Til Wykes

Summary

Affiliation: King's College London
Country: UK

Publications

  1. doi request reprint A meta-analysis of cognitive remediation for schizophrenia: methodology and effect sizes
    Til Wykes
    Institute of Psychiatry, King s College London, UK
    Am J Psychiatry 168:472-85. 2011
  2. pmc Integrating mobile-phone based assessment for psychosis into people's everyday lives and clinical care: a qualitative study
    Jasper E Palmier-Claus
    Division of Clinical Psychology, School of Psychological Sciences, The University of Manchester, Oxford Road, Manchester, United Kingdom
    BMC Psychiatry 13:34. 2013
  3. pmc Effectiveness and cost-effectiveness of body psychotherapy in the treatment of negative symptoms of schizophrenia--a multi-centre randomised controlled trial
    Stefan Priebe
    Unit for Social and Community Psychiatry, Queen Mary University of London, Newham Centre for Mental Health, London E13 8SP, UK
    BMC Psychiatry 13:26. 2013
  4. pmc The feasibility and validity of ambulatory self-report of psychotic symptoms using a smartphone software application
    Jasper E Palmier-Claus
    School of Community Based Medicine, University of Manchester, Oxford Road, Manchester, UK
    BMC Psychiatry 12:172. 2012
  5. pmc Understanding service user-defined continuity of care and its relationship to health and social measures: a cross-sectional study
    Angela Sweeney
    Mental Health Sciences Unit, University College London, London, UK
    BMC Health Serv Res 12:145. 2012
  6. pmc Working alliance and its relationship to outcomes in a randomized controlled trial (RCT) of antipsychotic medication
    Til Wykes
    NIHR MHRN and Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    BMC Psychiatry 13:28. 2013
  7. pmc Developing models of how cognitive improvements change functioning: mediation, moderation and moderated mediation
    Til Wykes
    King s College London, Institute of Psychiatry, London SE5 8AF, UK
    Schizophr Res 138:88-93. 2012
  8. pmc A multi-centre, randomised controlled trial of cognitive therapy to prevent harmful compliance with command hallucinations
    Max Birchwood
    School of Psychology, University of Birmingham, Edgbaston, B15 2TT, Birmingham, UK
    BMC Psychiatry 11:155. 2011
  9. doi request reprint Does age matter? Effects of cognitive rehabilitation across the age span
    Til Wykes
    King s College, Institute of Psychiatry London, UK
    Schizophr Res 113:252-8. 2009
  10. pmc Thinking about the future cognitive remediation therapy--what works and could we do better?
    Til Wykes
    Institute of Psychiatry, King s College London, London SE5 8AF, UK
    Schizophr Bull 37:S80-90. 2011

Detail Information

Publications45

  1. doi request reprint A meta-analysis of cognitive remediation for schizophrenia: methodology and effect sizes
    Til Wykes
    Institute of Psychiatry, King s College London, UK
    Am J Psychiatry 168:472-85. 2011
    ..The present meta-analysis will determine the effects of treatment and whether study method or potential moderators influence the estimates...
  2. pmc Integrating mobile-phone based assessment for psychosis into people's everyday lives and clinical care: a qualitative study
    Jasper E Palmier-Claus
    Division of Clinical Psychology, School of Psychological Sciences, The University of Manchester, Oxford Road, Manchester, United Kingdom
    BMC Psychiatry 13:34. 2013
    ..Little is currently understood about patients' perceptions of these systems, and how they might be implemented into their everyday routine and clinical care...
  3. pmc Effectiveness and cost-effectiveness of body psychotherapy in the treatment of negative symptoms of schizophrenia--a multi-centre randomised controlled trial
    Stefan Priebe
    Unit for Social and Community Psychiatry, Queen Mary University of London, Newham Centre for Mental Health, London E13 8SP, UK
    BMC Psychiatry 13:26. 2013
    ..We designed a large multi-site trial to assess the effectiveness of a manualised BPT intervention in reducing negative symptoms, compared to an active control...
  4. pmc The feasibility and validity of ambulatory self-report of psychotic symptoms using a smartphone software application
    Jasper E Palmier-Claus
    School of Community Based Medicine, University of Manchester, Oxford Road, Manchester, UK
    BMC Psychiatry 12:172. 2012
    ....
  5. pmc Understanding service user-defined continuity of care and its relationship to health and social measures: a cross-sectional study
    Angela Sweeney
    Mental Health Sciences Unit, University College London, London, UK
    BMC Health Serv Res 12:145. 2012
    ..This paper aims to explore a new construct of service user-defined COC and its relationship to a range of health and social outcomes...
  6. pmc Working alliance and its relationship to outcomes in a randomized controlled trial (RCT) of antipsychotic medication
    Til Wykes
    NIHR MHRN and Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    BMC Psychiatry 13:28. 2013
    ..Long acting injections (LAI) have been associated with perceptions of coercion in cross sectional studies but there have been no longitudinal studies of the effects on clinical relationships with newer depot medications...
  7. pmc Developing models of how cognitive improvements change functioning: mediation, moderation and moderated mediation
    Til Wykes
    King s College London, Institute of Psychiatry, London SE5 8AF, UK
    Schizophr Res 138:88-93. 2012
    ..Cognitive remediation (CRT) affects functioning but the extent and type of cognitive improvements necessary are unknown...
  8. pmc A multi-centre, randomised controlled trial of cognitive therapy to prevent harmful compliance with command hallucinations
    Max Birchwood
    School of Psychology, University of Birmingham, Edgbaston, B15 2TT, Birmingham, UK
    BMC Psychiatry 11:155. 2011
    ..A cognitive therapy grounded in the principles of the Social Rank Theory, is being evaluated in terms of its effectiveness in reducing harmful compliance with command hallucinations...
  9. doi request reprint Does age matter? Effects of cognitive rehabilitation across the age span
    Til Wykes
    King s College, Institute of Psychiatry London, UK
    Schizophr Res 113:252-8. 2009
    ..Cognitive remediation (CR) therapy in its various disguises can be helpful for people with schizophrenia but it is not clear if patient characteristics are likely to interfere with its effectiveness...
  10. pmc Thinking about the future cognitive remediation therapy--what works and could we do better?
    Til Wykes
    Institute of Psychiatry, King s College London, London SE5 8AF, UK
    Schizophr Bull 37:S80-90. 2011
    ....
  11. ncbi request reprint Cognitive remediation therapy (CRT) for young early onset patients with schizophrenia: an exploratory randomized controlled trial
    Til Wykes
    Institute of Psychiatry, Kings College London, De Crespigny Park, London, SE5 8AF, UK
    Schizophr Res 94:221-30. 2007
    ..The objective of this study is to evaluate the efficacy of CRT in alleviating cognitive deficits compared to treatment as usual and explore the mediating and moderating effects of cognitive improvement...
  12. ncbi request reprint Cognitive remediation therapy in schizophrenia: randomised controlled trial
    Til Wykes
    Department of Psychology, Kings College London, Institute of Psychiatry, London, UK
    Br J Psychiatry 190:421-7. 2007
    ..Cognitive difficulties are prevalent in people with a diagnosis of schizophrenia and are associated with poor long-term functioning...
  13. doi request reprint Cognitive remediation therapy in schizophrenia: cost-effectiveness analysis
    Anita Patel
    Centre for the Economics of Mental Health, Health Service and Population Research Department, Box 24, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, United Kingdom
    Schizophr Res 120:217-24. 2010
    ..There is a lack of evidence on the cost-effectiveness of cognitive remediation therapy (CRT)...
  14. pmc VOICE: developing a new measure of service users' perceptions of inpatient care, using a participatory methodology
    Jo Evans
    Health Service and Population Department, Institute of Psychiatry, Kings College London, London, UK
    J Ment Health 21:57-71. 2012
    ..Traditionally, satisfaction with acute care has been assessed using measures designed by clinicians or academics...
  15. ncbi request reprint Effect of a medication management training package for nurses on clinical outcomes for patients with schizophrenia: cluster randomised controlled trial
    Richard Gray
    PO 30, Health Services Research Department, Institute of Psychiatry, De Crespigny Park, London SE5 8AF
    Br J Psychiatry 185:157-62. 2004
    ..Non-compliance attenuates the efficacy of treatments for physical and mental disorders...
  16. ncbi request reprint Are the effects of cognitive remediation therapy (CRT) durable? Results from an exploratory trial in schizophrenia
    Til Wykes
    Department of Psychology, Institute of Psychiatry, De Crespigny Park, SE5 8AF, London, UK
    Schizophr Res 61:163-74. 2003
    ..At the end of treatment, CRT conferred a benefit to people with schizophrenia in cognition and self-esteem [Schizophr. Bull. 25 (1999) 291]. This study investigates these outcomes 6 months after the therapies were withdrawn...
  17. ncbi request reprint Cognitive remediation for schizophrenia: it is even more complicated
    Til Wykes
    Department of Psychology, Institute of Psychiatry, King s College London, London, UK
    Curr Opin Psychiatry 22:161-7. 2009
    ..This review summarizes findings of induced cognitive change in schizophrenia, with reference to the remediation method, the presence of accompanying treatment(s), how cognitive change generalizes and its value...
  18. pmc Schizophrenia patients with cognitive deficits: factors associated with costs
    Anita Patel
    Centre for the Economics of Mental Health, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Schizophr Bull 32:776-85. 2006
    ..Further investigation in larger samples is needed to confirm this finding and to explore its generalizability to those with less severe deficits...
  19. ncbi request reprint Understanding processing speed--its subcomponents and their relationship to characteristics of people with schizophrenia
    Matteo Cella
    a Department of Psychology, Institute of Psychiatry, King s College London, London, UK
    Cogn Neuropsychiatry 18:437-51. 2013
    ..This study explores potential subcomponents of processing speed in schizophrenia and their relationship with demographic, clinical, and neuropsychological characteristics...
  20. doi request reprint Different components of metacognition and their relationship to psychotic-like experiences
    Clare Reeder
    Institute of Psychiatry, King s College London, UK
    Behav Cogn Psychother 38:49-57. 2010
    ..However, studies offering supporting evidence have failed to distinguish between metacognitive beliefs about the consequences of having certain thoughts, and metacognitive beliefs about one's own cognitive skills...
  21. ncbi request reprint Impact of patient involvement in mental health research: longitudinal study
    Liam Ennis
    Liam Ennis, Bsc, Health Services and Population Research Department, Institute of Psychiatry, London Til Wykes, PhD, Psychology Department, Institute of Psychiatry, London, UK
    Br J Psychiatry 203:381-6. 2013
    ..It is deemed good practice to involve patients routinely in research but no study has investigated the practical benefits, particularly to successful recruitment...
  22. pmc Inpatient care 50 years after the process of deinstitutionalisation
    Emese Csipke
    Department of Psychology, Institute of Psychiatry, King s College London, 16 De Crespigny Park, London, SE5 8AF, UK
    Soc Psychiatry Psychiatr Epidemiol 49:665-71. 2014
    ..In particular, it may be that the changing levels of symptoms over the past 50 years may affect engagement with ward activities...
  23. doi request reprint Treating impaired cognition in schizophrenia: the case for combining cognitive-enhancing drugs with cognitive remediation
    Panayiota G Michalopoulou
    Section on Schizophrenia, Imaging and Therapeutics, Department of Psychosis Studies, Institute of Psychiatry, King s College London, UK
    Eur Neuropsychopharmacol 23:790-8. 2013
    ....
  24. ncbi request reprint The self or the voice? Relative contributions of self-esteem and voice appraisal in persistent auditory hallucinations
    Dominic Fannon
    Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, Kings College London, Denmark Hill, London, UK
    Schizophr Res 112:174-80. 2009
    ..It was hypothesized that low self-esteem is prominent in, and contributes to, depression in voice hearers...
  25. ncbi request reprint Effects on the brain of a psychological treatment: cognitive remediation therapy: functional magnetic resonance imaging in schizophrenia
    Til Wykes
    Department of Psychiatry, Institute of Psychiatry, London, UK
    Br J Psychiatry 181:144-52. 2002
    ..The results of one randomised control trial testing a psychological rehabilitation programme aimed at information processing strategies showed improvements in cognition post-treatment...
  26. pmc Can't surf, won't surf: the digital divide in mental health
    Liam Ennis
    Health Services and Population Research Department, Institute of Psychiatry, London, UK
    J Ment Health 21:395-403. 2012
    ..However, there is a danger that those who do not use or have access to technology will not benefit from HIT innovations, thus creating a "digital divide"...
  27. pmc Cognitive predictors of social functioning improvements following cognitive remediation for schizophrenia
    Clare Reeder
    Department of Psychology, Institute of Psychiatry, Kings College, De Crespigny Park, London SE5 8AF, UK
    Schizophr Bull 32:S123-31. 2006
    ..Improvement in the ability to generate new schemas has a beneficial impact on social functioning...
  28. ncbi request reprint Which executive skills should we target to affect social functioning and symptom change? A study of a cognitive remediation therapy program
    Clare Reeder
    Department of Psychology, Institute of Psychiatry, London, UK
    Schizophr Bull 30:87-100. 2004
    ..Regardless of treatment type, increased response inhibition speed was associated with reduced negative symptoms. Stimulus-driven responding and response inhibition speed may therefore make useful targets for intervention...
  29. doi request reprint Close to the bench as well as at the bedside: involving service users in all phases of translational research
    Felicity Callard
    Stakeholder Participation Theme, NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, King s College London, London, UK
    Health Expect 15:389-400. 2012
    ..The paper aims to develop a model of translational research in which service user and other stakeholder involvement are central to each phase...
  30. doi request reprint A model for developing outcome measures from the perspectives of mental health service users
    Diana Rose
    Service User Research Enterprise, Institute of Psychiatry, King s College London, UK
    Int Rev Psychiatry 23:41-6. 2011
    ..The final measure is subject to psychometric testing both to ensure it is robust and to explore similarities and differences with conventionally derived measures...
  31. pmc Cognitive behavior therapy for schizophrenia: effect sizes, clinical models, and methodological rigor
    Til Wykes
    Department of Psychology, Institute of Psychiatry, King s College London, London, UK
    Schizophr Bull 34:523-37. 2008
    ..But recent advances have widened the CBTp targets to other symptoms and have different methods of provision, eg, in groups...
  32. doi request reprint A comparison of participant information elicited by service user and non-service user researchers
    Diana Rose
    Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, United Kingdom
    Psychiatr Serv 62:210-3. 2011
    ..The study examined whether data collected by researchers who were service users differed from data collected by non-service user researchers in a study that measured perceived coercion...
  33. ncbi request reprint What are the effects of group cognitive behaviour therapy for voices? A randomised control trial
    Til Wykes
    Department of Psychology, Institute of Psychiatry, Kings College London, United Kingdom
    Schizophr Res 77:201-10. 2005
    ..This study tested whether a group based on cognitive behavioural principles could produce beneficial effects on hallucinations...
  34. ncbi request reprint Negative symptoms and specific cognitive impairments as combined targets for improved functional outcome within cognitive remediation therapy
    Kathryn E Greenwood
    Department of Psychology, Institute of Psychiatry, London
    Schizophr Bull 31:910-21. 2005
    ..Both cognitive processes and negative symptoms should be targeted in cognitive remediation to effect the greatest change in community functions...
  35. doi request reprint Executive functioning in schizophrenia and the relationship with symptom profile and chronicity
    Kathryn E Greenwood
    Department of Psychology, Institute of Psychiatry, London, United Kingdom
    J Int Neuropsychol Soc 14:782-92. 2008
    ..The executive profile, therefore, is related to symptom type rather than chronicity...
  36. pmc The challenge of change in acute mental health services: measuring staff perceptions of barriers to change and their relationship to job status and satisfaction using a new measure (VOCALISE)
    Caroline Laker
    Department of Psychology, Institute of Psychiatry, King s College, PO77, Room 2, 11, London Henry Wellcome Building, 16 De Crespigny Park, London, SE5 8AF, UK
    Implement Sci 9:23. 2014
    ..As there were no available instruments capturing staff perceptions of barriers to change, we created a new measure (VOCALISE) to assess this construct...
  37. doi request reprint Measuring community functioning in schizophrenia with the Social Behaviour Schedule
    Matteo Cella
    Institute of Psychiatry, King s College London, UK
    Schizophr Res 153:220-4. 2014
    ..This study aims to re-assess the Social Behaviour Schedule (SBS) to fulfil this measurement role...
  38. doi request reprint Effects of age and cognitive reserve on cognitive remediation therapy outcome in patients with schizophrenia
    Dimitris Kontis
    Department of Psychology, King s College London, Institute of Psychiatry London, United Kingdom
    Am J Geriatr Psychiatry 21:218-30. 2013
    ..Older people with a diagnosis of schizophrenia seem to show fewer benefits following cognitive remediation therapy (CRT). It is not clear whether cognitive reserve modifies the relationship with age...
  39. doi request reprint No association between the Catechol-O-Methyltransferase (COMT) val158met polymorphism and cognitive improvement following cognitive remediation therapy (CRT) in schizophrenia
    Kathryn Greenwood
    Institute of Psychiatry, King s College London, UK
    Neurosci Lett 496:65-9. 2011
    ..A complex set of factors may influence cognitive change, however, such that the COMT genotype might still have a subtle effect on response to CRT or similar interventions...
  40. ncbi request reprint It is all in the factors: effects of cognitive remediation on symptom dimensions
    Matteo Cella
    King s College London, Institute of Psychiatry, London, UK
    Schizophr Res 156:60-2. 2014
    ..This limited effect may be because the symptom clusters considered are too broad and heterogeneous. This study explores, for the first time, the effect of CR on five empirically defined symptom dimensions of schizophrenia...
  41. doi request reprint Hearing the voices of service user researchers in collaborative qualitative data analysis: the case for multiple coding
    Angela Sweeney
    Department of Mental Health Sciences, University College London, UK Health Service and Population Research Department, Institute of Psychiatry, King s College, London
    Health Expect 16:e89-99. 2013
    ..This means that a unique and significant perspective on the data is absent...
  42. pmc Taking part in a pharmacogenetic clinical trial: assessment of trial participants understanding of information disclosed during the informed consent process
    Diana Rose
    Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    BMC Med Ethics 14:34. 2013
    ..This study is the first to examine the understandings that participants have of the consent process in a pharmacogenetic trial of anti-depressant medication...
  43. pmc Patients' perspectives on electroconvulsive therapy: systematic review
    Diana Rose
    Service User Research Enterprise, PO34, Institute of Psychiatry, De Crespigny Park, London SE5 8AF
    BMJ 326:1363. 2003
    ..To ascertain patients' views on the benefits of and possible memory loss from electroconvulsive therapy...
  44. pmc Rapid progress or lengthy process? Electronic personal health records in mental health
    Liam Ennis
    Health Services and Population Research Department, Institute of Psychiatry, London SE5 8AF, UK
    BMC Psychiatry 11:117. 2011
    ..Special attention is paid to the concept of 'empowerment' and what this means in relation to ePHRs...
  45. ncbi request reprint The effect of medication management training on community mental health nurse's clinical skills
    Richard Gray
    Health Services Research Department, Institute of Psychiatry, De Crespigny Park, SE5 8AF, London, UK
    Int J Nurs Stud 40:163-9. 2003
    ..Conclusions. In this uncontrolled study training improved the medication management skills of CMHNs...