David Mackintosh

Summary

Affiliation: Kingston University
Country: UK

Publications

  1. pmc Treatment with a combination of the ErbB (HER) family blocker afatinib and the IGF-IR inhibitor, NVP-AEW541 induces synergistic growth inhibition of human pancreatic cancer cells
    Nikolaos Ioannou
    School of Life Sciences, Kingston University London, Kingston upon Thames, Surrey KT1 2EE, UK
    BMC Cancer 13:41. 2013
  2. ncbi request reprint Mitogenic activity of insulin in the culture of a trypanosome: duration and dose response
    David Mackintosh
    Faculty of Science, School of Life Sciences, Kingston University, Penrhyn Road, Kingston, Surrey KT1 2EE, UK
    Cell Biol Int 27:75-8. 2003
  3. ncbi request reprint Beta-1, 3-glucan modulates PKC signalling in Lymnaea stagnalis defence cells: a role for PKC in H2O2 production and downstream ERK activation
    Audrey H Lacchini
    School of Life Sciences, Kingston University, Penrhyn Road, Kingston upon Thames, Surrey, KT1 2EE, UK
    J Exp Biol 209:4829-40. 2006
  4. doi request reprint Spreading by snail (Lymnaea stagnalis) defence cells is regulated through integrated PKC, FAK and Src signalling
    Anthony J Walker
    School of Life Sciences, Kingston University, Kingston upon Thames, Surrey, UK
    Cell Tissue Res 341:131-45. 2010

Collaborators

Detail Information

Publications4

  1. pmc Treatment with a combination of the ErbB (HER) family blocker afatinib and the IGF-IR inhibitor, NVP-AEW541 induces synergistic growth inhibition of human pancreatic cancer cells
    Nikolaos Ioannou
    School of Life Sciences, Kingston University London, Kingston upon Thames, Surrey KT1 2EE, UK
    BMC Cancer 13:41. 2013
    ..In this study, we investigated the effect of simultaneous targeting of IGF-IR and HER (erbB) family, with NVP-AEW541 and afatinib, on proliferation of pancreatic cancer cells...
  2. ncbi request reprint Mitogenic activity of insulin in the culture of a trypanosome: duration and dose response
    David Mackintosh
    Faculty of Science, School of Life Sciences, Kingston University, Penrhyn Road, Kingston, Surrey KT1 2EE, UK
    Cell Biol Int 27:75-8. 2003
    ..These findings suggest a possible role for host insulin and/or trypanosomal insulin-like molecules in regulating parasite growth in vivo...
  3. ncbi request reprint Beta-1, 3-glucan modulates PKC signalling in Lymnaea stagnalis defence cells: a role for PKC in H2O2 production and downstream ERK activation
    Audrey H Lacchini
    School of Life Sciences, Kingston University, Penrhyn Road, Kingston upon Thames, Surrey, KT1 2EE, UK
    J Exp Biol 209:4829-40. 2006
    ..Given that H(2)O(2) is an important anti-pathogen molecule, and that haemocytes play a crucial role in the elimination of invading organisms, PKC signalling in these cells is likely to be crucial to the molluscan innate defence response...
  4. doi request reprint Spreading by snail (Lymnaea stagnalis) defence cells is regulated through integrated PKC, FAK and Src signalling
    Anthony J Walker
    School of Life Sciences, Kingston University, Kingston upon Thames, Surrey, UK
    Cell Tissue Res 341:131-45. 2010
    ..stagnalis haemocytes. We propose a model in which integrin engagement mediates association of PKC with FAK/Src complexes to promote focal adhesion assembly during immune recognition by these cells...