homology region drive virus immune escape and fitness constraints compensated for by intracodon variation
    Isobella Honeyborne
    Department of Paediatrics, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, United Kingdom
    J Virol 84:11279-88. 2010
    ....
  4. ncbi Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection
    Hayley Crawford
    Department of Pediatrics, University of Oxford, Peter Medawar Building for Pathogen Research, South Parks Rd, Oxford OX1 3SY, United Kingdom
    J Virol 81:8346-51. 2007
    ..These data may help explain the observed association between HLA-B*5703 and long-term control of viremia...
  5. ncbi The hypervariable HIV-1 capsid protein residues comprise HLA-driven CD8+ T-cell escape mutations and covarying HLA-independent polymorphisms
    Hayley Crawford
    Department of Paediatrics, University of Oxford, Peter Medawar Building for Pathogen Research, South Parks Rd, Oxford OX1 3SY, United Kingdom
    J Virol 85:1384-90. 2011
    ..Our results demonstrate complex patterns of adaptation of HIV under immune selection pressure, the understanding of which should aid vaccine design...
  6. ncbi HLA-A*7401-mediated control of HIV viremia is independent of its linkage disequilibrium with HLA-B*5703
    Philippa C Matthews
    Department of Paediatrics, University of Oxford, Oxford OX1 3SY, United Kingdom
    J Immunol 186:5675-86. 2011
    ..In addition, these studies identify a factor contributing to different HIV disease outcomes in individuals expressing HLA-B*5703...
  7. ncbi Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes
    Isobella Honeyborne
    Department of Paediatrics, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, United Kingdom
    J Virol 81:3667-72. 2007
    ..These data are consistent with data from studies of other HLA-class I alleles associated with HIV control that have shown that the targeting of multiple Gag epitopes is associated with relative suppression of viremia...
  8. ncbi Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1
    Javier Martinez-Picado
    IrsiCaixa Foundation, University Hospital Germans Trias i Pujol, Barcelona, Spain
    J Virol 80:3617-23. 2006
    ....
  9. ncbi Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA
    Alasdair Leslie
    Peter Medawar Building, University of Oxford, Oxford OX13SY, UK
    J Exp Med 201:891-902. 2005
    ..These data help to explain how HIV is evolving at a population level. Understanding the direction of HIV evolution has important implications for vaccine development...
  10. ncbi CD8+ T-cell responses to different HIV proteins have discordant associations with viral load
    Photini Kiepiela
    HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu Natal, Durban 4013, South Africa
    Nat Med 13:46-53. 2007
    ..These population-based data, suggesting the existence of both effective immune responses and responses lacking demonstrable biological impact in chronic HIV infection, are of relevance to HIV vaccine design and evaluation...