Research Topics
Genomes and GenesSpecies | G ZhaiSummaryAffiliation: King's College London Country: UK Publications
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Detail Information
Publications
Natural history and clinical significance of MRI-detected bone marrow lesions at the knee: a prospective study in community dwelling older adultsDawn Dore
Menzies Research Institute Tasmania, University of Tasmania, Private Bag 23, Hobart, 7000, Australia
Arthritis Res Ther 12:R223. 2010....- Bone marrow lesions predict site-specific cartilage defect development and volume loss: a prospective study in older adultsDawn Dore
Menzies Research Institute Tasmania, University of Tasmania, Private Bag 23, Hobart, 7000, Australia
Arthritis Res Ther 12:R222. 2010.... - Familial, structural, and environmental correlates of MRI-defined bone marrow lesions: a sibpair studyGuangju Zhai
Menzies Research Institute, University of Tasmania, Level 2, Surrey House, 199 Macquarie Street, Hobart, TAS 7000, Australia
Arthritis Res Ther 8:R137. 2006..They commonly coexist with chondral defects and ROA but only share common genetic mechanisms to a limited degree. They are also more common with increasing age, male sex, and increasing BMI... 
Natural history and risk factors for bone loss in postmenopausal Caucasian women: a 15-year follow-up population-based studyG Zhai
Twin Research and Genetic Epidemiology Unit, King s College London School of Medicine, St Thomas Hospital Campus, Lambeth Palace Road, London SE1 7EH, UK
Osteoporos Int 19:1211-7. 2008..67% per year, but quadratic for lumbar spine (LS) at a rate of 3.12% initially, and slowing down with age. We also confirmed the protective role of HRT, increasing weight, and lean mass in long-term bone loss...
Genetic influence on the progression of radiographic knee osteoarthritis: a longitudinal twin studyG Zhai
Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
Osteoarthritis Cartilage 15:222-5. 2007..Genetic influences on rates of osteoarthritis (OA) progression are unknown. Our aim was to estimate the heritability of progression of radiographic knee OA using a longitudinal twin study...- Reduction of leucocyte telomere length in radiographic hand osteoarthritis: a population-based studyG Zhai
Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
Ann Rheum Dis 65:1444-8. 2006..Although age is the strongest predictor of osteoarthritis, the exact mechanism underlying this disorder remains elusive... - Genetic and environmental determinants on bone loss in postmenopausal Caucasian women: a 14-year longitudinal twin studyG Zhai
Twin Research and Genetic Epidemiology Unit, King s College London School of Medicine, St Thomas Hospital Campus, Westminster Bridge Road, London SE1 7EH, UK
Osteoporos Int 20:949-53. 2009.... - A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortiumG Zhai
Department of Twin Research and Genetic Epidemiology, King s College London, UK
J Med Genet 46:614-6. 2009..01), suggesting the potential mechanism of the gene in hand OA might be via effects on subchondral bone. The authors' findings provide a potential new insight into genetic mechanisms in the development of hand OA... - Serum branched-chain amino acid to histidine ratio: a novel metabolomic biomarker of knee osteoarthritisGuangju Zhai
Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, Westminster Bridge Road, London SE1 7EH, UK
Ann Rheum Dis 69:1227-31. 2010..There is a pressing need to develop reliable molecular biomarkers in osteoarthritis. The aim of the study was to identify novel serum biomarkers for osteoarthritis using a metabolomics approach... - The interaction of genes and smoking on forced expiratory volume: a classic twin studyGuangju Zhai
Twin Research and Genetic Epidemiology Unit, King s College London School of Medicine, St Thomas Hospital Campus, Lambeth Palace Rd, London SE1 7EH, UK
Chest 132:1772-7. 2007..The aims of this study were to estimate heritability of the ratio of measured FEV1 (mFEV1) to expected FEV(1) (eFEV1) in a white population, and to examine the interaction between genetic factors and smoking on this ratio... - A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere lengthM Mangino
Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
J Med Genet 46:451-4. 2009..Telomere length is a predictor for a number of common age related diseases and is a heritable trait... - Association between KLOTHO gene and hand osteoarthritis in a female Caucasian populationF Zhang
Twin Research and Genetic Epidemiology Unit, King s College London, St Thomas Hospital Campus, London, UK
Osteoarthritis Cartilage 15:624-9. 2007..In this study, we investigated the association between four putatively functional genetic variants in KLOTHO gene, a strong ageing-related gene, and hand OA in a large female Caucasian population... - Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association studyJ B Richards
Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
Lancet 371:1505-12. 2008..Osteoporosis is diagnosed by the measurement of bone mineral density, which is a highly heritable and multifactorial trait. We aimed to identify genetic loci that are associated with bone mineral density... - A longitudinal study of the association between knee alignment and change in cartilage volume and chondral defects in a largely non-osteoarthritic populationGuangju Zhai
Menzies Research Institute, University of Tasmania, Hobart, Australia
J Rheumatol 34:181-6. 2007..We investigated whether baseline malalignment of the knee predicts subsequent change in knee cartilage volume and chondral defects in subjects with and without radiographic knee osteoarthritis (OA)... - Genomewide linkage scan of hand osteoarthritis in female twin pairs showing replication of quantitative trait loci on chromosomes 2 and 19Gregory Livshits
Tel Aviv University, Tel Aviv, Israel
Ann Rheum Dis 66:623-7. 2007..The purpose of this study was to conduct a whole-genome linkage scan to identify susceptibility loci for idiopathic hand OA in a large, population-based sample of females... - Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritisAna M Valdes
Twin Research Unit, St Thomas Hospital Campus, Kings College London School of Medicine, London SE1 7EH, UK
Am J Hum Genet 82:1231-40. 2008..Our results and previous studies on the role of the cyclooxygenase 2 enzyme encoded by PTGS2 underscore the importance of this signaling pathway in the pathogenesis of knee OA... - The genetic contribution to longitudinal changes in knee structure and muscle strength: a sibpair studyGuangju Zhai
Menzies Research Institute, University of Tasmania, Tasmania, Australia
Arthritis Rheum 52:2830-4. 2005.... - Optimal sampling of MRI slices for the assessment of knee cartilage volume for cross-sectional and longitudinal studiesGuangju Zhai
Menzies Research Institute, University of Tasmania, Hobart, Australia
BMC Musculoskelet Disord 6:10. 2005..The aim of this study was to determine the optimal sampling of 1.5 mm thick slices of MRI scans to estimate knee cartilage volume in males and females for cross-sectional and longitudinal studies... - A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritisVelandai K Srikanth
The Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7001, Australia
Osteoarthritis Cartilage 13:769-81. 2005..To resolve uncertainty regarding sex differences in osteoarthritis (OA) by performing a meta-analysis of sex differences in OA prevalence, incidence and severity... - Correlates of knee pain in younger subjectsGuangju Zhai
Menzies Research Institute, University of Tasmania, Hobart, Tasmania, 7001, Australia
Clin Rheumatol 26:75-80. 2007..MRI and biochemical measures can add to radiographs in defining unexplained knee pain in younger subjects... - Correlates of knee pain in older adults: Tasmanian Older Adult Cohort StudyGuangju Zhai
Menzies Research Institute, University of Tasmania, Hobart, Tasmania 7001, Australia
Arthritis Rheum 55:264-71. 2006..The association between radiographic hip OA and knee pain indicates that referred pain from the hip needs to be considered in unexplained knee pain... - The genetic contribution to muscle strength, knee pain, cartilage volume, bone size, and radiographic osteoarthritis: a sibpair studyGuangju Zhai
University of Tasmania, Hobart, Tasmania, Australia
Arthritis Rheum 50:805-10. 2004..Cartilage volume, bone size, and muscle strength all have the potential to be studied in quantitative trait linkage analyses, but their exact relevance with regard to OA remains uncertain at this time...