Robert J Williams

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi Flavonoids: antioxidants or signalling molecules?
    Robert J Williams
    Wolfson Centre for Age Related Diseases, GKT School of Biomedical Sciences, King s College London, Guy s Campus, London SE1 9RT, UK
    Free Radic Biol Med 36:838-49. 2004
  2. ncbi Zinc-histidine complex protects cultured cortical neurons against oxidative stress-induced damage
    Robert J Williams
    The Wolfson Centre for Age Related Diseases, GKT School of Biomedical Sciences, Wolfson Wing, Hodgkin Building, Guy s Campus, London SE11UL, UK
    Neurosci Lett 371:106-10. 2004
  3. doi Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation
    Stephanie Rainey-Smith
    King s College London, The Wolfson Centre for Age Related Diseases, Guy s Hospital Campus, London SE1 1UL, UK
    Neurosci Lett 438:29-33. 2008
  4. ncbi Modulation of pro-survival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability
    Jeremy P E Spencer
    Wolfson Centre for Age Related Diseases, Guy s, King s and St Thomas School of Biomedical Sciences, Hodgkin Building, King s College, Guy s Campus, London, SE1 9RT, United Kingdom
    J Biol Chem 278:34783-93. 2003
  5. ncbi Inhibiting Src family tyrosine kinase activity blocks glutamate signalling to ERK1/2 and Akt/PKB but not JNK in cultured striatal neurones
    Andrew J Crossthwaite
    Centre for Neuroscience Research, GKT School of Biomedical Sciences, King s College London, London, UK
    J Neurochem 88:1127-39. 2004
  6. pmc Neuroprotective effects of phenolic antioxidant tBHQ associate with inhibition of FoxO3a nuclear translocation and activity
    Parmvir K Bahia
    Wolfson Centre for Age Related Diseases, King s College London, London, UK
    J Neurochem 123:182-91. 2012
  7. doi Dietary flavonoid (-)epicatechin stimulates phosphatidylinositol 3-kinase-dependent anti-oxidant response element activity and up-regulates glutathione in cortical astrocytes
    Parmvir K Bahia
    The Wolfson Centre for Age Related Diseases, King s College London, London, UK
    J Neurochem 106:2194-204. 2008
  8. doi Tumour necrosis factor alpha induces rapid reduction in AMPA receptor-mediated calcium entry in motor neurones by increasing cell surface expression of the GluR2 subunit: relevance to neurodegeneration
    Stephanie R Rainey-Smith
    Wolfson Centre for Age Related Diseases, King s College London, London, UK
    J Neurochem 113:692-703. 2010
  9. ncbi Activity-dependent phosphorylation of Akt/PKB in adult DRG neurons
    Sophie Pezet
    King s College London, Center for Age Related Diseases, Wolfson Wing, Guy s Campus, London Bridge, London SE1 1UL, UK
    Eur J Neurosci 21:1785-97. 2005
  10. doi Neuroprotective actions of deferiprone in cultured cortical neurones and SHSY-5Y cells
    Francisco Molina-Holgado
    Wolfson Centre for Age Related Diseases, King s College London, London, UK
    J Neurochem 105:2466-76. 2008

Collaborators

Detail Information

Publications30

  1. ncbi Flavonoids: antioxidants or signalling molecules?
    Robert J Williams
    Wolfson Centre for Age Related Diseases, GKT School of Biomedical Sciences, King s College London, Guy s Campus, London SE1 9RT, UK
    Free Radic Biol Med 36:838-49. 2004
    ..antioxidants or modulators of cell signalling, and the influence of their metabolism on these properties are key to the evaluation of these potent biomolecules as anticancer agents, cardioprotectants, and inhibitors of neurodegeneration..
  2. ncbi Zinc-histidine complex protects cultured cortical neurons against oxidative stress-induced damage
    Robert J Williams
    The Wolfson Centre for Age Related Diseases, GKT School of Biomedical Sciences, Wolfson Wing, Hodgkin Building, Guy s Campus, London SE11UL, UK
    Neurosci Lett 371:106-10. 2004
    ....
  3. doi Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation
    Stephanie Rainey-Smith
    King s College London, The Wolfson Centre for Age Related Diseases, Guy s Hospital Campus, London SE1 1UL, UK
    Neurosci Lett 438:29-33. 2008
    ..The effects of hesperetin are cell-type dependent and, unlike the flavanol (-)epicatechin, neuroprotection in vitro is not associated with enhanced CREB phosphorylation or CRE-mediated gene expression...
  4. ncbi Modulation of pro-survival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability
    Jeremy P E Spencer
    Wolfson Centre for Age Related Diseases, Guy s, King s and St Thomas School of Biomedical Sciences, Hodgkin Building, King s College, Guy s Campus, London, SE1 9RT, United Kingdom
    J Biol Chem 278:34783-93. 2003
    ....
  5. ncbi Inhibiting Src family tyrosine kinase activity blocks glutamate signalling to ERK1/2 and Akt/PKB but not JNK in cultured striatal neurones
    Andrew J Crossthwaite
    Centre for Neuroscience Research, GKT School of Biomedical Sciences, King s College London, London, UK
    J Neurochem 88:1127-39. 2004
    ..These results demonstrate that Src family tyrosine kinases and PI3-kinase are pivotal regulators of NMDA receptor signalling to ERK/Akt and JNK in striatal neurones...
  6. pmc Neuroprotective effects of phenolic antioxidant tBHQ associate with inhibition of FoxO3a nuclear translocation and activity
    Parmvir K Bahia
    Wolfson Centre for Age Related Diseases, King s College London, London, UK
    J Neurochem 123:182-91. 2012
    ..Collectively, these data suggest that phenolic antioxidants such as tBHQ oppose stress-induced activation of FoxO3a and therefore have potential neuroprotective utility in neurodegeneration...
  7. doi Dietary flavonoid (-)epicatechin stimulates phosphatidylinositol 3-kinase-dependent anti-oxidant response element activity and up-regulates glutathione in cortical astrocytes
    Parmvir K Bahia
    The Wolfson Centre for Age Related Diseases, King s College London, London, UK
    J Neurochem 106:2194-204. 2008
    ..Together, this suggests that flavonoids may be cytoprotective by increasing anti-oxidant gene expression...
  8. doi Tumour necrosis factor alpha induces rapid reduction in AMPA receptor-mediated calcium entry in motor neurones by increasing cell surface expression of the GluR2 subunit: relevance to neurodegeneration
    Stephanie R Rainey-Smith
    Wolfson Centre for Age Related Diseases, King s College London, London, UK
    J Neurochem 113:692-703. 2010
    ..Our data therefore, suggest that TNFalpha acts primarily as a physiological regulator of synaptic activity in motor neurones rather than a pathological drive in amyotrophic lateral sclerosis...
  9. ncbi Activity-dependent phosphorylation of Akt/PKB in adult DRG neurons
    Sophie Pezet
    King s College London, Center for Age Related Diseases, Wolfson Wing, Guy s Campus, London Bridge, London SE1 1UL, UK
    Eur J Neurosci 21:1785-97. 2005
    ..Our results show that p-Akt Ser 473 is a marker of nociceptor activation and suggest a novel role for Akt in the transduction of intracellular signals in adult DRG neurons...
  10. doi Neuroprotective actions of deferiprone in cultured cortical neurones and SHSY-5Y cells
    Francisco Molina-Holgado
    Wolfson Centre for Age Related Diseases, King s College London, London, UK
    J Neurochem 105:2466-76. 2008
    ....
  11. doi Pro-oxidant diet enhances β/γ secretase-mediated APP processing in APP/PS1 transgenic mice
    Fahd Choudhry
    Wolfson Centre for Age Related Diseases, King s College London, London, UK
    Neurobiol Aging 33:960-8. 2012
    ..Thus, pro-oxidant conditions increase APP levels and enhance BACE1-mediated APP processing and in doing so might contribute to pathogenesis in AD...
  12. ncbi Expression of SOD1 G93A or wild-type SOD1 in primary cultures of astrocytes down-regulates the glutamate transporter GLT-1: lack of involvement of oxidative stress
    Massimo Tortarolo
    Biochemical Neuropharmacology Group, GKT Centre for Neuroscience Research, King s College London, Guy s Hospital Campus, London, UK
    J Neurochem 88:481-93. 2004
    ....
  13. doi Synaptic NMDA receptor activation stimulates alpha-secretase amyloid precursor protein processing and inhibits amyloid-beta production
    Sarah E Hoey
    King s College London, Wolfson Centre for Age Related Diseases, London, United Kingdom
    J Neurosci 29:4442-60. 2009
    ..Altogether, these data suggest that calcium influx through synaptic NMDA receptors promotes nonamyloidogenic alpha-secretase-mediated APP processing...
  14. doi Tau phosphorylation in human brain: relationship to behavioral disturbance in dementia
    Simone Guadagna
    King s College London, Wolfson Centre for Age Related Diseases, London, UK
    Neurobiol Aging 33:2798-806. 2012
    ..01) in the frontal cortex of patients with high tau phosphorylation. This study confirms a link between tau phosphorylation and agitation/aggression and suggests that reducing tau phosphorylation may provide symptomatic relief...
  15. pmc Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites
    Jeremy P E Spencer
    Wolfson Centre for Age Related Diseases, GKT School of Biomedical Sciences, Hodgkin Building, King s College, Guy s Campus, London SE1 9RT, U K
    Biochem J 372:173-81. 2003
    ..Our data suggest that the actions of quercetin and its metabolites in vivo are mediated by intracellular metabolites...
  16. ncbi Noxious stimulation induces Trk receptor and downstream ERK phosphorylation in spinal dorsal horn
    Sophie Pezet
    Centre for Neuroscience Research, Guy s King s and St Thomas School of Biomedical Sciences, King s College London, London SE1, United Kingdom
    Mol Cell Neurosci 21:684-95. 2002
    ..These data suggest that BDNF, once released with activity from primary afferent nociceptors, exerts a neuromodulatory role in pain processing through stimulation of postsynaptic TrkB receptors and subsequent activation of ERK...
  17. ncbi MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide
    Hagen Schroeter
    Antioxidant Research Group, Wolfson Centre for Age Related Diseases and Centre for Neuroscience Research, Guy s, King s and St Thomas s School of Biomedical Sciences, King s College, Guy s Campus, Hodgkin Bldg, 3rd Floor, London SE1 9RT, UK
    Neurobiol Aging 23:861-80. 2002
    ..This review addresses recent findings on the biological effects of flavonoids and nitric oxide in neurodegeneration and aims to elucidate the rationale for their prospective use as modulators of cellular signal transduction...
  18. ncbi CB2 cannabinoid receptors promote mouse neural stem cell proliferation
    Francisco Molina-Holgado
    The Wolfson Centre for Age Related Diseases, King s College London, Hodking Building, Guy s Campus, London SE1 1UL, UK
    Eur J Neurosci 25:629-34. 2007
    ..Together, our results suggest that cannabinoids stimulate proliferation of neural stem/precursor cells acting on both CB1 and CB2 cannabinoid receptors through a phosphoinositide-3 kinase/Akt pathway...
  19. ncbi Hydrogen peroxide-mediated phosphorylation of ERK1/2, Akt/PKB and JNK in cortical neurones: dependence on Ca(2+) and PI3-kinase
    Andrew J Crossthwaite
    Centre for Neuroscience Research, Guy s, King s and St Thomas School of Biomedical Sciences, Guy s Campus, London, UK
    J Neurochem 80:24-35. 2002
    ..It is likely, therefore, that subjecting neurones to moderate oxidative-stress recruits pro-survival signals to CREB but during severe oxidative stress pro-death signals through JNK and c-jun are dominant...
  20. pmc AMPA receptor activation promotes non-amyloidogenic amyloid precursor protein processing and suppresses neuronal amyloid-β production
    Sarah E Hoey
    King s College London, Wolfson Centre for Age Related Diseases, London, United Kingdom
    PLoS ONE 8:e78155. 2013
    ....
  21. ncbi Abeta(1-42) modulation of Akt phosphorylation via alpha7 nAChR and NMDA receptors
    Jonathan J Abbott
    King s College London, Wolfson Centre for Age Related Diseases, Guy s Campus, St Thomas Street, London SE1 1UL, UK
    Neurobiol Aging 29:992-1001. 2008
    ....
  22. ncbi The 'glial' glutamate transporter, EAAT2 (Glt-1) accounts for high affinity glutamate uptake into adult rodent nerve endings
    Sachin K Suchak
    Biochemical Neuropharmacology Group, Centre for Neuroscience Research, GKT School of Biomedical Sciences, King s College London, United Kingdom
    J Neurochem 84:522-32. 2003
    ..The data presented in this study indicate that EAAT2 is the predominant nerve terminal glutamate transporter in the adult rodent CNS...
  23. ncbi Phosphatidylinositol 3-kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2), Akt/PKB and CREB in striatal neurones
    Michael S Perkinton
    Centre for Neuroscience Research, Guy s, King s and St Thomas School of Biomedical Sciences, London, UK
    J Neurochem 80:239-54. 2002
    ..We propose that NMDA receptor stimulation can activate Erk1/2 and Akt signalling pathways in a PI 3-kinase dependent manner which may target CREB in the nucleus...
  24. ncbi Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons
    David Vauzour
    Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading, UK
    J Neurochem 103:1355-67. 2007
    ..Thus, flavanones may protect neurons against oxidative insults via the modulation of neuronal apoptotic machinery...
  25. ncbi (-)Epicatechin stimulates ERK-dependent cyclic AMP response element activity and up-regulates GluR2 in cortical neurons
    Hagen Schroeter
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, CA, USA
    J Neurochem 101:1596-606. 2007
    ..Thus, (-)epicatechin has the potential to increase CREB-regulated gene expression and increase GluR2 levels and thus modulate neurotransmission, plasticity and synaptogenesis...
  26. pmc Phosphatidylinositol 3-kinase is a key mediator of central sensitization in painful inflammatory conditions
    Sophie Pezet
    Neurorestoration Group, Wolfson Center for Age Related Diseases, King s College London, London SE1 1UL, United Kingdom
    J Neurosci 28:4261-70. 2008
    ..Our study suggests that PI3K is a major factor in the expression of central sensitization after noxious inflammatory stimuli...
  27. doi Glial metabolism of quercetin reduces its neurotoxic potential
    Katerina Vafeiadou
    Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG2 6AP, UK
    Arch Biochem Biophys 478:195-200. 2008
    ..We propose that glial cells act to protect neurons against the neurotoxic effects of quercetin and that 2'-glutathionyl-quercetin represents a novel quercetin metabolite...
  28. ncbi Antipsychotic drug use in Canadian long-term care facilities: prevalence, and patterns following resident relocation
    Brad Hagen
    School of Health Sciences, The University of Lethbridge, 4401 University Drive, Lethbridge, Alberta T1K 3M4, Canada
    Int Psychogeriatr 17:179-93. 2005
    ..During the one-year study, residents in one facility were relocated to a new facility, allowing examination of the changes in antipsychotic use associated with relocation...
  29. ncbi Pharmacodynamic response and inhibition of growth of human tumor xenografts by the novel histone deacetylase inhibitor PXD101
    Jane A Plumb
    Department of Medical Oncology, University of Glasgow, Cancer Research United Kingdom Beatson Laboratories, Glasgow, G61 1BD, United Kingdom
    Mol Cancer Ther 2:721-8. 2003
    ..Furthermore, the ability to measure histone acetylation in blood samples could provide a suitable pharmacodynamic end point to monitor drug activity...
  30. ncbi Serotonin transporter expression is not sufficient to confer cytotoxicity to 3,4-methylenedioxymethamphetamine (MDMA) in vitro
    Shaista Hayat
    Laboratory of Molecular Signalling, The Babraham Institute, Cambridge, UK
    J Psychopharmacol 20:257-63. 2006
    ..We conclude that SERT expression is not sufficient to confer MDMA toxicity to cell lines. Therefore SERT-expressing cell lines do not offer a simple model system to elucidate the mechanisms underlying MDMA toxicity...