Annapurna Vyakarnam

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint Evidence for Gag p24-specific CD4 T cells with reduced susceptibility to R5 HIV-1 infection in a UK cohort of HIV-exposed-seronegative subjects
    Josiah Eyeson
    Department of Immunology, Guy s, King s and St Thomas School of Medicine and Dentistry, King s College Hospital, London SE5 9NU, UK
    AIDS 17:2299-311. 2003
  2. pmc Increased sensitivity of CD4+ T-effector cells to CD4+CD25+ Treg suppression compensates for reduced Treg number in asymptomatic HIV-1 infection
    Georgina Thorborn
    Department of Infectious Diseases, King s College London, Guys Hospital, London, England
    PLoS ONE 5:e9254. 2010
  3. pmc Innate immunity against HIV: a priority target for HIV prevention research
    Persephone Borrow
    Nuffield Department of Clinical Medicine, University of Oxford, The Jenner Institute, Compton, Newbury, Berkshire, UK
    Retrovirology 7:84. 2010
  4. pmc Possession of human leucocyte antigen DQ6 alleles and the rate of CD4 T-cell decline in human immunodeficiency virus-1 infection
    Annapurna Vyakarnam
    Department of Infectious Diseases, Guy s, King s and St Thomas School of Medicine, London, UK
    Immunology 112:136-42. 2004
  5. ncbi request reprint Intracellular cytokines may model immunoregulation of abacavir hypersensitivity in HIV-infected subjects
    Deborah King
    Department of Immunology, King s College London, UK
    J Allergy Clin Immunol 115:1081-7. 2005
  6. ncbi request reprint Presence of HIV-1 Gag-specific IFN-gamma+IL-2+ and CD28+IL-2+ CD4 T cell responses is associated with nonprogression in HIV-1 infection
    Mark J Boaz
    Department of Immunology, Guy s, King s, and St Thomas School of Medicine and Dentistry, King s College London, United Kingdom
    J Immunol 169:6376-85. 2002
  7. doi request reprint Elevated effector cell sensitivity to Treg-cell suppression that is not associated with reduced Th17-cell expression distinguishes HIV+ asymptomatic subjects from progressors
    Georgina S Thorborn
    Department of Infectious Diseases, King s College London, Borough Wing, Guys Hospital, London, England, UK
    Eur J Immunol 42:138-46. 2012
  8. ncbi request reprint Suppression of human immunodeficiency virus replication in human brain tissue by nucleoside reverse transcriptase inhibitors
    Apsara Kandanearatchi
    Section of Experimental Neuropathologyand Psychiatry, Institute of Psychiatry, King s College London, London, United Kingdom
    J Neurovirol 10:136-9. 2004
  9. doi request reprint Whey acidic proteins (WAPs): novel modulators of innate immunity to HIV infection
    James L Reading
    Department of Infectious Diseases, King s College London, London, UK
    Curr Opin HIV AIDS 7:172-9. 2012
  10. pmc WFDC1 expression identifies memory CD4 T-lymphocytes rendered vulnerable to cell-cell HIV-1 transfer by promoting intercellular adhesive junctions
    Raymond A Alvarez
    Department of Infectious Diseases, King s College London, UK
    Retrovirology 8:29. 2011

Collaborators

  • Apsara Kandanearatchi
  • Philippa J Easterbrook
  • Raymond A Alvarez
  • Francois Raffi
  • Angus G Dalgleish
  • Ian Paul Everall
  • Melvyn Smith
  • James L Reading
  • Georgina S Thorborn
  • Deborah King
  • Laura Pomeroy
  • Anele Waters
  • Georgina Thorborn
  • Persephone Borrow
  • Mark J Boaz
  • Sarah Tomkins
  • Josiah Eyeson
  • Heidi Ishohanni
  • Barry S Peters
  • Adrienne F A Meyers
  • Maria Teresa De Magistris
  • Manuel Romaris
  • Greg Towers
  • Erik Lindblad
  • Teunis Geijtenbeek
  • Willy Bogers
  • Heidi Isohanni
  • Martin Goodier
  • Steve Patterson
  • Guido Poli
  • Gustavo Doncel
  • Patrice Debre
  • Barry Peters
  • Roberto Speck
  • William Paxton
  • Hermann Wagner
  • Frank Kirchhoff
  • Robin J Shattock
  • Guido Silvestri
  • Donata Medaglini
  • Tom Lehner
  • Charles Kelly
  • Melissa Perry
  • D Mike Kemeny
  • Daren E Thorborn
  • Linda M Thurmond
  • Eseberuo Sefia
  • Shahed Murad

Detail Information

Publications11

  1. ncbi request reprint Evidence for Gag p24-specific CD4 T cells with reduced susceptibility to R5 HIV-1 infection in a UK cohort of HIV-exposed-seronegative subjects
    Josiah Eyeson
    Department of Immunology, Guy s, King s and St Thomas School of Medicine and Dentistry, King s College Hospital, London SE5 9NU, UK
    AIDS 17:2299-311. 2003
    ..To characterize HIV-1 Gag p24-specific CD4 cell responses in HIV-exposed-seronegative (ES) individuals...
  2. pmc Increased sensitivity of CD4+ T-effector cells to CD4+CD25+ Treg suppression compensates for reduced Treg number in asymptomatic HIV-1 infection
    Georgina Thorborn
    Department of Infectious Diseases, King s College London, Guys Hospital, London, England
    PLoS ONE 5:e9254. 2010
    ..However, qualitative aspects of Treg function in HIV infection, specifically the balance between Treg cell suppressive potency versus suppressibility of effector cells, remain poorly understood. This report addresses this issue...
  3. pmc Innate immunity against HIV: a priority target for HIV prevention research
    Persephone Borrow
    Nuffield Department of Clinical Medicine, University of Oxford, The Jenner Institute, Compton, Newbury, Berkshire, UK
    Retrovirology 7:84. 2010
    ..Priority areas are identified where there are opportunities to accelerate the translation of recent gains in understanding of innate immunity into the design of improved or novel vaccine and microbicide strategies against HIV infection...
  4. pmc Possession of human leucocyte antigen DQ6 alleles and the rate of CD4 T-cell decline in human immunodeficiency virus-1 infection
    Annapurna Vyakarnam
    Department of Infectious Diseases, Guy s, King s and St Thomas School of Medicine, London, UK
    Immunology 112:136-42. 2004
    ..9% LTNPs versus 18.18% IPs, P = 0.04). Our results highlight the potential protective effect of HLA DQB1*06 alleles on the course of HIV disease...
  5. ncbi request reprint Intracellular cytokines may model immunoregulation of abacavir hypersensitivity in HIV-infected subjects
    Deborah King
    Department of Immunology, King s College London, UK
    J Allergy Clin Immunol 115:1081-7. 2005
    ..Given that the T-cell type 2 cytokine IL-4 may be overproduced by patients with allergy or other immunologic dysregulation, an index cytokine profile could help elucidate the character of a drug-specific hypersensitivity reaction...
  6. ncbi request reprint Presence of HIV-1 Gag-specific IFN-gamma+IL-2+ and CD28+IL-2+ CD4 T cell responses is associated with nonprogression in HIV-1 infection
    Mark J Boaz
    Department of Immunology, Guy s, King s, and St Thomas School of Medicine and Dentistry, King s College London, United Kingdom
    J Immunol 169:6376-85. 2002
    ..Accumulation of specific CD28(-)IL-2(+) helpers and loss of IFN-gamma(+)IL-2(+) CD4 T cells may compromise specific CD8 responses and, in turn, immunity to HIV...
  7. doi request reprint Elevated effector cell sensitivity to Treg-cell suppression that is not associated with reduced Th17-cell expression distinguishes HIV+ asymptomatic subjects from progressors
    Georgina S Thorborn
    Department of Infectious Diseases, King s College London, Borough Wing, Guys Hospital, London, England, UK
    Eur J Immunol 42:138-46. 2012
    ....
  8. ncbi request reprint Suppression of human immunodeficiency virus replication in human brain tissue by nucleoside reverse transcriptase inhibitors
    Apsara Kandanearatchi
    Section of Experimental Neuropathologyand Psychiatry, Institute of Psychiatry, King s College London, London, United Kingdom
    J Neurovirol 10:136-9. 2004
    ..55, df = 17, P =.021). Decreased viral replication observed with zidovudine and abacavir was not statistically significant...
  9. doi request reprint Whey acidic proteins (WAPs): novel modulators of innate immunity to HIV infection
    James L Reading
    Department of Infectious Diseases, King s College London, London, UK
    Curr Opin HIV AIDS 7:172-9. 2012
    ..To discuss how whey acidic proteins (WAPs), a new class of immunomodulatory soluble mediators, impact innate immunity to HIV infection...
  10. pmc WFDC1 expression identifies memory CD4 T-lymphocytes rendered vulnerable to cell-cell HIV-1 transfer by promoting intercellular adhesive junctions
    Raymond A Alvarez
    Department of Infectious Diseases, King s College London, UK
    Retrovirology 8:29. 2011
    ..Since ICAM-1 is pivotal in cell conjugation and intercellular HIV-1 transfer, this study examines ps20 effects on HIV-1 spread between T lymphocytes...
  11. ncbi request reprint Granulocyte-macrophage colony-stimulating factor enhances viral load in human brain tissue: amelioration with stavudine
    Apsara Kandanearatchi
    Institute of Psychiatry, King s College, DeCrespigny Park, London SE5 8AF, UK
    AIDS 16:413-20. 2002
    ..Granulocyte-macrophage colony-stimulating factor (GM-CSF) is elevated in cerebrospinal fluid in HIV- associated dementia; in addition, therapeutic GM-CSF elevates plasma viral load...