David F Horrobin

Summary

Affiliation: Laxdale Ltd
Country: UK

Publications

  1. ncbi request reprint A new category of psychotropic drugs: neuroactive lipids as exemplified by ethyl eicosapentaenoate (E-E)
    David F Horrobin
    Laxdale Ltd, Kings Park House, Laurelhill Business Park, Stirling, FK7 9JQ Scotland
    Prog Drug Res 59:171-99. 2002
  2. ncbi request reprint omega-3 Fatty acid for schizophrenia
    David F Horrobin
    Am J Psychiatry 160:188-9; author reply 189. 2003
  3. ncbi request reprint Are large clinical trials in rapidly lethal diseases usually unethical?
    David F Horrobin
    Laxdale Ltd, Stirling, UK
    Lancet 361:695-7. 2003
  4. ncbi request reprint A low toxicity maintenance regime, using eicosapentaenoic acid and readily available drugs, for mantle cell lymphoma and other malignancies with excess cyclin D1 levels
    David F Horrobin
    Laxdale Ltd, Stirling, Scotland, UK
    Med Hypotheses 60:615-23. 2003
  5. ncbi request reprint Effective clinical innovation: an ethical imperative
    David F Horrobin
    Laxdale, Park House, Laurelhill Business Park, Polmaise Road, Stirling FK7 9QL, UK
    Lancet 359:1857-8. 2002
  6. ncbi request reprint Eicosapentaenoic acid and arachidonic acid: collaboration and not antagonism is the key to biological understanding
    D F Horrobin
    Laxdale Ltd, King Park House, LaurelhiIl Business Park, Stirling FK7 9JQ, Scotland
    Prostaglandins Leukot Essent Fatty Acids 66:83-90. 2002
  7. ncbi request reprint The effects on plasma, red cell and platelet fatty acids of taking 12 g/day of ethyl-eicosapentaenoate for 16 months: dihomogammalinolenic, arachidonic and docosahexaenoic acids and relevance to Inuit metabolism
    David Horrobin
    Laxdale Ltd, Kings Park House, Laurelhill Business Park, Stirling, FK7 9JQ, Scotland, UK
    Prostaglandins Leukot Essent Fatty Acids 68:301-4. 2003
  8. ncbi request reprint Ethyl-eicosapentaenoate and dexamethasone resistance in therapy-refractory depression
    Harald Murck
    Laxdale Ltd, Stirling, Scotland, UK, FK7 9JQ
    Int J Neuropsychopharmacol 7:341-9. 2004
  9. ncbi request reprint Evidence-based medicine and the need for non-commercial clinical research directed towards therapeutic innovation
    David F Horrobin
    Laxdale Limited, Kings Park House, Laurelhill Business Park, Polmaise Road, Stirling, FK79JQ Scotland, UK
    Exp Biol Med (Maywood) 227:435-7. 2002
  10. ncbi request reprint Modern biomedical research: an internally self-consistent universe with little contact with medical reality?
    David F Horrobin
    Laxdale Ltd, Kings Park House, Laurelhill Business Park, Stirling FK7 9JQ, Scotland
    Nat Rev Drug Discov 2:151-4. 2003

Collaborators

  • Basant K Puri
  • Frits A J Muskiet
  • Harald Murck
  • Manfred Uhr
  • Brian E Leonard
  • Sahebarao P Mahadik
  • Cai Song
  • Peter E Lonergan
  • Agnes K Ayton
  • Darren S D Martin
  • Malcolm Peet
  • Marina A Lynch
  • Amer Azaz
  • Donald J Macdonald
  • Paul F Boston
  • Mehar Manku
  • Meena Arvindakshan
  • Mehar S Manku
  • Crispin N Bennett
  • Amanda Bennett
  • Alastair C A Glen
  • Rose M Boyle
  • Xuwen Li
  • Crispin Bennett
  • Denise Evans
  • Iain Glen
  • Fiona Duffy
  • Prabhakar K Ranjekar
  • Sandhya Sitasawad
  • David Boal
  • Susan McGoldrick
  • Madhav Ghate
  • Vijay Debsikdar
  • Amanda Green
  • Marie P Fogarty
  • Marcella Brady
  • Barry Boland
  • Veronica A Campbell

Detail Information

Publications29

  1. ncbi request reprint A new category of psychotropic drugs: neuroactive lipids as exemplified by ethyl eicosapentaenoate (E-E)
    David F Horrobin
    Laxdale Ltd, Kings Park House, Laurelhill Business Park, Stirling, FK7 9JQ Scotland
    Prog Drug Res 59:171-99. 2002
    ..It is extremely well tolerated with none of the usual side-effects of either antidepressants or neuroleptics. It probably works by modulating postreceptor signal transduction processes...
  2. ncbi request reprint omega-3 Fatty acid for schizophrenia
    David F Horrobin
    Am J Psychiatry 160:188-9; author reply 189. 2003
  3. ncbi request reprint Are large clinical trials in rapidly lethal diseases usually unethical?
    David F Horrobin
    Laxdale Ltd, Stirling, UK
    Lancet 361:695-7. 2003
  4. ncbi request reprint A low toxicity maintenance regime, using eicosapentaenoic acid and readily available drugs, for mantle cell lymphoma and other malignancies with excess cyclin D1 levels
    David F Horrobin
    Laxdale Ltd, Stirling, Scotland, UK
    Med Hypotheses 60:615-23. 2003
    ..The mechanisms of action of these various agents are discussed, and specific suggestions are made for low toxicity maintenance therapy of mantle cell lymphoma and of other tumours which overexpress cyclin D1...
  5. ncbi request reprint Effective clinical innovation: an ethical imperative
    David F Horrobin
    Laxdale, Park House, Laurelhill Business Park, Polmaise Road, Stirling FK7 9QL, UK
    Lancet 359:1857-8. 2002
  6. ncbi request reprint Eicosapentaenoic acid and arachidonic acid: collaboration and not antagonism is the key to biological understanding
    D F Horrobin
    Laxdale Ltd, King Park House, LaurelhiIl Business Park, Stirling FK7 9JQ, Scotland
    Prostaglandins Leukot Essent Fatty Acids 66:83-90. 2002
    ..We suggest that elevation of concentrations of both AA and EPA in cell membranes may be important for health...
  7. ncbi request reprint The effects on plasma, red cell and platelet fatty acids of taking 12 g/day of ethyl-eicosapentaenoate for 16 months: dihomogammalinolenic, arachidonic and docosahexaenoic acids and relevance to Inuit metabolism
    David Horrobin
    Laxdale Ltd, Kings Park House, Laurelhill Business Park, Stirling, FK7 9JQ, Scotland, UK
    Prostaglandins Leukot Essent Fatty Acids 68:301-4. 2003
    ..The implications for understanding of fatty acid metabolism in humans are discussed...
  8. ncbi request reprint Ethyl-eicosapentaenoate and dexamethasone resistance in therapy-refractory depression
    Harald Murck
    Laxdale Ltd, Stirling, Scotland, UK, FK7 9JQ
    Int J Neuropsychopharmacol 7:341-9. 2004
    ..EPA may, furthermore, enhance the action of antidepressants, like many SSRIs that are p-gp substrates, which are actively transported out of the intracerebral space at the level of the blood-brain barrier...
  9. ncbi request reprint Evidence-based medicine and the need for non-commercial clinical research directed towards therapeutic innovation
    David F Horrobin
    Laxdale Limited, Kings Park House, Laurelhill Business Park, Polmaise Road, Stirling, FK79JQ Scotland, UK
    Exp Biol Med (Maywood) 227:435-7. 2002
  10. ncbi request reprint Modern biomedical research: an internally self-consistent universe with little contact with medical reality?
    David F Horrobin
    Laxdale Ltd, Kings Park House, Laurelhill Business Park, Stirling FK7 9JQ, Scotland
    Nat Rev Drug Discov 2:151-4. 2003
  11. ncbi request reprint Dietary ethyl-eicosapentaenoic acid but not soybean oil reverses central interleukin-1-induced changes in behavior, corticosterone and immune response in rats
    Cai Song
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Stress 7:43-54. 2004
    ..Food enriched with ethyl-EPA but not soybean oil, significantly attenuated most of these changes. These results demonstrate that ethyl-EPA has anti-inflammatory, anti-stress and anti-anxiety effects in rats...
  12. ncbi request reprint Ethyl-EPA in Alzheimer's disease--a pilot study
    Paul F Boston
    Michael Carlisle Centre, Nether Edge Hospital, 75 Osborne Road, Sheffield, S Yorks S11 9BF, UK
    Prostaglandins Leukot Essent Fatty Acids 71:341-6. 2004
    ..A longer treatment period may be necessary to demonstrate efficacy of ethyl-EPA in this disorder...
  13. ncbi request reprint A dose-ranging exploratory study of the effects of ethyl-eicosapentaenoate in patients with persistent schizophrenic symptoms
    Malcolm Peet
    Swallownest Court, Aughton Road, S26 4TH, Sheffield, UK
    J Psychiatr Res 36:7-18. 2002
    ..This effect was greatest at 2 g/day. There was a positive relationship between improvement on rating scales and rise in red blood cell arachidonic acid concentration...
  14. ncbi request reprint Effects of dietary n-3 or n-6 fatty acids on interleukin-1beta-induced anxiety, stress, and inflammatory responses in rats
    Cai Song
    Department of Psychiatry, University of British Columbia, Canada
    J Lipid Res 44:1984-91. 2003
    ..Ethyl-GLA only antagonised IL-1-induced inflammatory changes, whereas AA caused an increase in the secretion of corticosterone and PGE2, and induced anxiety-like behavior without enhancing the effects of IL-1...
  15. ncbi request reprint Long-chain polyunsaturated fatty acids modulate interleukin-1beta-induced changes in behavior, monoaminergic neurotransmitters, and brain inflammation in rats
    Cai Song
    Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, Canada C1A 4P3
    J Nutr 138:954-63. 2008
    ..01). AA did not counteract any of the changes induced by IL-1. These results suggest that EPA, GLA, and AA play different roles in the neuroendocrine-immune network...
  16. ncbi request reprint A dose-ranging study of the effects of ethyl-eicosapentaenoate in patients with ongoing depression despite apparently adequate treatment with standard drugs
    Malcolm Peet
    Swallownest Court Hospital, Sheffield, England
    Arch Gen Psychiatry 59:913-9. 2002
    ..In depressed patients, low blood levels of eicosapentaenoic acid are seen. We tested the antidepressive effect of ethyl-eicosapentaenoate in these patients...
  17. ncbi request reprint Eicosapentaenoic acid in treatment-resistant depression
    Basant K Puri
    Arch Gen Psychiatry 59:91-2. 2002
  18. ncbi request reprint Neuroprotective actions of eicosapentaenoic acid on lipopolysaccharide-induced dysfunction in rat hippocampus
    Peter E Lonergan
    Trinity College Institute of Neuroscience, Department of Physiology, Trinity College, Dublin, Ireland
    J Neurochem 91:20-9. 2004
    ..We propose that the neuroprotective effect of EPA may be dependent on its ability to inhibit the downstream consequences of JNK activation...
  19. ncbi request reprint A pilot open case series of ethyl-EPA supplementation in the treatment of anorexia nervosa
    Agnes K Ayton
    Hull and East Riding Hospitals Trust, UK
    Prostaglandins Leukot Essent Fatty Acids 71:205-9. 2004
    ..Three of them recovered and four improved. Randomised controlled trials are warranted to examine the effectiveness of E-EPA in AN further...
  20. ncbi request reprint Rapid improvement of severe anorexia nervosa during treatment with ethyl-eicosapentaenoate and micronutrients
    Agnes K Ayton
    Huntercombe Stafford Hospital, Ivetsey Bank, Wheaton Aston, Stafford, ST17 0XA, UK
    Eur Psychiatry 19:317-9. 2004
  21. ncbi request reprint Neuroprotective effect of eicosapentaenoic acid in hippocampus of rats exposed to gamma-irradiation
    Peter E Lonergan
    Trinity College Institute of Neuroscience, Department of Physiology, Trinity College, Dublin 2, Ireland
    J Biol Chem 277:20804-11. 2002
    ..Significantly, when the compromise in cell viability induced by irradiation was prevented by eicosapentaenoic acid, long term potentiation was sustained in a manner similar to that in the sham-treated control group...
  22. ncbi request reprint Dr. David F. Horrobin
    Mehar Manku
    Prostaglandins Leukot Essent Fatty Acids 69:1-26. 2003
  23. ncbi request reprint MRI and neuropsychological improvement in Huntington disease following ethyl-EPA treatment
    Basant K Puri
    Magnetic Resonance Unit, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital, London UK
    Neuroreport 13:123-6. 2002
    ..We conclude that treatment with ethyl-EPA is associated with beneficial motor and MRI changes...
  24. ncbi request reprint Ideas in biomedical science: reasons for the foundation of Medical Hypotheses
    David F Horrobin
    Med Hypotheses 62:3-4. 2004
  25. ncbi request reprint Cytosolic phospholipase A2 type IVA is present in human red cells
    Donald J Macdonald
    Biochemistry Department, Victoria Infirmary, Glasgow, G42 9TY, United Kingdom
    Blood 103:3562-4. 2004
    ..We show that IVAPLA(2) is present in red cells as a 90-kDa protein...
  26. ncbi request reprint Apoptotic changes in the aged brain are triggered by interleukin-1beta-induced activation of p38 and reversed by treatment with eicosapentaenoic acid
    Darren S D Martin
    Department of Physiology, Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland
    J Biol Chem 277:34239-46. 2002
    ....
  27. ncbi request reprint Peer review of statistics in medical research. Rationale for requiring power calculations is needed
    David F Horrobin
    BMJ 325:491; author reply 491. 2002
  28. ncbi request reprint Food, micronutrients, and psychiatry
    David F Horrobin
    Int Psychogeriatr 14:331-4. 2002
  29. ncbi request reprint Essential polyunsaturated fatty acid and lipid peroxide levels in never-medicated and medicated schizophrenia patients
    Meena Arvindakshan
    Division of Biochemical Sciences, National Chemical Laboratory, Pune, India
    Biol Psychiatry 53:56-64. 2003
    ..To minimize these confounds, their levels were compared among never-medicated patients in early illness, medicated patients and control subjects with similar lifestyle and common ethnic background...