Alasdair Leslie

Summary

Country: UK

Publications

  1. ncbi request reprint Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype
    Alasdair Leslie
    Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, United Kingdom
    J Immunol 177:4699-708. 2006
  2. pmc Central role of reverting mutations in HLA associations with human immunodeficiency virus set point
    Philippa C Matthews
    Department of Paediatrics, Peter Medawar Building for Pathogen Research, United Kingdom
    J Virol 82:8548-59. 2008
  3. pmc HLA-Cw*03-restricted CD8+ T-cell responses targeting the HIV-1 gag major homology region drive virus immune escape and fitness constraints compensated for by intracodon variation
    Isobella Honeyborne
    Department of Paediatrics, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, United Kingdom
    J Virol 84:11279-88. 2010
  4. pmc HLA-specific intracellular epitope processing shapes an immunodominance pattern for HLA-B*57 that is distinct from HLA-B*58:01
    Henrik N Kløverpris
    Department of Paediatrics, University of Oxford, Oxford, United Kingdom
    J Virol 87:10889-94. 2013
  5. pmc Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection
    Hayley Crawford
    Department of Pediatrics, University of Oxford, Peter Medawar Building for Pathogen Research, South Parks Rd, Oxford OX1 3SY, United Kingdom
    J Virol 81:8346-51. 2007
  6. pmc The hypervariable HIV-1 capsid protein residues comprise HLA-driven CD8+ T-cell escape mutations and covarying HLA-independent polymorphisms
    Hayley Crawford
    Department of Paediatrics, University of Oxford, Peter Medawar Building for Pathogen Research, South Parks Rd, Oxford OX1 3SY, United Kingdom
    J Virol 85:1384-90. 2011
  7. pmc HLA-A*7401-mediated control of HIV viremia is independent of its linkage disequilibrium with HLA-B*5703
    Philippa C Matthews
    Department of Paediatrics, University of Oxford, Oxford OX1 3SY, United Kingdom
    J Immunol 186:5675-86. 2011
  8. pmc Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes
    Isobella Honeyborne
    Department of Paediatrics, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, United Kingdom
    J Virol 81:3667-72. 2007
  9. pmc Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1
    Javier Martinez-Picado
    IrsiCaixa Foundation, University Hospital Germans Trias i Pujol, Barcelona, Spain
    J Virol 80:3617-23. 2006
  10. pmc Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA
    Alasdair Leslie
    Peter Medawar Building, University of Oxford, Oxford OX13SY, UK
    J Exp Med 201:891-902. 2005

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype
    Alasdair Leslie
    Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, United Kingdom
    J Immunol 177:4699-708. 2006
    ..These findings are of relevance to vaccine approaches that seek to exploit HLA supertypes to overcome the problem of HLA diversity...
  2. pmc Central role of reverting mutations in HLA associations with human immunodeficiency virus set point
    Philippa C Matthews
    Department of Paediatrics, Peter Medawar Building for Pathogen Research, United Kingdom
    J Virol 82:8548-59. 2008
    ..The significance of these results is in highlighting the rationale for an HIV vaccine that can induce these broad responses...
  3. pmc HLA-Cw*03-restricted CD8+ T-cell responses targeting the HIV-1 gag major homology region drive virus immune escape and fitness constraints compensated for by intracodon variation
    Isobella Honeyborne
    Department of Paediatrics, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, United Kingdom
    J Virol 84:11279-88. 2010
    ....
  4. pmc HLA-specific intracellular epitope processing shapes an immunodominance pattern for HLA-B*57 that is distinct from HLA-B*58:01
    Henrik N Kløverpris
    Department of Paediatrics, University of Oxford, Oxford, United Kingdom
    J Virol 87:10889-94. 2013
    ..This unexpected finding demonstrates that immunodominance patterns can be influenced by intracellular events independent of HLA binding motifs. ..
  5. pmc Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection
    Hayley Crawford
    Department of Pediatrics, University of Oxford, Peter Medawar Building for Pathogen Research, South Parks Rd, Oxford OX1 3SY, United Kingdom
    J Virol 81:8346-51. 2007
    ..These data may help explain the observed association between HLA-B*5703 and long-term control of viremia...
  6. pmc The hypervariable HIV-1 capsid protein residues comprise HLA-driven CD8+ T-cell escape mutations and covarying HLA-independent polymorphisms
    Hayley Crawford
    Department of Paediatrics, University of Oxford, Peter Medawar Building for Pathogen Research, South Parks Rd, Oxford OX1 3SY, United Kingdom
    J Virol 85:1384-90. 2011
    ..Our results demonstrate complex patterns of adaptation of HIV under immune selection pressure, the understanding of which should aid vaccine design...
  7. pmc HLA-A*7401-mediated control of HIV viremia is independent of its linkage disequilibrium with HLA-B*5703
    Philippa C Matthews
    Department of Paediatrics, University of Oxford, Oxford OX1 3SY, United Kingdom
    J Immunol 186:5675-86. 2011
    ..In addition, these studies identify a factor contributing to different HIV disease outcomes in individuals expressing HLA-B*5703...
  8. pmc Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes
    Isobella Honeyborne
    Department of Paediatrics, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, United Kingdom
    J Virol 81:3667-72. 2007
    ..These data are consistent with data from studies of other HLA-class I alleles associated with HIV control that have shown that the targeting of multiple Gag epitopes is associated with relative suppression of viremia...
  9. pmc Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1
    Javier Martinez-Picado
    IrsiCaixa Foundation, University Hospital Germans Trias i Pujol, Barcelona, Spain
    J Virol 80:3617-23. 2006
    ....
  10. pmc Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA
    Alasdair Leslie
    Peter Medawar Building, University of Oxford, Oxford OX13SY, UK
    J Exp Med 201:891-902. 2005
    ..These data help to explain how HIV is evolving at a population level. Understanding the direction of HIV evolution has important implications for vaccine development...
  11. ncbi request reprint CD8+ T-cell responses to different HIV proteins have discordant associations with viral load
    Photini Kiepiela
    HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu Natal, Durban 4013, South Africa
    Nat Med 13:46-53. 2007
    ..These population-based data, suggesting the existence of both effective immune responses and responses lacking demonstrable biological impact in chronic HIV infection, are of relevance to HIV vaccine design and evaluation...