A J Walker

Summary

Affiliation: Kingston University
Country: UK

Publications

  1. ncbi request reprint Specific tyrosine phosphorylation induced in Schistosoma mansoni miracidia by haemolymph from schistosome susceptible, but not resistant, Biomphalaria glabrata
    A J Walker
    School of Life Sciences, Kingston University, Penrhyn Road, Kingston upon Thames, Surrey KT1 2EE, UK
    Parasitology 135:337-45. 2008
  2. pmc Differences in the gene expression profiles of haemocytes from schistosome-susceptible and -resistant biomphalaria glabrata exposed to Schistosoma mansoni excretory-secretory products
    Zahida Zahoor
    Molecular Parasitology Laboratory, School of Life Science, Kingston University, Kingston upon Thames, Surrey, United Kingdom Wolfson Wellcome Biomedical Laboratory, Natural History Museum, London, United Kingdom
    PLoS ONE 9:e93215. 2014
  3. pmc Functional mapping of protein kinase A reveals its importance in adult Schistosoma mansoni motor activity
    Paulu S R de Saram
    Molecular Parasitology Laboratory, School of Life Sciences, Kingston University, Kingston upon Thames, United Kingdom
    PLoS Negl Trop Dis 7:e1988. 2013
  4. pmc A role for p38 MAPK in the regulation of ciliary motion in a eukaryote
    Margarida Ressurreição
    School of Life Sciences, Kingston University, Penrhyn Road, Kingston upon Thames, Surrey KT1 2EE, UK
    BMC Cell Biol 12:6. 2011
  5. pmc Insights into the functional biology of schistosomes
    Anthony John Walker
    School of Life Sciences, Kingston University, Kingston upon Thames, Surrey KT12EE, UK
    Parasit Vectors 4:203. 2011
  6. doi request reprint Spreading by snail (Lymnaea stagnalis) defence cells is regulated through integrated PKC, FAK and Src signalling
    Anthony J Walker
    School of Life Sciences, Kingston University, Kingston upon Thames, Surrey, UK
    Cell Tissue Res 341:131-45. 2010
  7. pmc Nitric oxide production by Biomphalaria glabrata haemocytes: effects of Schistosoma mansoni ESPs and regulation through the extracellular signal-regulated kinase pathway
    Zahida Zahoor
    School of Life Sciences, Kingston University, Penrhyn Road, Kingston upon Thames, Surrey, KT1 2EE, UK
    Parasit Vectors 2:18. 2009
  8. ncbi request reprint Bacterial lipopolysaccharide modulates protein kinase C signalling in Lymnaea stagnalis haemocytes
    Anthony J Walker
    School of Life Sciences, Kingston University, Penrhyn Road, Kingston upon Thames, Surrey, KT1 2EE, UK
    Biol Cell 95:527-33. 2003
  9. ncbi request reprint Do trematode parasites disrupt defence-cell signalling in their snail hosts?
    Anthony J Walker
    School of Life Sciences, Kingston University, Penrhyn Road, Kingston upon Thames, Surrey, UK, KT1 2EE
    Trends Parasitol 22:154-9. 2006
  10. ncbi request reprint Beta-1, 3-glucan modulates PKC signalling in Lymnaea stagnalis defence cells: a role for PKC in H2O2 production and downstream ERK activation
    Audrey H Lacchini
    School of Life Sciences, Kingston University, Penrhyn Road, Kingston upon Thames, Surrey, KT1 2EE, UK
    J Exp Biol 209:4829-40. 2006

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Specific tyrosine phosphorylation induced in Schistosoma mansoni miracidia by haemolymph from schistosome susceptible, but not resistant, Biomphalaria glabrata
    A J Walker
    School of Life Sciences, Kingston University, Penrhyn Road, Kingston upon Thames, Surrey KT1 2EE, UK
    Parasitology 135:337-45. 2008
    ..mansoni larvae...
  2. pmc Differences in the gene expression profiles of haemocytes from schistosome-susceptible and -resistant biomphalaria glabrata exposed to Schistosoma mansoni excretory-secretory products
    Zahida Zahoor
    Molecular Parasitology Laboratory, School of Life Science, Kingston University, Kingston upon Thames, Surrey, United Kingdom Wolfson Wellcome Biomedical Laboratory, Natural History Museum, London, United Kingdom
    PLoS ONE 9:e93215. 2014
    ..Such immunomodulation may benefit the schistosome, enabling its survival and successful development in the snail host. ..
  3. pmc Functional mapping of protein kinase A reveals its importance in adult Schistosoma mansoni motor activity
    Paulu S R de Saram
    Molecular Parasitology Laboratory, School of Life Sciences, Kingston University, Kingston upon Thames, United Kingdom
    PLoS Negl Trop Dis 7:e1988. 2013
    ..mansoni, provides valuable insight into the intricacies of functional protein kinase signalling in the context of whole schistosome physiology...
  4. pmc A role for p38 MAPK in the regulation of ciliary motion in a eukaryote
    Margarida Ressurreição
    School of Life Sciences, Kingston University, Penrhyn Road, Kingston upon Thames, Surrey KT1 2EE, UK
    BMC Cell Biol 12:6. 2011
    ..Here we present evidence for p38 mitogen-activated protein kinase (p38 MAPK) playing a role in the ciliary beat of a multicellular eukaryote, the free-living miracidium stage of the platyhelminth parasite Schistosoma mansoni...
  5. pmc Insights into the functional biology of schistosomes
    Anthony John Walker
    School of Life Sciences, Kingston University, Kingston upon Thames, Surrey KT12EE, UK
    Parasit Vectors 4:203. 2011
    ....
  6. doi request reprint Spreading by snail (Lymnaea stagnalis) defence cells is regulated through integrated PKC, FAK and Src signalling
    Anthony J Walker
    School of Life Sciences, Kingston University, Kingston upon Thames, Surrey, UK
    Cell Tissue Res 341:131-45. 2010
    ..stagnalis haemocytes. We propose a model in which integrin engagement mediates association of PKC with FAK/Src complexes to promote focal adhesion assembly during immune recognition by these cells...
  7. pmc Nitric oxide production by Biomphalaria glabrata haemocytes: effects of Schistosoma mansoni ESPs and regulation through the extracellular signal-regulated kinase pathway
    Zahida Zahoor
    School of Life Sciences, Kingston University, Penrhyn Road, Kingston upon Thames, Surrey, KT1 2EE, UK
    Parasit Vectors 2:18. 2009
    ..abstract:..
  8. ncbi request reprint Bacterial lipopolysaccharide modulates protein kinase C signalling in Lymnaea stagnalis haemocytes
    Anthony J Walker
    School of Life Sciences, Kingston University, Penrhyn Road, Kingston upon Thames, Surrey, KT1 2EE, UK
    Biol Cell 95:527-33. 2003
    ....
  9. ncbi request reprint Do trematode parasites disrupt defence-cell signalling in their snail hosts?
    Anthony J Walker
    School of Life Sciences, Kingston University, Penrhyn Road, Kingston upon Thames, Surrey, UK, KT1 2EE
    Trends Parasitol 22:154-9. 2006
    ..The hypothesis is that, to facilitate survival and replication in their intermediate hosts, trematode parasites down regulate host defence responses by interfering with key signal-transduction pathways in snail defence cells...
  10. ncbi request reprint Beta-1, 3-glucan modulates PKC signalling in Lymnaea stagnalis defence cells: a role for PKC in H2O2 production and downstream ERK activation
    Audrey H Lacchini
    School of Life Sciences, Kingston University, Penrhyn Road, Kingston upon Thames, Surrey, KT1 2EE, UK
    J Exp Biol 209:4829-40. 2006
    ..Given that H(2)O(2) is an important anti-pathogen molecule, and that haemocytes play a crucial role in the elimination of invading organisms, PKC signalling in these cells is likely to be crucial to the molluscan innate defence response...
  11. ncbi request reprint Integrin engagement modulates the phosphorylation of focal adhesion kinase, phagocytosis, and cell spreading in molluscan defence cells
    Louise D Plows
    School of Life Sciences, Kingston University, Penrhyn Road, Kingston upon Thames, Surrey, KT1 2EE, UK
    Biochim Biophys Acta 1763:779-86. 2006
    ..Taken together, these results demonstrate a role for integrins in L. stagnalis haemocyte adhesion and defence reactions and, for the first time, link integrin engagement to FAK activation in molluscs...
  12. ncbi request reprint Carbohydrates that mimic schistosome surface coat components affect ERK and PKC signalling in Lymnaea stagnalis haemocytes
    Louise D Plows
    School of Life Sciences, Kingston University, Penrhyn Road, Kingston upon Thames, Surrey KT1 2EE, UK
    Int J Parasitol 35:293-302. 2005
    ..We therefore propose that the establishment of a compatible relationship between a schistosome and its snail host is at least in part due to down-regulation of cell signalling events in haemocytes...
  13. ncbi request reprint Activation of extracellular-signal regulated kinase is required for phagocytosis by Lymnaea stagnalis haemocytes
    Louise D Plows
    School of Life Sciences, Kingston University, Penrhyn Road, Kingston upon Thames, Surrey, KT1 2EE, UK
    Biochim Biophys Acta 1692:25-33. 2004
    ..Overall, this study has furthered knowledge of ERK signalling in molluscan immunity and has shown that the ERK pathway regulates the phagocytic activity of molluscan haemocytes...
  14. doi request reprint Protein kinase C signalling during miracidium to mother sporocyst development in the helminth parasite, Schistosoma mansoni
    Marthe H R Ludtmann
    School of Life Sciences, Kingston University, Penrhyn Road, Kingston upon Thames, Surrey KT1 2EE, UK
    Int J Parasitol 39:1223-33. 2009
    ..These results highlight the dynamic nature of PKC signalling during S. mansoni postembryonic development and support a role for active PKC in restricting transformation of S. mansoni miracidia into mother sporocysts...
  15. ncbi request reprint Regulation of nitric oxide production in snail (Lymnaea stagnalis) defence cells: a role for PKC and ERK signalling pathways
    Bernice Wright
    School of Life Sciences, Kingston University, Kingston upon Thames, Surrey, UK
    Biol Cell 98:265-78. 2006
    ..The present study focused on the role of cell signalling pathways in NO production by primary haemocytes from the snail Lymnaea stagnalis...
  16. ncbi request reprint Phagocytosis by Lymnaea stagnalis haemocytes: a potential role for phosphatidylinositol 3-kinase but not protein kinase A
    Louise D Plows
    School of Life Sciences, Kingston University, Kingston upon Thames, Surrey KT1 2EE, UK
    J Invertebr Pathol 91:74-7. 2006
    ..001). In contrast, the protein kinase A (PKA) inhibitor KT5720 was without effect. Therefore, PI3-K, but not PKA, appears to control phagocytosis by haemocytes in these gastropod molluscs...
  17. pmc Biomphalaria glabrata transcriptome: identification of cell-signalling, transcriptional control and immune-related genes from open reading frame expressed sequence tags (ORESTES)
    Anne E Lockyer
    Wolfson Wellcome Biomedical Laboratory, The Natural History Museum, Cromwell Road, London SW7 5BD, UK
    Dev Comp Immunol 31:763-82. 2007
    ....