Michael L Ginger

Summary

Affiliation: Lancaster University
Country: UK

Publications

  1. doi request reprint Swimming with protists: perception, motility and flagellum assembly
    Michael L Ginger
    School of Health and Medicine, Division of Biomedical and Life Sciences, Lancaster University, Lancaster LA1 4YQ, UK
    Nat Rev Microbiol 6:838-50. 2008
  2. doi request reprint Calmodulin is required for paraflagellar rod assembly and flagellum-cell body attachment in trypanosomes
    Michael L Ginger
    Faculty of Health and Medicine, Division of Biomedical and Life Sciences, Lancaster University, Lancaster LA1 4YQ, UK
    Protist 164:528-40. 2013
  3. pmc Intermediary metabolism in protists: a sequence-based view of facultative anaerobic metabolism in evolutionarily diverse eukaryotes
    Michael L Ginger
    School of Health and Medicine, Division of Biomedical and Life Sciences, Lancaster University, Lancaster LA1 4YQ, UK
    Protist 161:642-71. 2010
  4. pmc Rewiring and regulation of cross-compartmentalized metabolism in protists
    Michael L Ginger
    Division of Biomedical and Life Sciences, School of Health and Medicine, Lancaster University, Lancaster LA1 4YQ, UK
    Philos Trans R Soc Lond B Biol Sci 365:831-45. 2010
  5. pmc The evolution of organellar metabolism in unicellular eukaryotes
    Michael L Ginger
    School of Health and Medicine, Division of Biomedical and Life Sciences, Lancaster University, Lancaster LA1 4YQ, UK
    Philos Trans R Soc Lond B Biol Sci 365:693-8. 2010
  6. ncbi request reprint Flagellar motility is required for the viability of the bloodstream trypanosome
    Richard Broadhead
    Department of Biological Sciences, Lancaster University, Lancaster LA1 4YQ, UK
    Nature 440:224-7. 2006
  7. pmc An alternative model for the role of RP2 protein in flagellum assembly in the African trypanosome
    Jane Andre
    From the Faculty of Health and Medicine, Biomedical and Life Sciences, Lancaster University, Lancaster LA1 4YQ, United Kingdom
    J Biol Chem 289:464-75. 2014
  8. doi request reprint Probing why trypanosomes assemble atypical cytochrome c with an AxxCH haem-binding motif instead of CxxCH
    Michael L Ginger
    Faculty of Health and Medicine, Division of Biomedical and Life Sciences, Lancaster University, Lancaster LA1 4YQ, UK
    Biochem J 448:253-60. 2012
  9. doi request reprint The tubulin cofactor C family member TBCCD1 orchestrates cytoskeletal filament formation
    Jane Andre
    Faculty of Health and Medicine, Division of Biomedical and Life Sciences, Lancaster University, Lancaster LA1 4YQ, UK
    J Cell Sci 126:5350-6. 2013
  10. pmc RNA interference mutant induction in vivo demonstrates the essential nature of trypanosome flagellar function during mammalian infection
    Samantha Griffiths
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    Eukaryot Cell 6:1248-50. 2007

Collaborators

Detail Information

Publications15

  1. doi request reprint Swimming with protists: perception, motility and flagellum assembly
    Michael L Ginger
    School of Health and Medicine, Division of Biomedical and Life Sciences, Lancaster University, Lancaster LA1 4YQ, UK
    Nat Rev Microbiol 6:838-50. 2008
    ..In particular, we discuss energy metabolism in eukaryotic flagella, modifications to the canonical assembly pathway and flagellum function in parasite virulence...
  2. doi request reprint Calmodulin is required for paraflagellar rod assembly and flagellum-cell body attachment in trypanosomes
    Michael L Ginger
    Faculty of Health and Medicine, Division of Biomedical and Life Sciences, Lancaster University, Lancaster LA1 4YQ, UK
    Protist 164:528-40. 2013
    ....
  3. pmc Intermediary metabolism in protists: a sequence-based view of facultative anaerobic metabolism in evolutionarily diverse eukaryotes
    Michael L Ginger
    School of Health and Medicine, Division of Biomedical and Life Sciences, Lancaster University, Lancaster LA1 4YQ, UK
    Protist 161:642-71. 2010
    ....
  4. pmc Rewiring and regulation of cross-compartmentalized metabolism in protists
    Michael L Ginger
    Division of Biomedical and Life Sciences, School of Health and Medicine, Lancaster University, Lancaster LA1 4YQ, UK
    Philos Trans R Soc Lond B Biol Sci 365:831-45. 2010
    ..Significantly, the example of trypanosomatid glycolysis illustrates nicely how mathematical modelling and systems biology can be used to uncover or understand novel modes of pathway regulation...
  5. pmc The evolution of organellar metabolism in unicellular eukaryotes
    Michael L Ginger
    School of Health and Medicine, Division of Biomedical and Life Sciences, Lancaster University, Lancaster LA1 4YQ, UK
    Philos Trans R Soc Lond B Biol Sci 365:693-8. 2010
    ..Moreover, the study of organellar metabolism in protists continues to provide critical insight into our understanding of eukaryotic evolution...
  6. ncbi request reprint Flagellar motility is required for the viability of the bloodstream trypanosome
    Richard Broadhead
    Department of Biological Sciences, Lancaster University, Lancaster LA1 4YQ, UK
    Nature 440:224-7. 2006
    ..A postgenomic meta-analysis, comparing the evolutionarily ancient trypanosome with other eukaryotes including humans, identifies numerous trypanosome-specific flagellar proteins, suggesting new avenues for selective intervention...
  7. pmc An alternative model for the role of RP2 protein in flagellum assembly in the African trypanosome
    Jane Andre
    From the Faculty of Health and Medicine, Biomedical and Life Sciences, Lancaster University, Lancaster LA1 4YQ, United Kingdom
    J Biol Chem 289:464-75. 2014
    ....
  8. doi request reprint Probing why trypanosomes assemble atypical cytochrome c with an AxxCH haem-binding motif instead of CxxCH
    Michael L Ginger
    Faculty of Health and Medicine, Division of Biomedical and Life Sciences, Lancaster University, Lancaster LA1 4YQ, UK
    Biochem J 448:253-60. 2012
    ..Moreover, the presence of the CxxCH cytochrome c resulted in a fitness cost in respiration. The level of cytochrome c biogenesis in trypanosomatids was also found to be limited, with the cells operating at close to maximum capacity...
  9. doi request reprint The tubulin cofactor C family member TBCCD1 orchestrates cytoskeletal filament formation
    Jane Andre
    Faculty of Health and Medicine, Division of Biomedical and Life Sciences, Lancaster University, Lancaster LA1 4YQ, UK
    J Cell Sci 126:5350-6. 2013
    ....
  10. pmc RNA interference mutant induction in vivo demonstrates the essential nature of trypanosome flagellar function during mammalian infection
    Samantha Griffiths
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    Eukaryot Cell 6:1248-50. 2007
    ..This validation provides a paradigm for the flagellum as a target for future assays and interventions against this human pathogen...
  11. ncbi request reprint Trypanosome IFT mutants provide insight into the motor location for mobility of the flagella connector and flagellar membrane formation
    Jacqueline A Davidge
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
    J Cell Sci 119:3935-43. 2006
    ..Movement of the FC in the apparent absence of intraflagellar transport raises the possibility of a new form of motility within a eukaryotic flagellum...
  12. pmc Niche metabolism in parasitic protozoa
    Michael L Ginger
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Philos Trans R Soc Lond B Biol Sci 361:101-18. 2006
    ....
  13. ncbi request reprint Intracellular positioning of isoforms explains an unusually large adenylate kinase gene family in the parasite Trypanosoma brucei
    Michael L Ginger
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, United Kingdom
    J Biol Chem 280:11781-9. 2005
    ..The anchoring of specific adenylate kinases within two distinct flagellar structures provides a paradigm for metabolic organization and efficiency in other flagellates...
  14. ncbi request reprint More than one way to build a flagellum: comparative genomics of parasitic protozoa
    Laura J Briggs
    Curr Biol 14:R611-2. 2004
  15. pmc Protein targeting of an unusual, evolutionarily conserved adenylate kinase to a eukaryotic flagellum
    Timothy J Pullen
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    Mol Biol Cell 15:3257-65. 2004
    ....