Frances M K Williams

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi A new 5-lipoxygenase inhibitor seems to be safe and effective for the treatment of osteoarthritis
    Frances M K Williams
    Rheumatology at Guy s and St Thomas NHS Foundation Trust, London, UK
    Nat Clin Pract Rheumatol 5:132-3. 2009
  2. pmc Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects
    Frances M K Williams
    Department Twin Research and Genetic Epidemiology, King s College London, London, UK
    Ann Rheum Dis 72:1141-8. 2013
  3. pmc Ischemic stroke is associated with the ABO locus: the EuroCLOT study
    Frances M K Williams
    Department of Twin Research and Genetic Epidemiology, King s College London, United Kingdom
    Ann Neurol 73:16-31. 2013
  4. pmc Progression of lumbar disc degeneration over a decade: a heritability study
    Frances M K Williams
    Department of Twin Research and Genetic Epidemiology, King s College London, UK
    Ann Rheum Dis 70:1203-7. 2011
  5. pmc Dietary garlic and hip osteoarthritis: evidence of a protective effect and putative mechanism of action
    Frances M K Williams
    Dept Twin Research and Genetic Epidemiology, King s College London, London, UK
    BMC Musculoskelet Disord 11:280. 2010
  6. pmc Evidence that bone mineral density plays a role in degenerative disc disease: the UK Twin Spine study
    Gregory Livshits
    Department of Twin Research and Genetic Epidemiology, King s College London, UK
    Ann Rheum Dis 69:2102-6. 2010
  7. pmc Pain reporting at different body sites is explained by a single underlying genetic factor
    Frances M K Williams
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital Campus, London SE1 7EH, UK
    Rheumatology (Oxford) 49:1753-5. 2010
  8. pmc Identification of quantitative trait loci for fibrin clot phenotypes: the EuroCLOT study
    Frances M K Williams
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, UK
    Arterioscler Thromb Vasc Biol 29:600-5. 2009
  9. doi Neck and back pain and intervertebral disc degeneration: role of occupational factors
    F M K Williams
    Department of Twin Research and Genetic Epidemiology, King s College London, UK
    Best Pract Res Clin Rheumatol 25:69-79. 2011
  10. pmc GDF5 single-nucleotide polymorphism rs143383 is associated with lumbar disc degeneration in Northern European women
    F M K Williams
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
    Arthritis Rheum 63:708-12. 2011

Detail Information

Publications26

  1. ncbi A new 5-lipoxygenase inhibitor seems to be safe and effective for the treatment of osteoarthritis
    Frances M K Williams
    Rheumatology at Guy s and St Thomas NHS Foundation Trust, London, UK
    Nat Clin Pract Rheumatol 5:132-3. 2009
    ..Although a putative mechanism of action suggests a disease-modifying effect, the important outcomes from this trial are good symptom response and a low adverse effect profile, albeit in the small number of patients studied...
  2. pmc Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects
    Frances M K Williams
    Department Twin Research and Genetic Epidemiology, King s College London, London, UK
    Ann Rheum Dis 72:1141-8. 2013
    ..To date, the agnostic search of the genome by genome-wide association (GWA) to identify common variants associated with LDD has not been fruitful. This study is the first GWA meta-analysis of LDD...
  3. pmc Ischemic stroke is associated with the ABO locus: the EuroCLOT study
    Frances M K Williams
    Department of Twin Research and Genetic Epidemiology, King s College London, United Kingdom
    Ann Neurol 73:16-31. 2013
    ..We explored whether genetic variants associated with end-stage coagulation in healthy volunteers account for the genetic predisposition to ischemic stroke and examined their influence on stroke subtype...
  4. pmc Progression of lumbar disc degeneration over a decade: a heritability study
    Frances M K Williams
    Department of Twin Research and Genetic Epidemiology, King s College London, UK
    Ann Rheum Dis 70:1203-7. 2011
    ..Cross-sectional LDD as determined by MRI scan is known to be highly heritable. The authors postulated that the rate of progression might also be controlled by genetic factors...
  5. pmc Dietary garlic and hip osteoarthritis: evidence of a protective effect and putative mechanism of action
    Frances M K Williams
    Dept Twin Research and Genetic Epidemiology, King s College London, London, UK
    BMC Musculoskelet Disord 11:280. 2010
    ..Patterns of food intake and prevalent osteoarthritis of the hand, hip, and knee were studied using the twin design to limit the effect of confounding factors. Compounds found in associated food groups were further studied in vitro...
  6. pmc Evidence that bone mineral density plays a role in degenerative disc disease: the UK Twin Spine study
    Gregory Livshits
    Department of Twin Research and Genetic Epidemiology, King s College London, UK
    Ann Rheum Dis 69:2102-6. 2010
    ..The present work aimed to confirm this association in a large population sample using MRI and explore the relationship further, in particular to determine whether it is mediated genetically...
  7. pmc Pain reporting at different body sites is explained by a single underlying genetic factor
    Frances M K Williams
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital Campus, London SE1 7EH, UK
    Rheumatology (Oxford) 49:1753-5. 2010
    ....
  8. pmc Identification of quantitative trait loci for fibrin clot phenotypes: the EuroCLOT study
    Frances M K Williams
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, UK
    Arterioscler Thromb Vasc Biol 29:600-5. 2009
    ..The aims of the current study from the EU consortium EuroCLOT were to (1) determine the heritability of fibrin phenotypes and (2) identify QTLs associated with fibrin phenotypes...
  9. doi Neck and back pain and intervertebral disc degeneration: role of occupational factors
    F M K Williams
    Department of Twin Research and Genetic Epidemiology, King s College London, UK
    Best Pract Res Clin Rheumatol 25:69-79. 2011
    ..This article examines the contribution of genetic and environmental factors to back pain and disc disease, with a specific focus on occupational exposures...
  10. pmc GDF5 single-nucleotide polymorphism rs143383 is associated with lumbar disc degeneration in Northern European women
    F M K Williams
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
    Arthritis Rheum 63:708-12. 2011
    ..In vitro, the gene product growth differentiation factor 5 has been shown to promote growth and repair of animal disc. This study was undertaken to investigate whether the GDF5 gene plays a role in LDD...
  11. pmc Lumbar disc degeneration and genetic factors are the main risk factors for low back pain in women: the UK Twin Spine Study
    Gregory Livshits
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
    Ann Rheum Dis 70:1740-5. 2011
    ..The authors examined the contribution of genetic factors, lumbar disc degeneration (LDD) and other risk factors in a female sample of the general population...
  12. pmc A common genetic factor underlies hypertension and other cardiovascular disorders
    Frances M K Williams
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London SE1 7EH, UK
    BMC Cardiovasc Disord 4:20. 2004
    ..This study used a classical twin design to examine whether these conditions are linked through shared environmental exposures or by a common underlying genetic propensity to vasospasm...
  13. pmc Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford Study
    Gregory Livshits
    King s College London, London, UK
    Arthritis Rheum 60:2037-45. 2009
    ....
  14. ncbi The UK Adult Twin Registry (TwinsUK)
    Tim D Spector
    Twin Research and Genetic Epidemiology Unit, Kings College London, St Thomas Hospital Campus, London, UK
    Twin Res Hum Genet 9:899-906. 2006
    ..The resource has led to many successful and innovative research projects particularly in common age-related diseases, and has led to collaborations with over 80 groups worldwide...
  15. pmc Longitudinal study of variation in body mass index in middle-aged UK females
    Gregory Livshits
    Department of Twin Research and Genetic Epidemiology, Kings College London, St Thomas Hospital, London, SE1 7EH, UK
    Age (Dordr) 34:1285-94. 2012
    ..Therefore, simply combining all individuals into groups by any other criteria (age, sex, etc.) and overlooking the distinctive patterns of BMI change may lead to biased inferences in epidemiologic and etiologic research of the future...
  16. ncbi The heritable determinants of cartilage oligomeric matrix protein
    Frances M K Williams
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Arthritis Rheum 54:2147-51. 2006
    ..An association between COMP and OA has been shown, yet the precise factors governing serum levels of COMP remain unclear. The aim of this study was to determine whether genetic factors influence serum levels of COMP...
  17. pmc Reduced telomere length in rheumatoid arthritis is independent of disease activity and duration
    Sophia E Steer
    Department of Rheumatology, Twin Research and Genetic Epidemiology Unit, Kings College London School of Medicine at Guy s, King s and St Thomas, London SE1 7EH, UK
    Ann Rheum Dis 66:476-80. 2007
    ..Telomere loss in white blood cells (WBC) is accelerated by oxidative stress and inflammation in vitro. It was postulated that the accelerated WBC telomere shortening in RA occurs as a result of exposure to chronic inflammation...
  18. pmc Epigenome-wide DNA methylation in hearing ability: new mechanisms for an old problem
    Lisa E Wolber
    Department of Twin Research and Genetic Epidemiology, King s College London, London, United Kingdom
    PLoS ONE 9:e105729. 2014
    ..2 × 10(-4)) and MEF2D (cg08156349, r= -0.75, p=1.4 × 10(-4)). Examination of gene expression in skin, suggests an influence of differential methylation on expression, which may account for the variation in hearing ability with age...
  19. pmc Genetic Factors Influencing Coagulation Factor XIII B-Subunit Contribute to Risk of Ischemic Stroke
    Ken B Hanscombe
    From the Department of Medical and Molecular Genetics K B H, C M L, Department of Twin Research and Genetic Epidemiology P G H, F M K W, and MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience C M L, King s College London, London, UK Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK M T, S B, H S M Institut für Schlaganfallund Demenzforschung, Klinikum der Universitat Munchen, Ludwig Maximilians Universitat Munchen, Feodor Lynen Straße 17, Munich, Germany M D Munich Cluster for Systems Neurology SyNergy, Munich, Germany M D Stroke Prevention Research Unit, Nuffield Department of Clinical Neurosciences, University of Oxford P M R Center for Public Health Genomics, and Cardiovascular Research Center, University of Virginia, Charlottesville, VA B B W Department of Biostatistics, Boston University School of Public Health, Boston, MA B B W Department of Neurology, Boston University School of Medicine, Boston, MA S S and Division of Clinical Neurosciences, University of Edinburgh, UK C S
    Stroke 46:2069-74. 2015
    ..We determined the shared genetic risk between 14 coagulation factors and ischemic stroke and its subtypes...
  20. ncbi The genetics of osteoporosis
    Frances M K Williams
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Acta Reumatol Port 32:231-40. 2007
    ..Cost-effective large scale genetic testing is becoming available and lends itself to combining large multi-national populations for candidate gene analysis, meta-analyses, DNA pooling studies and gene expression studies...
  21. doi Genetic and Environmental Factors in Age-Related Hearing Impairment
    Sukhleen K Momi
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
    Twin Res Hum Genet 18:383-92. 2015
    ..The findings suggest SIN is less heritable than pure tone audiogram (PTA) ability and highly influenced by the environment unique to each twin. Furthermore, a possible role of dietary fat in the etiology of ARHI is highlighted...
  22. pmc Genes contributing to pain sensitivity in the normal population: an exome sequencing study
    Frances M K Williams
    Department of Twin Research and Genetic Epidemiology, King s College London, London, United Kingdom
    PLoS Genet 8:e1003095. 2012
    ..The approach of sequencing extreme exome variation in normal individuals has provided important insights into gene networks mediating pain sensitivity in humans and will be applicable to other common complex traits...
  23. doi Epigenetics and methylation in the rheumatic diseases
    Flore Zufferey
    Department of Twin Research and Genetic Epidemiology, King s College London, London, United Kingdom
    Semin Arthritis Rheum 43:692-700. 2014
    ..Epigenetic studies are providing new insights into disease pathogenesis. Recent rheumatology literature related to DNA methylation studies-both epigenome-wide and candidate gene-are discussed, as well as methodological issues...
  24. pmc A cross-sectional randomised study of fracture risk in people with HIV infection in the probono 1 study
    Barry S Peters
    Department of Infectious Diseases, Kings College London, London, United Kingdom Honorary Consultant Physician, Guys and St Thomas Foundation Hospitals, London, United Kingdom
    PLoS ONE 8:e78048. 2013
    ..To determine comparative fracture risk in HIV patients compared with uninfected controls...
  25. pmc Hearing ability with age in northern European women: a new web-based approach to genetic studies
    Lisa E Wolber
    Department of Twin Research and Genetic Epidemiology, King s College London, London, United Kingdom
    PLoS ONE 7:e35500. 2012
    ..We have shown that the SNR test provides a useful surrogate marker of hearing. This will enable a much larger sample to be collected at a fraction of the cost, facilitating future genetic association studies...