D F Horrobin

Summary

Affiliation: Laxdale Ltd
Country: UK

Publications

  1. ncbi Essential fatty acid metabolism and its modification in atopic eczema
    D F Horrobin
    Laxdale Research, Stirling, Scotland, United Kingdom
    Am J Clin Nutr 71:367S-72S. 2000
  2. ncbi Long-term potentiation in aged rats is restored when the age-related decrease in polyunsaturated fatty acid concentration is reversed
    D S D Martin
    Department of Physiology, Trinity College, Dublin, Ireland
    Prostaglandins Leukot Essent Fatty Acids 67:121-30. 2002
  3. ncbi Eicosapentaenoic acid and arachidonic acid: collaboration and not antagonism is the key to biological understanding
    D F Horrobin
    Laxdale Ltd, King Park House, LaurelhiIl Business Park, Stirling FK7 9JQ, Scotland
    Prostaglandins Leukot Essent Fatty Acids 66:83-90. 2002
  4. ncbi Ethyl-EPA in Huntington disease: a double-blind, randomized, placebo-controlled trial
    B K Puri
    Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, London, UK
    Neurology 65:286-92. 2005
  5. ncbi Cerebral metabolism in male patients with schizophrenia who have seriously and dangerously violently offended: a 31P magnetic resonance spectroscopy study
    B K Puri
    MRI Unit, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK
    Prostaglandins Leukot Essent Fatty Acids 70:409-11. 2004
  6. ncbi Ethyl-eicosapentaenoic acid ingestion prevents corticosterone-mediated memory impairment induced by central administration of interleukin-1beta in rats
    C Song
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Mol Psychiatry 9:630-8. 2004
  7. ncbi Abnormalities in dihomo-gamma-linolenic acid release in the pathogenesis of hypertension
    J P Mtabaji
    Efamol Research Institute, Kentville, Nova Scotia, Canada
    Am J Hypertens 6:458-62. 1993
  8. ncbi The effect of gamma-linolenic acid on plasma and membrane lipids and renal prostaglandin synthesis in older subjects
    A Hornych
    Broussais Hospital, Paris, France
    Bratisl Lek Listy 103:101-7. 2002
  9. ncbi Eicosapentaenoic acid in treatment-resistant depression associated with symptom remission, structural brain changes and reduced neuronal phospholipid turnover
    B K Puri
    MRI Unit, Imperial College School of Medicine, Hammersmith Hospital, London, W12 0HS, UK
    Int J Clin Pract 55:560-3. 2001
  10. ncbi The comparison of changes in behavior, neurochemistry, endocrine, and immune functions after different routes, doses and durations of administrations of IL-1beta in rats
    C Song
    Department of Biomedical Science, AVC, University of Prince Edward Island, Charlottetown, Canada
    Pharmacopsychiatry 39:88-99. 2006

Collaborators

  • Basant K Puri
  • C Song
  • B E Leonard
  • A Hornych
  • D S D Martin
  • A G Phillips
  • B Forette
  • P Spencer
  • S Oravec
  • M A Lynch
  • F Girault
  • J P Mtabaji
  • M S Manku

Detail Information

Publications10

  1. ncbi Essential fatty acid metabolism and its modification in atopic eczema
    D F Horrobin
    Laxdale Research, Stirling, Scotland, United Kingdom
    Am J Clin Nutr 71:367S-72S. 2000
    ..Atopic eczema may be a minor inherited abnormality of EFA metabolism...
  2. ncbi Long-term potentiation in aged rats is restored when the age-related decrease in polyunsaturated fatty acid concentration is reversed
    D S D Martin
    Department of Physiology, Trinity College, Dublin, Ireland
    Prostaglandins Leukot Essent Fatty Acids 67:121-30. 2002
    ....
  3. ncbi Eicosapentaenoic acid and arachidonic acid: collaboration and not antagonism is the key to biological understanding
    D F Horrobin
    Laxdale Ltd, King Park House, LaurelhiIl Business Park, Stirling FK7 9JQ, Scotland
    Prostaglandins Leukot Essent Fatty Acids 66:83-90. 2002
    ..We suggest that elevation of concentrations of both AA and EPA in cell membranes may be important for health...
  4. ncbi Ethyl-EPA in Huntington disease: a double-blind, randomized, placebo-controlled trial
    B K Puri
    Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, London, UK
    Neurology 65:286-92. 2005
    ..Preliminary evidence suggests beneficial effects of pure ethyl-eicosapentaenoate (ethyl-EPA) in Huntington disease (HD)...
  5. ncbi Cerebral metabolism in male patients with schizophrenia who have seriously and dangerously violently offended: a 31P magnetic resonance spectroscopy study
    B K Puri
    MRI Unit, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK
    Prostaglandins Leukot Essent Fatty Acids 70:409-11. 2004
    ..betaNTP was lower (P < 0.04) and gammaNTP was higher (P < 0.04) in the patient group compared with the normal control group. Our results are suggestive of increased cerebral energy metabolism taking place in the forensic patients...
  6. ncbi Ethyl-eicosapentaenoic acid ingestion prevents corticosterone-mediated memory impairment induced by central administration of interleukin-1beta in rats
    C Song
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Mol Psychiatry 9:630-8. 2004
    ..These findings in turn may indicate beneficial effects of ethyl-EPA in the treatment of cognitive and affective disorders in which inflammation and stress play a critical role...
  7. ncbi Abnormalities in dihomo-gamma-linolenic acid release in the pathogenesis of hypertension
    J P Mtabaji
    Efamol Research Institute, Kentville, Nova Scotia, Canada
    Am J Hypertens 6:458-62. 1993
    ..It is suggested that the defect in the release of DGLA may be involved in the pathogenesis of hypertension because it occurs early before hypertension has actually occurred...
  8. ncbi The effect of gamma-linolenic acid on plasma and membrane lipids and renal prostaglandin synthesis in older subjects
    A Hornych
    Broussais Hospital, Paris, France
    Bratisl Lek Listy 103:101-7. 2002
    ..CONCLUSION: Dietary supplementation of essential fatty acids such as gamma-linolenic acid to old subjects has beneficial effect on their health condition. (Tab. 6, Fig. 5, Ref. 37.)..
  9. ncbi Eicosapentaenoic acid in treatment-resistant depression associated with symptom remission, structural brain changes and reduced neuronal phospholipid turnover
    B K Puri
    MRI Unit, Imperial College School of Medicine, Hammersmith Hospital, London, W12 0HS, UK
    Int J Clin Pract 55:560-3. 2001
    ..Registered difference images showed that the EPA treatment was accompanied by structural brain changes including, in particular, a reduction in the lateral ventricular volume...
  10. ncbi The comparison of changes in behavior, neurochemistry, endocrine, and immune functions after different routes, doses and durations of administrations of IL-1beta in rats
    C Song
    Department of Biomedical Science, AVC, University of Prince Edward Island, Charlottetown, Canada
    Pharmacopsychiatry 39:88-99. 2006
    ..However, results from different IL-1 sources, administrating routes, doses and treatment duration were inconsistent and confused. The neuroendocrine-immune mechanism by which IL-1-induced behavioral changes occur is still unclear...