G Zhai

Summary

Affiliation: King's College London
Country: UK

Publications

  1. pmc Natural history and clinical significance of MRI-detected bone marrow lesions at the knee: a prospective study in community dwelling older adults
    Dawn Dore
    Menzies Research Institute Tasmania, University of Tasmania, Private Bag 23, Hobart, 7000, Australia
    Arthritis Res Ther 12:R223. 2010
  2. pmc Bone marrow lesions predict site-specific cartilage defect development and volume loss: a prospective study in older adults
    Dawn Dore
    Menzies Research Institute Tasmania, University of Tasmania, Private Bag 23, Hobart, 7000, Australia
    Arthritis Res Ther 12:R222. 2010
  3. pmc Familial, structural, and environmental correlates of MRI-defined bone marrow lesions: a sibpair study
    Guangju Zhai
    Menzies Research Institute, University of Tasmania, Level 2, Surrey House, 199 Macquarie Street, Hobart, TAS 7000, Australia
    Arthritis Res Ther 8:R137. 2006
  4. doi request reprint Natural history and risk factors for bone loss in postmenopausal Caucasian women: a 15-year follow-up population-based study
    G Zhai
    Twin Research and Genetic Epidemiology Unit, King s College London School of Medicine, St Thomas Hospital Campus, Lambeth Palace Road, London SE1 7EH, UK
    Osteoporos Int 19:1211-7. 2008
  5. ncbi request reprint Genetic influence on the progression of radiographic knee osteoarthritis: a longitudinal twin study
    G Zhai
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Osteoarthritis Cartilage 15:222-5. 2007
  6. pmc Reduction of leucocyte telomere length in radiographic hand osteoarthritis: a population-based study
    G Zhai
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Ann Rheum Dis 65:1444-8. 2006
  7. doi request reprint Genetic and environmental determinants on bone loss in postmenopausal Caucasian women: a 14-year longitudinal twin study
    G Zhai
    Twin Research and Genetic Epidemiology Unit, King s College London School of Medicine, St Thomas Hospital Campus, Westminster Bridge Road, London SE1 7EH, UK
    Osteoporos Int 20:949-53. 2009
  8. pmc A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium
    G Zhai
    Department of Twin Research and Genetic Epidemiology, King s College London, UK
    J Med Genet 46:614-6. 2009
  9. doi request reprint Serum branched-chain amino acid to histidine ratio: a novel metabolomic biomarker of knee osteoarthritis
    Guangju Zhai
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, Westminster Bridge Road, London SE1 7EH, UK
    Ann Rheum Dis 69:1227-31. 2010
  10. ncbi request reprint The interaction of genes and smoking on forced expiratory volume: a classic twin study
    Guangju Zhai
    Twin Research and Genetic Epidemiology Unit, King s College London School of Medicine, St Thomas Hospital Campus, Lambeth Palace Rd, London SE1 7EH, UK
    Chest 132:1772-7. 2007

Collaborators

Detail Information

Publications23

  1. pmc Natural history and clinical significance of MRI-detected bone marrow lesions at the knee: a prospective study in community dwelling older adults
    Dawn Dore
    Menzies Research Institute Tasmania, University of Tasmania, Private Bag 23, Hobart, 7000, Australia
    Arthritis Res Ther 12:R223. 2010
    ....
  2. pmc Bone marrow lesions predict site-specific cartilage defect development and volume loss: a prospective study in older adults
    Dawn Dore
    Menzies Research Institute Tasmania, University of Tasmania, Private Bag 23, Hobart, 7000, Australia
    Arthritis Res Ther 12:R222. 2010
    ....
  3. pmc Familial, structural, and environmental correlates of MRI-defined bone marrow lesions: a sibpair study
    Guangju Zhai
    Menzies Research Institute, University of Tasmania, Level 2, Surrey House, 199 Macquarie Street, Hobart, TAS 7000, Australia
    Arthritis Res Ther 8:R137. 2006
    ..They commonly coexist with chondral defects and ROA but only share common genetic mechanisms to a limited degree. They are also more common with increasing age, male sex, and increasing BMI...
  4. doi request reprint Natural history and risk factors for bone loss in postmenopausal Caucasian women: a 15-year follow-up population-based study
    G Zhai
    Twin Research and Genetic Epidemiology Unit, King s College London School of Medicine, St Thomas Hospital Campus, Lambeth Palace Road, London SE1 7EH, UK
    Osteoporos Int 19:1211-7. 2008
    ..67% per year, but quadratic for lumbar spine (LS) at a rate of 3.12% initially, and slowing down with age. We also confirmed the protective role of HRT, increasing weight, and lean mass in long-term bone loss...
  5. ncbi request reprint Genetic influence on the progression of radiographic knee osteoarthritis: a longitudinal twin study
    G Zhai
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Osteoarthritis Cartilage 15:222-5. 2007
    ..Genetic influences on rates of osteoarthritis (OA) progression are unknown. Our aim was to estimate the heritability of progression of radiographic knee OA using a longitudinal twin study...
  6. pmc Reduction of leucocyte telomere length in radiographic hand osteoarthritis: a population-based study
    G Zhai
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Ann Rheum Dis 65:1444-8. 2006
    ..Although age is the strongest predictor of osteoarthritis, the exact mechanism underlying this disorder remains elusive...
  7. doi request reprint Genetic and environmental determinants on bone loss in postmenopausal Caucasian women: a 14-year longitudinal twin study
    G Zhai
    Twin Research and Genetic Epidemiology Unit, King s College London School of Medicine, St Thomas Hospital Campus, Westminster Bridge Road, London SE1 7EH, UK
    Osteoporos Int 20:949-53. 2009
    ....
  8. pmc A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium
    G Zhai
    Department of Twin Research and Genetic Epidemiology, King s College London, UK
    J Med Genet 46:614-6. 2009
    ..01), suggesting the potential mechanism of the gene in hand OA might be via effects on subchondral bone. The authors' findings provide a potential new insight into genetic mechanisms in the development of hand OA...
  9. doi request reprint Serum branched-chain amino acid to histidine ratio: a novel metabolomic biomarker of knee osteoarthritis
    Guangju Zhai
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, Westminster Bridge Road, London SE1 7EH, UK
    Ann Rheum Dis 69:1227-31. 2010
    ..There is a pressing need to develop reliable molecular biomarkers in osteoarthritis. The aim of the study was to identify novel serum biomarkers for osteoarthritis using a metabolomics approach...
  10. ncbi request reprint The interaction of genes and smoking on forced expiratory volume: a classic twin study
    Guangju Zhai
    Twin Research and Genetic Epidemiology Unit, King s College London School of Medicine, St Thomas Hospital Campus, Lambeth Palace Rd, London SE1 7EH, UK
    Chest 132:1772-7. 2007
    ..The aims of this study were to estimate heritability of the ratio of measured FEV1 (mFEV1) to expected FEV(1) (eFEV1) in a white population, and to examine the interaction between genetic factors and smoking on this ratio...
  11. pmc A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length
    M Mangino
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
    J Med Genet 46:451-4. 2009
    ..Telomere length is a predictor for a number of common age related diseases and is a heritable trait...
  12. ncbi request reprint Association between KLOTHO gene and hand osteoarthritis in a female Caucasian population
    F Zhang
    Twin Research and Genetic Epidemiology Unit, King s College London, St Thomas Hospital Campus, London, UK
    Osteoarthritis Cartilage 15:624-9. 2007
    ..In this study, we investigated the association between four putatively functional genetic variants in KLOTHO gene, a strong ageing-related gene, and hand OA in a large female Caucasian population...
  13. pmc Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study
    J B Richards
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
    Lancet 371:1505-12. 2008
    ..Osteoporosis is diagnosed by the measurement of bone mineral density, which is a highly heritable and multifactorial trait. We aimed to identify genetic loci that are associated with bone mineral density...
  14. doi request reprint Association between leptin, body composition, sex and knee cartilage morphology in older adults: the Tasmanian older adult cohort (TASOAC) study
    C Ding
    Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7000, Australia
    Ann Rheum Dis 67:1256-61. 2008
    ..To describe the associations between leptin, body composition, sex and knee cartilage volume/defects in older adults...
  15. ncbi request reprint A longitudinal study of the association between knee alignment and change in cartilage volume and chondral defects in a largely non-osteoarthritic population
    Guangju Zhai
    Menzies Research Institute, University of Tasmania, Hobart, Australia
    J Rheumatol 34:181-6. 2007
    ..We investigated whether baseline malalignment of the knee predicts subsequent change in knee cartilage volume and chondral defects in subjects with and without radiographic knee osteoarthritis (OA)...
  16. pmc Genomewide linkage scan of hand osteoarthritis in female twin pairs showing replication of quantitative trait loci on chromosomes 2 and 19
    Gregory Livshits
    Tel Aviv University, Tel Aviv, Israel
    Ann Rheum Dis 66:623-7. 2007
    ..The purpose of this study was to conduct a whole-genome linkage scan to identify susceptibility loci for idiopathic hand OA in a large, population-based sample of females...
  17. pmc Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis
    Ana M Valdes
    Twin Research Unit, St Thomas Hospital Campus, Kings College London School of Medicine, London SE1 7EH, UK
    Am J Hum Genet 82:1231-40. 2008
    ..Our results and previous studies on the role of the cyclooxygenase 2 enzyme encoded by PTGS2 underscore the importance of this signaling pathway in the pathogenesis of knee OA...
  18. ncbi request reprint The genetic contribution to longitudinal changes in knee structure and muscle strength: a sibpair study
    Guangju Zhai
    Menzies Research Institute, University of Tasmania, Tasmania, Australia
    Arthritis Rheum 52:2830-4. 2005
    ..To estimate the heritability of longitudinal changes in knee cartilage volume, chondral defects, subchondral bone size, and lower limb muscle strength...
  19. pmc Optimal sampling of MRI slices for the assessment of knee cartilage volume for cross-sectional and longitudinal studies
    Guangju Zhai
    Menzies Research Institute, University of Tasmania, Hobart, Australia
    BMC Musculoskelet Disord 6:10. 2005
    ..The aim of this study was to determine the optimal sampling of 1.5 mm thick slices of MRI scans to estimate knee cartilage volume in males and females for cross-sectional and longitudinal studies...
  20. ncbi request reprint A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis
    Velandai K Srikanth
    The Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7001, Australia
    Osteoarthritis Cartilage 13:769-81. 2005
    ..To resolve uncertainty regarding sex differences in osteoarthritis (OA) by performing a meta-analysis of sex differences in OA prevalence, incidence and severity...
  21. ncbi request reprint Correlates of knee pain in younger subjects
    Guangju Zhai
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania, 7001, Australia
    Clin Rheumatol 26:75-80. 2007
    ..MRI and biochemical measures can add to radiographs in defining unexplained knee pain in younger subjects...
  22. ncbi request reprint Correlates of knee pain in older adults: Tasmanian Older Adult Cohort Study
    Guangju Zhai
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania 7001, Australia
    Arthritis Rheum 55:264-71. 2006
    ..To describe the association between chondral defects, bone marrow lesions, knee and hip radiographic osteoarthritis (OA), and knee pain...
  23. ncbi request reprint The genetic contribution to muscle strength, knee pain, cartilage volume, bone size, and radiographic osteoarthritis: a sibpair study
    Guangju Zhai
    University of Tasmania, Hobart, Tasmania, Australia
    Arthritis Rheum 50:805-10. 2004
    ..To estimate the heritability of muscle strength, knee pain, cartilage volume, bone size, and radiographic osteoarthritis (ROA), and to assess whether heritability of the knee structural components is independent of ROA...