Research Topics
| S WarnakulasuriyaSummaryAffiliation: King's College London Country: UK Publications
| Collaborators
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Detail Information
Publications
Malignant transformation of oral potentially malignant disorders in males: a retrospective cohort studyPei Shan Ho
Division of Oral and Maxillofacial Surgery, Department of Dentistry, Kaoshiung Medical University Hospital, Kaohsiung, Taiwan, Republic of China
BMC Cancer 9:260. 2009..The aim of our study was to estimate the rate of malignant transformation of OPMDs taking into account the duration of follow-up and to identify the significant factors indicative of malignant potential...
Is workplace screening for potentially malignant oral disorders feasible in India?S Warnakulasuriya
Department of Oral Medicine, King s College London, London, UK
J Oral Pathol Med 39:672-6. 2010..However, those who work during the day may not visit screening centers or be at home during the day of the screening by a visiting health care worker. Workplace screening overcomes these challenges...
Tobacco, oral cancer, and treatment of dependenceSaman Warnakulasuriya
Department of Oral Medicine and Pathology, Guy s, King s and St Thomas School of Dentistry, WHO Collaborating Centre for Oral Cancer and Precancer, King s College London, Denmark Hill Campus, Caldecot Road, London SE5 9RW, UK
Oral Oncol 41:244-60. 2005..This review makes recommendations for interventions by health professionals to encourage and aid cessation of tobacco use as a part of prevention of oral cancer...- Clinical, pathological, cellular and molecular lesions caused by oral smokeless tobacco--a reviewK A A S Warnakulasuriya
Department of Oral Medicine and Pathology, WHO Collaborating Centre for Oral Cancer and Precancer, King s College Dental Institute at Guy s, King s and St Thomas Hospitals, London, UK
J Oral Pathol Med 36:63-77. 2007..Genetic aberrations caused by ST include activation of ras, uncommon in smokers but mutational hot spots in p53 encountered are similar to those in smokers... - Oral cancer survival in young people in South East EnglandSaman Warnakulasuriya
Department of Oral Medicine, King s College Dental Institute at Guy s, King s and St Thomas Hospitals, WHO Collaborating Centre for Oral Cancer and Precancer, Denmark Hill Campus, Caldecot Road, London SE5 9RW, UK
Oral Oncol 43:982-6. 2007..For the young age group (0-44 years) mean relative survival for the period under study was relatively constant but consistently higher in younger women than in younger men... - Nomenclature and classification of potentially malignant disorders of the oral mucosaS Warnakulasuriya
Department of Oral Medicine, King s College London Dental Institute at Guy s, Denmark Hill Campus, Caldecot Road, London, UK
J Oral Pathol Med 36:575-80. 2007..The terminology presented in this report reflects our best understanding of multi-step carcinogenesis in the oral mucosa, and aspires to engender consistency in use... - Oral epithelial dysplasia classification systems: predictive value, utility, weaknesses and scope for improvementS Warnakulasuriya
Department of Oral Medicine, King s College Dental Institute at Guy s, King s and St Thomas Hospitals, London, UK
J Oral Pathol Med 37:127-33. 2008.... - Global epidemiology of oral and oropharyngeal cancerSaman Warnakulasuriya
Department of Oral Medicine and Experimental Oral Pathology, King s College Dental Institute, Bessemer Road, London SE5 9RS, UK
Oral Oncol 45:309-16. 2009.... - Oral health risks of tobacco use and effects of cessationSaman Warnakulasuriya
King s College London and WHO Collaborating Centre for Oral Cancer and Precancer, UK
Int Dent J 60:7-30. 2010..Substantial oral health benefits can be expected from abstention and successful smoking cessation in a variety of populations across all ages... - Living with oral cancer: epidemiology with particular reference to prevalence and life-style changes that influence survivalSaman Warnakulasuriya
Department of Oral Medicine and Pathology, King s College Dental Institute, Bessemer Rd, London SE5 9RS, UK
Oral Oncol 46:407-10. 2010..Smoking cessation in particular improves prognostic outcomes reducing the risk of secondary disease by approximately 2-3-fold... - Multiple primary tumours following head and neck cancer in southern England during 1961-98K A A S Warnakulasuriya
Department of Oral Medicine and Pathology, Guy s, King s and St Thomas Dental Institute and WHO Collaborating Centre for Oral Cancer and Precancer, Demark Hill Campus, Caldecot Road, London SE5 9RW, UK
J Oral Pathol Med 32:443-9. 2003..Successful initial treatment of oral and oro-phayngeal cancer has led to the emergence of second primary tumours (SPTs). Population data are meagre... - Effectiveness of tobacco counseling in the dental officeSaman Warnakulasuriya
Department of Oral Medicine and Experimental Pathology, WHO Collaborating Centre for Oral Cancer and Precancer, Guy s, King s and St Thomas School of Dentistry, King s College London, UK
J Dent Educ 66:1079-87. 2002..The challenge is implementing effective treatment in one's practice or institution while using available primary care resources to provide additional benefit... - Cancer of mouth, pharynx and nasopharynx in Asian and Chinese immigrants resident in Thames regionsK A Warnakulasuriya
Department of Oral Medicine and Pathology, Guy s, King s and St Thomas School of Dentistry, London, UK
Oral Oncol 35:471-5. 1999..The south Asian and Chinese ethnic minorities constitute important high risk groups for oral and nasopharyngeal cancer, for whom targeted prevention is indicated... - Histological grading of oral epithelial dysplasia: revisitedS Warnakulasuriya
Department of Oral Medicine and Pathology, WHO Collaborating Centre for Oral Cancer and Precancer, Guy s, King s and St Thomas School of Medicine and Dentistry, King s College London, Denmark Hill Campus, Caldecot Road, London, UK
J Pathol 194:294-7. 2001..They are potential biomarker candidates but their utility in prognosis of oral precancer deserves further study... - Fluoride content of alcoholic beveragesSaman Warnakulasuriya
Department of Oral Medicine and Pathology, Guy s, King s and St Thomas Schools of Medicine and Dentistry, Denmark Hill Campus, King s College London, Caldecot Road, London SE5 9RW, UK
Clin Chim Acta 320:1-4. 2002..In view of the conflicting reports of the extent and severity of dental caries in alcohol misusing subjects, a systematic survey of the fluoride content of alcoholic beverages was undertaken... - Causes of oral cancer--an appraisal of controversiesS Warnakulasuriya
Department of Oral Medicine WHO Collaborating Centre for Oral Cancer and Precancer, King s College London Dental Institute, Denmark Hill Campus, Bessemer Road, London
Br Dent J 207:471-5. 2009..Some controversies related to the aetiology of this disease also need clarification. The objective of this paper is to provide an opinion on these debated controversies... - Utility of toluidine blue as a diagnostic adjunct in the detection of potentially malignant disorders of the oral cavity--a clinical and histological assessmentKh Awan
Oral Medicine and Head and Neck Pathology, Department of Clinical and Diagnostic Sciences, King s College London Dental Institute, London, UK
Oral Dis 18:728-33. 2012..The value of chairside adjunctive tests in the detection of oral potentially malignant disorders (OPMDs) remains uncertain... - Utility of chemiluminescence (ViziLite™) in the detection of oral potentially malignant disorders and benign keratosesK H Awan
Oral Medicine, King s College London Dental Institute, London, UK
J Oral Pathol Med 40:541-4. 2011..Data derived were compared in relation to conventional oral examination and surgical biopsy... - The oral health consequences of chewing areca nutC R Trivedy
Department of Oral Pathology and Medicine, WHO Collaborating Center for Oral Cancer and Precancer, The Guy's Medical and Dental School of King's College, London, UK
Addict Biol 7:115-25. 2002..Public health measures to quit areca use are recommended to control disabling conditions such as submucous fibrosis and oral cancer among Asian populations... - Areca nut use following migration and its consequencesS Warnakulasuriya
Department of Oral Medicine and Pathology, Guy's School of Dentistry, WHO Collaborating Centre for Oral Cancer and Precancer, King's College London, Denmark Hill Campus, London, UK
Addict Biol 7:127-32. 2002..The two products are psychologically addictive and a dependency syndrome related to their use among Asian immigrants to the United Kingdom has been described recently... - Role of p16/MTS1, cyclin D1 and RB in primary oral cancer and oral cancer cell linesM Sartor
Department of Oral Medicine and Pathology, The Rayne Institute, King s College School of Medicine and Dentistry, London, UK
Br J Cancer 80:79-86. 1999..The RB protein was expressed in about half (44%) of OSCCs and its expression inversely correlated with p16/MTS1 expression. In conclusion, we show that abnormalities of the RB pathway are a common mechanism of oral carcinogenesis... - Effective management of smoking in an oral dysplasia clinic in LondonT W J Poate
Department of Oral Medicine and Pathology, WHO Collaborating Centre for Oral Cancer and Precancer, Guy's, King's and St Thomas' Dental Institute, King's College, London, UK
Oral Dis 12:22-6. 2006.... - The two-week wait cancer initiative on oral cancer; the predictive value of urgent referrals to an oral medicine unitP Singh
Department of Oral Medicine and Pathology, WHO Collaborating Centre for Oral Cancer and Precancer, King's College London Dental Institute, Denmark Hill Campus, Caldecot Road, London, UK
Br Dent J 201:717-20; discussion 714. 2006..Moreover, development of other appropriate adjuncts that aid visual inspection for the detection of oral cancer may improve the sensitivity of positive detections in primary care... - The impact of stomatological disease on oral health-related quality of lifeCarrie Diane Llewellyn
Department of Oral Medicine and Pathology, Guy s, King s and St Thomas Schools of Medicine and Dentistry, King s College Hospital, London, UK
Eur J Oral Sci 111:297-304. 2003..Patient centred, routine assessment of OHR-QoL provides an additional dimension that may help to improve awareness of the impact of disease on the individual's life and enhance the clinical decision-making process... - Effect of areca nut on salivary copper concentration in chronic chewersKishor B Raja
Department of Clinical Biochemistry, Guy s, King s and St Thomas School of Medicine, Denmark Hill Campus, London, SE5 9RS, UK
Biometals 20:43-7. 2007..These data indicate that soluble copper found in areca nut is released into the oral environment of habitual chewers. Its buccal absorption may contribute to the oral fibrosis in Asians who regularly chew this nut... - Evaluation of tobacco use cessation (TUC) counselling in the dental officeIan Needleman
International Centre for Evidence Based Oral Health, Unit of Periodontology, UCL Eastman Dental Institute, London, UK
Oral Health Prev Dent 4:27-47. 2006..Therefore both self-reported and biochemical measures of tobacco use should be reported in evaluation studies. It is also clear that feedback from biochemical testing of tobacco use can increase success rates in tobacco use cessation... - Oral submucous fibrosis: review on aetiology and pathogenesisW M Tilakaratne
The Centre for Research in Clinical and Diagnostic Oral Sciences, School of Medicine and Dentistry, Barts and The London, London, UK
Oral Oncol 42:561-8. 2006..The individual mechanisms operating at various stages of the disease-initial, intermediate and advanced-need further study in order to propose appropriate therapeutic interventions... - Demonstration of ethanol-induced protein adducts in oral leukoplakia (pre-cancer) and cancerSaman Warnakulasuriya
Department of Oral Medicine, King s College London Dental Institute at Guy s, King s and St Thomas Hospitals, WHO Collaborating Centre for Oral Cancer and Precancer, London, UK
J Oral Pathol Med 37:157-65. 2008..Excessive alcohol consumption is a common cause for upper gastrointestinal tract cancers. However, the primary mechanisms of alcohol-induced carcinogenesis have remained poorly defined... - An analysis of risk factors for oral cancer in young people: a case-control studyCarrie D Llewellyn
Department of Oral Medicine and Pathology, WHO Collaborating Centre for Oral Cancer and Precancer, Guy's, King's and St Thomas' School of Dentistry, King's College London, Denmark Hill Campus, Caldecot Road, London SE5 9RW, UK
Oral Oncol 40:304-13. 2004.... - Factors associated with delay in presentation among younger patients with oral cancerCarrie D Llewellyn
Department of Oral Medicine and Pathology, WHO Collaborating Centre for Oral Cancer and Precancer, Guy's, King's, and St Thomas' Schools of Medicine and Dentistry, King's College London, UK
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97:707-13. 2004..This has important implications for increasing sign and symptom awareness among the public and primary health care professionals such as general medical practitioners and general dentists... - Chemical and analytical aspects of areca nutG A Lord
MRC Bioanalytical Science Group, School of Biological and Chemical Sciences, Birkbeck, University of London, London, UK
Addict Biol 7:99-102. 2002..6) as the running buffer at a voltage of 20 kV and temperature of 30 degrees C. The method is applicable to the analysis of alkaloids in the nut, commercial preparations (pan masala) and in the saliva of areca nut chewers... - Aplasia of submandibular salivary glands associated with ectodermal dysplasiaParmjit Singh
Department of Oral Medicine, Guy's, King's and St Thomas' Dental Institute, Denmark Hill Campus, London, UK
J Oral Pathol Med 33:634-6. 2004..The case highlights that hypoplasia and aplasia of exocrine glands could be rare features of ED. In the management of ED, early detection of xerostomia is important to limit any potential damage to the already hypodontic dentition... - Angioleiomyoma: an unusual diagnosis for a lump in the cheekHelen McParland
Department Oral Medicine, King s College London Dental Institute, London, United Kingdom
Br J Oral Maxillofac Surg 47:641-2. 2009..Deep dissection to excise the mass completely caused no damage to nerves and there has been no recurrence... - Oral pre-cancer and the associated risk factors among industrial workers in Japan's overseas enterprises in the UKToru Nagao
Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University, Japan
J Oral Pathol Med 32:257-64. 2003..Regular dental/oral check up and tobacco education programmes are encouraged for oral cancer/pre-cancer control in industrial settings... - Annual screening for oral cancer detectionToru Nagao
Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University, 2-11 Suemori-dori, Chikusa-ku, 464-8651, Nagoya, Japan
Cancer Detect Prev 27:333-7. 2003.... - Oral precancerous disorders associated with areca quid chewing, smoking, and alcohol drinking in southern TaiwanChing-Hung Chung
Graduate Institutes of Dental Sciences, Oral Health Sciences and Oral Health Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan
J Oral Pathol Med 34:460-6. 2005..CONCLUSION: This study reinforces the association of current areca quid chewing without tobacco, cigarette smoking, and alcohol drinking to leukoplakia, OSF, and verrucous lesions in Taiwan... - Incidence rates for oral leukoplakia and lichen planus in a Japanese populationToru Nagao
Department of Oral and Maxillofacial Surgery II, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan
J Oral Pathol Med 34:532-9. 2005..A high incidence of idiopathic leukoplakia found in this study raises challenges to the strategy of screening high-risk populations aimed at conserving resources... - Areca nut use: an independent risk factor for oral cancerSaman Warnakulasuriya
BMJ 324:799-800. 2002 - Gene expression profile of oral squamous cell carcinomas from Sri Lankan betel quid usersMai Lill Suhr
Department of Biomedicine, University of Bergen, Jonas Lies Vej 91, 5009 Bergen, Norway
Oncol Rep 18:1061-75. 2007..These findings provide valuable information that might help in the selection of possible biomarkers that can be used in early detection of the alarming problem of oral cancer in Southeast Asia... - The role of the dental team in preventing and diagnosing cancer: 4. Risk factor reduction: tobacco cessationCrispian Scully
Eastman Dental Institute for Oral Health Care Sciences, 256 Gray's Inn Road, University College London, London WC1 X 8LD
Dent Update 32:394-6, 399-401. 2005..CLINICAL RELEVANCE: Health professionals should encourage and aid cessation of tobacco use as a part of prevention of oral and other cancers... - Oral lichen planus and oral lichenoid lesions: diagnostic and therapeutic considerationsIbtisam Al Hashimi
Salivary Dysfunction Clinic, Baylor College of Dentistry, Houston, TX, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:S25.e1-12. 2007..Oral lichenoid lesions of graft-versus-host disease (OLL-GVHD) are recognized to have an association with malignancy. Local therapy for these lesions rests in topical agents, predominantly corticosteroids... - Areca (betel) nut chewing habit among high-school children in the Commonwealth of the Northern Mariana Islands (Micronesia)Eric Oakley
Saipan Seventh-Day Adventist Clinic, Saipan
Bull World Health Organ 83:656-60. 2005..8% of children. CONCLUSION: These findings from Saipan suggest that areca nut chewing starts at a young age in Micronesia. As many users develop dependency this raises important concerns regarding its consequences for oral health... - Management of oral epithelial dysplasia: a reviewMichael Brennan
Carolinas Medical Center, Charlotte, NC, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:S19.e1-12. 2007..Because of the lack of randomized controlled trials that have shown effectiveness in the prevention of malignant transformation, no recommendations can be provided for specific surgical interventions of dysplastic oral lesions either...