Feng Zhang

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint TGF beta1 expression and angiogenesis in colorectal cancer tissue
    Bin Xiong
    Department of Oncology, Affiliated Zhongnan Hospital of Wuhan University Wuhan 430071, Hubei, Provice, China
    World J Gastroenterol 8:496-8. 2002
  2. ncbi request reprint Lack of association between leukocyte telomere length and genetic variants in two ageing-related candidate genes
    Feng Zhang
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, King s College London, United Kingdom
    Mech Ageing Dev 128:415-22. 2007
  3. ncbi request reprint Association between KLOTHO gene and hand osteoarthritis in a female Caucasian population
    F Zhang
    Twin Research and Genetic Epidemiology Unit, King s College London, St Thomas Hospital Campus, London, UK
    Osteoarthritis Cartilage 15:624-9. 2007
  4. doi request reprint Variation at the ANP32A gene is associated with risk of hip osteoarthritis in women
    Ana M Valdes
    Kings College London, London, UK
    Arthritis Rheum 60:2046-54. 2009
  5. pmc Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22
    Evangelos Evangelou
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Ann Rheum Dis 70:349-55. 2011
  6. pmc A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium
    G Zhai
    Department of Twin Research and Genetic Epidemiology, King s College London, UK
    J Med Genet 46:614-6. 2009
  7. pmc Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis
    Ana M Valdes
    Twin Research Unit, St Thomas Hospital Campus, Kings College London School of Medicine, London SE1 7EH, UK
    Am J Hum Genet 82:1231-40. 2008
  8. pmc Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia
    Chris Wallace
    Clinical Pharmacology and The Genome Centre, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, EC1M 6BQ, UK
    Am J Hum Genet 82:139-49. 2008
  9. pmc Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study
    J B Richards
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
    Lancet 371:1505-12. 2008
  10. pmc The chemokine (C-C-motif) receptor 3 (CCR3) gene is linked and associated with age at menarche in Caucasian females
    Fang Yang
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, People s Republic of China
    Hum Genet 121:35-42. 2007

Detail Information

Publications41

  1. ncbi request reprint TGF beta1 expression and angiogenesis in colorectal cancer tissue
    Bin Xiong
    Department of Oncology, Affiliated Zhongnan Hospital of Wuhan University Wuhan 430071, Hubei, Provice, China
    World J Gastroenterol 8:496-8. 2002
    ..We investigate the relationship between transforming growth factor beta(1) and angiogenesis by analyzing the expression of transforming growth factor TGF beta(1) in colorectal cancer, as well as its association with VEGF and MVD...
  2. ncbi request reprint Lack of association between leukocyte telomere length and genetic variants in two ageing-related candidate genes
    Feng Zhang
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, King s College London, United Kingdom
    Mech Ageing Dev 128:415-22. 2007
    ....
  3. ncbi request reprint Association between KLOTHO gene and hand osteoarthritis in a female Caucasian population
    F Zhang
    Twin Research and Genetic Epidemiology Unit, King s College London, St Thomas Hospital Campus, London, UK
    Osteoarthritis Cartilage 15:624-9. 2007
    ..In this study, we investigated the association between four putatively functional genetic variants in KLOTHO gene, a strong ageing-related gene, and hand OA in a large female Caucasian population...
  4. doi request reprint Variation at the ANP32A gene is associated with risk of hip osteoarthritis in women
    Ana M Valdes
    Kings College London, London, UK
    Arthritis Rheum 60:2046-54. 2009
    ..We undertook this study to test whether genetic variation at ANP32A was associated with osteoarthritis (OA) in women...
  5. pmc Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22
    Evangelos Evangelou
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Ann Rheum Dis 70:349-55. 2011
    ..It is characterised by changes in joint structure, including degeneration of the articular cartilage, and its aetiology is multifactorial with a strong postulated genetic component...
  6. pmc A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium
    G Zhai
    Department of Twin Research and Genetic Epidemiology, King s College London, UK
    J Med Genet 46:614-6. 2009
    ..01), suggesting the potential mechanism of the gene in hand OA might be via effects on subchondral bone. The authors' findings provide a potential new insight into genetic mechanisms in the development of hand OA...
  7. pmc Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis
    Ana M Valdes
    Twin Research Unit, St Thomas Hospital Campus, Kings College London School of Medicine, London SE1 7EH, UK
    Am J Hum Genet 82:1231-40. 2008
    ..Our results and previous studies on the role of the cyclooxygenase 2 enzyme encoded by PTGS2 underscore the importance of this signaling pathway in the pathogenesis of knee OA...
  8. pmc Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia
    Chris Wallace
    Clinical Pharmacology and The Genome Centre, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, EC1M 6BQ, UK
    Am J Hum Genet 82:139-49. 2008
    ..This finding provides a potential biological mechanism for the recent association of this same allele of the same SNP with increased risk of coronary disease...
  9. pmc Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study
    J B Richards
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
    Lancet 371:1505-12. 2008
    ..Osteoporosis is diagnosed by the measurement of bone mineral density, which is a highly heritable and multifactorial trait. We aimed to identify genetic loci that are associated with bone mineral density...
  10. pmc The chemokine (C-C-motif) receptor 3 (CCR3) gene is linked and associated with age at menarche in Caucasian females
    Fang Yang
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, People s Republic of China
    Hum Genet 121:35-42. 2007
    ..ANOVA confirmed the results by QTDT. For the first time we reported that CCR3 is linked and associated with AAM variation in Caucasian women. However, further studies are necessary to substantiate our conclusions...
  11. pmc HDC gene polymorphisms are associated with age at natural menopause in Caucasian women
    Feng Zhang
    The Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an 710049, PR China
    Biochem Biophys Res Commun 348:1378-82. 2006
    ..0397). Our results suggest that the HDC gene polymorphisms are significantly associated with AANM in Caucasian women...
  12. ncbi request reprint Genetic association between schizophrenia and the DISC1 gene in the Scottish population
    Feng Zhang
    Department of Mental Health, Institute of Medical Sciences, University of Aberdeen, Aberdeen, Scotland, UK
    Am J Med Genet B Neuropsychiatr Genet 141:155-9. 2006
    ..This analysis further strengthens the candidacy of DISC1 as a risk factor for schizophrenia in the general population, and suggests that more intensive searching for causative variants is justified...
  13. ncbi request reprint The monoamine oxidase B gene exhibits significant association to ADHD
    Jun Li
    Institute of Mental Health, Peking University Peking University sixth hospital, China
    Am J Med Genet B Neuropsychiatr Genet 147:370-4. 2008
    ..20E-6) and haplotype-based TDT analyses also found distorted transmission. In conclusion, this study provides the strongest evidence for the involvement of MAOB gene in the etiology of ADHD to date, at least in Han Chinese population...
  14. pmc Promoter polymorphisms of DNMT3B and the risk of colorectal cancer in Chinese: a case-control study
    Hong Fan
    Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Southeast University, 210009, Nanjing, PR China
    J Exp Clin Cancer Res 27:24. 2008
    ..Polymorphisms of the DNMT3B gene may influence DNMT3B activity on DNA methylation in several cancers, thereby modulating the susceptibility to cancer...
  15. pmc Association of CFH, LOC387715, and HTRA1 polymorphisms with exudative age-related macular degeneration in a northern Chinese population
    Yule Xu
    Beijing Tongren Eye Center, Capital Medical University, Beijing, China
    Mol Vis 14:1373-81. 2008
    ..The purpose of this study was to investigate the association of reported common single-nucleotide polymorphisms (SNPs) in CFH, LOC387715, and HTRA1 with exudative AMD in a northern Chinese population...
  16. pmc HAPSIMU: a genetic simulation platform for population-based association studies
    Feng Zhang
    Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an 710049, PR China
    BMC Bioinformatics 9:331. 2008
    ..Due to lack of structural information in real populations, it is difficult to evaluate the impact of population structure on PBAS in real populations...
  17. pmc Transposition of reversed Ac element ends generates novel chimeric genes in maize
    Jianbo Zhang
    Genetics, Development, and Cell Biology, Iowa State University, Ames, Iowa, United States of America
    PLoS Genet 2:e164. 2006
    ..To our knowledge, this is the first report demonstrating that alternative transposition reactions can recombine gene segments, leading to the creation of new genes...
  18. doi request reprint A spatial analysis of genetic structure of human populations in China reveals distinct difference between maternal and paternal lineages
    Fuzhong Xue
    MOE Key Laboratory of Contemporary Anthropology and Center for Evolutionary Biology, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai, China
    Eur J Hum Genet 16:705-17. 2008
    ..On the paternal side, however, no obvious genetic differentiation between northern and southern populations is revealed...
  19. ncbi request reprint [Risk features of HBV in human hepatocarcinogenesis: a nested case-controlled study]
    Feng Zhang
    Hepatic Surgery Centre, Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Zhonghua Wai Ke Za Zhi 45:1482-4. 2007
    ....
  20. ncbi request reprint Association study of the oestrogen signalling pathway genes in relation to age at natural menopause
    Li Na He
    The Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an 710049, China
    J Genet 86:269-76. 2007
    ..No significant association was observed between CYP17 and AANM. Our results suggest that genetic variation in the ESR2 and CYP19 genes may influence the variation in AANM in Caucasian women...
  21. doi request reprint Lack of association of Clara cell 10-kDa protein gene variant with chronic rhinosinusitis in a Chinese Han population
    Feng Zhang
    Department of Otolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Am J Rhinol 22:376-80. 2008
    ..The purpose of this study is to examine whether there is an association between the CC10 A + 38G SNP, plasma CC10 levels, and CRS in a central Chinese population of Han nationality...
  22. ncbi request reprint Genetic structure of Hmong-Mien speaking populations in East Asia as revealed by mtDNA lineages
    Bo Wen
    State Key Laboratory of Genetic Engineering and Center for Anthropological Studies, School of Life Sciences, Fudan University, Shanghai, China
    Mol Biol Evol 22:725-34. 2005
    ..Moreover, our data defined some new (sub-)haplogroups (A6, B4e, B4f, C5, F1a1, F1a1a, and R9c), which will direct further efforts to improve the phylogeny of East Asian mtDNAs...
  23. pmc DNMT3B 579 G>T promoter polymorphism and risk of esophagus carcinoma in Chinese
    Hong Fan
    Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Southeast University, Nanjing 210009, Jiangsu Province, China
    World J Gastroenterol 14:2230-4. 2008
    ..To investigate the relationship between 579 G>T polymorphisms in the DNMT3B gene, which is involved in de novo methylation and associated with the risk of esophagus cancer (EC) in Chinese...
  24. doi request reprint Simultaneous identification of multiple receptors of natural product using an optimized cDNA phage display cloning
    Qing Li He
    State Key Laboratory of Bio organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China
    Bioorg Med Chem Lett 18:3995-8. 2008
    ..This optimized protocol can be used to select protein targets of chemicals dependent on the binding affinity rather than on the relative abundance in cells...
  25. doi request reprint Constitutive plasma membrane targeting and microdomain localization of Dok5 studied by single-molecule microscopy
    Guo Fu
    Institute of Neuroscience, Department of Neurobiology, Second Military Medical University, Shanghai 200433, China
    Biophys Chem 136:13-8. 2008
    ..Finally, the potential mechanism of microdomain localization of Dok5 was discussed. This study provided insights into the characteristics of plasma membrane targeting and microdomain localization of Dok5 in living CHO cells...
  26. ncbi request reprint Impact of rosiglitazone on the expression of beta3-AR in the stable cell lines expressed beta3-AR gene
    Xin Zhao
    Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University Xiang Ya School of Medicine, Changsha, Hunan, P R China
    Clin Chem Lab Med 45:1511-6. 2007
    ....
  27. ncbi request reprint The association of Y chromosome haplogroups with spermatogenic failure in the Han Chinese
    Chuncheng Lu
    Jiangsu Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing 210029, China
    J Hum Genet 52:659-63. 2007
    ..10-12.36] (P = 0.028). However, in the other haplogroups no significant differences were found. In conclusion, Y haplogroup-K might bear a risk factor of male infertility, and the individuals in the haplogroup need to be further examined...
  28. ncbi request reprint Transforming growth factor-beta1 in invasion and metastasis in colorectal cancer
    Bin Xiong
    Department of Oncology, Affiliated Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei Province, China
    World J Gastroenterol 8:674-8. 2002
    ..To investigate the role of TGFbeta1 in invasion and metastasis in colorectal cancer by analysing TGFbeta1 correlated with depth of tumor invasion, stage and metastasis...
  29. ncbi request reprint [Epidemiological study of nasopharyngeal carcinoma risk in relatives of high-risk families in Guangdong]
    Wei Hua Jia
    Department of Experimental Research, Cancer Center, Sun Yat Sen University, Guangzhou, Guangdong, 510060, P R China
    Ai Zheng 23:767-70. 2004
    ..The purpose of the study was to estimate NPC risk among relatives of high-risk pedigrees in Guangong province, so as to provide information for genetic epidemiology and clinical genetic consultation...
  30. ncbi request reprint Genetic evidence supports demic diffusion of Han culture
    Bo Wen
    State Key Laboratory of Genetic Engineering and Center for Anthropological Studies, School of Life Sciences and Morgan Tan International Center for Life Sciences, Fudan University, Shanghai 200433, China
    Nature 431:302-5. 2004
    ..16 billion (2000 census), and are by far the largest ethnic group in the world. The expansion process of Han culture is thus of great interest to researchers in many fields...
  31. ncbi request reprint Complete genome sequences of the SARS-CoV: the BJ Group (Isolates BJ01-BJ04)
    Shengli Bi
    Center of Disease Control and Prevention, Beijing 100050, China
    Genomics Proteomics Bioinformatics 1:180-92. 2003
    ..This result appears to suggest a possible transmission path from Guangdong to Beijing/Hong Kong, then to other countries and regions...
  32. ncbi request reprint Heme oxygenase-1 alleviates ischemia/reperfusion injury in aged liver
    Xue Hao Wang
    Liver Transplantation Center of the First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China
    World J Gastroenterol 11:690-4. 2005
    ..To investigate if ischemia/reperfusion (I/R) injury in aged liver could be alleviated by heme oxygenase-1 (HO-1)...
  33. pmc Comparisons of maize pericarp color1 alleles reveal paralogous gene recombination and an organ-specific enhancer region
    Feng Zhang
    Department of Genetics, Development, and Cell Biology, Iowa State University, Ames, Iowa 50010, USA
    Plant Cell 17:903-14. 2005
    ..An independently derived P1-rw allele contains an Ac insertion into the same sequence, indicating that this site likely contains cob glume-specific regulatory elements...
  34. ncbi request reprint Modified distally based sural neuro-veno-fasciocutaneous flap: anatomical study and clinical applications
    Fa Hui Zhang
    Clinical Anatomic Center, General Hospital of People s Liberation Army Nanjing District, Fuzhou, China
    Microsurgery 25:543-50. 2005
    ..5 cm proximal to the tip of the lateral malleolus. This modified flap provides a valuable tool for repair of foot and ankle soft-tissue defects...
  35. ncbi request reprint A functional variant in the transcriptional regulatory region of gene LOC344967 cosegregates with disease phenotype in familial nasopharyngeal carcinoma
    Ri Cheng Jiang
    State Key Laboratory of Oncology in Southern China Departments of Experimental Research, Sun Yat sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510 060, China
    Cancer Res 66:693-700. 2006
    ..Collectively, these results provide evidence that the -32A variant is a functional sequence change and may be related to nasopharyngeal carcinoma susceptibility in the families studied...
  36. pmc Evaluation of a susceptibility gene for schizophrenia: genotype based meta-analysis of RGS4 polymorphisms from thirteen independent samples
    Michael E Talkowski
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 60:152-62. 2006
    ..Yet, similar to other SCZ candidate genes, studies have been inconsistent with respect to the associated alleles...
  37. pmc Gene conversion between direct noncoding repeats promotes genetic and phenotypic diversity at a regulatory locus of Zea mays (L.)
    Feng Zhang
    Department of Genetics, Development and Cell Biology and Department of Agronomy, Iowa State University, Ames, Iowa 50011, USA
    Genetics 174:753-62. 2006
    ....
  38. ncbi request reprint A rat surgical model of esophageal metaplasia and adenocarcinoma-induced by mixed reflux of gastric acid and duodenal contents
    Tao Zhang
    Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi an, Shaanxi 710038, China
    Dig Dis Sci 52:3202-8. 2007
    ..Such a model may provide a useful tool in study of human reflux-induced carcinogenesis...
  39. pmc Partial deletions are associated with an increased risk of complete deletion in AZFc: a new insight into the role of partial AZFc deletions in male infertility
    Feng Zhang
    MOE Key Laboratory of Contemporary Anthropology and Center for Evolutionary Biology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China
    J Med Genet 44:437-44. 2007
    ..Complete AZFc deletion is one of the most frequent causes of male infertility and the roles of partial AZFc deletions (gr/gr and b2/b3 deletions) in spermatogenesis are controversial...
  40. ncbi request reprint Variations in RANK gene are associated with adult height in Caucasians
    Yuan Chen
    Laboratory of Molecular and Statistical Genetics, College of Life Science, Hunan Normal University, Changsha, Hunan 410081, People s Republic of China
    Am J Hum Biol 19:559-65. 2007
    ..Further researches need to be launched to replicate the present results and further unravel the molecular mechanism underlying the significant associations discovered...
  41. ncbi request reprint Genome-wide scan for familial nasopharyngeal carcinoma reveals evidence of linkage to chromosome 4
    Bing Jian Feng
    Cancer Institute, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Nat Genet 31:395-9. 2002
    ..70 (P = 2.0 x 10(-5)) and 5.36 (P = 4.36 x 10(-6)) for D4S405 and D4S3002, respectively. Our findings provide evidence of a major susceptibility locus for NPC on chromosome 4 in a subset of families...