A J Mitchell

Summary

Affiliation: Leicester General Hospital
Country: UK

Publications

  1. ncbi request reprint High medication discontinuation rates in psychiatry: how often is it understandable?
    Alex J Mitchell
    J Clin Psychopharmacol 26:109-12. 2006
  2. ncbi request reprint Depressed patients and treatment adherence
    Alex J Mitchell
    Department of Liaison Psychiatry, Brandon Unit, Leicester General Hospital, Leicester LE5 4PW, UK
    Lancet 367:2041-3. 2006
  3. ncbi request reprint Acceptability of common screening methods used to detect distress and related mood disorders-preferences of cancer specialists and non-specialists
    Alex J Mitchell
    Liaison Psychiatry, University of Leicester, Brandon Unit, Leicester, UK
    Psychooncology 17:226-36. 2008
  4. doi request reprint Is it time to separate subjective cognitive complaints from the diagnosis of mild cognitive impairment?
    Alex J Mitchell
    Department of Cancer and Molecular Medicine, Leicester Royal Infirmary, Leicester General Hospital, Leicester, UK
    Age Ageing 37:497-9. 2008
  5. doi request reprint Guideline concordant monitoring of metabolic risk in people treated with antipsychotic medication: systematic review and meta-analysis of screening practices
    A J Mitchell
    Psycho Oncology, Leicester General Hospital, Leicestershire Partnership Trust, Leicester, UK
    Psychol Med 42:125-47. 2012
  6. doi request reprint Clinical recognition and recording of alcohol disorders by clinicians in primary and secondary care: meta-analysis
    Alex J Mitchell
    Leicester General Hospital, Leicester Partnership Trust, Leicester, UK
    Br J Psychiatry 201:93-100. 2012
  7. doi request reprint Validation of simple visual-analogue thermometer screen for mood complications of cardiovascular disease: the Emotion Thermometers
    Alex J Mitchell
    Psycho Oncology, Leicestershire Partnership Trust, LE5 OTD UK
    J Affect Disord 136:1257-63. 2012
  8. ncbi request reprint [Prognosis of depression in the elderly in comparison with adult age. Is there a significant clinical difference?]
    A J Mitchell
    MRCPsych, Department of Liaison Psychiatry, Brandon Unit, Leicester General Hospital, Leicester Reino Unido
    Actas Esp Psiquiatr 37:289-96. 2009
  9. doi request reprint Can the Distress Thermometer be improved by additional mood domains? Part I. Initial validation of the Emotion Thermometers tool
    Alex J Mitchell
    Department of Cancer and Molecular Medicine, Leicester Royal Infirmary, Leicester LE1 5WW, UK
    Psychooncology 19:125-33. 2010
  10. doi request reprint Can the Distress Thermometer be improved by additional mood domains? Part II. What is the optimal combination of Emotion Thermometers?
    Alex J Mitchell
    Department of Cancer and Molecular Medicine, Leicester Royal Infirmary, Leicester LE1 5WW, UK
    Psychooncology 19:134-40. 2010

Detail Information

Publications57

  1. ncbi request reprint High medication discontinuation rates in psychiatry: how often is it understandable?
    Alex J Mitchell
    J Clin Psychopharmacol 26:109-12. 2006
  2. ncbi request reprint Depressed patients and treatment adherence
    Alex J Mitchell
    Department of Liaison Psychiatry, Brandon Unit, Leicester General Hospital, Leicester LE5 4PW, UK
    Lancet 367:2041-3. 2006
  3. ncbi request reprint Acceptability of common screening methods used to detect distress and related mood disorders-preferences of cancer specialists and non-specialists
    Alex J Mitchell
    Liaison Psychiatry, University of Leicester, Brandon Unit, Leicester, UK
    Psychooncology 17:226-36. 2008
    ..We suggest that future field studies of screening tools should also measure the issue of acceptability...
  4. doi request reprint Is it time to separate subjective cognitive complaints from the diagnosis of mild cognitive impairment?
    Alex J Mitchell
    Department of Cancer and Molecular Medicine, Leicester Royal Infirmary, Leicester General Hospital, Leicester, UK
    Age Ageing 37:497-9. 2008
    ..Despite a close association, SCC may be neither necessary nor sufficient for a diagnosis of either MCI or dementia...
  5. doi request reprint Guideline concordant monitoring of metabolic risk in people treated with antipsychotic medication: systematic review and meta-analysis of screening practices
    A J Mitchell
    Psycho Oncology, Leicester General Hospital, Leicestershire Partnership Trust, Leicester, UK
    Psychol Med 42:125-47. 2012
    ..Despite increased cardiometabolic risk in individuals with mental illness taking antipsychotic medication, metabolic screening practices are often incomplete or inconsistent...
  6. doi request reprint Clinical recognition and recording of alcohol disorders by clinicians in primary and secondary care: meta-analysis
    Alex J Mitchell
    Leicester General Hospital, Leicester Partnership Trust, Leicester, UK
    Br J Psychiatry 201:93-100. 2012
    ..Clinicians have considerable difficulty identifying and helping those people with alcohol problems but no previous study has looked at this systematically...
  7. doi request reprint Validation of simple visual-analogue thermometer screen for mood complications of cardiovascular disease: the Emotion Thermometers
    Alex J Mitchell
    Psycho Oncology, Leicestershire Partnership Trust, LE5 OTD UK
    J Affect Disord 136:1257-63. 2012
    ..We therefore examined the value of a single item NCCN Distress Thermometer and an enhanced visual-analogue method (Emotion Thermometers, ET) that incorporates four emotion thermometers...
  8. ncbi request reprint [Prognosis of depression in the elderly in comparison with adult age. Is there a significant clinical difference?]
    A J Mitchell
    MRCPsych, Department of Liaison Psychiatry, Brandon Unit, Leicester General Hospital, Leicester Reino Unido
    Actas Esp Psiquiatr 37:289-96. 2009
    ..The effect of age on prognosis may be largely explained by factors such as previous episodes and medical comorbidity...
  9. doi request reprint Can the Distress Thermometer be improved by additional mood domains? Part I. Initial validation of the Emotion Thermometers tool
    Alex J Mitchell
    Department of Cancer and Molecular Medicine, Leicester Royal Infirmary, Leicester LE1 5WW, UK
    Psychooncology 19:125-33. 2010
    ..To examine the value of a new screening instrument in a visual-analogue format...
  10. doi request reprint Can the Distress Thermometer be improved by additional mood domains? Part II. What is the optimal combination of Emotion Thermometers?
    Alex J Mitchell
    Department of Cancer and Molecular Medicine, Leicester Royal Infirmary, Leicester LE1 5WW, UK
    Psychooncology 19:134-40. 2010
    ..To examine the added value of an algorithmic combination of visual-analogue thermometers compared with the Distress Thermometer (DT) when attempting to detect depression, anxiety or distress in early cancer...
  11. doi request reprint Rate of progression of mild cognitive impairment to dementia--meta-analysis of 41 robust inception cohort studies
    A J Mitchell
    Liaison Psychiatry, Leicester Partnership Trust and University of Leicester, Leicester, UK
    Acta Psychiatr Scand 119:252-65. 2009
    ..To quantify the risk of developing dementia in those with mild cognitive impairment (MCI)...
  12. doi request reprint Temporal trends in the long term risk of progression of mild cognitive impairment: a pooled analysis
    A J Mitchell
    University of Leicester, Brandon Unit Leicester General Hospital, Leicester LE54PW, UK
    J Neurol Neurosurg Psychiatry 79:1386-91. 2008
    ..Recently, a number of long term studies have been published with observation periods of 5 years of longer...
  13. doi request reprint Accuracy of specific symptoms in the diagnosis of major depressive disorder in psychiatric out-patients: data from the MIDAS project
    A J Mitchell
    Liaison Psychiatry, Leicester General Hospital and Department of Cancer and Molecular Medicine, Leicester Royal Infirmary, Leicester, UK
    Psychol Med 39:1107-16. 2009
    ..Our aim was to elucidate the best possible specific symptoms that would assist in ruling in or ruling out a major depressive episode in a psychiatric out-patient setting...
  14. doi request reprint A meta-analysis of the accuracy of the mini-mental state examination in the detection of dementia and mild cognitive impairment
    Alex J Mitchell
    Department of Liaison Psychiatry, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK
    J Psychiatr Res 43:411-31. 2009
    ..In conclusion the MMSE offers modest accuracy with best value for ruling-out a diagnosis of dementia in community and primary care. For all other used it should be combined with or replaced by other methods...
  15. pmc Are one or two simple questions sufficient to detect depression in cancer and palliative care? A Bayesian meta-analysis
    A J Mitchell
    Department of Cancer and Molecular Medicine, Leicester Royal Infirmary, Leicester LE1 5WW, UK
    Br J Cancer 98:1934-43. 2008
    ..The 'two question' method is significantly more accurate than either single question but clinicians should not rely on these simple questions alone and should be prepared to assess the patient more thoroughly...
  16. doi request reprint The clinical significance of subjective memory complaints in the diagnosis of mild cognitive impairment and dementia: a meta-analysis
    Alex J Mitchell
    Department of Liaison Psychiatry, Brandon Unit, Leciester General Hospital, Leicester, UK
    Int J Geriatr Psychiatry 23:1191-202. 2008
    ..Subjective memory complaints (SMC) are frequently reported by individuals with objective evidence of cognitive decline although the exact rate of complaints and their diagnostic value is uncertain...
  17. ncbi request reprint Pooled results from 38 analyses of the accuracy of distress thermometer and other ultra-short methods of detecting cancer-related mood disorders
    Alex J Mitchell
    Department of Cancer and Molecular Medicine, Leicester Royal Infirmary, Leicester, United Kingdom
    J Clin Oncol 25:4670-81. 2007
    ..Ultra-short methods cannot be used alone to diagnose depression, anxiety, or distress in cancer patients but they may be considered as a first-stage screen to rule out cases of depression...
  18. doi request reprint CSF phosphorylated tau in the diagnosis and prognosis of mild cognitive impairment and Alzheimer's disease: a meta-analysis of 51 studies
    A J Mitchell
    Department of Liaison Psychiatry, Brandon Unit, Leicester General Hospital, Leicester Partnership Trust, Leicester LE5 4PW, UK
    J Neurol Neurosurg Psychiatry 80:966-75. 2009
    ..To evaluate the accuracy and clinical utility of phosphorylated tau (p-tau) for the diagnosis and prognosis of Alzheimer's disease (AD) and mild cognitive impairment (MCI)...
  19. doi request reprint Quality of medical care for people with and without comorbid mental illness and substance misuse: systematic review of comparative studies
    Alex J Mitchell
    Department of Liaison Psychiatry, Leicester General Hospital, Leicester LE5 4PW, UK
    Br J Psychiatry 194:491-9. 2009
    ..There has been long-standing concern about the quality of medical care offered to people with mental illness...
  20. doi request reprint Clinical recognition of dementia and cognitive impairment in primary care: a meta-analysis of physician accuracy
    Alex J Mitchell
    Leicester General Hospital, Leicestershire Partnership Trust, UK
    Acta Psychiatr Scand 124:165-83. 2011
    ..We aimed to examine the ability of the general practitioners (GPs) to recognize a spectrum of cognitive impairment from mild cognitive impairment (MCI) to severe dementia in routine practice using their own clinical judgment...
  21. doi request reprint Revascularisation and mortality rates following acute coronary syndromes in people with severe mental illness: comparative meta-analysis
    Alex J Mitchell
    Department of Liaison Psychiatry, Leicestershire Partnership Trust and Department of Cancer Studies and Molecular Medicine, Leicester Royal Infirmary, Leicester, UK
    Br J Psychiatry 198:434-41. 2011
    ..High levels of comorbid physical illness and excess mortality rates have been previously documented in people with severe mental illness, but outcomes following myocardial infarction and other acute coronary syndromes are less clear...
  22. pmc International comparison of clinicians' ability to identify depression in primary care: meta-analysis and meta-regression of predictors
    Alex J Mitchell
    Department of Cancer Studies and Molecular Medicine, University of Leicester, UK
    Br J Gen Pract 61:e72-80. 2011
    ..There are international differences in the epidemiology of depression and the performance of primary care physicians but the factors underlying these national differences are uncertain...
  23. pmc Do deficits in cardiac care influence high mortality rates in schizophrenia? A systematic review and pooled analysis
    Alex J Mitchell
    Department of Liaison Psychiatry, Leicester General Hospital, Leicester, UK
    J Psychopharmacol 24:69-80. 2010
    ..Every effort should be made to deliver high-quality medical care to people with severe mental illness...
  24. doi request reprint Screening and case-finding tools for the detection of dementia. Part II: evidence-based meta-analysis of single-domain tests
    Alex J Mitchell
    Department of Liaison Psychiatry, Liecestershire Partnership Trust, Leicester General Hospital, Leicester, UK
    Am J Geriatr Psychiatry 18:783-800. 2010
    ..To evaluate the diagnostic validity of single-domain cognitive tests for detecting dementia. These methods were defined as those that focus mainly on one domain of cognitive function such as orientation, memory, or executive function...
  25. doi request reprint Can general practitioners identify people with distress and mild depression? A meta-analysis of clinical accuracy
    Alex J Mitchell
    Leicester General Hospital, Leicestershire Partnership Trust, Leicester LE5 4PW, United Kingdom
    J Affect Disord 130:26-36. 2011
    ..There is increasing emphasis on distress and mild depression but uncertainty regarding how well general practitioners (GPs) identify these conditions. Further, the proportion of attendees suffering distress is also unclear...
  26. doi request reprint Do CSF biomarkers help clinicians predict the progression of mild cognitive impairment to dementia?
    Alex J Mitchell
    Department of Liaison Psychiatry, Leicester General Hospital, Leicester LE5 4PWl, UK
    Pract Neurol 10:202-7. 2010
    ....
  27. doi request reprint Diagnostic validity of the Hospital Anxiety and Depression Scale (HADS) in cancer and palliative settings: a meta-analysis
    Alex J Mitchell
    Department of Cancer and Molecular Medicine, Leicester Royal Infirmary, University of Leicester LE1 5WW, United Kingdom
    J Affect Disord 126:335-48. 2010
    ..To examine the validity of the Hospital Anxiety and Depression Scale (HADS) in the identification of psychiatric complications of cancer, as defined by a robust criterion standard...
  28. doi request reprint Clinical diagnosis of depression in primary care: a meta-analysis
    Alex J Mitchell
    Leicestershire Partnership Trust, Leicester General Hospital, Leicester, UK
    Lancet 374:609-19. 2009
    ..Most care for depression is delivered by general practitioners (GPs). We assessed the rate of true positives and negatives, and false positives and negatives in primary care when GPs make routine diagnoses of depression...
  29. ncbi request reprint A comparative survey of missed initial and follow-up appointments to psychiatric specialties in the United kingdom
    Alex J Mitchell
    Department of Liaison Psychiatry, Leicester General Hospital, UK
    Psychiatr Serv 58:868-71. 2007
    ..This study examined the frequency of missed appointments among 9,511 initial outpatient appointments and 7,700 follow-up appointments across ten psychiatric subspecialties in a publicly funded mental health service in the United Kingdom...
  30. ncbi request reprint Prognosis of depression in old age compared to middle age: a systematic review of comparative studies
    Alex J Mitchell
    Department of Liaison Psychiatry, Brandon Unit, Leicester General Hospital, Leicester, UK LE5 4PW
    Am J Psychiatry 162:1588-601. 2005
    ..The authors sought to identify research that has compared the prognosis of depression in late life with depression in midlife under similar conditions...
  31. ncbi request reprint Quality of life and its assessment in multiple sclerosis: integrating physical and psychological components of wellbeing
    Alex J Mitchell
    Department of Liasion Psychiatry, Brandon Mental Health Unit, Leicester General Hospital, Leicester, UK
    Lancet Neurol 4:556-66. 2005
    ..Subjective (self-report) HRQoL measures may serve to alert clinicians to areas that would otherwise be overlooked. Studies of new interventions should include an assessment of HRQoL not just impairment or disability alone...
  32. ncbi request reprint Physical health and schizophrenia
    Alex J Mitchell
    Department of Liason Psychiatry, Brandon Unit, Leicester General Hospital, Leicester, UK
    Curr Opin Psychiatry 19:432-7. 2006
    ..It is debatable whether this is related to shared risk factors, antipsychotic medication or inherent to the condition itself. This review will describe this association and the recent advances in the field...
  33. pmc Self harm and attempted suicide in adults: 10 practical questions and answers for emergency department staff
    A J Mitchell
    Department of Liaison Psychiatry, Leicester General Hospital, Leicester, UK
    Emerg Med J 23:251-5. 2006
    ..It is also recommended that adolescents and elderly people warrant a mandatory specialist assessment...
  34. doi request reprint Screening and case finding tools for the detection of dementia. Part I: evidence-based meta-analysis of multidomain tests
    Alex J Mitchell
    Department of Liaison Psychiatry, Brandon Unit, Leicester General Hospital, Leicester, UK
    Am J Geriatr Psychiatry 18:759-82. 2010
    ..To evaluate the diagnostic accuracy of all brief multidomain alternatives to the Mini-Mental State Examination (MMSE) in the detection of dementia...
  35. ncbi request reprint Adherence behaviour with psychotropic medication is a form of self-medication
    Alex J Mitchell
    Leicester Royal Infirmary, Leicester, United Kingdom
    Med Hypotheses 68:12-21. 2007
    ..The self-medication hypothesis applied to prescribed psychotropic medication should assist rather than heed clinicians in improving adherence by taking a patient centred approach and where possible promoting patient autonomy...
  36. pmc Do ultra-short screening instruments accurately detect depression in primary care? A pooled analysis and meta-analysis of 22 studies
    Alex J Mitchell
    Department of Liaison Psychology, Leicester General Hospital, Leicester
    Br J Gen Pract 57:144-51. 2007
    ..Ultra-short (one-, two-, three- or four-item) tests have appeal due to their simple administration but their accuracy has not been established...
  37. ncbi request reprint Reluctance to disclose difficult diagnoses: a narrative review comparing communication by psychiatrists and oncologists
    Alex J Mitchell
    Department of Cancer Studies and Molecular Medicine, Leicester Royal Infirmary, Osbourne Building, Leicester LE1 5WW, UK
    Support Care Cancer 15:819-28. 2007
    ..National guidance in most medical specialties supports the full and open disclosure of diagnoses to patients...
  38. doi request reprint Diagnostic validity and added value of the Geriatric Depression Scale for depression in primary care: a meta-analysis of GDS30 and GDS15
    Alex J Mitchell
    Leicester General Hospital, Leicester Partnership Trust, Leicester LE5 4PW, United Kingdom
    J Affect Disord 125:10-7. 2010
    ..We therefore conducted a meta-analysis analysing the diagnostic accuracy, clinical utility and added value of the GDS in primary care...
  39. ncbi request reprint Predictors of A&E staff attitudes to self-harm patients who use self-laceration: influence of previous training and experience
    Trevor Friedman
    Department of Liaison Psychiatry, Brandon Unit, Leicester General Hospital, Leicester LE5 4PW, United Kingdom
    J Psychosom Res 60:273-7. 2006
    ..The aim of this study was to investigate the attitudes of accident and emergency (A&E) staff towards patients who self-harm through laceration...
  40. ncbi request reprint Short screening tools for cancer-related distress: a review and diagnostic validity meta-analysis
    Alex J Mitchell
    Leicester General Hospital, Leicester LE5 4PW, United Kingdom
    J Natl Compr Canc Netw 8:487-94. 2010
    ..Nevertheless, short methods seem to be at least as successful as the HADS, although substantially more efficient and hence more acceptable, and therefore may be a suitable initial method of assessment in busy clinical settings...
  41. doi request reprint Do primary care physicians have particular difficulty identifying late-life depression? A meta-analysis stratified by age
    Alex J Mitchell
    Leicester General Hospital, Leicestershire Partnership Trust, Leicester Royal Infirmary, Leicester, UK
    Psychother Psychosom 79:285-94. 2010
    ..There is long-standing concern regarding poor recognition of depression in primary care, especially in older people...
  42. pmc The national service framework for long term conditions
    Niruj Agrawal
    BMJ 330:1280-1. 2005
  43. pmc Efficiency of a two-item pre-screen to reduce the burden of depression screening in pregnancy and postpartum: an IMPLICIT network study
    Ian M Bennett
    Department of Family Medicine and Community Health, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Am Board Fam Med 21:317-25. 2008
    ..Here we assess the diagnostic accuracy of a modified 2-item patient health questionnaire (PHQ-2) as a pre-screen in assessing depression...
  44. ncbi request reprint Quality of life is not favorable for most patients with multiple sclerosis
    Alex J Mitchell
    Arch Neurol 61:1807-8; author reply 1808. 2004
  45. doi request reprint Depression screening and patient outcomes in cardiovascular care: a systematic review
    Brett D Thombs
    Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    JAMA 300:2161-71. 2008
    ..Several practice guidelines recommend that depression be evaluated and treated in patients with cardiovascular disease, but the potential benefits of this are unclear...
  46. pmc Antidepressants and suicide: risk of completed suicide is not the same as risk of deliberate self harm
    Alex J Mitchell
    BMJ 329:461; author reply 461-2. 2004
  47. ncbi request reprint The prognosis of depression in late life versus mid-life: implications for the treatment of older adults
    Hari Subramaniam
    Int Psychogeriatr 17:533-7. 2005
  48. ncbi request reprint Measuring outcome in psychogenic nonepileptic seizures: how relevant is seizure remission?
    Markus Reuber
    Academic Neurology Unit, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
    Epilepsia 46:1788-95. 2005
    ..To examine whether seizure remission is a comprehensive marker of outcome in psychogenic nonepileptic seizures (PNESs)...
  49. pmc Hospital management of self harm in adults in England: study contains important data not reported in the paper
    Alex J Mitchell
    BMJ 328:1440; author reply 1440. 2004
  50. ncbi request reprint Depression as a risk factor for later dementia: a robust relationship?
    Alex J Mitchell
    Age Ageing 34:207-9. 2005
  51. pmc Do selective serotonin reuptake inhibitors cause suicide? Data seem to be incorrect
    Alex J Mitchell
    BMJ 330:1149-50; author reply 1150. 2005
  52. ncbi request reprint Guillain-Barré-like syndrome associated with olanzapine hypersensitivity reaction
    Julian Benito-Leon
    Department of Neurology, Mostoles General Hospital, Madrid, Spain
    Clin Neuropharmacol 28:150-1. 2005
    ..The presence of progressive numbness, motor weakness, or pain in the limbs of patients receiving olanzapine should raise suspicion of Guillain-Barré syndrome...
  53. ncbi request reprint Anxiety in patients with epilepsy: systematic review and suggestions for clinical management
    Stefan Beyenburg
    Department of Neurology, Centre Hospitalier de Luxembourg, Rue Barblé 4, L 1210 Luxembourg, Luxembourg
    Epilepsy Behav 7:161-71. 2005
    ..Nevertheless, a practical approach based on the temporal relationship between anxiety and epileptic seizures allows clinicians to consider appropriate treatment strategies to reduce the psychiatric comorbidity in patients with epilepsy...
  54. pmc NICE may be discouraging detection of postpartum depression
    James C Coyne
    BMJ 334:550. 2007
  55. ncbi request reprint Unusually rapid and severe cognitive deterioration after mild traumatic brain injury
    Steven Kemp
    St James s University Hospital, Leeds, UK
    Brain Inj 19:1269-76. 2005
    ..AB is presented as an unusual case of rapid progressive AD following a mild head injury...
  56. ncbi request reprint Two-week delay in onset of action of antidepressants: new evidence
    Alex J Mitchell
    Br J Psychiatry 188:105-6. 2006
    ..Recent data using weekly or daily mood ratings demonstrate that maximum improvement occurs during the first 2 weeks, with some improvement within the first 3 days. Methodological issues may underlie the delayed-onset hypothesis...
  57. pmc General practice based interventions to prevent repeat episodes of deliberate self harm. GPs have to manage this problem
    Alex J Mitchell
    BMJ 325:281. 2002