Research Topics
| A J MitchellSummaryAffiliation: Leicester General Hospital Country: UK Publications
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Detail Information
Publications
High medication discontinuation rates in psychiatry: how often is it understandable?Alex J Mitchell
J Clin Psychopharmacol 26:109-12. 2006
Depressed patients and treatment adherenceAlex J Mitchell
Department of Liaison Psychiatry, Brandon Unit, Leicester General Hospital, Leicester LE5 4PW, UK
Lancet 367:2041-3. 2006
Acceptability of common screening methods used to detect distress and related mood disorders-preferences of cancer specialists and non-specialistsAlex J Mitchell
Liaison Psychiatry, University of Leicester, Brandon Unit, Leicester, UK
Psychooncology 17:226-36. 2008..We suggest that future field studies of screening tools should also measure the issue of acceptability...
Is it time to separate subjective cognitive complaints from the diagnosis of mild cognitive impairment?Alex J Mitchell
Department of Cancer and Molecular Medicine, Leicester Royal Infirmary, Leicester General Hospital, Leicester, UK
Age Ageing 37:497-9. 2008..Despite a close association, SCC may be neither necessary nor sufficient for a diagnosis of either MCI or dementia...
Guideline concordant monitoring of metabolic risk in people treated with antipsychotic medication: systematic review and meta-analysis of screening practicesA J Mitchell
Psycho Oncology, Leicester General Hospital, Leicestershire Partnership Trust, Leicester, UK
Psychol Med 42:125-47. 2012..Despite increased cardiometabolic risk in individuals with mental illness taking antipsychotic medication, metabolic screening practices are often incomplete or inconsistent...
Clinical recognition and recording of alcohol disorders by clinicians in primary and secondary care: meta-analysisAlex J Mitchell
Leicester General Hospital, Leicester Partnership Trust, Leicester, UK
Br J Psychiatry 201:93-100. 2012..Clinicians have considerable difficulty identifying and helping those people with alcohol problems but no previous study has looked at this systematically...
Validation of simple visual-analogue thermometer screen for mood complications of cardiovascular disease: the Emotion ThermometersAlex J Mitchell
Psycho Oncology, Leicestershire Partnership Trust, LE5 OTD UK
J Affect Disord 136:1257-63. 2012..We therefore examined the value of a single item NCCN Distress Thermometer and an enhanced visual-analogue method (Emotion Thermometers, ET) that incorporates four emotion thermometers...
[Prognosis of depression in the elderly in comparison with adult age. Is there a significant clinical difference?]A J Mitchell
MRCPsych, Department of Liaison Psychiatry, Brandon Unit, Leicester General Hospital, Leicester Reino Unido
Actas Esp Psiquiatr 37:289-96. 2009..The effect of age on prognosis may be largely explained by factors such as previous episodes and medical comorbidity...
Can the Distress Thermometer be improved by additional mood domains? Part I. Initial validation of the Emotion Thermometers toolAlex J Mitchell
Department of Cancer and Molecular Medicine, Leicester Royal Infirmary, Leicester LE1 5WW, UK
Psychooncology 19:125-33. 2010..To examine the value of a new screening instrument in a visual-analogue format...
Can the Distress Thermometer be improved by additional mood domains? Part II. What is the optimal combination of Emotion Thermometers?Alex J Mitchell
Department of Cancer and Molecular Medicine, Leicester Royal Infirmary, Leicester LE1 5WW, UK
Psychooncology 19:134-40. 2010..To examine the added value of an algorithmic combination of visual-analogue thermometers compared with the Distress Thermometer (DT) when attempting to detect depression, anxiety or distress in early cancer...
Rate of progression of mild cognitive impairment to dementia--meta-analysis of 41 robust inception cohort studiesA J Mitchell
Liaison Psychiatry, Leicester Partnership Trust and University of Leicester, Leicester, UK
Acta Psychiatr Scand 119:252-65. 2009..To quantify the risk of developing dementia in those with mild cognitive impairment (MCI)...
Temporal trends in the long term risk of progression of mild cognitive impairment: a pooled analysisA J Mitchell
University of Leicester, Brandon Unit Leicester General Hospital, Leicester LE54PW, UK
J Neurol Neurosurg Psychiatry 79:1386-91. 2008..Recently, a number of long term studies have been published with observation periods of 5 years of longer...
Accuracy of specific symptoms in the diagnosis of major depressive disorder in psychiatric out-patients: data from the MIDAS projectA J Mitchell
Liaison Psychiatry, Leicester General Hospital and Department of Cancer and Molecular Medicine, Leicester Royal Infirmary, Leicester, UK
Psychol Med 39:1107-16. 2009..Our aim was to elucidate the best possible specific symptoms that would assist in ruling in or ruling out a major depressive episode in a psychiatric out-patient setting...
A meta-analysis of the accuracy of the mini-mental state examination in the detection of dementia and mild cognitive impairmentAlex J Mitchell
Department of Liaison Psychiatry, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK
J Psychiatr Res 43:411-31. 2009..In conclusion the MMSE offers modest accuracy with best value for ruling-out a diagnosis of dementia in community and primary care. For all other used it should be combined with or replaced by other methods...
Are one or two simple questions sufficient to detect depression in cancer and palliative care? A Bayesian meta-analysisA J Mitchell
Department of Cancer and Molecular Medicine, Leicester Royal Infirmary, Leicester LE1 5WW, UK
Br J Cancer 98:1934-43. 2008..The 'two question' method is significantly more accurate than either single question but clinicians should not rely on these simple questions alone and should be prepared to assess the patient more thoroughly...
The clinical significance of subjective memory complaints in the diagnosis of mild cognitive impairment and dementia: a meta-analysisAlex J Mitchell
Department of Liaison Psychiatry, Brandon Unit, Leciester General Hospital, Leicester, UK
Int J Geriatr Psychiatry 23:1191-202. 2008..Subjective memory complaints (SMC) are frequently reported by individuals with objective evidence of cognitive decline although the exact rate of complaints and their diagnostic value is uncertain...
Pooled results from 38 analyses of the accuracy of distress thermometer and other ultra-short methods of detecting cancer-related mood disordersAlex J Mitchell
Department of Cancer and Molecular Medicine, Leicester Royal Infirmary, Leicester, United Kingdom
J Clin Oncol 25:4670-81. 2007..Ultra-short methods cannot be used alone to diagnose depression, anxiety, or distress in cancer patients but they may be considered as a first-stage screen to rule out cases of depression...
CSF phosphorylated tau in the diagnosis and prognosis of mild cognitive impairment and Alzheimer's disease: a meta-analysis of 51 studiesA J Mitchell
Department of Liaison Psychiatry, Brandon Unit, Leicester General Hospital, Leicester Partnership Trust, Leicester LE5 4PW, UK
J Neurol Neurosurg Psychiatry 80:966-75. 2009..To evaluate the accuracy and clinical utility of phosphorylated tau (p-tau) for the diagnosis and prognosis of Alzheimer's disease (AD) and mild cognitive impairment (MCI)...
Quality of medical care for people with and without comorbid mental illness and substance misuse: systematic review of comparative studiesAlex J Mitchell
Department of Liaison Psychiatry, Leicester General Hospital, Leicester LE5 4PW, UK
Br J Psychiatry 194:491-9. 2009..There has been long-standing concern about the quality of medical care offered to people with mental illness...
Clinical recognition of dementia and cognitive impairment in primary care: a meta-analysis of physician accuracyAlex J Mitchell
Leicester General Hospital, Leicestershire Partnership Trust, UK
Acta Psychiatr Scand 124:165-83. 2011..We aimed to examine the ability of the general practitioners (GPs) to recognize a spectrum of cognitive impairment from mild cognitive impairment (MCI) to severe dementia in routine practice using their own clinical judgment...
Revascularisation and mortality rates following acute coronary syndromes in people with severe mental illness: comparative meta-analysisAlex J Mitchell
Department of Liaison Psychiatry, Leicestershire Partnership Trust and Department of Cancer Studies and Molecular Medicine, Leicester Royal Infirmary, Leicester, UK
Br J Psychiatry 198:434-41. 2011..High levels of comorbid physical illness and excess mortality rates have been previously documented in people with severe mental illness, but outcomes following myocardial infarction and other acute coronary syndromes are less clear...
International comparison of clinicians' ability to identify depression in primary care: meta-analysis and meta-regression of predictorsAlex J Mitchell
Department of Cancer Studies and Molecular Medicine, University of Leicester, UK
Br J Gen Pract 61:e72-80. 2011..There are international differences in the epidemiology of depression and the performance of primary care physicians but the factors underlying these national differences are uncertain...
Do deficits in cardiac care influence high mortality rates in schizophrenia? A systematic review and pooled analysisAlex J Mitchell
Department of Liaison Psychiatry, Leicester General Hospital, Leicester, UK
J Psychopharmacol 24:69-80. 2010..Every effort should be made to deliver high-quality medical care to people with severe mental illness...
Screening and case-finding tools for the detection of dementia. Part II: evidence-based meta-analysis of single-domain testsAlex J Mitchell
Department of Liaison Psychiatry, Liecestershire Partnership Trust, Leicester General Hospital, Leicester, UK
Am J Geriatr Psychiatry 18:783-800. 2010..To evaluate the diagnostic validity of single-domain cognitive tests for detecting dementia. These methods were defined as those that focus mainly on one domain of cognitive function such as orientation, memory, or executive function...
Can general practitioners identify people with distress and mild depression? A meta-analysis of clinical accuracyAlex J Mitchell
Leicester General Hospital, Leicestershire Partnership Trust, Leicester LE5 4PW, United Kingdom
J Affect Disord 130:26-36. 2011..There is increasing emphasis on distress and mild depression but uncertainty regarding how well general practitioners (GPs) identify these conditions. Further, the proportion of attendees suffering distress is also unclear...
Do CSF biomarkers help clinicians predict the progression of mild cognitive impairment to dementia?Alex J Mitchell
Department of Liaison Psychiatry, Leicester General Hospital, Leicester LE5 4PWl, UK
Pract Neurol 10:202-7. 2010....
Diagnostic validity of the Hospital Anxiety and Depression Scale (HADS) in cancer and palliative settings: a meta-analysisAlex J Mitchell
Department of Cancer and Molecular Medicine, Leicester Royal Infirmary, University of Leicester LE1 5WW, United Kingdom
J Affect Disord 126:335-48. 2010..To examine the validity of the Hospital Anxiety and Depression Scale (HADS) in the identification of psychiatric complications of cancer, as defined by a robust criterion standard...
Clinical diagnosis of depression in primary care: a meta-analysisAlex J Mitchell
Leicestershire Partnership Trust, Leicester General Hospital, Leicester, UK
Lancet 374:609-19. 2009..Most care for depression is delivered by general practitioners (GPs). We assessed the rate of true positives and negatives, and false positives and negatives in primary care when GPs make routine diagnoses of depression...
A comparative survey of missed initial and follow-up appointments to psychiatric specialties in the United kingdomAlex J Mitchell
Department of Liaison Psychiatry, Leicester General Hospital, UK
Psychiatr Serv 58:868-71. 2007..This study examined the frequency of missed appointments among 9,511 initial outpatient appointments and 7,700 follow-up appointments across ten psychiatric subspecialties in a publicly funded mental health service in the United Kingdom...
Prognosis of depression in old age compared to middle age: a systematic review of comparative studiesAlex J Mitchell
Department of Liaison Psychiatry, Brandon Unit, Leicester General Hospital, Leicester, UK LE5 4PW
Am J Psychiatry 162:1588-601. 2005..The authors sought to identify research that has compared the prognosis of depression in late life with depression in midlife under similar conditions...
Quality of life and its assessment in multiple sclerosis: integrating physical and psychological components of wellbeingAlex J Mitchell
Department of Liasion Psychiatry, Brandon Mental Health Unit, Leicester General Hospital, Leicester, UK
Lancet Neurol 4:556-66. 2005..Subjective (self-report) HRQoL measures may serve to alert clinicians to areas that would otherwise be overlooked. Studies of new interventions should include an assessment of HRQoL not just impairment or disability alone...
Physical health and schizophreniaAlex J Mitchell
Department of Liason Psychiatry, Brandon Unit, Leicester General Hospital, Leicester, UK
Curr Opin Psychiatry 19:432-7. 2006..It is debatable whether this is related to shared risk factors, antipsychotic medication or inherent to the condition itself. This review will describe this association and the recent advances in the field...
Self harm and attempted suicide in adults: 10 practical questions and answers for emergency department staffA J Mitchell
Department of Liaison Psychiatry, Leicester General Hospital, Leicester, UK
Emerg Med J 23:251-5. 2006..It is also recommended that adolescents and elderly people warrant a mandatory specialist assessment...
Screening and case finding tools for the detection of dementia. Part I: evidence-based meta-analysis of multidomain testsAlex J Mitchell
Department of Liaison Psychiatry, Brandon Unit, Leicester General Hospital, Leicester, UK
Am J Geriatr Psychiatry 18:759-82. 2010..To evaluate the diagnostic accuracy of all brief multidomain alternatives to the Mini-Mental State Examination (MMSE) in the detection of dementia...
Adherence behaviour with psychotropic medication is a form of self-medicationAlex J Mitchell
Leicester Royal Infirmary, Leicester, United Kingdom
Med Hypotheses 68:12-21. 2007..The self-medication hypothesis applied to prescribed psychotropic medication should assist rather than heed clinicians in improving adherence by taking a patient centred approach and where possible promoting patient autonomy...
Do ultra-short screening instruments accurately detect depression in primary care? A pooled analysis and meta-analysis of 22 studiesAlex J Mitchell
Department of Liaison Psychology, Leicester General Hospital, Leicester
Br J Gen Pract 57:144-51. 2007..Ultra-short (one-, two-, three- or four-item) tests have appeal due to their simple administration but their accuracy has not been established...
Reluctance to disclose difficult diagnoses: a narrative review comparing communication by psychiatrists and oncologistsAlex J Mitchell
Department of Cancer Studies and Molecular Medicine, Leicester Royal Infirmary, Osbourne Building, Leicester LE1 5WW, UK
Support Care Cancer 15:819-28. 2007..National guidance in most medical specialties supports the full and open disclosure of diagnoses to patients...
Diagnostic validity and added value of the Geriatric Depression Scale for depression in primary care: a meta-analysis of GDS30 and GDS15Alex J Mitchell
Leicester General Hospital, Leicester Partnership Trust, Leicester LE5 4PW, United Kingdom
J Affect Disord 125:10-7. 2010..We therefore conducted a meta-analysis analysing the diagnostic accuracy, clinical utility and added value of the GDS in primary care...
Predictors of A&E staff attitudes to self-harm patients who use self-laceration: influence of previous training and experienceTrevor Friedman
Department of Liaison Psychiatry, Brandon Unit, Leicester General Hospital, Leicester LE5 4PW, United Kingdom
J Psychosom Res 60:273-7. 2006..The aim of this study was to investigate the attitudes of accident and emergency (A&E) staff towards patients who self-harm through laceration...
Short screening tools for cancer-related distress: a review and diagnostic validity meta-analysisAlex J Mitchell
Leicester General Hospital, Leicester LE5 4PW, United Kingdom
J Natl Compr Canc Netw 8:487-94. 2010..Nevertheless, short methods seem to be at least as successful as the HADS, although substantially more efficient and hence more acceptable, and therefore may be a suitable initial method of assessment in busy clinical settings...
Do primary care physicians have particular difficulty identifying late-life depression? A meta-analysis stratified by ageAlex J Mitchell
Leicester General Hospital, Leicestershire Partnership Trust, Leicester Royal Infirmary, Leicester, UK
Psychother Psychosom 79:285-94. 2010..There is long-standing concern regarding poor recognition of depression in primary care, especially in older people...
The national service framework for long term conditionsNiruj Agrawal
BMJ 330:1280-1. 2005
Efficiency of a two-item pre-screen to reduce the burden of depression screening in pregnancy and postpartum: an IMPLICIT network studyIan M Bennett
Department of Family Medicine and Community Health, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Am Board Fam Med 21:317-25. 2008..Here we assess the diagnostic accuracy of a modified 2-item patient health questionnaire (PHQ-2) as a pre-screen in assessing depression...
Quality of life is not favorable for most patients with multiple sclerosisAlex J Mitchell
Arch Neurol 61:1807-8; author reply 1808. 2004
Depression screening and patient outcomes in cardiovascular care: a systematic reviewBrett D Thombs
Department of Psychiatry, McGill University, Montreal, Quebec, Canada
JAMA 300:2161-71. 2008..Several practice guidelines recommend that depression be evaluated and treated in patients with cardiovascular disease, but the potential benefits of this are unclear...
Antidepressants and suicide: risk of completed suicide is not the same as risk of deliberate self harmAlex J Mitchell
BMJ 329:461; author reply 461-2. 2004
The prognosis of depression in late life versus mid-life: implications for the treatment of older adultsHari Subramaniam
Int Psychogeriatr 17:533-7. 2005
Measuring outcome in psychogenic nonepileptic seizures: how relevant is seizure remission?Markus Reuber
Academic Neurology Unit, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
Epilepsia 46:1788-95. 2005..To examine whether seizure remission is a comprehensive marker of outcome in psychogenic nonepileptic seizures (PNESs)...
Hospital management of self harm in adults in England: study contains important data not reported in the paperAlex J Mitchell
BMJ 328:1440; author reply 1440. 2004
Depression as a risk factor for later dementia: a robust relationship?Alex J Mitchell
Age Ageing 34:207-9. 2005
Do selective serotonin reuptake inhibitors cause suicide? Data seem to be incorrectAlex J Mitchell
BMJ 330:1149-50; author reply 1150. 2005
Guillain-Barré-like syndrome associated with olanzapine hypersensitivity reactionJulian Benito-Leon
Department of Neurology, Mostoles General Hospital, Madrid, Spain
Clin Neuropharmacol 28:150-1. 2005..The presence of progressive numbness, motor weakness, or pain in the limbs of patients receiving olanzapine should raise suspicion of Guillain-Barré syndrome...
Anxiety in patients with epilepsy: systematic review and suggestions for clinical managementStefan Beyenburg
Department of Neurology, Centre Hospitalier de Luxembourg, Rue Barblé 4, L 1210 Luxembourg, Luxembourg
Epilepsy Behav 7:161-71. 2005..Nevertheless, a practical approach based on the temporal relationship between anxiety and epileptic seizures allows clinicians to consider appropriate treatment strategies to reduce the psychiatric comorbidity in patients with epilepsy...
NICE may be discouraging detection of postpartum depressionJames C Coyne
BMJ 334:550. 2007
Unusually rapid and severe cognitive deterioration after mild traumatic brain injurySteven Kemp
St James s University Hospital, Leeds, UK
Brain Inj 19:1269-76. 2005..AB is presented as an unusual case of rapid progressive AD following a mild head injury...
Two-week delay in onset of action of antidepressants: new evidenceAlex J Mitchell
Br J Psychiatry 188:105-6. 2006..Recent data using weekly or daily mood ratings demonstrate that maximum improvement occurs during the first 2 weeks, with some improvement within the first 3 days. Methodological issues may underlie the delayed-onset hypothesis...
General practice based interventions to prevent repeat episodes of deliberate self harm. GPs have to manage this problemAlex J Mitchell
BMJ 325:281. 2002
