Colin McGuckin

Summary

Affiliation: Kingston University
Country: UK

Publications

  1. ncbi AC133+ umbilical cord blood progenitors demonstrate rapid self-renewal and low apoptosis
    Nicolas Forraz
    King-George Laboratory, St George's Hospital Medical School and Kingston University, London, UK
    Br J Haematol 119:516-24. 2002
  2. ncbi Characterization of a lineage-negative stem-progenitor cell population optimized for ex vivo expansion and enriched for LTC-IC
    Nicolas Forraz
    King-George Laboratory, St. George's Hospital Medical School and Kingston University, London, UK
    Stem Cells 22:100-8. 2004
  3. ncbi Diaminofluorene stain detects erythroid differentiation in immature haemopoietic cells treated with EPO, IL-3, SCF, TGFbeta1, MIP-1alpha and IFNgamma
    Colin P McGuckin
    King George Laboratory, St George s Hospital Medical School, London, UK
    Eur J Haematol 70:106-14. 2003
  4. ncbi Colocalization analysis of sialomucins CD34 and CD164
    Colin P McGuckin
    King George Laboratory, St George s Hospital Medical School and Kingston University, London, United Kingdom
    Stem Cells 21:162-70. 2003
  5. ncbi Hematopoietic cells in pregnancyietic stem cells
    Colin McGuckin
    King-George Laboratory, St George's Hospital Medical School and Kingston University, London, UK
    Haematologica 90:146. 2005
  6. ncbi Multiparametric analysis of immature cell populations in umbilical cord blood and bone marrow
    Colin P McGuckin
    King George Laboratory, St George s Hospital Medical School and Kingston University, London, UK
    Eur J Haematol 71:341-50. 2003
  7. ncbi Thrombopoietin, flt3-ligand and c-kit-ligand modulate HOX gene expression in expanding cord blood CD133 cells
    C P McGuckin
    King George Stem Cell Therapy Laboratory, St George s Hospital Medical School and Kingston University, London, UK
    Cell Prolif 37:295-306. 2004
  8. ncbi Umbilical cord blood stem cells can expand hematopoietic and neuroglial progenitors in vitro
    Colin P McGuckin
    King George Laboratory, St George s Hospital Medical School and Kingston University, London, UK
    Exp Cell Res 295:350-9. 2004
  9. ncbi Endolyn (CD164) modulates the CXCL12-mediated migration of umbilical cord blood CD133+ cells
    Sinead Forde
    Stem Cell Laboratory, National Blood Service and Transplant Authority, United Kindom
    Blood 109:1825-33. 2007
  10. ncbi Three-dimensional analysis of CD34 sialomucin distribution on cord blood and bone marrow
    Karen A Whiting
    King-George Laboratory, St George's Hospital Medical School and Kingston University, London, UK
    Br J Haematol 122:771-7. 2003

Collaborators

  • Suzanne M Watt
  • Wai M Liu
  • Jon Smythe
  • Nicolas Forraz
  • Ruth Pettengell
  • Sinead Forde
  • Karen A Whiting
  • Sarah E Newey
  • Britt Jorgensen Tye
  • Maria Roubelakis
  • David Wertheim
  • Daniel Pearce
  • Pierre-Antoine Deglesne

Detail Information

Publications12

  1. ncbi AC133+ umbilical cord blood progenitors demonstrate rapid self-renewal and low apoptosis
    Nicolas Forraz
    King-George Laboratory, St George's Hospital Medical School and Kingston University, London, UK
    Br J Haematol 119:516-24. 2002
    ..50 +/- 2.36; TPOFL: 47.00 +/- 7.69; P < 0.05). In conclusion, TPOFL synergism demonstrated the potential for AC133+ HSPC ex vivo expansion inducing self-renewal, early HSPC maintenance and promoting cell survival status...
  2. ncbi Characterization of a lineage-negative stem-progenitor cell population optimized for ex vivo expansion and enriched for LTC-IC
    Nicolas Forraz
    King-George Laboratory, St. George's Hospital Medical School and Kingston University, London, UK
    Stem Cells 22:100-8. 2004
    ..Additionally, this work provides an optimized and well-characterized cell population for expansion of UCB for a wider therapeutic potential, including adult stem cell transplantation...
  3. ncbi Diaminofluorene stain detects erythroid differentiation in immature haemopoietic cells treated with EPO, IL-3, SCF, TGFbeta1, MIP-1alpha and IFNgamma
    Colin P McGuckin
    King George Laboratory, St George s Hospital Medical School, London, UK
    Eur J Haematol 70:106-14. 2003
    ..This differential cytokine stimulation analysis combined with sensitive DAF haemoglobin detection could be applied in the study of many erythropoiesis-deficient patients or primitive erythropoiesis...
  4. ncbi Colocalization analysis of sialomucins CD34 and CD164
    Colin P McGuckin
    King George Laboratory, St George s Hospital Medical School and Kingston University, London, United Kingdom
    Stem Cells 21:162-70. 2003
    ....
  5. ncbi Hematopoietic cells in pregnancyietic stem cells
    Colin McGuckin
    King-George Laboratory, St George's Hospital Medical School and Kingston University, London, UK
    Haematologica 90:146. 2005
  6. ncbi Multiparametric analysis of immature cell populations in umbilical cord blood and bone marrow
    Colin P McGuckin
    King George Laboratory, St George s Hospital Medical School and Kingston University, London, UK
    Eur J Haematol 71:341-50. 2003
    ..The presence of cells which lacked extracellular CD34 antigen, in both CB and BM, but which possessed CD133, has important implications for purification of human stem cells in clinical applications...
  7. ncbi Thrombopoietin, flt3-ligand and c-kit-ligand modulate HOX gene expression in expanding cord blood CD133 cells
    C P McGuckin
    King George Stem Cell Therapy Laboratory, St George s Hospital Medical School and Kingston University, London, UK
    Cell Prolif 37:295-306. 2004
    ..These results suggest that TPOFLK induces CD133+ HSPC proliferation, self-renewal and maintenance, up-regulation of HOX B3, B4 and A9 and down-regulation of HOX B8 and A10 gene expression...
  8. ncbi Umbilical cord blood stem cells can expand hematopoietic and neuroglial progenitors in vitro
    Colin P McGuckin
    King George Laboratory, St George s Hospital Medical School and Kingston University, London, UK
    Exp Cell Res 295:350-9. 2004
    ..Our study supports that a single CB specimen can be pre-expanded in TPOFLK to produce both primitive hematopoietic and neuropoietic progenitors, hence widening CB clinical potential for cellular therapies...
  9. ncbi Endolyn (CD164) modulates the CXCL12-mediated migration of umbilical cord blood CD133+ cells
    Sinead Forde
    Stem Cell Laboratory, National Blood Service and Transplant Authority, United Kindom
    Blood 109:1825-33. 2007
    ..We propose that this lends specificity to the homing and lodgment of these cells within the bone marrow niche...
  10. ncbi Three-dimensional analysis of CD34 sialomucin distribution on cord blood and bone marrow
    Karen A Whiting
    King-George Laboratory, St George's Hospital Medical School and Kingston University, London, UK
    Br J Haematol 122:771-7. 2003
    ..True CD34 distribution, not previously discernible by confocal laser scanning microscopy alone, suggests a possible role in cell adhesion/homing revealed by three-dimensional imaging...
  11. ncbi Haemopoietic and neuroglial progenitors are promoted during cord blood ex vivo expansion
    Nicolas Forraz
    King-George Laboratory, Haematology, St George's Hospital Medical School and Kingston University, School of Life Sciences, London, UK
    Br J Haematol 119:888. 2002
  12. ncbi Umbilical cord blood stem cells--an ethical source for regenerative medicine
    Colin P McGuckin
    Newcastle Centre for Cord Blood, Stem Cell Institute, Institute of Human Genetics, Newcastle University
    Med Law 27:147-65. 2008
    ..With ongoing clinical trials and research predicting new avenues, the future seems assured for this stem cell source. What does this predict, however, for cord blood banking? More importantly, what does it justify?..