G Viberti

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint [The kidney as a target organ in diabetic patients with arterial hypertension]
    Giancarlo Viberti
    Département de Diabétologie, d Endocrinologie et de Médecine Interne, Ecole de Médecine GKT, Guy s Hospital, King s College, Londres, GB
    Drugs 63:31-7. 2003
  2. ncbi request reprint A Diabetes Outcome Progression Trial (ADOPT): baseline characteristics of Type 2 diabetic patients in North America and Europe
    G Viberti
    Unit for Metabolic Medicine, KCL Guy s Hospital, London, UK
    Diabet Med 23:1289-94. 2006
  3. ncbi request reprint Regression of albuminuria: latest evidence for a new approach
    Giancarlo Viberti
    Department of Diabetes, Endocrinology and Internal Medicine, Guy s, King s and St Thomas School of Medicine, 5th Floor, Thomas Guy House, King s College London Guy s Hospital, London SE1 9RT, UK
    J Hypertens Suppl 21:S24-8. 2003
  4. ncbi request reprint Thiazolidinediones-benefits on microvascular complications of type 2 diabetes
    Giancarlo Viberti
    Department of Endocrinology, Diabetes and Internal Medicine, Guy s, King s and St Thomas School of Medicine, King s College London, London, UK
    J Diabetes Complications 19:168-77. 2005
  5. ncbi request reprint Microalbuminuria reduction with valsartan in patients with type 2 diabetes mellitus: a blood pressure-independent effect
    Giancarlo Viberti
    Department of Diabetes, Endocrinology, and Internal Medicine, GKT School of Medicine, Guy s Hospital, King s College London, London, UK
    Circulation 106:672-8. 2002
  6. ncbi request reprint A diabetes outcome progression trial (ADOPT): an international multicenter study of the comparative efficacy of rosiglitazone, glyburide, and metformin in recently diagnosed type 2 diabetes
    Giancarlo Viberti
    Guy s, King s, and St Thomas School of Medicine, King s College, London, U K
    Diabetes Care 25:1737-43. 2002
  7. ncbi request reprint Microalbuminuria and coronary heart disease in NIDDM: an incidence study
    M B Mattock
    Department of Diabetes, United Medical and Dental Schools of Guy s and St Thomas Hospital, London, UK
    Diabetes 47:1786-92. 1998
  8. ncbi request reprint Targeting albumin excretion rate in the treatment of the hypertensive diabetic patient with renal disease
    Michael J Krimholtz
    Unit for Metabolic Medicine, Department of Diabetes Endocrinology and Internal Medicine, GKT School of Medicine, Kings College London, Guys Hospital, London, United Kingdom
    J Am Soc Nephrol 16:S42-7. 2005
  9. ncbi request reprint [The need for strict control of cardiovascular risk factors in type 2 diabetic patients]
    G Viberti
    Service de Diabetologie, Endocrinologie et Médecine interne, Ecole de Médecine Guy s, King s et Saint Thomas, Londres, GB
    Presse Med 31:S5-8. 2002
  10. ncbi request reprint Angiotensin converting enzyme inhibitors in diabetic patients with microalbuminuria or normoalbuminuria
    G Viberti
    Unit for Metabolic Medicine, UMDS, Guy s Hospital, London, England, United Kingdom
    Kidney Int Suppl 63:S32-5. 1997

Collaborators

Detail Information

Publications47

  1. ncbi request reprint [The kidney as a target organ in diabetic patients with arterial hypertension]
    Giancarlo Viberti
    Département de Diabétologie, d Endocrinologie et de Médecine Interne, Ecole de Médecine GKT, Guy s Hospital, King s College, Londres, GB
    Drugs 63:31-7. 2003
    ..In both type 1 and type 2 diabetes mellitus, the level of arterial hypertension closely correlates with the subsequent decline in glomerular filtration rate and with accelerated renal damage...
  2. ncbi request reprint A Diabetes Outcome Progression Trial (ADOPT): baseline characteristics of Type 2 diabetic patients in North America and Europe
    G Viberti
    Unit for Metabolic Medicine, KCL Guy s Hospital, London, UK
    Diabet Med 23:1289-94. 2006
    ..To examine baseline characteristics of patients recruited into ADOPT, a multinational trial comparing three oral glucose-lowering monotherapies...
  3. ncbi request reprint Regression of albuminuria: latest evidence for a new approach
    Giancarlo Viberti
    Department of Diabetes, Endocrinology and Internal Medicine, Guy s, King s and St Thomas School of Medicine, 5th Floor, Thomas Guy House, King s College London Guy s Hospital, London SE1 9RT, UK
    J Hypertens Suppl 21:S24-8. 2003
    ....
  4. ncbi request reprint Thiazolidinediones-benefits on microvascular complications of type 2 diabetes
    Giancarlo Viberti
    Department of Endocrinology, Diabetes and Internal Medicine, Guy s, King s and St Thomas School of Medicine, King s College London, London, UK
    J Diabetes Complications 19:168-77. 2005
    ..Reducing insulin resistance, therefore, has the potential to reduce both microvascular and macrovascular complications...
  5. ncbi request reprint Microalbuminuria reduction with valsartan in patients with type 2 diabetes mellitus: a blood pressure-independent effect
    Giancarlo Viberti
    Department of Diabetes, Endocrinology, and Internal Medicine, GKT School of Medicine, Guy s Hospital, King s College London, London, UK
    Circulation 106:672-8. 2002
    ..The MicroAlbuminuria Reduction With VALsartan (MARVAL) study was designed to evaluate the BP-independent effect of valsartan on UAER in type 2 diabetic patients with microalbuminuria...
  6. ncbi request reprint A diabetes outcome progression trial (ADOPT): an international multicenter study of the comparative efficacy of rosiglitazone, glyburide, and metformin in recently diagnosed type 2 diabetes
    Giancarlo Viberti
    Guy s, King s, and St Thomas School of Medicine, King s College, London, U K
    Diabetes Care 25:1737-43. 2002
    ....
  7. ncbi request reprint Microalbuminuria and coronary heart disease in NIDDM: an incidence study
    M B Mattock
    Department of Diabetes, United Medical and Dental Schools of Guy s and St Thomas Hospital, London, UK
    Diabetes 47:1786-92. 1998
    ..Preexisting CHD is also a risk factor for incident microalbuminuria in men, however, suggesting that microalbuminuria and CHD are not causally related but rather reflect common determinants...
  8. ncbi request reprint Targeting albumin excretion rate in the treatment of the hypertensive diabetic patient with renal disease
    Michael J Krimholtz
    Unit for Metabolic Medicine, Department of Diabetes Endocrinology and Internal Medicine, GKT School of Medicine, Kings College London, Guys Hospital, London, United Kingdom
    J Am Soc Nephrol 16:S42-7. 2005
    ..The fall in ACR was disproportionate to the fall of systemic BP and independent of it. The mechanism of the reduction in albuminuria seen with these agents in combination with an ACEI remains to be elucidated...
  9. ncbi request reprint [The need for strict control of cardiovascular risk factors in type 2 diabetic patients]
    G Viberti
    Service de Diabetologie, Endocrinologie et Médecine interne, Ecole de Médecine Guy s, King s et Saint Thomas, Londres, GB
    Presse Med 31:S5-8. 2002
    ..Regular screening for microalbuminuria and renal dysfunction (creatinine clearance) is also recommended, as well as more rigorous objectives for lipid levels...
  10. ncbi request reprint Angiotensin converting enzyme inhibitors in diabetic patients with microalbuminuria or normoalbuminuria
    G Viberti
    Unit for Metabolic Medicine, UMDS, Guy s Hospital, London, England, United Kingdom
    Kidney Int Suppl 63:S32-5. 1997
    ....
  11. ncbi request reprint Mechanical stretch induces monocyte chemoattractant activity via an NF-kappaB-dependent monocyte chemoattractant protein-1-mediated pathway in human mesangial cells: inhibition by rosiglitazone
    Gabriella Gruden
    Department of Diabetes and Endocrinology, Cardiovascular Division, King s College, London, UK
    J Am Soc Nephrol 16:688-96. 2005
    ..In conclusion, stretching of mesangial cells stimulates their monocyte chemoattractant activity via an NF-kappaB-mediated, MCP-1-dependent pathway, and this effect is prevented by rosiglitazone...
  12. ncbi request reprint Mechanical forces in diabetic kidney disease: a trigger for impaired glucose metabolism
    Luigi Gnudi
    Cardiovascular Division, King s College London, Guy s Hospital, London SE1 9RT, UK
    J Am Soc Nephrol 18:2226-32. 2007
    ..This mechanical and metabolic coupling suggests a novel pathophysiologic mechanism of injury in the kidney in diabetes and possibly other glomerular diseases...
  13. doi request reprint Proteinuria in diabetes: bystander or pathway to cardiorenal disease?
    Janaka Karalliedde
    Cardiovascular Division, King s College London School of Medicine, London, United Kingdom
    J Am Soc Nephrol 21:2020-7. 2010
    ..Albuminuria of any degree is unlikely to be causally related to diabetic cardiovascular disease, but its onset might be useful to identify those subjects at cardiovascular risk and to detect and treat other modifiable risk factors...
  14. ncbi request reprint GLUT-1 overexpression: Link between hemodynamic and metabolic factors in glomerular injury?
    Luigi Gnudi
    Department of Diabetes, Endocrinology, and Internal Medicine, King s College, 5th Floor, Thomas Guy House, Guy s Hospital, London SE1 9RT, UK
    Hypertension 42:19-24. 2003
    ..These studies suggest a novel link between hemodynamic and metabolic factors that may cooperate in inducing progressive glomerular injury in conditions characterized by glomerular hypertension...
  15. ncbi request reprint Aortic pulse wave velocity and albuminuria in patients with type 2 diabetes
    Andrew Smith
    Unit for Metabolic Medicine, 5th Floor, Department of Diabetes and Endocrinology, Cardiovascular Division, GKT School of Medicine, King s College London, Guy s Hospital, St Thomas Street, London SE1 9RT, UK
    J Am Soc Nephrol 16:1069-75. 2005
    ..The association of Ao-PWV with reduced GFR suggests that even modest renal dysfunction may affect the viscoelastic properties of large arteries...
  16. ncbi request reprint Effect of various diuretic treatments on rosiglitazone-induced fluid retention
    Janaka Karalliedde
    Unit for Metabolic Medicine, Department of Diabetes and Endocrinology, Cardiovascular Division, King s College London School of Medicine, Guy s Hospital, King s College London, London, London SE1 9RT, UK
    J Am Soc Nephrol 17:3482-90. 2006
    ....
  17. doi request reprint Valsartan improves arterial stiffness in type 2 diabetes independently of blood pressure lowering
    Janaka Karalliedde
    Cardiovascular Division, King s College London School of Medicine, United Kingdom
    Hypertension 51:1617-23. 2008
    ..These 2 effects, which appear independent of each other, may explain the specific cardio-renal protective properties of ARBs...
  18. ncbi request reprint Evidence for renoprotection by blockade of the renin-angiotensin-aldosterone system in hypertension and diabetes
    J Karalliedde
    Unit for Metabolic Medicine, Department of Diabetes, Endocrinology and Internal Medicine, Cardiovascular Division, King s College London School of Medicine, King s College London, London, UK
    J Hum Hypertens 20:239-53. 2006
    ..In this way, agents that block the RAAS should be considered the drugs of first choice as they provide enhanced renoprotection compared with other classes of antihypertensive agents such as calcium channel blockers and beta-blockers...
  19. ncbi request reprint The need for tighter control of cardiovascular risk factors in diabetic patients
    Giancarlo Viberti
    Unit for Metabolic Medicine, Guy s Hospital, Kings College London, London, UK
    J Hypertens Suppl 21:S3-6. 2003
    ..There is a clear need to translate the results of clinical trials into everyday clinical practice...
  20. ncbi request reprint Sex differences in age-related stiffening of the aorta in subjects with type 2 diabetes
    Lorenita De Angelis
    Department of Diabetes and Endocrinology, Guy s and St Thomas Hospital, Center for Cardiovascular Biology and Medicine, King s College, London, UK
    Hypertension 44:67-71. 2004
    ..The interaction of diabetic status with age and with sex was significant (P=0.01). Type 2 diabetes is associated with a greater age-related stiffening of the aorta in women compared with men, and this is not explained by hypertension...
  21. ncbi request reprint Vascular endothelial growth factor receptors in human mesangium in vitro and in glomerular disease
    S Thomas
    Department of Endocrinology, King s College London Guy s Hospital, London, United Kingdom
    J Am Soc Nephrol 11:1236-43. 2000
    ..In conclusion, flt-1, KDR, and neuropilin-1 are present on cultured HMC, and VEGF(165) induces HMC proliferation. In addition, the flt-1 and KDR receptors are expressed in the mesangium in mesangioproliferative disease...
  22. ncbi request reprint Direct regulation of insulin secretion by angiotensin II in human islets of Langerhans
    R D Ramracheya
    Beta Cell Development and Function Group, Division of Reproductive Health, Endocrinology and Development, King s College London, Room 2 9N Hodgkin Building Guy s Campus, London SE1 1UL, UK
    Diabetologia 49:321-31. 2006
    ..This study aimed to identify the expression of angiotensin II receptors in isolated human islets and beta cells and to examine the functional consequences of their activation...
  23. pmc Circulating vascular progenitor cells in patients with type 1 diabetes and microalbuminuria
    Cecile Dessapt
    Cardiovascular Division, King s College, London, UK
    Diabetes Care 33:875-7. 2010
    ..Patients with type 1 diabetes and microalbuminuria are at increased risk of cardiovascular disease (CVD). Abnormalities in vascular progenitor cells, which participate in vascular repair, may be implicated in this susceptibility...
  24. pmc Inducible overexpression of sFlt-1 in podocytes ameliorates glomerulopathy in diabetic mice
    Ching Hsin Ku
    Cardiovascular Division, King s College London School of Medicine, Guy s Hospital, King s College London, London, UK
    Diabetes 57:2824-33. 2008
    ....
  25. ncbi request reprint Hypertension and microalbuminuria: risk factors for cardiovascular disease in diabetes
    Janaka Karalliedde
    Department of Diabetes, Endocrinology and Internal Medicine, GKT School of Medicine, King s College London, 5th Floor Thomas Guy House, KCL Guy s Hospital Campus, London SE1 9RT, UK
    Curr Hypertens Rep 7:1-2. 2005
  26. ncbi request reprint IGF-I induces vascular endothelial growth factor in human mesangial cells via a Src-dependent mechanism
    Gabriella Gruden
    Department of Diabetes and Endocrinology, GKT School of Medicine, King s College London, London, England, United Kingdom
    Kidney Int 63:1249-55. 2003
    ..Furthermore, we studied the intracellular signaling pathway involved and the interaction of IGF-I with mechanical stretch, a known VEGF inducer...
  27. doi request reprint Mechanical forces and TGFbeta1 reduce podocyte adhesion through alpha3beta1 integrin downregulation
    Cecile Dessapt
    King s College London, UK
    Nephrol Dial Transplant 24:2645-55. 2009
    ..This study investigated the role of mechanical forces and transforming growth factor beta1 (TGFbeta1) in podocyte adhesion and integrin expression...
  28. ncbi request reprint Podocyte-specific expression of angiopoietin-2 causes proteinuria and apoptosis of glomerular endothelia
    Belinda Davis
    Cardiovascular Division, King s College London School of Medicine, Guy s Hospital, London SE1 9RT, UK
    J Am Soc Nephrol 18:2320-9. 2007
    ....
  29. ncbi request reprint Microalbuminuria and cardiovascular risk
    Janaka Karalliedde
    Department of Diabetes, Endocrinology and Internal Medicine, Guy s, King s and St Thomas GKT School of Medicine, King s College London, London, United Kingdom
    Am J Hypertens 17:986-93. 2004
    ..These drugs have successfully halted or delayed the progression to nephropathy and have reversed elevated rates of albumin excretion to normal values, even when blood pressure reduction has been minimal...
  30. ncbi request reprint HDL composition predicts new-onset cardiovascular disease in patients with type 1 diabetes
    Per Henrik Groop
    Folkhalsan Research Center, Biomedicum Helsinki, P O Box 63, FIN 00014 University of Helsinki, Finland
    Diabetes Care 30:2706-7. 2007
  31. ncbi request reprint Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy
    Steven E Kahn
    Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle 98108, USA
    N Engl J Med 355:2427-43. 2006
    ..The efficacy of thiazolidinediones, as compared with other oral glucose-lowering medications, in maintaining long-term glycemic control in type 2 diabetes is not known...
  32. doi request reprint Rosiglitazone-associated fractures in type 2 diabetes: an Analysis from A Diabetes Outcome Progression Trial (ADOPT)
    Steven E Kahn
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, Washington 98108, USA
    Diabetes Care 31:845-51. 2008
    ..The purpose of this study was to examine possible factors associated with the increased risk of fractures observed with rosiglitazone in A Diabetes Outcome Progression Trial (ADOPT)...
  33. ncbi request reprint Albuminuria response to very high-dose valsartan in type 2 diabetes mellitus
    Norman K Hollenberg
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Hypertens 25:1921-6. 2007
    ..We aimed to investigate whether high doses of valsartan, an angiotensin receptor blocker, are superior to conventional doses to reduce urinary albumin excretion rates (UAER) in such patients...
  34. ncbi request reprint The link between mechanical stretch and glucose metabolism--a conceptual advance in understanding diabetic (and non diabetic?) renal disease
    Luigi Gnudi
    Nephrol Dial Transplant 22:318-21. 2007
  35. ncbi request reprint Does microalbuminuria predict diabetic nephropathy?
    Han Henrik Parving
    Steno Diabetes Center, Niels Steensensvej 2, DK 2820 Gentofte, Denmark
    Diabetes Care 25:406-7. 2002
  36. ncbi request reprint Serum lipids and the progression of nephropathy in type 1 diabetes
    Merlin C Thomas
    The Baker Heart Research Institute, Melbourne, Australia
    Diabetes Care 29:317-22. 2006
    ..However, different lipid variables may be important at different stages of nephropathy. This study examines the pattern of dyslipidemia associated with the progression of nephropathy in patients with type 1 diabetes...
  37. ncbi request reprint Determinants of response to insulin therapy following failure of oral agents in type 2 diabetes
    Janaka Karalliedde
    Diabetes Care 28:2589-90. 2005
  38. ncbi request reprint The role of PC-1 and ACE genes in diabetic nephropathy in type 1 diabetic patients: evidence for a polygenic control of kidney disease progression
    Salvatore De Cosmo
    Unit of Endocrinology, Scientific Institute Casa Sollievo della Sofferenza San Giovanni Rotondo FG, Italy
    Nephrol Dial Transplant 17:1402-7. 2002
    ..We investigated here whether the combination of the ACE DD genotype and the PC-1 Q121 variant predicts the development and/or progression of DN in type 1 diabetic patients...
  39. ncbi request reprint Impaired glucose tolerance in obese children and adolescents
    Cecilia Invitti
    N Engl J Med 347:290-2; author reply 290-2. 2002
  40. ncbi request reprint Podocyte number in normotensive type 1 diabetic patients with albuminuria
    Kathryn E White
    Department of Medicine, Medical School, University of Newcastle upon Tyne, UK
    Diabetes 51:3083-9. 2002
    ..Longitudinal data provide evidence for an association between podocyte loss and AER, but whether cellular changes are a response to, a cause of, or concomitant with the progression of nephropathy remains uncertain...
  41. ncbi request reprint Atherosclerosis in type 2 diabetes mellitus and insulin resistance: mechanistic links and therapeutic targets
    Jorge Plutzky
    Department of Cardiovascular Medicine, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    J Diabetes Complications 16:401-15. 2002
    ....
  42. ncbi request reprint Effect of low-dose perindopril/indapamide on albuminuria in diabetes: preterax in albuminuria regression: PREMIER
    Carl Erik Mogensen
    Medical Department M, Aarhus Komunehospital, Aarhus University Hospital, 8000 Aarhus, Denmark
    Hypertension 41:1063-71. 2003
    ..A BP-independent effect of the combination may increase renal protection...
  43. ncbi request reprint Prevalence and concomitants of glucose intolerance in European obese children and adolescents
    Cecilia Invitti
    Department of Metabolic Diseases and Diabetes, Istituto Auxologico Italiano, Milan, Italy
    Diabetes Care 26:118-24. 2003
    ..The prevalence of glucose intolerance and its determinants and the relation of cardiovascular risk factors with levels of glycemia and degree of obesity were studied in grossly obese children of European origin...
  44. ncbi request reprint Screening for chronic kidney disease in patients with diabetes: are we missing the point?
    Merlin C Thomas
    Diabetes and Metabolic Division, Baker Heart Research Institute, Melbourne, Victoria, Australia
    Nat Clin Pract Nephrol 4:2-3. 2008
  45. ncbi request reprint Accurate measurement of albuminuria at reduced cost
    Mike Krimholtz
    Nephrol Dial Transplant 19:1934-5. 2004
  46. ncbi request reprint Obesity and the metabolic syndrome in children and adolescents
    Cecilia Invitti
    N Engl J Med 351:1146-8; author reply 1146-8. 2004
  47. ncbi request reprint Period prevalence of abnormal glucose tolerance and cardiovascular risk factors among obese children attending an obesity centre in Italy
    Cecilia Invitti
    Department of Metabolic Diseases and Diabetes, Istituto Auxologico Italiano, Via Ariosto 13, 20145 Milan, Italy
    Nutr Metab Cardiovasc Dis 16:256-62. 2006
    ..The aim of this study was to examine the prevalence of glucose intolerance and other cardiovascular risk factors in obese children over a 24-year period...