Sun Ying

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint TH1/TH2 cytokines and inflammatory cells in skin biopsy specimens from patients with chronic idiopathic urticaria: comparison with the allergen-induced late-phase cutaneous reaction
    Sun Ying
    Department of Allergy and Clinical Immunology, Faculty of Medicine, Imperial College, National Heart and Lung Institute, London, UK
    J Allergy Clin Immunol 109:694-700. 2002
  2. pmc Airway epithelium in atopic and nonatopic asthma: similarities and differences
    Prathap Pillai
    MRC and Asthma UK Centre for Allergic Mechanisms of Asthma, The Department of Asthma, Allergy and Respiratory Science, Tower Wing, Guy s Hospital, King s College London, London SE1 9RT, UK
    ISRN Allergy 2011:195846. 2011
  3. ncbi request reprint Identifying and testing potential new anti-asthma agents
    Cailong Fang
    Guy s Hospital, King s College London, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Department of Asthma, Allergy and Respiratory Science, 5th Floor, Tower Wing, London SE1 9RT, UK 44 207 188 3392
    Expert Opin Drug Discov 6:1027-44. 2011
  4. doi request reprint Resistin-like molecule-β is a human airway remodelling mediator
    C Fang
    Dept of Asthma, Allergy and Respiratory Science 5th Floor Tower Wing Guy s Hospital, King s College London, London SE1 9RT, UK
    Eur Respir J 39:458-66. 2012
  5. ncbi request reprint Expression and cellular provenance of thymic stromal lymphopoietin and chemokines in patients with severe asthma and chronic obstructive pulmonary disease
    Sun Ying
    King s College London, Division of Asthma, Allergy and Lung Biology, Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom
    J Immunol 181:2790-8. 2008
  6. ncbi request reprint How much do we know about atopic asthma: where are we now?
    Sun Ying
    King s College London, Division of Asthma, Allergy and Lung Biology, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK
    Cell Mol Immunol 3:321-32. 2006
  7. ncbi request reprint Aspirin-sensitive rhinosinusitis is associated with reduced E-prostanoid 2 receptor expression on nasal mucosal inflammatory cells
    Sun Ying
    King s College London, MRC and Asthma UK Centre, Department of Asthma, Allergy and Respiratory Science, UK
    J Allergy Clin Immunol 117:312-8. 2006
  8. ncbi request reprint Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity
    Sun Ying
    Department of Asthma, Allergy and Respiratory Science, Guy s, King s and St Thomas GKT School of Medicine, London, United Kingdom
    J Immunol 174:8183-90. 2005
  9. ncbi request reprint Expression of prostaglandin E(2) receptor subtypes on cells in sputum from patients with asthma and controls: effect of allergen inhalational challenge
    Sun Ying
    Department of Asthma, Allergy and Respiratory Science, Guy s King s and St Thomas School of Medicine, London, UK
    J Allergy Clin Immunol 114:1309-16. 2004
  10. doi request reprint Allergen-induced expression of IL-25 and IL-25 receptor in atopic asthmatic airways and late-phase cutaneous responses
    Chris J Corrigan
    King s College London, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, London, United Kingdom
    J Allergy Clin Immunol 128:116-24. 2011

Collaborators

Detail Information

Publications25

  1. ncbi request reprint TH1/TH2 cytokines and inflammatory cells in skin biopsy specimens from patients with chronic idiopathic urticaria: comparison with the allergen-induced late-phase cutaneous reaction
    Sun Ying
    Department of Allergy and Clinical Immunology, Faculty of Medicine, Imperial College, National Heart and Lung Institute, London, UK
    J Allergy Clin Immunol 109:694-700. 2002
    ....
  2. pmc Airway epithelium in atopic and nonatopic asthma: similarities and differences
    Prathap Pillai
    MRC and Asthma UK Centre for Allergic Mechanisms of Asthma, The Department of Asthma, Allergy and Respiratory Science, Tower Wing, Guy s Hospital, King s College London, London SE1 9RT, UK
    ISRN Allergy 2011:195846. 2011
    ..Similarities outnumber the differences, until we unravel the mystery surrounding these two important phenotypes of asthma in more detail...
  3. ncbi request reprint Identifying and testing potential new anti-asthma agents
    Cailong Fang
    Guy s Hospital, King s College London, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Department of Asthma, Allergy and Respiratory Science, 5th Floor, Tower Wing, London SE1 9RT, UK 44 207 188 3392
    Expert Opin Drug Discov 6:1027-44. 2011
    ..Further studies are required to clarify the relationship between airways remodeling and asthma severity so that appropriate patients may be targeted...
  4. doi request reprint Resistin-like molecule-β is a human airway remodelling mediator
    C Fang
    Dept of Asthma, Allergy and Respiratory Science 5th Floor Tower Wing Guy s Hospital, King s College London, London SE1 9RT, UK
    Eur Respir J 39:458-66. 2012
    ....
  5. ncbi request reprint Expression and cellular provenance of thymic stromal lymphopoietin and chemokines in patients with severe asthma and chronic obstructive pulmonary disease
    Sun Ying
    King s College London, Division of Asthma, Allergy and Lung Biology, Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom
    J Immunol 181:2790-8. 2008
    ..Increased expression of these chemokines is not, however, associated with selective accumulation of T cells bearing their receptors...
  6. ncbi request reprint How much do we know about atopic asthma: where are we now?
    Sun Ying
    King s College London, Division of Asthma, Allergy and Lung Biology, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK
    Cell Mol Immunol 3:321-32. 2006
    ....
  7. ncbi request reprint Aspirin-sensitive rhinosinusitis is associated with reduced E-prostanoid 2 receptor expression on nasal mucosal inflammatory cells
    Sun Ying
    King s College London, MRC and Asthma UK Centre, Department of Asthma, Allergy and Respiratory Science, UK
    J Allergy Clin Immunol 117:312-8. 2006
    ..PGE(2) acts via G-protein-coupled receptors, E-prostanoid (EP)(1-4,) but there is little information on the expression of PGE(2) receptors in this condition...
  8. ncbi request reprint Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity
    Sun Ying
    Department of Asthma, Allergy and Respiratory Science, Guy s, King s and St Thomas GKT School of Medicine, London, United Kingdom
    J Immunol 174:8183-90. 2005
    ..Our data implicate TSLP, TARC/CCL17, MDC/CCL22, and IP-10/CXCL10 in asthma pathogenesis. These may act partly through selective development and retention, or recruitment of Th2 cells bearing their receptors...
  9. ncbi request reprint Expression of prostaglandin E(2) receptor subtypes on cells in sputum from patients with asthma and controls: effect of allergen inhalational challenge
    Sun Ying
    Department of Asthma, Allergy and Respiratory Science, Guy s King s and St Thomas School of Medicine, London, UK
    J Allergy Clin Immunol 114:1309-16. 2004
    ..Prostaglandin (PG) E 2 binds to 4 G-protein-coupled receptors designated EP 1 through EP 4 . Although PGE 2 plays an immunomodulatory role in asthma, there is little information on the expression of PGE 2 receptors in this disease...
  10. doi request reprint Allergen-induced expression of IL-25 and IL-25 receptor in atopic asthmatic airways and late-phase cutaneous responses
    Chris J Corrigan
    King s College London, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, London, United Kingdom
    J Allergy Clin Immunol 128:116-24. 2011
    ..IL-25 is thought to participate in allergic inflammation by propagating T(h)2-type responses...
  11. ncbi request reprint Expression of the cysteinyl leukotriene receptors cysLT(1) and cysLT(2) in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis
    Chris Corrigan
    Department of Asthma, Allergy and Respiratory Science, Guy s Hospital, London, UK
    J Allergy Clin Immunol 115:316-22. 2005
    ..We previously compared expression of cysLT 1 on mucosal leukocytes in patients with aspirin-sensitive and aspirin-tolerant rhinosinusitis...
  12. doi request reprint Reduced expression of the prostaglandin E2 receptor E-prostanoid 2 on bronchial mucosal leukocytes in patients with aspirin-sensitive asthma
    Chris J Corrigan
    Division of Asthma, Allergy and Lung Biology, King s College London, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom
    J Allergy Clin Immunol 129:1636-46. 2012
    ..Prostaglandin E(2) (PGE(2)) is thought to play a role in the pathogenesis of aspirin-sensitive asthma (ASA)...
  13. ncbi request reprint Anti-IgE (omalizumab) inhibits late-phase reactions and inflammatory cells after repeat skin allergen challenge
    Yee Ean Ong
    Department of Allergy and Clinical Immunology, Imperial College London, National Heart and Lung Institute, South Kensington, London, UK
    J Allergy Clin Immunol 116:558-64. 2005
    ..The effect of chronic allergen exposure on these outcomes is unknown. Repeat allergen challenge in human skin represents a suitable model to address this question...
  14. ncbi request reprint Systemic glucocorticoid reduces bronchial mucosal activation of activator protein 1 components in glucocorticoid-sensitive but not glucocorticoid-resistant asthmatic patients
    Tuck Kay Loke
    King s College London, MRC, London SE1 9RT
    J Allergy Clin Immunol 118:368-75. 2006
    ..Overexpression of the transcriptional regulatory factor activator protein 1 might contribute to T-cell glucocorticoid (GC) refractoriness in GC-resistant asthma...
  15. pmc Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics
    Patrick Flood-Page
    Department of Allergy and Clinical Immunology, Imperial College London, National Heart and Lung Institute, London, United Kingdom
    J Clin Invest 112:1029-36. 2003
    ..Therefore eosinophils may contribute to tissue remodeling processes in asthma by regulating the deposition of ECM proteins...
  16. pmc T-helper cell type 2 (Th2) memory T cell-potentiating cytokine IL-25 has the potential to promote angiogenesis in asthma
    Chris J Corrigan
    Division of Asthma, Allergy and Lung Biology, King s College London, Medical Research Council, and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 9RT, United Kingdom
    Proc Natl Acad Sci U S A 108:1579-84. 2011
    ..Our findings suggest that IL-25 is elevated in asthma and contributes to angiogenesis, at least partly by increasing endothelial cell VEGF/VEGF receptor expression through PI3K/Akt and Erk/MAPK pathways...
  17. doi request reprint The role of thymic stromal lymphopoietin in allergic inflammation and chronic obstructive pulmonary disease
    Cailong Fang
    Division of Asthma, Allergy and Lung Biology, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, London, UK
    Arch Immunol Ther Exp (Warsz) 58:81-90. 2010
    ..In this review we will discuss TSLP expression, function, and available and potential mechanisms in both allergic inflammation and COPD...
  18. doi request reprint Activin and transforming growth factor-beta signaling pathways are activated after allergen challenge in mild asthma
    Harsha H Kariyawasam
    Allergy and Clinical Immunology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom
    J Allergy Clin Immunol 124:454-62. 2009
    ..Both transforming growth factor (TGF)-beta(1) and activin-A have been implicated in airway remodeling in asthma, but the modulation of their specific signaling pathways after disease activation remains undefined...
  19. ncbi request reprint Eotaxin (CCL11) and eotaxin-2 (CCL24) induce recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions following cutaneous injection in human atopic and nonatopic volunteers
    Andrew Menzies-Gow
    Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College, London, United Kingdom
    J Immunol 169:2712-8. 2002
    ..Thus, intradermal injection of eotaxin and eotaxin-2 in humans induced infiltration of eosinophils and other inflammatory cells as well as changes consistent with CC chemokine-induced mast cell degranulation...
  20. ncbi request reprint The relationship between allergen-induced tissue eosinophilia and markers of repair and remodeling in human atopic skin
    Simon Phipps
    Department of Allergy and Clinical Immunology, Faculty of Medicine, Imperial College, National Heart and Lung Institute, Dovehouse Street, London, UK, SW3 6LY
    J Immunol 169:4604-12. 2002
    ..TGF-beta1 and IL-13 also induced tenascin expression. We conclude that TGF-beta1 and IL-13, provided partially by eosinophils, contribute to repair and remodeling events in allergic inflammation in human atopic skin...
  21. pmc Diminished sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) expression contributes to airway remodelling in bronchial asthma
    Katharina Mahn
    Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, London SE1 9RT, United Kingdom
    Proc Natl Acad Sci U S A 106:10775-80. 2009
    ..Our findings implicate a deficiency in SERCA2 in ASM in asthma that contributes to its secretory and hyperproliferative phenotype in asthma, and which may play a key role in mechanisms of airway remodeling...
  22. ncbi request reprint The treatment targets of asthma: from laboratory to clinic
    Cailong Fang
    MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Department of Asthma, Allergy and Respiratory Science, King s College London, London, UK
    Inflamm Allergy Drug Targets 7:119-28. 2008
    ..In this review we will discuss current drugs and potential targets in the treatment of asthma...
  23. pmc IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells
    Yui Hsi Wang
    Department of Immunology and Center of Cancer Immunology Research, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Med 204:1837-47. 2007
    ..Our results provide a plausible explanation that IL-25 produced by innate effector eosinophils and basophils may augment the allergic inflammation by enhancing the maintenance and functions of adaptive Th2 memory cells...
  24. pmc Allergen-induced fluctuation in CC chemokine receptor 3 expression on bone marrow CD34+ cells from asthmatic subjects: significance for mobilization of haemopoietic progenitor cells in allergic inflammation
    Roma Sehmi
    Firestone Institute of Respiratory Health, Asthma Research Group, St Joseph s Healthcare, Divisions of Clinical Immunology, McMaster University, Hamilton, Ontario, Canada
    Immunology 109:536-46. 2003
    ....
  25. ncbi request reprint Lack of filaggrin expression in the human bronchial mucosa
    Sun Ying
    J Allergy Clin Immunol 118:1386-8. 2006