J P Ward

Summary

Affiliation: King's College London
Country: UK

Publications

  1. pmc Mechanisms of hypoxic pulmonary vasoconstriction and their roles in pulmonary hypertension: new findings for an old problem
    Jeremy P T Ward
    King s College London, Division of Asthma, Allergy and Lung Biology, London SE1 9RT, UK
    Curr Opin Pharmacol 9:287-96. 2009
  2. ncbi request reprint Curiouser and curiouser: the perplexing conundrum of reactive oxygen species and hypoxic pulmonary vasoconstriction
    Jeremy P T Ward
    King s College London School of Medicine, Division of Asthma, Allergy and Lung Biology, London SE1 9RT, UK
    Exp Physiol 92:819-20. 2007
  3. ncbi request reprint Point: Hypoxic pulmonary vasoconstriction is mediated by increased production of reactive oxygen species
    Jeremy P T Ward
    Division of Asthma, Allergy and Lung Biology, King s College London School of Medicine, UK
    J Appl Physiol 101:993-5; discussion 999. 2006
  4. pmc Mitochondria and oxygen sensing: fueling the controversy
    Jeremy P T Ward
    Department of Asthma, Allergy and Respiratory Science, GKT School of Medicine, King s College London, London SE1 9RT, UK
    J Physiol 548:664. 2003
  5. ncbi request reprint Communication and information technology in medical education
    J P Ward
    Department of Respiratory Medicine and Allergy, Guy s Hospital, London, UK
    Lancet 357:792-6. 2001
  6. ncbi request reprint Calcium, mitochondria and oxygen sensing in the pulmonary circulation
    Jeremy P T Ward
    Department of Asthma, Allergy and Respiratory Science, Guy s, King s and St Thomas School of Medicine, 5th Floor Thomas Guy House, King s College London, Guy s Campus, London SE1 9RT, UK
    Cell Calcium 36:209-20. 2004
  7. ncbi request reprint Mechanisms of hypoxic pulmonary vasoconstriction: can anyone be right?
    J P Ward
    Department of Respiratory Medicine and Allergy, Guy s Hospital Medical and Dental School, King s College London, UK
    Respir Physiol 115:261-71. 1999
  8. ncbi request reprint Protein kinases in vascular smooth muscle tone--role in the pulmonary vasculature and hypoxic pulmonary vasoconstriction
    Jeremy P T Ward
    Division of Asthma, Allergy and Lung Biology, Guy s, King s and St Thomas School of Medicine, King s College London, London, UK
    Pharmacol Ther 104:207-31. 2004
  9. pmc Inhibition of sustained hypoxic vasoconstriction by Y-27632 in isolated intrapulmonary arteries and perfused lung of the rat
    T P Robertson
    Department of Respiratory Medicine and Allergy, GKT School of Medicine, King s College London, Guy s Campus, London SE1 9RT
    Br J Pharmacol 131:5-9. 2000
  10. ncbi request reprint Modulation of PGF2alpha- and hypoxia-induced contraction of rat intrapulmonary artery by p38 MAPK inhibition: a nitric oxide-dependent mechanism
    Greg A Knock
    Dept of Asthma, Allergy and Respiratory Science, School of Medicine, King s College London, London SE1 9RT, UK
    Am J Physiol Lung Cell Mol Physiol 289:L1039-48. 2005

Collaborators

Detail Information

Publications36

  1. pmc Mechanisms of hypoxic pulmonary vasoconstriction and their roles in pulmonary hypertension: new findings for an old problem
    Jeremy P T Ward
    King s College London, Division of Asthma, Allergy and Lung Biology, London SE1 9RT, UK
    Curr Opin Pharmacol 9:287-96. 2009
    ....
  2. ncbi request reprint Curiouser and curiouser: the perplexing conundrum of reactive oxygen species and hypoxic pulmonary vasoconstriction
    Jeremy P T Ward
    King s College London School of Medicine, Division of Asthma, Allergy and Lung Biology, London SE1 9RT, UK
    Exp Physiol 92:819-20. 2007
  3. ncbi request reprint Point: Hypoxic pulmonary vasoconstriction is mediated by increased production of reactive oxygen species
    Jeremy P T Ward
    Division of Asthma, Allergy and Lung Biology, King s College London School of Medicine, UK
    J Appl Physiol 101:993-5; discussion 999. 2006
  4. pmc Mitochondria and oxygen sensing: fueling the controversy
    Jeremy P T Ward
    Department of Asthma, Allergy and Respiratory Science, GKT School of Medicine, King s College London, London SE1 9RT, UK
    J Physiol 548:664. 2003
  5. ncbi request reprint Communication and information technology in medical education
    J P Ward
    Department of Respiratory Medicine and Allergy, Guy s Hospital, London, UK
    Lancet 357:792-6. 2001
    ....
  6. ncbi request reprint Calcium, mitochondria and oxygen sensing in the pulmonary circulation
    Jeremy P T Ward
    Department of Asthma, Allergy and Respiratory Science, Guy s, King s and St Thomas School of Medicine, 5th Floor Thomas Guy House, King s College London, Guy s Campus, London SE1 9RT, UK
    Cell Calcium 36:209-20. 2004
    ....
  7. ncbi request reprint Mechanisms of hypoxic pulmonary vasoconstriction: can anyone be right?
    J P Ward
    Department of Respiratory Medicine and Allergy, Guy s Hospital Medical and Dental School, King s College London, UK
    Respir Physiol 115:261-71. 1999
    ..Fundamental issues that remain unresolved are outlined...
  8. ncbi request reprint Protein kinases in vascular smooth muscle tone--role in the pulmonary vasculature and hypoxic pulmonary vasoconstriction
    Jeremy P T Ward
    Division of Asthma, Allergy and Lung Biology, Guy s, King s and St Thomas School of Medicine, King s College London, London, UK
    Pharmacol Ther 104:207-31. 2004
    ....
  9. pmc Inhibition of sustained hypoxic vasoconstriction by Y-27632 in isolated intrapulmonary arteries and perfused lung of the rat
    T P Robertson
    Department of Respiratory Medicine and Allergy, GKT School of Medicine, King s College London, Guy s Campus, London SE1 9RT
    Br J Pharmacol 131:5-9. 2000
    ..Furthermore, addition of Y-27632 at any point during hypoxia caused a reversal of HPV in perfused rat lungs. These results suggest that activation of Rho-associated kinase may be a pivotal step in the generation of sustained HPV...
  10. ncbi request reprint Modulation of PGF2alpha- and hypoxia-induced contraction of rat intrapulmonary artery by p38 MAPK inhibition: a nitric oxide-dependent mechanism
    Greg A Knock
    Dept of Asthma, Allergy and Respiratory Science, School of Medicine, King s College London, London SE1 9RT, UK
    Am J Physiol Lung Cell Mol Physiol 289:L1039-48. 2005
    ..We conclude that p38 MAPK contributes to PGF(2alpha)- and hypoxia-induced constriction of rat IPA primarily by antagonizing the underlying Ca(2+)-desensitizing actions of NO...
  11. ncbi request reprint Sphingosylphosphorylcholine-induced vasoconstriction of pulmonary artery: activation of non-store-operated Ca2+ entry
    Gavin D Thomas
    Department of Asthma, Allergy and Respiratory Science, GKT School of Medicine, King s College London, Guy s Campus, London SE1 9RT, UK
    Cardiovasc Res 68:56-64. 2005
    ..As it has not been studied in the pulmonary circulation, we examined its mechanisms of action in rat small intrapulmonary arteries (IPA)...
  12. pmc Divergent roles of glycolysis and the mitochondrial electron transport chain in hypoxic pulmonary vasoconstriction of the rat: identity of the hypoxic sensor
    R M Leach
    Department of Respiratory Medicine and Allergy, GKT School of Medicine, Centre for Cardiovascular Biology and Medicine, King's College London, Guy's Hospital Campus, London SE1 9RT, UK
    J Physiol 536:211-24. 2001
    ..Additionally, glucose and glycolysis are essential for development of the sustained phase 2 of HPV, and support an endothelium-dependent Ca(2+)-sensitisation pathway rather than the rise in [Ca(2+)](i)...
  13. ncbi request reprint Euhydric hypercapnia increases vasoreactivity of rat pulmonary arteries via HCO3- transport and depolarisation
    Marie Vankova
    Department of Asthma, Allergy and Respiratory Science, GKT School of Medicine, Guy s Hospital Campus, London SE1 1UL, UK
    Cardiovasc Res 65:505-12. 2005
    ..To examine whether altered PCO2 or HCO3- at normal pH potentiate agonist-induced vasoconstriction of small pulmonary arteries, and if so to determine the mechanism...
  14. pmc Mechanisms of leukotriene D4-induced constriction in human small bronchioles
    V A Snetkov
    Department of Respiratory Medicine and Allergy, Guy s, King s and St Thomas School of Medicine, King s College London, Guy s Campus, London SE1 9RT
    Br J Pharmacol 133:243-52. 2001
    ..We conclude that LTD4 causes constriction of these small bronchioles primarily by activating Ca2+ entry via non-voltage gated channels, possibly by a PC-PLC mediated pathway...
  15. ncbi request reprint Ion currents in smooth muscle cells from human small bronchioles: presence of an inward rectifier K+ current and three types of large conductance K+ channel
    V A Snetkov
    Department of Respiratory Medicine and Allergy, Guy s, King s and St Thomas School of Medicine, King s College London, St Thomas Campus, London SE1 7EH, UK
    Exp Physiol 84:835-846. 1999
    ..These results demonstrate that ASM from small bronchioles differs in terms of ion currents and channels from ASM derived from large airways, with possible implications for function...
  16. pmc Activation of nitric oxide synthase by beta 2-adrenoceptors in human umbilical vein endothelium in vitro
    A Ferro
    Department Clinical Pharmacology, King s College London, St Thomas Hospital
    Br J Pharmacol 126:1872-80. 1999
    ..7. These results indicate that endothelial beta2-adrenergic stimulation and cyclic AMP elevation activate the L-arginine/NO system, and give rise to vasorelaxation, in human umbilical vein...
  17. pmc Mechanisms of the prostaglandin F2alpha-induced rise in [Ca2+]i in rat intrapulmonary arteries
    Vladimir A Snetkov
    Department of Asthma, Allergy and Respiratory Science, New Hunt s House, Guy s Hospital Campus, King s College London, London SE1 1UL, UK
    J Physiol 571:147-63. 2006
    ....
  18. pmc Hypoxic pulmonary vasoconstriction: mechanisms and controversies
    Philip I Aaronson
    Department of Asthma, Allergy and Respiratory Science, New Hunt s House, Guy s Hospital Campus, King s College London, London SE1 1UL, UK
    J Physiol 570:53-8. 2006
    ..In this brief review, we highlight selected recent findings and ongoing controversies which continue to animate the study of this remarkable and unique response of the pulmonary vasculature to hypoxia...
  19. ncbi request reprint Dietary soy modulates endothelium-dependent relaxation in aged male rats: Increased agonist-induced endothelium-derived hyperpolarising factor and basal nitric oxide activity
    Greg A Knock
    King s College London, Division of Asthma, Allergy and Lung Biology, School of Medicine, London SE1 1UL, UK
    Free Radic Biol Med 41:731-9. 2006
    ..Our data also suggest a prorelaxant role for endogenous H(2)O(2) in small arteries, which is modulated by a soy diet...
  20. pmc Role of src-family kinases in hypoxic vasoconstriction of rat pulmonary artery
    Greg A Knock
    Department of Asthma, Allergy and Respiratory Science, School of Medicine, King s College London, Room 3 20, Franklin Wilkins Building, Stamford Street, London SE1 9NH, UK
    Cardiovasc Res 80:453-62. 2008
    ..We investigated the role of src-family kinases (srcFKs) in hypoxic pulmonary vasoconstriction (HPV) and how this relates to Rho-kinase-mediated Ca(2+) sensitization and changes in intracellular Ca(2+) concentration ([Ca(2+)](i))...
  21. ncbi request reprint Endothelium-derived mediators and hypoxic pulmonary vasoconstriction
    Philip I Aaronson
    Department of Respiratory Medicine and Allergy, Centre for Cardiovascular Biology and Medicine, Guy s, King s and St Thomas School of Medicine, 5th Floor Thomas Guy House, King s College London, Guy s Campus, London SE1 9RT, UK
    Respir Physiol Neurobiol 132:107-20. 2002
    ..In particular, we propose that in response to hypoxia the pulmonary vascular endothelium releases an as yet unidentified agent that causes Ca(2+) sensitisation in the smooth muscle...
  22. ncbi request reprint Interaction between src family kinases and rho-kinase in agonist-induced Ca2+-sensitization of rat pulmonary artery
    Greg A Knock
    Department of Asthma, Allergy and Respiratory Science, School of Medicine, King s College London, Room 3 20, Franklin Wilkins Building, Stamford Street, London SE1 9NH, UK
    Cardiovasc Res 77:570-9. 2008
    ..We investigated the role of src family kinases (srcFK) in agonist-mediated Ca2+-sensitization in pulmonary artery and whether this involves interaction with the rho/rho-kinase pathway...
  23. ncbi request reprint Oxygen sensors in context
    Jeremy P T Ward
    King s College London School of Medicine, Division of Asthma, Allergy and Lung Biology, London SE1 9RT, UK
    Biochim Biophys Acta 1777:1-14. 2008
    ....
  24. ncbi request reprint Role of capacitative Ca2+ entry but not Na+/Ca2+ exchange in hypoxic pulmonary vasoconstriction in rat intrapulmonary arteries
    Silke Becker
    Division of Asthma, Allergy and Lung Biology, Room 2 20, New Hunt s House, King s College London, London SE1 1UL, UK
    Novartis Found Symp 272:259-68; discussion 268-79. 2006
    ..Taken together with previous observations, these results suggest a role for CCE in HPV, but suggest that different CCE pathways may be involved for each phase...
  25. doi request reprint Constriction of pulmonary artery by peroxide: role of Ca2+ release and PKC
    Ghazaleh Esmaeil Pourmahram
    Division of Asthma, Allergy and Lung Biology, King s College London, London SE1 9RT, UK
    Free Radic Biol Med 45:1468-76. 2008
    ....
  26. pmc Capacitative calcium entry as a pulmonary specific vasoconstrictor mechanism in small muscular arteries of the rat
    Vladimir A Snetkov
    Department of Asthma, Allergy and Respiratory Science, GKT School of Medicine, Centre for Cardiovascular Biology and Medicine, Guy s Hospital Campus, London SE1 9RT
    Br J Pharmacol 140:97-106. 2003
    ..These results suggest that although CCE occurs in a number of types of small arteries, its coupling to contraction appears to be of particular importance in pulmonary arteries...
  27. ncbi request reprint Determination of signaling pathways responsible for hypoxic pulmonary vasoconstriction: use of the small vessel myograph
    Jeremy P T Ward
    Department of Asthma, Allergy, and Respiratory Science, Guy s King s and St Thomas School of Medicine, King s College London, United Kingdom
    Methods Enzymol 381:71-87. 2004
  28. ncbi request reprint Dietary soy isoflavone induced increases in antioxidant and eNOS gene expression lead to improved endothelial function and reduced blood pressure in vivo
    Katharina Mahn
    Cardiovascular Division, School of Biomedical and Health Sciences, King s College London, London, UK
    FASEB J 19:1755-7. 2005
    ..The improvement in endothelial function, increased gene expression, and reduced blood pressure by soy isoflavones have implications for alternative therapy for postmenopausal women and patients at risk of coronary heart disease...
  29. ncbi request reprint Hypoxia, energy state and pulmonary vasomotor tone
    Richard M Leach
    Department of Respiratory Medicine and Allergy, Centre for Cardiovascular Biology and Medicine, Guy s, King s and St Thomas School of Medicine, King s College London, Guy s Campus, London SE1 9RT, UK
    Respir Physiol Neurobiol 132:55-67. 2002
    ..This review examines the relationship between energy state, anaerobic respiration and hypoxic vasomotor tone, with a particular emphasis on hypoxic pulmonary vasoconstriction...
  30. pmc Inositol 1,4,5-trisphosphate- and guanosine 5'-O-(3-thiotriphosphate)-induced Ca2+ release in cultured airway smooth muscle
    L C Chopra
    Division of Medicine, United Medical School, Guy s Hospital, London
    Br J Pharmacol 104:901-6. 1991
    ..Ca2+ may be able to move from the GTP gamma S-sensitive pool into the InsP3- and ryanodine-sensitive pool when this becomes depleted. In contrast, the opposite movement of Ca2 + cannot occur...
  31. ncbi request reprint Oxygen regulates mitogen-stimulated proliferation of fetal human airway smooth muscle cells
    Hitesh C Pandya
    Department of Respiratory Medicine and Allergy, The Guy s, King s, and St Thomas School of Medicine, King s College London, London SE1 9RT, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 283:L1220-30. 2002
    ..They also strongly suggest that, under these conditions, proliferation is mediated in part by generation of ROS...
  32. pmc Diminished sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) expression contributes to airway remodelling in bronchial asthma
    Katharina Mahn
    Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, London SE1 9RT, United Kingdom
    Proc Natl Acad Sci U S A 106:10775-80. 2009
    ..Our findings implicate a deficiency in SERCA2 in ASM in asthma that contributes to its secretory and hyperproliferative phenotype in asthma, and which may play a key role in mechanisms of airway remodeling...
  33. doi request reprint Ca(2+) homeostasis and structural and functional remodelling of airway smooth muscle in asthma
    Katharina Mahn
    King s College London, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK
    Thorax 65:547-52. 2010
    ....
  34. ncbi request reprint Capacitative calcium entry: a central role in hypoxic pulmonary vasoconstriction?
    Jeremy P T Ward
    Am J Physiol Lung Cell Mol Physiol 289:L2-4. 2005
  35. pmc Low concentrations of sphingosylphosphorylcholine enhance pulmonary artery vasoreactivity: the role of protein kinase C delta and Ca2+ entry
    Vladimir A Snetkov
    Department of Physiology, Henriette Raphael House, King s College London, Guy s Hospital Campus, London SE1 1UL, United Kingdom
    Hypertension 51:239-45. 2008
    ..This has implications for the physiological role of SPC, especially in cardiovascular disease, where SPC is reported to be elevated...
  36. ncbi request reprint Ca2+ sensitization during sustained hypoxic pulmonary vasoconstriction is endothelium dependent
    Tom P Robertson
    Department of Physiology and Pharmacology, Institute of Comparative Medicine, University of Georgia, Athens, Georgia 30602 7389, USA
    Am J Physiol Lung Cell Mol Physiol 284:L1121-6. 2003
    ..These results are consistent with sustained HPV being mediated by an endothelium-derived constrictor factor that is distinct from endothelin-1 and that elicits vasoconstriction via Ca(2+) sensitization...