Alan Wiseman

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint Crohn's disease leading to bowel cancer may be avoided by consumption of soya isoflavones: adjunct-chemotherapy with oxaliplatin
    Alan Wiseman
    School of Biomedical and Molecular Sciences, University of Surrey, Guildford, UK
    Med Hypotheses 66:934-5. 2006
  2. ncbi request reprint The bioavailability of non-nutrient plant factors: dietary flavonoids and phyto-oestrogens
    H Wiseman
    Department of Nutrition and Dietetics, King s College London, UK
    Proc Nutr Soc 58:139-46. 1999
  3. ncbi request reprint Isoflavone phytoestrogens consumed in soy decrease F(2)-isoprostane concentrations and increase resistance of low-density lipoprotein to oxidation in humans
    H Wiseman
    Department of Nutrition and Dietetics, The Nutrition, Food, and Health Research Centre, King s College London, UK
    Am J Clin Nutr 72:395-400. 2000
  4. ncbi request reprint The therapeutic potential of phytoestrogens
    H Wiseman
    Nutrition, Food and Health Research Centre, Department of Nutrition and Dietetics, King s College London, Franklin Wilkins Building, 150 Stamford Street, London SE1 8WA, UK
    Expert Opin Investig Drugs 9:1829-40. 2000
  5. ncbi request reprint New advances in the understanding of the role of steroids and steroid receptors in disease
    H Wiseman
    Department of Nutrition and Dietetics, Nutrition, Food and Health Research Centre King s College London, Franklin Wilkins Building, 150 Stamford Street, London SE1 9NN, U K
    Biochem Soc Trans 29:205-9. 2001
  6. ncbi request reprint Elimination of major side effects due to ROS of therapeuticals through biotransformation control of the 57 cytochromes P450 isoenzymes
    Alan Wiseman
    School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, UK
    Med Hypotheses 64:802-5. 2005
  7. ncbi request reprint Avoidance of oxidative-stress perturbation in yeast bioprocesses by proteomic and genomic biostrategies?
    A Wiseman
    Molecular Toxicology Group, School of Biomedical and Life Sciences, University of Surrey, Guildford, Surrey, UK
    Lett Appl Microbiol 40:37-43. 2005
  8. ncbi request reprint Influence of 10 wk of soy consumption on plasma concentrations and excretion of isoflavonoids and on gut microflora metabolism in healthy adults
    Helen Wiseman
    Nutrition, Food and Health Research Centre, the Department of Nutrition and Dietetics, King s College London, 150 Stamford Street, London SE1 9NN, UK
    Am J Clin Nutr 80:692-9. 2004
  9. ncbi request reprint Oestrogen-receptors (ER) are likely to be promiscuous: wider role for oestrogens and mimics
    Alan Wiseman
    School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, UK
    Med Hypotheses 65:760-5. 2005
  10. ncbi request reprint Limitations of in silico predictability of specificity of co-immobilised cytochromes P450 and mimics in food-bioprocessing
    Alan Wiseman
    Biochemistry Group, School of Biomedical and Life Sciences, University of Surrey, Guildford, GU2 7XH, UK
    Biotechnol Lett 25:515-9. 2003

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Crohn's disease leading to bowel cancer may be avoided by consumption of soya isoflavones: adjunct-chemotherapy with oxaliplatin
    Alan Wiseman
    School of Biomedical and Molecular Sciences, University of Surrey, Guildford, UK
    Med Hypotheses 66:934-5. 2006
    ....
  2. ncbi request reprint The bioavailability of non-nutrient plant factors: dietary flavonoids and phyto-oestrogens
    H Wiseman
    Department of Nutrition and Dietetics, King s College London, UK
    Proc Nutr Soc 58:139-46. 1999
    ..Further studies on the bioavailability of these non-nutrient plant factors and related influencing factors are clearly still required...
  3. ncbi request reprint Isoflavone phytoestrogens consumed in soy decrease F(2)-isoprostane concentrations and increase resistance of low-density lipoprotein to oxidation in humans
    H Wiseman
    Department of Nutrition and Dietetics, The Nutrition, Food, and Health Research Centre, King s College London, UK
    Am J Clin Nutr 72:395-400. 2000
    ....
  4. ncbi request reprint The therapeutic potential of phytoestrogens
    H Wiseman
    Nutrition, Food and Health Research Centre, Department of Nutrition and Dietetics, King s College London, Franklin Wilkins Building, 150 Stamford Street, London SE1 8WA, UK
    Expert Opin Investig Drugs 9:1829-40. 2000
    ..The findings from the current ongoing studies are all likely to contribute to determining the potential use of phytoestrogens as therapeutic agents...
  5. ncbi request reprint New advances in the understanding of the role of steroids and steroid receptors in disease
    H Wiseman
    Department of Nutrition and Dietetics, Nutrition, Food and Health Research Centre King s College London, Franklin Wilkins Building, 150 Stamford Street, London SE1 9NN, U K
    Biochem Soc Trans 29:205-9. 2001
    ..This may arise in part from the suboptimal configuration induced in the transactivation helix of oestrogen receptor-beta...
  6. ncbi request reprint Elimination of major side effects due to ROS of therapeuticals through biotransformation control of the 57 cytochromes P450 isoenzymes
    Alan Wiseman
    School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, UK
    Med Hypotheses 64:802-5. 2005
    ..Furthermore, gene therapy could be arranged to augment (or replace activities lost) for example the production of insulin in the Islets of Langerhans of the pancreas by production of the appropriate form of human insulin in the liver...
  7. ncbi request reprint Avoidance of oxidative-stress perturbation in yeast bioprocesses by proteomic and genomic biostrategies?
    A Wiseman
    Molecular Toxicology Group, School of Biomedical and Life Sciences, University of Surrey, Guildford, Surrey, UK
    Lett Appl Microbiol 40:37-43. 2005
    ....
  8. ncbi request reprint Influence of 10 wk of soy consumption on plasma concentrations and excretion of isoflavonoids and on gut microflora metabolism in healthy adults
    Helen Wiseman
    Nutrition, Food and Health Research Centre, the Department of Nutrition and Dietetics, King s College London, 150 Stamford Street, London SE1 9NN, UK
    Am J Clin Nutr 80:692-9. 2004
    ..Little information is currently available on the role of the gut microflora in modulating isoflavone bioavailability or on sex differences in isoflavone metabolism and bioavailability...
  9. ncbi request reprint Oestrogen-receptors (ER) are likely to be promiscuous: wider role for oestrogens and mimics
    Alan Wiseman
    School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, UK
    Med Hypotheses 65:760-5. 2005
    ....
  10. ncbi request reprint Limitations of in silico predictability of specificity of co-immobilised cytochromes P450 and mimics in food-bioprocessing
    Alan Wiseman
    Biochemistry Group, School of Biomedical and Life Sciences, University of Surrey, Guildford, GU2 7XH, UK
    Biotechnol Lett 25:515-9. 2003
    ....
  11. ncbi request reprint p53 protein or BID protein select the route to either apoptosis (programmed cell death) or to cell cycle arrest opposing carcinogenesis after DNA damage by ROS
    Alan Wiseman
    School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, UK
    Med Hypotheses 67:296-9. 2006
    ..Phosphorylation of the BID protein may lead to the recovery from DNA-damage by ROS...
  12. ncbi request reprint Consumption of flavonoids in onions and black tea: lack of effect on F2-isoprostanes and autoantibodies to oxidized LDL in healthy humans
    A I Mallet
    Nutrition, Food and Health Research Centre, the Department of Nutrition and Dietetics, King's College London, United Kingdom
    Am J Clin Nutr 73:1040-4. 2001
    ..2 nmol/L. CONCLUSION: Flavonoid consumption in onions and tea had no significant effect on plasma F2-isoprostane concentrations and MDA-LDL autoantibody titer in this study and thus does not seem to inhibit lipid peroxidation in humans...
  13. ncbi request reprint Eating soya improves human memory
    S E File
    Psychopharmacology Research Unit, Centre for Neuroscience, Hodgkin Building, King s College London, Guy s Campus, London SE1 1UL, UK
    Psychopharmacology (Berl) 157:430-6. 2001
    ..Soya foods are rich in isoflavone phytoestrogens with weak agonist activity at oestrogen receptors. Oestrogen treatment has been found to improve memory in men awaiting gender reassignment and in post-menopausal women...
  14. ncbi request reprint Oxygen-induced reperfusion-injury is caused by ROS: Amelioration is possible by recombinant-DNA antioxidant enzymes and mimics in selected tissues
    Alan Wiseman
    School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, United Kingdom
    Med Hypotheses 66:329-31. 2006
    ..Some of this is caused by isoforms of cytochromes P450 (CYP; EC 1.14.14.1) such as 3A4, 2D6 and 2C19. These can generate ROS in the liver at low substrate concentrations by futile recycling of oxygen...
  15. ncbi request reprint p53 Protein is activated by Pin1: and also by Cu-SOD prion-like enzyme
    Alan Wiseman
    School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, UK
    Med Hypotheses 65:32-4. 2005
    ..In addition, this p53 tumour suppressor protein is activated by Cu-SOD...
  16. ncbi request reprint Therapeutic-antagonists of oestrogens can be produced for cancer and other therapies using cytochromes P450 (CYP)
    Alan Wiseman
    School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, UK
    Med Hypotheses 65:1088-90. 2005
    ..Cytochromes P450 can play an important part in these developments especially for the production of novel metabolites of oestrogens as therapeutic-antagonists of oestrogen-stimulated cancers...
  17. ncbi request reprint Dietary alkyl thiol free radicals (RSS) can be as toxic as reactive oxygen species (ROS)
    Alan Wiseman
    Molecular Toxicology Group, School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, UK
    Med Hypotheses 63:667-70. 2004
    ..Free radical injury to low density lipoprotein (LDL) has been identified in the causation of atherosclerosis implicated in arterial disease, which can lead to heart attack and strokes...
  18. ncbi request reprint Greener vaccine production with GM yeasts
    Alan Wiseman
    Biochemistry Group, School of Biomedical and Life Sciences, University of Surrey, Guildford GU2 7XH, UK
    Trends Biotechnol 22:3. 2004
  19. ncbi request reprint Replacement of immobilised cell bioreactors by smaller immobilised enzyme bioreactors: unique-outcome predictability for cytochromes P450 isoforms?
    Alan Wiseman
    Biochemistry Group, School of Biomedical and Life Sciences, University of Surrey, Guildford, GU2 7XH, UK
    Biotechnol Lett 25:1581-90. 2003
    ..Here, food-safe bioprocessing has to be achieved without incorporation of recognised biohazards; especially in the form of unacceptable levels of toxic metals that promote a risk-analysis uncertainty...
  20. ncbi request reprint Gene therapy for the circumvention of inborn errors of metabolism (IEM) caused by single-nucleotide-polymorphisms (SNPs)
    Alan Wiseman
    Molecular Toxicology Group, School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, UK
    Med Hypotheses 63:810-2. 2004
    ....
  21. ncbi request reprint Are food and environmental toxicants 'overdetected' by bioassay?
    Alan Wiseman
    Biochemistry Group, School of Biomedical and Life Sciences, University of Surrey, Guildford, UK GU2 7XH
    Trends Biotechnol 20:13-5. 2002
    ..The ability to detect even the tiniest amounts of toxicants may not be necessary. This 'overdetection' could lead to inappropriate courses of action in some situations...
  22. doi request reprint Health benefits of isoflavones in functional foods? Proteomic and metabonomic advances
    M C Y Wong
    King s College London, Nutritional Sciences Division, Franklin Wilkins Building, Stamford Street, London, SE1 9NH, UK
    Inflammopharmacology 16:235-9. 2008
    ..Furthermore, preliminary metabonomic data indicates an alteration in the urinary metabolite profile after isoflavone consumption, which may be of significance...
  23. ncbi request reprint Novel cytochromes P450 applications arising from the directed-evolution of recombinant micro-organisms
    A Wiseman
    Biochemistry Group, School of Biomedical and Life Sciences, University of Surrey, Guildford, UK
    Lett Appl Microbiol 37:264-7. 2003
    ....
  24. ncbi request reprint Gene therapies for diabetes
    Alan Wiseman
    J R Soc Promot Health 123:201-2. 2003
  25. ncbi request reprint Promiscuous-binding of insulin to adipocyte receptors in diabetes mellitus type 2 may be associated with overproduction of cyclic AMP (cAMP)
    Alan Wiseman
    Med Hypotheses 67:194-5. 2006
  26. ncbi request reprint Safe choice of metals in food bioprocess enzyme-mimicry?
    Alan Wiseman
    Trends Biotechnol 21:7-8. 2003
  27. ncbi request reprint Double humanized yeast makes hydrocortisone
    Alan Wiseman
    Trends Biotechnol 22:324-5. 2004