S J Whittaker

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint Biological insights into the pathogenesis of cutaneous T-cell lymphomas (CTCL)
    Sean Whittaker
    St Johns Institute of Dermatology, Guys and St Thomas Hospital, London, UK
    Semin Oncol 33:S3-6. 2006
  2. ncbi request reprint Joint British Association of Dermatologists and U.K. Cutaneous Lymphoma Group guidelines for the management of primary cutaneous T-cell lymphomas
    S J Whittaker
    St John s Institute of Dermatology, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, U K
    Br J Dermatol 149:1095-1107. 2003
  3. ncbi request reprint Efficacy and tolerability of currently available therapies for the mycosis fungoides and Sezary syndrome variants of cutaneous T-cell lymphoma
    Sean J Whittaker
    St John s Institute of Dermatology, Guys and St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Cancer Treat Rev 33:146-60. 2007
  4. doi request reprint Final results from a multicenter, international, pivotal study of romidepsin in refractory cutaneous T-cell lymphoma
    Sean J Whittaker
    Guy s and St Thomas National Health Service Foundation Trust, London, United Kingdom
    J Clin Oncol 28:4485-91. 2010
  5. ncbi request reprint Molecular staging of lymph nodes from 60 patients with mycosis fungoides and Sézary syndrome: correlation with histopathology and outcome suggests prognostic relevance in mycosis fungoides
    E A Fraser-Andrews
    Department of Dermatopathology, St John s Institute of Dermatology, St Thomas Hospital, London SE1 7EH, UK
    Br J Dermatol 155:756-62. 2006
  6. ncbi request reprint Absence of the t(14;18) chromosomal translocation in primary cutaneous B-cell lymphoma
    F J Child
    Skin Tumour Unit and Department of Dermatopathology, St John s Institute of Dermatology, St Thomas Hospital, London SE1 7EH, UK
    Br J Dermatol 144:735-44. 2001
  7. ncbi request reprint Detection of a peripheral blood T cell clone is an independent prognostic marker in mycosis fungoides
    E A Fraser-Andrews
    Skin Tumour Unit, St John s Institute of Dermatology, United Medical and Dental School of Guy s and St Thomas s Hospital, London, UK
    J Invest Dermatol 114:117-21. 2000
  8. ncbi request reprint Loss of heterozygosity on 10q and microsatellite instability in advanced stages of primary cutaneous T-cell lymphoma and possible association with homozygous deletion of PTEN
    J J Scarisbrick
    Skin Tumour Unit, St John s Institute Dermatology, St Thomas Hospital, London, United Kingdom
    Blood 95:2937-42. 2000
  9. ncbi request reprint A randomized cross-over study to compare PUVA and extracorporeal photopheresis in the treatment of plaque stage (T2) mycosis fungoides
    F J Child
    Skin Tumour Unit, St John s Institute of Dermatology, St Thomas Hospital, London, UK
    Clin Exp Dermatol 29:231-6. 2004
  10. ncbi request reprint Allelotyping in mycosis fungoides and Sézary syndrome: common regions of allelic loss identified on 9p, 10q, and 17p
    J J Scarisbrick
    Skin Tumour Unit, St John s Institute Dermatology, St Thomas Hospital, London, UK
    J Invest Dermatol 117:663-70. 2001

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Biological insights into the pathogenesis of cutaneous T-cell lymphomas (CTCL)
    Sean Whittaker
    St Johns Institute of Dermatology, Guys and St Thomas Hospital, London, UK
    Semin Oncol 33:S3-6. 2006
    ..This article reviews our current understanding of the pathogenetic abnormalities involving genomic mutations, abnormal cDNA expression, and dysregulation of signaling pathways in CTCL...
  2. ncbi request reprint Joint British Association of Dermatologists and U.K. Cutaneous Lymphoma Group guidelines for the management of primary cutaneous T-cell lymphomas
    S J Whittaker
    St John s Institute of Dermatology, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, U K
    Br J Dermatol 149:1095-1107. 2003
  3. ncbi request reprint Efficacy and tolerability of currently available therapies for the mycosis fungoides and Sezary syndrome variants of cutaneous T-cell lymphoma
    Sean J Whittaker
    St John s Institute of Dermatology, Guys and St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Cancer Treat Rev 33:146-60. 2007
    ....
  4. doi request reprint Final results from a multicenter, international, pivotal study of romidepsin in refractory cutaneous T-cell lymphoma
    Sean J Whittaker
    Guy s and St Thomas National Health Service Foundation Trust, London, United Kingdom
    J Clin Oncol 28:4485-91. 2010
    ..The primary objective of this study was to confirm the efficacy of romidepsin in patients with treatment refractory cutaneous T-cell lymphoma (CTCL)...
  5. ncbi request reprint Molecular staging of lymph nodes from 60 patients with mycosis fungoides and Sézary syndrome: correlation with histopathology and outcome suggests prognostic relevance in mycosis fungoides
    E A Fraser-Andrews
    Department of Dermatopathology, St John s Institute of Dermatology, St Thomas Hospital, London SE1 7EH, UK
    Br J Dermatol 155:756-62. 2006
    ..Histological evidence of lymph node involvement is associated with a poor prognosis in patients with cutaneous T-cell lymphoma (CTCL)...
  6. ncbi request reprint Absence of the t(14;18) chromosomal translocation in primary cutaneous B-cell lymphoma
    F J Child
    Skin Tumour Unit and Department of Dermatopathology, St John s Institute of Dermatology, St Thomas Hospital, London SE1 7EH, UK
    Br J Dermatol 144:735-44. 2001
    ..Bcl-2 protein prevents apoptosis and the translocation leads to overexpression of a functionally normal Bcl-2 protein that prevents apoptosis of neoplastic cells...
  7. ncbi request reprint Detection of a peripheral blood T cell clone is an independent prognostic marker in mycosis fungoides
    E A Fraser-Andrews
    Skin Tumour Unit, St John s Institute of Dermatology, United Medical and Dental School of Guy s and St Thomas s Hospital, London, UK
    J Invest Dermatol 114:117-21. 2000
    ..Keywords: polymerase chain reaction/single-strand conformational polymorphism/T cell receptor gene rearrangement. J Invest Dermatol 114:117-121, 2000..
  8. ncbi request reprint Loss of heterozygosity on 10q and microsatellite instability in advanced stages of primary cutaneous T-cell lymphoma and possible association with homozygous deletion of PTEN
    J J Scarisbrick
    Skin Tumour Unit, St John s Institute Dermatology, St Thomas Hospital, London, United Kingdom
    Blood 95:2937-42. 2000
    ..Furthermore, abnormalities of PTEN may be important in the pathogenesis of mycosis fungoides, but our data imply that this gene is rarely inactivated by small deletions or point mutations. (Blood. 2000;95:2937-2942)..
  9. ncbi request reprint A randomized cross-over study to compare PUVA and extracorporeal photopheresis in the treatment of plaque stage (T2) mycosis fungoides
    F J Child
    Skin Tumour Unit, St John s Institute of Dermatology, St Thomas Hospital, London, UK
    Clin Exp Dermatol 29:231-6. 2004
    ..Although PUVA was more effective than ECP, neither treatment modality cleared malignant T-cells from the peripheral blood...
  10. ncbi request reprint Allelotyping in mycosis fungoides and Sézary syndrome: common regions of allelic loss identified on 9p, 10q, and 17p
    J J Scarisbrick
    Skin Tumour Unit, St John s Institute Dermatology, St Thomas Hospital, London, UK
    J Invest Dermatol 117:663-70. 2001
    ..These results provide the basis for further studies defining more accurately chromosomal regions of deletions and candidate tumor suppressor genes involved in mycosis fungoides and Sézary syndrome...
  11. ncbi request reprint A trial of fludarabine and cyclophosphamide combination chemotherapy in the treatment of advanced refractory primary cutaneous T-cell lymphoma
    J J Scarisbrick
    Skin Tumour Unit, St John s Institute of Dermatology, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, U K
    Br J Dermatol 144:1010-5. 2001
    ..The combination of fludarabine and cyclophosphamide shows synergistic toxicity in vitro and has been used to treat nodal non-Hodgkin's lymphoma and relapsed chronic lymphocytic leukaemia...
  12. ncbi request reprint BCL2 and JUNB abnormalities in primary cutaneous lymphomas
    X Mao
    Skin Tumour Unit, St John s Institute of Dermatology, St Thomas Hospital, London SE1 7EH, UK
    Br J Dermatol 151:546-56. 2004
    ..BCL2 is upregulated in nodal and extranodal B-cell non-Hodgkin's lymphomas, with a consequent antiapoptotic effect. However, loss of BCL2 has also been noted in some malignancies, suggesting a different molecular pathogenesis...
  13. ncbi request reprint Diagnostic and prognostic importance of T-cell receptor gene analysis in patients with Sézary syndrome
    E A Fraser-Andrews
    Skin Tumor Unit, St John s Institute of Dermatology, St Thomas Hospital, Lambeth Palace Road, London, SE1 7EH, United Kingdom
    Cancer 92:1745-52. 2001
    ..Sézary syndrome (SS) is characterized by erythroderma, peripheral lymphadenopathy, and circulating Sézary cells and is clinically heterogeneous...
  14. ncbi request reprint Subcutaneous panniculitis-like T-cell lymphoma: a clinicopathological, immunophenotypic and molecular analysis of six patients
    S R Hoque
    Department of Dermatopathology, St John s Institute of Dermatology, St Thomas Hospital, London, UK
    Br J Dermatol 148:516-25. 2003
    ..In the World Health Organization classification of T-cell and natural killer cell lymphoma it is listed as an example of extranodal lymphoma. In practice, however, it is most likely to present to a dermatologist...
  15. doi request reprint Bexarotene therapy for mycosis fungoides and Sézary syndrome
    R A Abbott
    St John s Institute of Dermatology, St Thomas Hospital, London, UK
    Br J Dermatol 160:1299-307. 2009
    ..Bexarotene (Targretin) is a synthetic retinoid which is licensed for the treatment of advanced refractory cutaneous T-cell lymphoma (CTCL)...
  16. ncbi request reprint Molecular analysis of the immunoglobulin heavy chain gene in the diagnosis of primary cutaneous B cell lymphoma
    F J Child
    Skin Tumor Unit, St John s Institute of Dermatology, St Thomas Hospital, London, UK
    J Invest Dermatol 117:984-9. 2001
    ..Our data indicate that the FR3 consensus primer alone is not sufficient for a comprehensive analysis of primary cutaneous B cell lymphoma...
  17. ncbi request reprint Extracorporeal photopheresis in Sézary syndrome: hematologic parameters as predictors of response
    A V Evans
    Skin Tumour Unit, St John's Institute of Dermatology, St Thomas' Hospital, London, United Kingdom
    Blood 98:1298-301. 2001
    ..Alternatively, minimum tumor burden might be required for the induction of a cytotoxic response. Analysis of tumor-specific cytotoxic T cells is needed to investigate these possibilities further...
  18. ncbi request reprint T-cell depletion and autologous stem cell transplantation in the management of tumour stage mycosis fungoides with peripheral blood involvement
    E Olavarria
    Department of Haematology, Hammersmith Hospital, ICSM, London, UK
    Br J Haematol 114:624-31. 2001
    ..Despite a short relapse-free survival, most patients achieved good disease control at the time of relapse...
  19. pmc Promoter methylation of argininosuccinate synthetase-1 sensitises lymphomas to arginine deiminase treatment, autophagy and caspase-dependent apoptosis
    B Delage
    Barts Cancer Institute, Queen Mary University of London, Centre for Molecular Oncology, London, UK
    Cell Death Dis 3:e342. 2012
    ..In summary, ASS1 promoter methylation contributes to arginine auxotrophy and represents a novel biomarker for evaluating the efficacy of arginine deprivation in patients with lymphoma...
  20. ncbi request reprint Sézary syndrome with a complex, frameshift p53 gene mutation in a Chernobyl survivor
    E A Fraser-Andrews
    Skin Tumour Unit, Department of Photobiology, St John s Institute of Dermatology, St Thomas Hospital, London, UK
    Clin Exp Dermatol 26:683-5. 2001
    ..This is characteristic of damage caused by ionizing radiation, which suggests a causal link between exposure to ionizing radiation and the subsequent development of Sézary syndrome, a rare form of T-cell leukaemia/lymphoma...
  21. ncbi request reprint Can we safely diagnose pigmented lesions from stored video images? A diagnostic comparison between clinical examination and stored video images of pigmented lesions removed for histology
    V M Jolliffe
    Department of Dermatology, The Royal Free Hospital, London, UK
    Clin Exp Dermatol 26:84-7. 2001
    ..Further evaluation of the cost : benefit ratio of such a system to the health care provider must be undertaken before considering this technique as a potential adjunct to managing outpatient referrals...
  22. doi request reprint Constitutive activation of STAT3 in Sézary syndrome is independent of SHP-1
    R C T McKenzie
    Skin Tumour Unit, St John s Institute of Dermatology, Division of Genetics and Molecular Medicine, King s College London, London, UK
    Leukemia 26:323-31. 2012
    ..These data demonstrate that constitutive activation of STAT3 in SS is not due to the loss of SHP-1, but is mediated by constitutive aberrant activation of JAK family members...
  23. ncbi request reprint Granulomatous mycosis fungoides presenting as an acquired ichthyosis
    S Eisman
    Department of Dermatology, Royal Free Hospital, London, UK
    Clin Exp Dermatol 28:174-6. 2003
    ..Skin histology, immunophenotyping and molecular features were consistent with granulomatous mycosis fungoides. He has been successfully treated with twice weekly PUVA photochemotherapy...
  24. ncbi request reprint Blastic natural killer cell and extranodal natural killer cell-like T-cell lymphoma presenting in the skin: report of six cases from the UK
    F J Child
    Department of Dermatopathology, St John s Institute of Dermatology, St Thomas Hospital, London, UK
    Br J Dermatol 148:507-15. 2003
    ..The new World Health Organization classification of lymphoma/leukaemia recognizes several types of NK/T-cell neoplasm, including blastic NK-cell lymphoma, which characteristically presents with cutaneous lesions...
  25. doi request reprint Folliculotropic mycosis fungoides (stage IIA) progressing to Sézary syndrome: a case report
    N Agar
    St John s Institute of Dermatology, St Thomas Hospital, Lambeth Palace Rd SE1 7EH, London, U K
    Br J Dermatol 159:1197-9. 2008
    ..We present the first report detailing the stepwise progression of a patient with stage IIA folliculotropic MF to SS. This case demonstrates that MF and SS represent a clinical spectrum of the same disease...
  26. ncbi request reprint Cutaneous Waldenström's macroglobulinaemia
    I Chan
    St John s Institute of Dermatology, St Thomas Hospital, London
    Clin Exp Dermatol 28:491-2. 2003
    ..Direct cutaneous infiltration by neoplastic lymphoid cells is less common, and very rare as the initial presentation of Waldenström's macroglobulinaemia...
  27. ncbi request reprint Molecular cytogenetic analysis of cutaneous T-cell lymphomas: identification of common genetic alterations in Sézary syndrome and mycosis fungoides
    X Mao
    Skin Tumour Unit, St John s Institute of Dermatology, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, U K
    Br J Dermatol 147:464-75. 2002
    ..Data on genome-wide surveys for chromosome aberrations in primary cutaneous T-cell lymphoma (CTCL) are limited...
  28. doi request reprint A cutaneous lymphoma international prognostic index (CLIPi) for mycosis fungoides and Sezary syndrome
    E C Benton
    St John s Institute of Dermatology, Guy s and St Thomas NHS Foundation Trust, London, UK
    Eur J Cancer 49:2859-68. 2013
    ..There is no prognostic index for primary cutaneous T-cell lymphomas such as mycosis fungoides (MF) and Sezary syndrome (SS)...
  29. ncbi request reprint Can we use video images to triage pigmented lesions?
    V M Jolliffe
    Department of Dermatology, Royal Free Hospital, London, UK
    Br J Dermatol 145:904-10. 2001
    ..Advances in telemedicine permit consultations where the doctor and patient are at different sites...
  30. ncbi request reprint Amplification and overexpression of JUNB is associated with primary cutaneous T-cell lymphomas
    Xin Mao
    Skin Tumour Unit and Dermatopathology Department, St John s Institute of Dermatology, St Thomas Hospital, London, United Kingdom
    Blood 101:1513-9. 2003
    ..These results have revealed, for the first time, amplification and expression patterns of JUNB in PCL, suggesting that JUNB may be critical in the pathogenesis of primary cutaneous T-cell lymphomas...
  31. ncbi request reprint Fine mapping of chromosome 10q deletions in mycosis fungoides and sezary syndrome: identification of two discrete regions of deletion at 10q23.33-24.1 and 10q24.33-25.1
    E Mary Wain
    Skin Tumour Unit, St John s Institute of Dermatology, St Thomas Hospital, London, UK
    Genes Chromosomes Cancer 42:184-92. 2005
    ..1, around microsatellite marker D10S530 (3.92 Mb), encodes 11 genes, the majority of which have poorly identified functions. This extensive allelotyping study provides the basis for future highly selective candidate gene analyses...
  32. ncbi request reprint Heterogeneous abnormalities of CCND1 and RB1 in primary cutaneous T-Cell lymphomas suggesting impaired cell cycle control in disease pathogenesis
    Xin Mao
    Skin Tumour Unit, St John s Institute of Dermatology, St Thomas Hospital, King s College, London, UK
    J Invest Dermatol 126:1388-95. 2006
    ..These findings suggest heterogeneous abnormalities of CCND and RB in CTCL, in which dysregulated CCND and RB1 may lead to impaired cell cycle control...
  33. ncbi request reprint Molecular analysis of T-cell receptor beta genes in cutaneous T-cell lymphoma reveals Jbeta1 bias
    Suzanne M Morgan
    Molecular Pathology, Cancer Sciences Division, School of Medicine, General Hospital, Southampton University Hospitals NHS Trust, Southampton, UK
    J Invest Dermatol 126:1893-9. 2006
    ..Although we found that TCRB gene usage in CTCL and normal individuals share common features, our analysis also revealed preferential usage of Jbeta1 genes in all cases with advanced stages of disease...
  34. ncbi request reprint Outcome in 34 patients with juvenile-onset mycosis fungoides: a clinical, immunophenotypic, and molecular study
    E Mary Wain
    Skin Tumour Unit, St John s Institute of Dermatology, St Thomas Hospital, London, United Kingdom
    Cancer 98:2282-90. 2003
    ..The aims of the current study were to describe the clinical presentation, pathologic features, and disease progression (DP) in patients who developed MF before age 16 years...
  35. ncbi request reprint Cutaneous malignant melanoma in association with mycosis fungoides
    Alun V Evans
    Skin Tumour Unit, St John s Institute of Dermatology, London, United Kingdom
    J Am Acad Dermatol 50:701-5. 2004
    ..The reason for this association is unclear, but this report emphasizes the risk of second malignancies for patients with cutaneous T-cell lymphoma and melanoma...
  36. ncbi request reprint Frequent abnormalities of the p15 and p16 genes in mycosis fungoides and sezary syndrome
    Julia J Scarisbrick
    Skin Tumor Unit, St John s Institute Dermatology, St Thomas Hospital, Lambeth Palace Road, London, UK
    J Invest Dermatol 118:493-9. 2002
    ....
  37. ncbi request reprint Dysregulated expression of COOH-terminally truncated Stat5 and loss of IL2-inducible Stat5-dependent gene expression in Sezary Syndrome
    Tracey J Mitchell
    Skin Cancer Unit, St Johns Institute of Dermatology, Division of Skin Sciences, Kings College London, St Thomas Hospital, London, United Kingdom
    Cancer Res 63:9048-54. 2003
    ..Thus, aberrant expression of Stat5(t) may be one mechanism that contributes to the cellular transformation of T cells in this disease...
  38. ncbi request reprint Palliative care in patients with primary cutaneous lymphoma: symptom burden and characteristics of hospital palliative care team input
    Beata Lebon
    Arch Dermatol 143:423-4. 2007
  39. ncbi request reprint Microsatellite instability is associated with hypermethylation of the hMLH1 gene and reduced gene expression in mycosis fungoides
    Julia J Scarisbrick
    Skin Tumour Unit, St John s Institute Dermatology, St Thomas Hospital, London, UK
    J Invest Dermatol 121:894-901. 2003
    ..This suggests that the development of a mutator phenotype may contribute to disease progression in mycosis fungoides...
  40. ncbi request reprint Histopathology and genetics of cutaneous T-cell lymphoma
    Bruce R Smoller
    Department of Pathology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
    Hematol Oncol Clin North Am 17:1277-311. 2003
    ..It is hoped that greater understanding of these molecular abnormalities will permit the development of CTCL-specific therapies that alleviate suffering and prolong survival...
  41. ncbi request reprint Multiple familial pilomatricomas: an unusual case
    Virginia G Hubbard
    Department of Dermatology, Bart s Hospital, London, UK
    J Cutan Pathol 31:281-3. 2004
    ..We describe a 29-year-old man with multiple pilomatricomas whose father and brother also had similar lesions. There is no history of myotonic dystrophy...
  42. ncbi request reprint CD30(+) cutaneous lymphoma in association with atopic eczema
    Clair L Fletcher
    Department of Dermatopathology, St John s Institute of Dermatology, St Thomas Hospital, London, England
    Arch Dermatol 140:449-54. 2004
    ..Chronic atopic eczema is not regarded as a precursor of malignancy, and, to our knowledge, there has been only one previous case report of CD30(+) cutaneous lymphoma in association with atopic dermatitis...
  43. pmc Lack of suppressive CD4+CD25+FOXP3+ T cells in advanced stages of primary cutaneous T-cell lymphoma
    Machteld M Tiemessen
    Immunobiology Department, Division of Immunology, Infection and Inflammatory Disease, King s College London School of Medicine at Guy s, King s College and St Thomas Hospitals, London, UK
    J Invest Dermatol 126:2217-23. 2006
    ..Our findings thus indicate a dysfunction of peripheral Tregs in certain CTCL patients, which correlates with tumor burden...