Chung Soo Lee

Summary

Country: UK

Publications

  1. ncbi request reprint Modulation of 1-methyl-4-phenylpyridinium-induced mitochondrial dysfunction and cell death in PC12 cells by K(ATP) channel block
    C S Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul, South Korea
    J Neural Transm (Vienna) 114:297-305. 2007
  2. ncbi request reprint Inhibition of MPP+-induced mitochondrial damage and cell death by trifluoperazine and W-7 in PC12 cells
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Neurochem Int 46:169-78. 2005
  3. doi request reprint Topical application of two condensed tannins from the root of Rosa multiflora Thunberg for the treatment of atopic dermatitis (AD) in NC/Nga mice
    Kwan Hee Park
    College of Pharmacy, Chung Ang University, Seoul, Republic of Korea
    Phytother Res 25:1564-9. 2011
  4. ncbi request reprint Inhibition of 1-methyl-4-phenylpyridinium-induced mitochondrial dysfunction and cell death in PC12 cells by sulfonylurea glibenclamide
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Eur J Pharmacol 527:23-30. 2005
  5. ncbi request reprint Combined effect of dopamine and MPP+ on membrane permeability in mitochondria and cell viability in PC12 cells
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, 156 756, Seoul, South Korea
    Neurochem Int 43:147-54. 2003
  6. ncbi request reprint Lamotrigine inhibition of rotenone- or 1-methyl-4-phenylpyridinium-induced mitochondrial damage and cell death
    Yun Jeong Kim
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Brain Res Bull 71:633-40. 2007
  7. ncbi request reprint Celecoxib inhibits Na+ currents in rat dorsal root ganglion neurons
    Soon Yong Park
    Department of Pharmacology, Chung Ang University, College of Medicine, 221 Heuksuk Dong, Dongjak Ku, Seoul 156 756, Republic of Korea
    Brain Res 1148:53-61. 2007
  8. ncbi request reprint N-methylated beta-carbolines protect PC12 cells from cytotoxic effect of MPP+ by attenuation of mitochondrial membrane permeability change
    Tai Hwan Park
    Department of Neurology, College of Medicine, Chung Ang University, 156 756, Seoul, South Korea
    Neurosci Res 46:349-58. 2003
  9. doi request reprint 18β-Glycyrrhetinic acid potentiates apoptotic effect of trichostatin A on human epithelial ovarian carcinoma cell lines
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Eur J Pharmacol 649:354-61. 2010
  10. ncbi request reprint Differential effect of catecholamines and MPP(+) on membrane permeability in brain mitochondria and cell viability in PC12 cells
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Neurochem Int 40:361-9. 2002

Collaborators

  • Seong Jun Seo
  • Seong Soo Joo
  • Yoon Young Jang
  • Ji Young Kim
  • Seon Hwa Lee
  • Ki Young Moon
  • Eun Joo Kim
  • D Kim
  • Yun Jeong Kim
  • Min Won Lee
  • Sun Eun Choi
  • Hyoweon Bang
  • Young Wook Choi
  • Eun Sook Han
  • Mi Sook Jeong
  • Jin Ho Song
  • Kwan Hee Park
  • Mi Kyung Lee
  • Soon Chul Myung
  • Eun Ra Jang
  • Do Ik Lee
  • Yong Kyoo Shin
  • Mijung Park
  • Hong Im Kim
  • Jihyun Yun
  • Wonyong Kim
  • Eun Joo Choi
  • Soon Yong Park
  • Hyun Hee Ko
  • Myung Joo Kang
  • Inja Lim
  • Young Su Han
  • Jeong Ho Han
  • Tae Hoon Kim
  • Young Chul Youn
  • Sang Won Kwak
  • Eun Byul Jung
  • Jae Chon Yang
  • Hyemi Bae
  • Jae Hong Ko
  • Se Young Park
  • Kapsok Li
  • Sang Won Ha
  • Ji Young Ahn
  • Nam Ju Moon
  • Oh Sang Kwon
  • Sang Jin Choi
  • Soo Bin Yim
  • Y J Kim
  • H J Choo
  • Dong Hee Lee
  • Won Tae Choi
  • Min Pyo Hong
  • Jang Ho Bang
  • Jun Sik Hong
  • Tai Hwan Park
  • Hyang Mi Lee
  • Geon Young Lee
  • Eon Sub Park
  • Jong Weon Park
  • Young Ki Kim
  • Han Hyuk Kim
  • Min Soo Kim
  • Mean Hyung Kang
  • Jae Yoon Eum
  • Sang Han Park
  • Jong Chan Lee
  • Kap Sok Lee
  • Kap Sok Li
  • J H Song
  • Hyun Sun Lee
  • Sang Eun Park
  • S S Han
  • E S Han
  • J H Han
  • K M Choi
  • O B Kwon
  • Y G Ko
  • Y S Yoon
  • J Y Mun
  • G Yoon
  • Yong Kyu Shin
  • S S Ham
  • Y K Shin

Detail Information

Publications81

  1. ncbi request reprint Modulation of 1-methyl-4-phenylpyridinium-induced mitochondrial dysfunction and cell death in PC12 cells by K(ATP) channel block
    C S Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul, South Korea
    J Neural Transm (Vienna) 114:297-305. 2007
    ..This effect appears to be accomplished by the inhibitory action on the formation of reactive oxygen species and the depletion of GSH. The blockade of mitochondrial K(ATP) channels seems to prevent the MPP(+)-induced neuronal cell damage...
  2. ncbi request reprint Inhibition of MPP+-induced mitochondrial damage and cell death by trifluoperazine and W-7 in PC12 cells
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Neurochem Int 46:169-78. 2005
    ..Both compounds at the concentrations less than 5 microM may attenuate the MPP+-induced viability loss in PC12 cells by suppressing change in the mitochondrial membrane permeability and by lowering the intracellular Ca2+ levels...
  3. doi request reprint Topical application of two condensed tannins from the root of Rosa multiflora Thunberg for the treatment of atopic dermatitis (AD) in NC/Nga mice
    Kwan Hee Park
    College of Pharmacy, Chung Ang University, Seoul, Republic of Korea
    Phytother Res 25:1564-9. 2011
    ..01). Such results strongly suggest that ProB3 and RM-1 may be useful in the treatment allergic skin conditions, most notably atopic dermatitis...
  4. ncbi request reprint Inhibition of 1-methyl-4-phenylpyridinium-induced mitochondrial dysfunction and cell death in PC12 cells by sulfonylurea glibenclamide
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Eur J Pharmacol 527:23-30. 2005
    ....
  5. ncbi request reprint Combined effect of dopamine and MPP+ on membrane permeability in mitochondria and cell viability in PC12 cells
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, 156 756, Seoul, South Korea
    Neurochem Int 43:147-54. 2003
    ....
  6. ncbi request reprint Lamotrigine inhibition of rotenone- or 1-methyl-4-phenylpyridinium-induced mitochondrial damage and cell death
    Yun Jeong Kim
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Brain Res Bull 71:633-40. 2007
    ..Lamotrigine seems to exert a protective effect against the neuronal cell injury due to the mitochondrial respiratory complex I inhibition...
  7. ncbi request reprint Celecoxib inhibits Na+ currents in rat dorsal root ganglion neurons
    Soon Yong Park
    Department of Pharmacology, Chung Ang University, College of Medicine, 221 Heuksuk Dong, Dongjak Ku, Seoul 156 756, Republic of Korea
    Brain Res 1148:53-61. 2007
    ..All these effects combined would suppress the excitability of sensory neurons. Thus, beside COX-2 inhibition, the Na(+) channel inhibition is considered to contribute to celecoxib analgesia...
  8. ncbi request reprint N-methylated beta-carbolines protect PC12 cells from cytotoxic effect of MPP+ by attenuation of mitochondrial membrane permeability change
    Tai Hwan Park
    Department of Neurology, College of Medicine, Chung Ang University, 156 756, Seoul, South Korea
    Neurosci Res 46:349-58. 2003
    ..The results suggest that beta-carbolines may attenuate the MPP(+)-induced viability loss in PC12 cells by inhibition of change in the mitochondrial membrane permeability and by antioxidant effect...
  9. doi request reprint 18β-Glycyrrhetinic acid potentiates apoptotic effect of trichostatin A on human epithelial ovarian carcinoma cell lines
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Eur J Pharmacol 649:354-61. 2010
    ..18β-Glycyrrhetinic acid may enhance the therapeutic effect of trichostatin A against epithelial ovarian adenocarcinoma...
  10. ncbi request reprint Differential effect of catecholamines and MPP(+) on membrane permeability in brain mitochondria and cell viability in PC12 cells
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Neurochem Int 40:361-9. 2002
    ..MPP(+) appears to exert a toxic effect on neuronal cells by the action, which is different from catecholamines...
  11. ncbi request reprint Differential effect of calmodulin antagonists on MG132-induced mitochondrial dysfunction and cell death in PC12 cells
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Dong jak Gu, Seoul 156 756, South Korea
    Brain Res Bull 67:225-34. 2005
    ..5-1 microM may attenuate the MG132-induced viability loss in PC12 cells by suppressing change in the mitochondrial membrane permeability and by lowering of the intracellular Ca(2+) levels as well as calmodulin inhibition...
  12. ncbi request reprint Effect of change in cellular GSH levels on mitochondrial damage and cell viability loss due to mitomycin c in small cell lung cancer cells
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Biochem Pharmacol 68:1857-67. 2004
    ..The MMC-induced change in the mitochondrial membrane permeability, followed by cell death, in SCLC cells may be significantly enhanced by decrease in the intracellular GSH contents due to oxidative attack of free radicals...
  13. doi request reprint Effect of Alnus japonica extract on a model of atopic dermatitis in NC/Nga mice
    Sun Eun Choi
    College of Pharmacy, Chung Ang University, Seoul, Republic of Korea
    J Ethnopharmacol 136:406-13. 2011
    ....
  14. ncbi request reprint Inhibition of MG132-induced mitochondrial dysfunction and cell death in PC12 cells by 3-morpholinosydnonimine
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Brain Res 1036:18-26. 2005
    ..SIN-1 may inhibit the MG132-induced viability loss in PC12 cells by suppressing change in the mitochondrial membrane permeability that is associated with oxidative damage...
  15. doi request reprint Hirsutenone inhibits lipopolysaccharide-activated NF-kappaB-induced inflammatory mediator production by suppressing Toll-like receptor 4 and ERK activation
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Int Immunopharmacol 10:520-5. 2010
    ..These findings suggest that hirsutenone may exert a preventive effect against microbial endotoxin lipopolysaccharide-induced inflammatory skin diseases through inhibition of ERK pathway-mediated NF-kappaB activation...
  16. doi request reprint Prostaglandin analogue misoprostol attenuates neurotoxin 1-methyl-4-phenylpyridinium-induced mitochondrial damage and cell death in differentiated PC12 cells
    Eun Joo Choi
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Brain Res Bull 77:293-300. 2008
    ..The preventive effect seems to be ascribed to the inhibitory effect on the formation of reactive oxygen species and depletion of GSH...
  17. doi request reprint Guanylate cyclase activator YC-1 potentiates apoptotic effect of licochalcone A on human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathways
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Eur J Pharmacol 683:54-62. 2012
    ..The combination of licochalcone A and YC-1 may confer a benefit in the treatment of human epithelial ovarian adenocarcinoma...
  18. ncbi request reprint Protective effect of boldine on dopamine-induced membrane permeability transition in brain mitochondria and viability loss in PC12 cells
    Young Chul Youn
    Department of Neurology, College of Medicine, Chung Ang University, Seoul, South Korea
    Biochem Pharmacol 63:495-505. 2002
    ....
  19. ncbi request reprint Depressant effect of mitochondrial respiratory complex inhibitors on proteasome inhibitor-induced mitochondrial dysfunction and cell death in PC12 cells
    Sun Joo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, 156 756, Seoul, South Korea
    Neurochem Res 30:1191-200. 2005
    ..The cytoprotective effect of the mitochondrial permeability transition prevention not appears to be modulated by respiratory complex inhibition...
  20. doi request reprint Effect of taxifolin glycoside on atopic dermatitis-like skin lesions in NC/Nga mice
    Ji Young Ahn
    College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Phytother Res 24:1071-7. 2010
    ..These findings suggest that TAX is effective for the treatment of AD by preventing the production of inflammatory cytokines and by reducing skin inflammation...
  21. ncbi request reprint Piperine inhibition of 1-methyl-4-phenylpyridinium-induced mitochondrial dysfunction and cell death in PC12 cells
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Eur J Pharmacol 537:37-44. 2006
    ..The effects may be ascribed to its inhibitory action on the formation of reactive oxygen species and depletion of GSH...
  22. ncbi request reprint Econazole attenuates cytotoxicity of 1-methyl-4-phenylpyridinium by suppressing mitochondrial membrane permeability transition
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Brain Res Bull 69:687-94. 2006
    ....
  23. ncbi request reprint Differential involvement of intracellular Ca2+ in 1-methyl-4-phenylpyridinium- or 6-hydroxydopamine-induced cell viability loss in PC12 cells
    Dong Hee Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul, 156 756, South Korea
    Neurochem Res 31:851-60. 2006
    ..In contrast, the 6-OHDA-induced cell death seems to be mediated by Ca(2+)-independent manner...
  24. doi request reprint Licochalcone A enhances geldanamycin-induced apoptosis through reactive oxygen species-mediated caspase activation
    Yun Jeong Kim
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul, South Korea
    Pharmacology 92:49-59. 2013
    ....
  25. doi request reprint Taxifolin glycoside inhibits dendritic cell responses stimulated by lipopolysaccharide and lipoteichoic acid
    Yun Jeong Kim
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    J Pharm Pharmacol 60:1465-72. 2008
    ....
  26. ncbi request reprint Effects of free fatty acids on sodium currents in rat dorsal root ganglion neurons
    Min Pyo Hong
    Department of Pharmacology, Chung Ang University, College of Medicine, 221 Heuk Suk Dong, Dong Jak Ku, Seoul 156 756, South Korea
    Brain Res 1008:81-91. 2004
    ..The modulation of sodium currents by FFAs, especially PUFAs, may have considerable impact on the excitability of sensory neurons...
  27. doi request reprint Diarylheptanoid hirsutenone enhances apoptotic effect of TRAIL on epithelial ovarian carcinoma cell lines via activation of death receptor and mitochondrial pathway
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Invest New Drugs 30:548-57. 2012
    ..Hirsutenone may confer a benefit in the TRAIL treatment of epithelial ovarian adenocarcinoma...
  28. ncbi request reprint Depressant effects of ambroxol and erdosteine on cytokine synthesis, granule enzyme release, and free radical production in rat alveolar macrophages activated by lipopolysaccharide
    Yoon Young Jang
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Pharmacol Toxicol 92:173-9. 2003
    ....
  29. ncbi request reprint Differential effect of nitrogen species on changes in mitochondrial membrane permeability due to mitomycin c in lung epithelial cells
    Se Young Park
    Department of Pharmacology, College of Medicine, Chung Ang University, 156 756 Seoul, South Korea
    Naunyn Schmiedebergs Arch Pharmacol 369:312-21. 2004
    ..SIN-1 may inhibit the MMC-induced viability loss in lung epithelial cells by suppressing the mitochondrial membrane permeability change and by interaction of its products with MMC...
  30. ncbi request reprint Diarylheptanoid hirsutenoxime inhibits toll-like receptor 4-mediated NF-κB activation regulated by Akt pathway in keratinocytes
    Yun Jeong Kim
    Department of Pharmacology, Chung Ang University, Seoul, South Korea
    Am J Chin Med 38:1207-22. 2010
    ..Hirsutenoxime may reduce the Toll-like receptor 4 expression-mediated NF-κB activation, which is regulated by the Akt pathway in keratinocytes exposed to lipopolysaccharides. This effect may reduce the skin inflammatory response...
  31. ncbi request reprint Differential involvement of mitochondrial permeability transition in cytotoxicity of 1-methyl-4-phenylpyridinium and 6-hydroxydopamine
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Mol Cell Biochem 289:193-200. 2006
    ..In contrast, the 6-OHDA-induced cell injury appears to be mediated by increased oxidative stress without intervention of the mitochondrial membrane permeability transition...
  32. doi request reprint 18beta-Glycyrrhetinic acid induces apoptotic cell death in SiHa cells and exhibits a synergistic effect against antibiotic anti-cancer drug toxicity
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul, South Korea
    Life Sci 83:481-9. 2008
    ..The effect may be associated with increased formation of reactive oxygen species and depletion of glutathione. Combined treatment of antibiotic anti-cancer drug and 18beta-glycyrrhetinic acid seems to exhibit a synergistic toxic effect...
  33. doi request reprint 7-ketocholesterol induces apoptosis in differentiated PC12 cells via reactive oxygen species-dependent activation of NF-κB and Akt pathways
    Eun Ra Jang
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul, South Korea
    Neurochem Int 58:52-9. 2011
    ....
  34. doi request reprint Quercetin-3-O-(2"-galloyl)-α-l-rhamnopyranoside prevents TRAIL-induced apoptosis in human keratinocytes by suppressing the caspase-8- and Bid-pathways and the mitochondrial pathway
    Yun Jeong Kim
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Chem Biol Interact 204:144-52. 2013
    ..These data suggest that QGR could be effective in the prevention of TRAIL-induced apoptosis-mediated skin diseases. ..
  35. doi request reprint 3,4,5-tricaffeoylquinic Acid inhibits the lipopolysaccharide-stimulated production of inflammatory mediators in keratinocytes
    Seon Ae Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul, South Korea
    Pharmacology 90:183-92. 2012
    ..However, the effect of 3,4,5-tricaffeoylquinic acid (3,4,5-triCQA) on the production of microbial product-induced inflammatory mediators in keratinocytes has not yet been studied...
  36. doi request reprint 3,4,5-Tricaffeoylquinic acid inhibits tumor necrosis factor-α-stimulated production of inflammatory mediators in keratinocytes via suppression of Akt- and NF-κB-pathways
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Int Immunopharmacol 11:1715-23. 2011
    ..The findings suggest that 3,4,5-tricaffeoylquinic acid may exert an inhibitory effect against the pro-inflammatory mediator-induced skin disease...
  37. ncbi request reprint Glycyrrhizin protection against 3-morpholinosydnonime-induced mitochondrial dysfunction and cell death in lung epithelial cells
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Life Sci 80:1759-67. 2007
    ..The preventive effect may be ascribed to the inhibitory action on the formation of reactive oxygen species and depletion of GSH. The findings suggest that licorice compounds seem to prevent the nitrogen species-mediated lung cell damage...
  38. doi request reprint Fluoxetine induces apoptosis in ovarian carcinoma cell line OVCAR-3 through reactive oxygen species-dependent activation of nuclear factor-kappaB
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul, South Korea
    Basic Clin Pharmacol Toxicol 106:446-53. 2010
    ....
  39. doi request reprint Polyphenol acertannin prevents TRAIL-induced apoptosis in human keratinocytes by suppressing apoptosis-related protein activation
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul, South Korea
    Chem Biol Interact 189:52-9. 2011
    ..The preventive effect of acertannin on TRAIL-induced apoptosis may be associated with the inhibitory effect on formation of reactive oxygen/nitrogen species. Acertannin may prevent the TRAIL-induced apoptosis-mediated skin inflammation...
  40. ncbi request reprint Anandamide suppression of Na+ currents in rat dorsal root ganglion neurons
    Hong Im Kim
    Department of Pharmacology, Chung Ang University, College of Medicine, 221 Heuksuk Dong, Dongjak Ku, Seoul 156 756, Republic of Korea
    Brain Res 1062:39-47. 2005
    ..The inhibition of Na+ currents in sensory neurons may contribute to the anandamide analgesia...
  41. ncbi request reprint Inhibition of bleomycin-induced cell death in rat alveolar macrophages and human lung epithelial cells by ambroxol
    Jun Sik Hong
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Biochem Pharmacol 66:1297-306. 2003
    ..This effect may be due to inhibition of mitochondrial damage and due to the scavenging action on free radicals...
  42. ncbi request reprint Modulation of sodium currents in rat sensory neurons by nucleotides
    Soon Yong Park
    Department of Pharmacology, Chung Ang University, College of Medicine, 221 Heuk Suk Dong, Dong Jak Ku, Seoul 156 756, South Korea
    Brain Res 1006:168-76. 2004
    ..Particularly, the increase of the maximum conductance and the hyperpolarizing shift of the conductance-voltage relationship of s-TTX-R sodium current would result in an intensified nociception...
  43. doi request reprint Different effect of protein kinase B/Akt and extracellular signal-regulated kinase inhibition on trichostatin A-induced apoptosis in epithelial ovarian carcinoma cell lines
    Eun Ra Jang
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Mol Cell Biochem 353:1-11. 2011
    ..In contrast, ERK inhibitor may exhibit an additive toxic effect on trichostatin A toxicity by increasing apoptosis-related protein activation...
  44. pmc Atopic dermatitis-like skin lesions reduced by topical application and intraperitoneal injection of Hirsutenone in NC/Nga mice
    Mi Sook Jeong
    Department of Dermatology, College of Medicine, Chung Ang University, Seoul 156 756, Republic of Korea
    Clin Dev Immunol 2010:618517. 2010
    ..These results suggest that HIR might be an effective treatment for AD...
  45. ncbi request reprint Differential modulation of 7-ketocholesterol toxicity against PC12 cells by calmodulin antagonists and Ca2+ channel blockers
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Neurochem Res 32:87-98. 2007
    ....
  46. doi request reprint Quercetin-3-O-(2″-galloyl)-α-l-rhamnopyranoside inhibits TNF-α-activated NF-κB-induced inflammatory mediator production by suppressing ERK activation
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Int Immunopharmacol 16:481-7. 2013
    ..Additionally, QGR may exhibit a preventive effect against the proinflammatory mediator-induced skin diseases by inhibiting the activation of the ERK and NF-κB pathways...
  47. doi request reprint 18β-glycyrrhetinic acid potentiates Hsp90 inhibition-induced apoptosis in human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathway
    Jae Chon Yang
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul, South Korea
    Mol Cell Biochem 370:209-19. 2012
    ..Combination of Hsp90 inhibitors and 18β-glycyrrhetinic acid may confer a benefit in the treatment of epithelial ovarian adenocarcinoma...
  48. ncbi request reprint Hirsutenone directly blocks human ether-a-go-go related gene K+ channels
    Jihyun Yun
    Department of Physiology, College of Medicine, Chung Ang University, Seoul 156 756, Korea
    Biol Pharm Bull 34:1815-22. 2011
    ..In summary, hirsutenone potentially acts as a blocker of hERG K(+) channels functioning by modifying the channel inactivation kinetics...
  49. ncbi request reprint Differential response of MG132 cytotoxicity against small cell lung cancer cells to changes in cellular GSH contents
    Jang Ho Bang
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Biochem Pharmacol 68:659-66. 2004
    ..Removal of free radicals and recovery of GSH contents may attenuate MG132-induced apoptotic cell death. Nevertheless, depletion or oxidation of cellular GSH may not affect toxicity of MG132...
  50. ncbi request reprint Inhibition of SIN-1-induced change in mitochondrial membrane permeability in PC12 cells by dopamine
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul, South Korea
    Neurochem Res 29:1371-9. 2004
    ....
  51. doi request reprint Antidepressants reveal differential effect against 1-methyl-4-phenylpyridinium toxicity in differentiated PC12 cells
    Young Su Han
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Eur J Pharmacol 604:36-44. 2009
    ..In contrast, fluoxetine seems to exert an additive toxic effect against neuronal cell damage by increasing mitochondrial damage and oxidative stress...
  52. doi request reprint Parthenolide induces apoptosis by activating the mitochondrial and death receptor pathways and inhibits FAK-mediated cell invasion
    Sang Won Kwak
    Department of Pathology, College of Medicine, Chung Ang University, Seoul, 156 756, South Korea
    Mol Cell Biochem 385:133-44. 2014
    ..Therefore, parthenolide might be beneficial in the treatment of epithelial ovarian adenocarcinoma and combination therapy. ..
  53. pmc Taxifolin Glycoside Blocks Human ether-a-go-go Related Gene K(+) Channels
    Jihyun Yun
    Department of Physiology, College of Medicine, Chung Ang University, Seoul 156 756, Korea
    Korean J Physiol Pharmacol 17:37-42. 2013
    ..These results suggest that taxifolin glycoside blocks hERG K(+) channels that function by facilitating activation and inactivation process...
  54. doi request reprint Radicicol, an inhibitor of Hsp90, enhances TRAIL-induced apoptosis in human epithelial ovarian carcinoma cells by promoting activation of apoptosis-related proteins
    Yun Jeong Kim
    Department of Pharmacology, College of Medicine, Chung Ang University, and Department of Urology, Chung Ang University Hospital, Seoul, 156 756, South Korea
    Mol Cell Biochem 359:33-43. 2012
    ..Radicicol may confer a benefit in the TRAIL treatment of epithelial ovarian adenocarcinoma...
  55. ncbi request reprint Synergistic effects of hydrogen peroxide and ethanol on cell viability loss in PC12 cells by increase in mitochondrial permeability transition
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Biochem Pharmacol 70:317-25. 2005
    ..The findings suggest that ethanol as a promoting agent for the formation of mitochondrial permeability transition may enhance the neuronal cell injury caused by oxidants...
  56. doi request reprint Tyrosine kinase inhibitor AG126 reduces 7-ketocholesterol-induced cell death by suppressing mitochondria-mediated apoptotic process
    Yun Jeong Kim
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul, South Korea
    Neurochem Res 35:603-12. 2010
    ..The preventive effect seems to be associated with the inhibitory effect on the formation of reactive oxygen species and the depletion of GSH...
  57. doi request reprint Effect of topical application and intraperitoneal injection of oregonin on atopic dermatitis in NC/Nga mice
    Sun Eun Choi
    College of Pharmacy, Chung Ang University, Seoul, South Korea
    Exp Dermatol 19:e37-43. 2010
    ..The results presented in this report suggest that ORE might be beneficial in the treatment of AD...
  58. doi request reprint Effects of a polyacetylene from Panax ginseng on Na+ currents in rat dorsal root ganglion neurons
    Sang Jin Choi
    Department of Pharmacology, Chung Ang University, College of Medicine, 221 Heuksuk Dong, Dongjak Ku, Seoul 156 756, Republic of Korea
    Brain Res 1191:75-83. 2008
    ..This is the first report that a polyacetylene from ginseng inhibits Na(+) currents in primary sensory neurons. EHD by inhibiting Na(+) currents may contribute to the ginseng analgesia...
  59. pmc Tat peptide-admixed elastic liposomal formulation of hirsutenone for the treatment of atopic dermatitis in NC/Nga mice
    Myung Joo Kang
    College of Pharmacy, Chung Ang University, Heuksuk Dong, Dongjak Gu, Seoul, South Korea
    Int J Nanomedicine 6:2459-67. 2011
    ..The aim of the present study was to enhance a topical delivery of hirsutenone (HST), a naturally occuring immunomodulator, employing Tat peptide-admixed elastic liposomes (EL/T)...
  60. ncbi request reprint Effect of R-(-)-deprenyl and harmaline on dopamine- and peroxynitrite-induced membrane permeability transition in brain mitochondria
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul, Korea
    Neurochem Res 27:215-24. 2002
    ..In contrast, MAO inhibitors may not defend brain mitochondria against damaging action of peroxynitrite...
  61. ncbi request reprint Antioxidant effect of phenelzine on MPP+-induced cell viability loss in differentiated PC12 cells
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul, South Korea
    Neurochem Res 28:1833-41. 2003
    ..The results suggest that phenelzine attenuates the MPP+-induced viability loss in PC12 cells by reducing the alteration of mitochondrial membrane permeability that seems to be mediated by oxidative stress...
  62. doi request reprint Diarylheptanoid hirsutenone prevents tumor necrosis factor-alpha-stimulated production of inflammatory mediators in human keratinocytes through NF-kappaB inhibition
    Chung Soo Lee
    Department of Pharmacology, Chung Ang University, Seoul, South Korea
    Int Immunopharmacol 9:1097-104. 2009
    ..The findings suggest that hirsutenone may exert an inhibitory effect against the pro-inflammatory mediator-induced skin disease...
  63. ncbi request reprint Diclofenac inhibition of sodium currents in rat dorsal root ganglion neurons
    Hyang Mi Lee
    Department of Pharmacology, Chung Ang University, College of Medicine, 221 Heuk Suk Dong, Dong Jak Ku, Seoul 156 756, South Korea
    Brain Res 992:120-7. 2003
    ..The suppression of sodium currents in sensory neurons by diclofenac and flufenamic acid would contribute to their analgesic activity in addition to their inhibition of cyclooxygenase...
  64. doi request reprint Casein kinase 2 inhibition differentially modulates apoptotic effect of trichostatin A against epithelial ovarian carcinoma cell lines
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul, South Korea
    Mol Cell Biochem 338:157-66. 2010
    ..Casein kinase 2 inhibition, which does not induce a cytotoxic effect, may prevent histone deacetylase inhibitor-mediated apoptosis...
  65. doi request reprint Combined effect of protein kinase B inhibitor or extracellular signal-regulated kinase inhibitor against farnesyltransferase inhibition-induced apoptosis in SiHa cells
    Sun Joo Lee
    Department of Obstetrics and Gynecology, Konkuk University Hospital, Konkuk University, Seoul, 143 729, South Korea
    Naunyn Schmiedebergs Arch Pharmacol 379:291-303. 2009
    ....
  66. doi request reprint Inhibition of activated responses in dendritic cells exposed to lipopolysaccharide and lipoteichoic acid by diarylheptanoid oregonin
    Eun Joo Choi
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Int Immunopharmacol 8:748-55. 2008
    ..The findings suggest that oregonin may exert an inhibitory effect against the dendritic cell-mediated immune response...
  67. ncbi request reprint Protective effect of 1-methylated beta-carbolines against 3-morpholinosydnonimine-induced mitochondrial damage and cell viability loss in PC12 cells
    Won Tae Choi
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Neurochem Res 29:1807-16. 2004
    ..This results in the inhibition of caspase-9 and -3 and apoptotic cell death in PC12 cells by suppressing the toxic actions of reactive oxygen and nitrogen species, including the GSH depletion...
  68. ncbi request reprint Depressant effect of ambroxol on stimulated functional responses and cell death in rat alveolar macrophages exposed to silica in vitro
    Young Ki Kim
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul, South Korea
    J Pharmacol Exp Ther 300:629-37. 2002
    ..The inhibitory effect of ambroxol on silica-induced cell death appears to provide the protective effect on pulmonary tissues against the toxic action of silica...
  69. ncbi request reprint Protective effect of glycyrrhizin on 1-methyl-4-phenylpyridinium-induced mitochondrial damage and cell death in differentiated PC12 cells
    Soo Bin Yim
    Department of Neurology, Gangneung Asan Hospital, College of Medicine, University of Ulsan, Gangwon Do, South Korea
    J Pharmacol Exp Ther 321:816-22. 2007
    ..The preventive effect seems to be ascribed to the inhibitory effect on the formation of reactive oxygen species and depletion of GSH...
  70. ncbi request reprint Ambroxol inhibits peroxynitrite-induced damage of alpha1-antiproteinase and free radical production in activated phagocytic cells
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul, South Korea
    Pharmacol Toxicol 91:140-9. 2002
    ..Ambroxol may interfere with oxidative damage of alpha1-antiproteinase through a scavenging action on ONOO- and HOCl and inhibition of the respiratory burst of phagocytic cells...
  71. ncbi request reprint 7-Ketocholesterol enhances 1-methyl-4-phenylpyridinium-induced mitochondrial dysfunction and cell death in PC12 cells
    Y J Kim
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul, South Korea
    J Neural Transm 113:1877-85. 2006
    ..The findings suggest that 7-ketocholesterol as a promoting agent for the formation of mitochondrial permeability transition may enhance the toxic neuronal cell injury...
  72. doi request reprint Akt inhibitor enhances apoptotic effect of carboplatin on human epithelial ovarian carcinoma cell lines
    Chung Soo Lee
    Department of Pharmacology, Chung Ang University, Seoul, South Korea
    Eur J Pharmacol 632:7-13. 2010
    ..Combination of carboplatin and Akt inhibitor may provide a therapeutic benefit against ovarian adenocarcinoma...
  73. doi request reprint Differential effect of platelet activating factor on 1-methyl-4-phenylpyridinium-induced cell death through regulation of apoptosis-related protein activation
    Sang Won Ha
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul, South Korea
    Neurochem Int 56:819-28. 2010
    ..In contrast, PAF at higher concentrations may exhibit an additive toxic effect against the MPP(+) toxicity by increasing apoptosis-related protein activation...
  74. ncbi request reprint Protective effect of serotonin on 6-hydroxydopamine- and dopamine-induced oxidative damage of brain mitochondria and synaptosomes and PC12 cells
    Jong Weon Park
    Department of Neurology, College of Medicine, Chung Ang University, 156 756, Seoul, South Korea
    Neurochem Int 40:223-33. 2002
    ..Serotonin may show a prominent protective effect on the iron-mediated neuronal damage...
  75. ncbi request reprint Protective effect of harmaline and harmalol against dopamine- and 6-hydroxydopamine-induced oxidative damage of brain mitochondria and synaptosomes, and viability loss of PC12 cells
    D H Kim
    Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul 156-756, Korea
    Eur J Neurosci 13:1861-72. 2001
    ....
  76. ncbi request reprint Protective effect of harmalol and harmaline on MPTP neurotoxicity in the mouse and dopamine-induced damage of brain mitochondria and PC12 cells
    C S Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul, Korea Department of Neurology, Korean Veterans Hospital, Seoul, Korea
    J Neurochem 75:521-31. 2000
    ..The compounds may prevent dopamine-induced mitochondrial damage and PC12 cell death through a scavenging action on reactive oxygen species and inhibition of monoamine oxidase and thiol oxidation...
  77. ncbi request reprint Amitriptyline modulation of Na(+) channels in rat dorsal root ganglion neurons
    J H Song
    Department of Pharmacology, College of Medicine, Chung Ang University, 221 Heuk Suk Dong, Dong Jak Ku, 156 756, Seoul, South Korea
    Eur J Pharmacol 401:297-305. 2000
    ..It was concluded that amitriptyline blocked the two types of Na(+) channels in rat sensory neurons by modulating the activation and the inactivation kinetics...
  78. ncbi request reprint Effect of iron and ascorbate on cyclosporine-induced oxidative damage of kidney mitochondria and microsomes
    S H Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul, 156 756, South Korea
    Pharmacol Res 43:161-71. 2001
    ....
  79. ncbi request reprint Mitochondria are impaired in the adipocytes of type 2 diabetic mice
    H J Choo
    Graduate School of Life Sciences and Biotechnology, Korea University, 1, 5 Ka, Anam Dong, Sungbuk Gu, Seoul, 136 701, South Korea
    Diabetologia 49:784-91. 2006
    ..The aim of this study was to confirm a link between mitochondrial dysfunction and type 2 diabetes...
  80. ncbi request reprint Prevention of 7-ketocholesterol-induced mitochondrial damage and cell death by calmodulin inhibition
    Jeong Ho Han
    Department of Neurology, Seoul Veterans Hospital, Seoul 134 791, South Korea
    Brain Res 1137:11-9. 2007
    ..The findings suggest that calmodulin inhibition may exhibit a protective effect against the neurotoxicity of 7-ketocholesterol...
  81. ncbi request reprint Effects of arachidonic acid on sodium currents in rat dorsal root ganglion neurons
    Geon Young Lee
    Department of Pharmacology, Chung Ang University, College of Medicine, 221 Heuk Suk Dong, Dong Jak Ku, 156 756, Seoul, South Korea
    Brain Res 950:95-102. 2002
    ..It is suggested that arachidonic acid, by modulating sodium currents, may alter the excitability of sensory neurons depending on the resting membrane potential...