Affiliation: King's College London
Zeng L, Li Y, Yang J, Wang G, Margariti A, Xiao Q, et al
. XBP 1-Deficiency Abrogates Neointimal Lesion of Injured Vessels Via Cross Talk With the PDGF Signaling. Arterioscler Thromb Vasc Biol. 2015;35:2134-44 pubmed publisher
..This study demonstrates for the first time that XBP1 is crucial for SMC proliferation via modulating the platelet-derived growth factor/TGF-Î² pathways, leading to neointimal formation. ..
Zhang Y, Zhu D, Wei Y, Wu Y, Cui W, Liuqin L, et al
. A collagen hydrogel loaded with HDAC7-derived peptide promotes the regeneration of infarcted myocardium with functional improvement in a rodent model. Acta Biomater. 2019;: pubmed publisher
..Overall, these results highlighted the positive impact of implanting 7Ap-collagen as a novel constituent for MI repair. ..
Xu J, Yang J, Nyga A, Ehteramyan M, Moraga A, Wu Y, et al
. Cobalt (II) ions and nanoparticles induce macrophage retention by ROS-mediated down-regulation of RhoA expression. Acta Biomater. 2018;72:434-446 pubmed publisher
Yang J, Xu J, Danniel M, Wang X, Wang W, Zeng L, et al
. The interaction between XBP1 and eNOS contributes to endothelial cell migration. Exp Cell Res. 2018;363:262-270 pubmed publisher
..These results suggest that XBP1 splicing can regulate eNOS expression and cellular location, leading to EC migration and therefore contributing to wound healing and angiogenesis. ..
Zeng L, Xiao Q, Chen M, Margariti A, Martin D, Ivetic A, et al
. Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis. Circulation. 2013;127:1712-22 pubmed publisher
..These results suggest that XBP1 can function via growth factor signaling pathways to regulate endothelial proliferation and angiogenesis. ..
Martin D, Li Y, Yang J, Wang G, Margariti A, Jiang Z, et al
. Unspliced X-box-binding protein 1 (XBP1) protects endothelial cells from oxidative stress through interaction with histone deacetylase 3. J Biol Chem. 2014;289:30625-34 pubmed publisher
..Thus, we demonstrate that XBP1u and HDAC3 exert a protective effect on disturbed flow-induced oxidative stress via up-regulation of mTORC2-dependent Akt1 phosphorylation and Nrf2-mediated HO-1 expression. ..
Yang J, Margariti A, Zeng L. Analysis of Histone Deacetylase 7 (HDAC7) Alternative Splicing and Its Role in Embryonic Stem Cell Differentiation Toward Smooth Muscle Lineage. Methods Mol Biol. 2016;1436:95-108 pubmed publisher
..In this chapter, we describe a strategy to detect HDAC7 alternative splicing and analyze its function on ES cell differentiation. ..