Affiliation: King's College London
- Evidence for Gag p24-specific CD4 T cells with reduced susceptibility to R5 HIV-1 infection in a UK cohort of HIV-exposed-seronegative subjectsJosiah Eyeson
Department of Immunology, Guy s, King s and St Thomas School of Medicine and Dentistry, King s College Hospital, London SE5 9NU, UK
AIDS 17:2299-311. 2003..To characterize HIV-1 Gag p24-specific CD4 cell responses in HIV-exposed-seronegative (ES) individuals...
- Increased sensitivity of CD4+ T-effector cells to CD4+CD25+ Treg suppression compensates for reduced Treg number in asymptomatic HIV-1 infectionGeorgina Thorborn
Department of Infectious Diseases, King s College London, Guys Hospital, London, England
PLoS ONE 5:e9254. 2010..However, qualitative aspects of Treg function in HIV infection, specifically the balance between Treg cell suppressive potency versus suppressibility of effector cells, remain poorly understood. This report addresses this issue...
- Innate immunity against HIV: a priority target for HIV prevention researchPersephone Borrow
Nuffield Department of Clinical Medicine, University of Oxford, The Jenner Institute, Compton, Newbury, Berkshire, UK
Retrovirology 7:84. 2010..Priority areas are identified where there are opportunities to accelerate the translation of recent gains in understanding of innate immunity into the design of improved or novel vaccine and microbicide strategies against HIV infection...
- Possession of human leucocyte antigen DQ6 alleles and the rate of CD4 T-cell decline in human immunodeficiency virus-1 infectionAnnapurna Vyakarnam
Department of Infectious Diseases, Guy s, King s and St Thomas School of Medicine, London, UK
Immunology 112:136-42. 2004..9% LTNPs versus 18.18% IPs, P = 0.04). Our results highlight the potential protective effect of HLA DQB1*06 alleles on the course of HIV disease...
- Intracellular cytokines may model immunoregulation of abacavir hypersensitivity in HIV-infected subjectsDeborah King
Department of Immunology, King s College London, UK
J Allergy Clin Immunol 115:1081-7. 2005..Given that the T-cell type 2 cytokine IL-4 may be overproduced by patients with allergy or other immunologic dysregulation, an index cytokine profile could help elucidate the character of a drug-specific hypersensitivity reaction...
- Presence of HIV-1 Gag-specific IFN-gamma+IL-2+ and CD28+IL-2+ CD4 T cell responses is associated with nonprogression in HIV-1 infectionMark J Boaz
Department of Immunology, Guy s, King s, and St Thomas School of Medicine and Dentistry, King s College London, United Kingdom
J Immunol 169:6376-85. 2002..Accumulation of specific CD28(-)IL-2(+) helpers and loss of IFN-gamma(+)IL-2(+) CD4 T cells may compromise specific CD8 responses and, in turn, immunity to HIV...
- Elevated effector cell sensitivity to Treg-cell suppression that is not associated with reduced Th17-cell expression distinguishes HIV+ asymptomatic subjects from progressorsGeorgina S Thorborn
Department of Infectious Diseases, King s College London, Borough Wing, Guys Hospital, London, England, UK
Eur J Immunol 42:138-46. 2012....
- Suppression of human immunodeficiency virus replication in human brain tissue by nucleoside reverse transcriptase inhibitorsApsara Kandanearatchi
Section of Experimental Neuropathologyand Psychiatry, Institute of Psychiatry, King s College London, London, United Kingdom
J Neurovirol 10:136-9. 2004..55, df = 17, P =.021). Decreased viral replication observed with zidovudine and abacavir was not statistically significant...
- Whey acidic proteins (WAPs): novel modulators of innate immunity to HIV infectionJames L Reading
Department of Infectious Diseases, King s College London, London, UK
Curr Opin HIV AIDS 7:172-9. 2012..To discuss how whey acidic proteins (WAPs), a new class of immunomodulatory soluble mediators, impact innate immunity to HIV infection...
- WFDC1 expression identifies memory CD4 T-lymphocytes rendered vulnerable to cell-cell HIV-1 transfer by promoting intercellular adhesive junctionsRaymond A Alvarez
Department of Infectious Diseases, King s College London, UK
Retrovirology 8:29. 2011..Since ICAM-1 is pivotal in cell conjugation and intercellular HIV-1 transfer, this study examines ps20 effects on HIV-1 spread between T lymphocytes...
- Granulocyte-macrophage colony-stimulating factor enhances viral load in human brain tissue: amelioration with stavudineApsara Kandanearatchi
Institute of Psychiatry, King s College, DeCrespigny Park, London SE5 8AF, UK
AIDS 16:413-20. 2002..Granulocyte-macrophage colony-stimulating factor (GM-CSF) is elevated in cerebrospinal fluid in HIV- associated dementia; in addition, therapeutic GM-CSF elevates plasma viral load...