S Ahmed

Summary

Affiliation: Kingston University
Country: UK

Publications

  1. ncbi request reprint Structure activity relationship study of known inhibitors of the enzyme 5 alpha-reductase (5AR)
    S Ahmed
    School of Applied Chemistry, Kingston University, Surrey
    Bioorg Med Chem Lett 8:409-14. 1998
  2. ncbi request reprint Hydrophobicity, a physicochemical factor in the inhibition of the enzyme estrone sulfatase (ES)
    S Ahmed
    School of Chemical and Pharmaceutical Sciences, Kingston University, Penrhyn Road, Kingston upon Thames, KT1 2EE, Surrey, UK
    Bioorg Med Chem Lett 11:2525-8. 2001
  3. ncbi request reprint A novel molecular modelling study of inhibitors of the 17alpha-hydroxylase component of the enzyme system 17alpha-hydroxylase/17,20-lyase (P-450(17alpha))
    S Ahmed
    School of Applied Chemistry, Kingston University, Kingston upon Thames, UK
    Bioorg Med Chem 7:1487-96. 1999
  4. ncbi request reprint The mechanism of the irreversible inhibition of estrone sulfatase (ES) through the consideration of a range of methane- and amino-sulfonate-based compounds
    Sabbir Ahmed
    School of Chemical and Pharmaceutical Sciences, Kingston University, Penrhyn Road, Surrey, KT1 2EE, Kingston upon Thames, UK
    Bioorg Med Chem Lett 12:1279-82. 2002
  5. ncbi request reprint Inhibition of estrone sulfatase (ES) by derivatives of 4-[(aminosulfonyl)oxy] benzoic acid
    Sabbir Ahmed
    School of Chemical and Pharmaceutical Sciences, Kingston University, Kingston upon Thames, Surrey, UK
    Bioorg Med Chem Lett 12:2391-4. 2002
  6. ncbi request reprint Mechanism based representation of the active site of 5 alpha-reductase (5AR)
    S Ahmed
    School of Applied Chemistry, Kingston University, Kingston upon Thames, Surrey, UK
    Bioorg Med Chem Lett 8:2615-70. 1998
  7. ncbi request reprint Mechanism of 17 alpha-hydroxylase/17,20-lyase--an initial geometric perspective for the lyase of the C(17)-C(20) bond of C21 steroids
    S Ahmed
    School of Applied Chemistry, Kingston University, Kingston upon Thames, Surrey, UK
    Bioorg Med Chem Lett 8:1023-8. 1998
  8. ncbi request reprint Novel inhibitors of the enzyme estrone sulfatase (ES)
    S Ahmed
    School of Chemical and Pharmaceutical Sciences, Kingston University, Kingston upon Thames, Surrey, UK
    Bioorg Med Chem Lett 11:841-4. 2001
  9. ncbi request reprint Determination and use of a transition state for the enzyme estrone sulfatase (ES) from a proposed reaction mechanism
    S Ahmed
    School of Chemical and Pharmaceutical Sciences, Kingston University, Penrhyn Road, Kingston upon Thames, Surrey KT1 2EE, UK
    Bioorg Med Chem Lett 11:3001-5. 2001
  10. ncbi request reprint Acid dissociation constant, a potential physicochemical factor in the inhibition of the enzyme estrone sulfatase (ES)
    S Ahmed
    School of Chemical and Pharmaceutical Sciences, Kingston University, Kingston upon Thames, Surrey, UK
    Bioorg Med Chem Lett 11:899-902. 2001

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Structure activity relationship study of known inhibitors of the enzyme 5 alpha-reductase (5AR)
    S Ahmed
    School of Applied Chemistry, Kingston University, Surrey
    Bioorg Med Chem Lett 8:409-14. 1998
    ....
  2. ncbi request reprint Hydrophobicity, a physicochemical factor in the inhibition of the enzyme estrone sulfatase (ES)
    S Ahmed
    School of Chemical and Pharmaceutical Sciences, Kingston University, Penrhyn Road, Kingston upon Thames, KT1 2EE, Surrey, UK
    Bioorg Med Chem Lett 11:2525-8. 2001
    ..Analysis of the SAR data shows a strong correlation between IC(50) and logP but also supports our previous study, which suggests a very strong relationship between pK(a) and IC(50)...
  3. ncbi request reprint A novel molecular modelling study of inhibitors of the 17alpha-hydroxylase component of the enzyme system 17alpha-hydroxylase/17,20-lyase (P-450(17alpha))
    S Ahmed
    School of Applied Chemistry, Kingston University, Kingston upon Thames, UK
    Bioorg Med Chem 7:1487-96. 1999
    ..Overall, the study suggests that the novel substrate-heme complex approach has provided a good approximation of the 17alpha-OHase active site and has proved to be a useful tool in drug design and discovery...
  4. ncbi request reprint The mechanism of the irreversible inhibition of estrone sulfatase (ES) through the consideration of a range of methane- and amino-sulfonate-based compounds
    Sabbir Ahmed
    School of Chemical and Pharmaceutical Sciences, Kingston University, Penrhyn Road, Surrey, KT1 2EE, Kingston upon Thames, UK
    Bioorg Med Chem Lett 12:1279-82. 2002
    ....
  5. ncbi request reprint Inhibition of estrone sulfatase (ES) by derivatives of 4-[(aminosulfonyl)oxy] benzoic acid
    Sabbir Ahmed
    School of Chemical and Pharmaceutical Sciences, Kingston University, Kingston upon Thames, Surrey, UK
    Bioorg Med Chem Lett 12:2391-4. 2002
    ..Furthermore, the data suggest a strong correlation between logP and IC(50) and therefore adds further support to our previous report where we suggested a link between inhibitory activity and hydrophobicity...
  6. ncbi request reprint Mechanism based representation of the active site of 5 alpha-reductase (5AR)
    S Ahmed
    School of Applied Chemistry, Kingston University, Kingston upon Thames, Surrey, UK
    Bioorg Med Chem Lett 8:2615-70. 1998
    ....
  7. ncbi request reprint Mechanism of 17 alpha-hydroxylase/17,20-lyase--an initial geometric perspective for the lyase of the C(17)-C(20) bond of C21 steroids
    S Ahmed
    School of Applied Chemistry, Kingston University, Kingston upon Thames, Surrey, UK
    Bioorg Med Chem Lett 8:1023-8. 1998
    ....
  8. ncbi request reprint Novel inhibitors of the enzyme estrone sulfatase (ES)
    S Ahmed
    School of Chemical and Pharmaceutical Sciences, Kingston University, Kingston upon Thames, Surrey, UK
    Bioorg Med Chem Lett 11:841-4. 2001
    ..The results of the study show that these compounds are potent inhibitors, possessing greater inhibitory activity than COUMATE, but weaker activity than EMATE. Furthermore, the compounds are observed to be irreversible inhibitors...
  9. ncbi request reprint Determination and use of a transition state for the enzyme estrone sulfatase (ES) from a proposed reaction mechanism
    S Ahmed
    School of Chemical and Pharmaceutical Sciences, Kingston University, Penrhyn Road, Kingston upon Thames, Surrey KT1 2EE, UK
    Bioorg Med Chem Lett 11:3001-5. 2001
    ..Using the derived structure, we have undertaken the molecular modelling of several steroidal and non-steroidal inhibitors in an attempt to rationalise the inhibitory activity of a number of potent inhibitors...
  10. ncbi request reprint Acid dissociation constant, a potential physicochemical factor in the inhibition of the enzyme estrone sulfatase (ES)
    S Ahmed
    School of Chemical and Pharmaceutical Sciences, Kingston University, Kingston upon Thames, Surrey, UK
    Bioorg Med Chem Lett 11:899-902. 2001
    ..We postulate that the stability of the phenoxide ion, as indicated by the acid dissociation constant, is an important factor in the irreversible inhibition of this enzyme...
  11. ncbi request reprint First report of the investigation into the importance of pK(a) in the inhibition of estrone sulfatase by sulfamate containing compounds
    S Ahmed
    School of Chemical and Pharmaceutical Sciences, Kingston University, Kingston upon Thames, Surrey, United Kingdom
    Biochem Biophys Res Commun 272:583-5. 2000
    ..The results of the study suggest that there is a strong correlation between the inhibitory activity and the stability of the resulting O(-) anion (i.e., the pK(a) of the starting phenol)...
  12. ncbi request reprint Derivation of a possible transition-state for the reaction catalysed by the enzyme estrone Sulfatase (ES)
    S Ahmed
    School of Applied Chemistry, Kingston University, Kingston upon Thames, Surrey, UK
    Bioorg Med Chem Lett 9:1645-50. 1999
    ..Using the derived structure, we have superimposed several steroidal and non-steroidal inhibitors in an attempt to rationalise the inhibitory activity of a number of potent inhibitors...
  13. ncbi request reprint The use of the substrate-heme complex approach in the design, synthesis, biochemical evaluation, and rationalization of the inhibitory activity of a range of azole compounds against cholesterol side chain cleavage enzyme
    S Ahmed
    School of Chemical and Pharmaceutical Sciences, Kingston University, Penrhyn Road, Kingston upon Thames, Surrey, KT1 2EE, United Kingdom
    Biochem Biophys Res Commun 275:75-6. 2000
    ....
  14. ncbi request reprint Synthesis and biochemical evaluation of novel inhibitors of aromatase (AR) using an enhanced representation of the active site of AR derived from the consideration of the reaction mechanism
    S Ahmed
    School of Applied Chemistry, Kingston University, Penrhyn Road, Kingston upon Thames, Surrey, KT1 2EE, United Kingdom
    Biochem Biophys Res Commun 267:356-61. 2000
    ....
  15. ncbi request reprint Structure-activity relationship study of steroidal and nonsteroidal inhibitors of the enzyme estrone sulfatase
    S Ahmed
    School of Applied Chemistry, School of Life Sciences, Kingston University, Penrhyn Road, Kingston upon Thames, Surrey, KT1 2EE, United Kingdom
    Biochem Biophys Res Commun 254:811-5. 1999
    ..g., an inhibitor based upon trichloroethanol has been shown to possess 46% inhibition at 0.76mM)...
  16. ncbi request reprint The use of the novel substrate-heme complex approach in the derivation of a representation of the active site of the enzyme cholesterol side chain cleavage
    S Ahmed
    School of Chemical and Pharmaceutical Sciences, Kingston University, Penrhyn Road, Surrey, Kingston upon Thames, KT1 2EE, United Kingdom
    Biochem Biophys Res Commun 274:821-4. 2000
    ..Using the derived model, we have rationalised the inhibitory activity of a number of compounds including aminoglutethimide and pyridoglutethimide and the enantiomers of ketoconazole...
  17. ncbi request reprint Folic acid prevents nitroglycerin-induced nitric oxide synthase dysfunction and nitrate tolerance: a human in vivo study
    T Gori
    Division of Cardiology, Department of Medicine, Mount Sinai Hospital, and the University of Toronto, Toronto, Canada
    Circulation 104:1119-23. 2001
    ..We hypothesize that the reduced bioavailability of tetrahydrobiopterin is involved in the pathogenesis of both phenomena. Our results confirm the view that oxidative stress contributes to nitrate tolerance...
  18. ncbi request reprint Gleevec (STI571) influences metabolic enzyme activities and glucose carbon flow toward nucleic acid and fatty acid synthesis in myeloid tumor cells
    J Boren
    Department of Biochemistry and Molecular Biology, Institut d'Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Marti i Franques 1, Barcelona 08028, Spain
    J Biol Chem 276:37747-53. 2001
    ....
  19. ncbi request reprint Hydrophobicity and functionality maps of farnesyltransferase
    S Ahmed
    Department of Biochemistry, , , Switzerland
    J Mol Graph Model 19:307-17, 380-7. 2001
    ..The functionality maps are also used to design a library of disubstituted indoles that might prevent the binding of the protein substrates...
  20. ncbi request reprint An evolutionary approach for structure-based design of natural and non-natural peptidic ligands
    N Budin
    Department of Biochemistry, , Winterthurerstrasse 190, CH-8057, , Switzerland
    Comb Chem High Throughput Screen 4:661-73. 2001
    ..For farnesyltransferase, it is shown that electrostatic solvation is necessary for the correct design of peptidic inhibitors...
  21. ncbi request reprint Abl inhibitor BMS354825 binding mode in Abelson kinase revealed by molecular docking studies
    C Gambacorti-Passerini
    Leukemia 19:1267-9. 2005
  22. ncbi request reprint Effects of NOS inhibition on the cardiopulmonary system and brain microvascular markers after intermittent hypoxia in rats
    G R Barer
    Wolfson Research Centre, Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Brain Res 1098:196-203. 2006
    ..However, whether cerebral effects are due to systemic hypertension or changes in cerebral nitric oxide production needs to be evaluated...
  23. ncbi request reprint Arylpropanolamines: selective beta3 agonists arising from strategies to mitigate phase I metabolic transformations
    W N Washburn
    Bristol Myers Squibb Pharmaceutical Research Institute, PO Box 4000, Princeton, NJ 08543, USA
    Bioorg Med Chem Lett 17:4290-6. 2007
    ....