Research Topics
Genomes and Genes
| Ana M ValdesSummaryAffiliation: King's College London Country: UK Publications
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Detail Information
Publications
Telomere length in leukocytes correlates with bone mineral density and is shorter in women with osteoporosisA M Valdes
Twin Research and Genetic Epidemiology Unit, King s College London, St Thomas Hospital Campus, London, SE1 7EH, UK
Osteoporos Int 18:1203-10. 2007..Clinical osteoporosis was associated with shorter telomeres, suggesting that telomere length can be used as a marker of bone aging...
Genetic contribution to radiographic severity in osteoarthritis of the kneeAna M Valdes
Correspondence to Dr Ana M Valdes, Kings College London, Twin Research Unit, St Thomas Hospital, Lambeth Palace Rd, London SE1 7EH, UK
Ann Rheum Dis 71:1537-40. 2012..The authors have assessed the role of three variants reported to influence risk of knee OA with p<5×10-8 in determining patellofemoral and tibiofemoral Kellgren Lawrence (K/L) grade in knee OA cases...- Use of class I and class II HLA loci for predicting age at onset of type 1 diabetes in multiple populationsA M Valdes
Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London SE1 7EH, UK
Diabetologia 55:2394-401. 2012..The study aimed to assess, in multiple populations, the role of HLA alleles on early and late age at onset of type 1 diabetes... 
Inverse relationship between preoperative radiographic severity and postoperative pain in patients with osteoarthritis who have undergone total joint arthroplastyAna M Valdes
Department of Twin Research, King s College London, St Thomas Hospital, London, UK
Semin Arthritis Rheum 41:568-75. 2012..To determine cross-sectionally the influence of risk factors on chronic pain following total joint replacement (TJR) of the knee (TKR) or the hip (THR)...- Improved weight management using genetic information to personalize a calorie controlled dietIoannis Arkadianos
Sciona Inc, Boulder, 80302, Colorado, USA
Nutr J 6:29. 2007..This study investigated whether the inclusion of genetic information to personalize a patient's diet (nutrigenetics) could improve long term weight management... - Conditional genotype analysis: detecting secondary disease loci in linkage disequilibrium with a primary disease locusGlenys Thomson
Department of Integrative Biology, University of California, 3060 VLSB MC 3140, Berkeley, California 94720, USA
BMC Proc 1:S163. 2007..12 cM from DR, rare allele increases RA risk five-fold). No false negatives were found. Power calculations were performed... - Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysisHanneke J M Kerkhof
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
BMC Med Genet 11:164. 2010..The objective of this study was to examine the relationship between common genetic variation of the ESR2 gene and osteoarthritis... - Association of the DVWA and GDF5 polymorphisms with osteoarthritis in UK populationsA M Valdes
Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London SE1 7EH, UK
Ann Rheum Dis 68:1916-20. 2009..Variants in the growth differentiation factor 5 (GDF5) and in the double von Willebrand factor A (DVWA) have recently been reported to be associated with osteoarthritis (OA) in Asian populations... - Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritisAna M Valdes
Twin Research Unit, St Thomas Hospital Campus, Kings College London School of Medicine, London SE1 7EH, UK
Am J Hum Genet 82:1231-40. 2008..Our results and previous studies on the role of the cyclooxygenase 2 enzyme encoded by PTGS2 underscore the importance of this signaling pathway in the pathogenesis of knee OA... - The contribution of genes to osteoarthritisAna M Valdes
Twin Research and Genetic Epidemiology Unit, St Thomas Hospital Campus, Kings College London School of Medicine, London SE1 7EH, UK
Rheum Dis Clin North Am 34:581-603. 2008..The authors discuss the impact that future genome-wide association scans can have on our understanding of the pathogenesis of OA and on identifying individuals at high risk for developing severe OA... - Leukocyte telomere length is associated with cognitive performance in healthy womenA M Valdes
Twin Research and Genetic Epidemiology Unit, Kings College London, School of Medicine, St Thomas Hospital, London, UK
Neurobiol Aging 31:986-92. 2010..Age-related cognitive decline begins in mid-life and continues with advancing age. Leukocyte telomere length (LTL) shortens with age, and inflammation and oxidative stress enhance this process. Shorter LTL is associated with dementia... - The contribution of genes to osteoarthritisAna M Valdes
Twin Research and Genetic Epidemiology Unit, St Thomas Hospital Campus, Kings College, London School of Medicine, London SE1 7EH, UK
Med Clin North Am 93:45-66, x. 2009..This article discusses the impact that future genome-wide association scans can have on our understanding of the pathogenesis of OA and on identifying individuals at high risk for developing severe OA... - Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1A M Valdes
Twin Research Unit, King s College London, St Thomas Hospital, London, UK
Diabetes Obes Metab 11:46-52. 2009..The aim of this study was to assess if markers in the class III Major Histocompatibility Complex (MHC) region are associated with T1D after accounting for linkage disequilibrium (LD) with DRB1-DQB1... - Variation at the ANP32A gene is associated with risk of hip osteoarthritis in womenAna M Valdes
Kings College London, London, UK
Arthritis Rheum 60:2046-54. 2009..We undertook this study to test whether genetic variation at ANP32A was associated with osteoarthritis (OA) in women... - Genetic variation within the HLA class III influences T1D susceptibility conferred by high-risk HLA haplotypesA M Valdes
King s College London, Department of Twin Research and Genetic Epidemiology, UK
Genes Immun 11:209-18. 2010..82) with each other, but a joint analysis showed that the association for each SNP was not solely because of LD. Our data support a role for more than one locus in the class III region contributing to risk of T1D... - Large scale replication study of the association between HLA class II/BTNL2 variants and osteoarthritis of the knee in European-descent populationsAna M Valdes
Department of Twin Research and Genetic Epidemiology, King s College London, London, United Kingdom
PLoS ONE 6:e23371. 2011..07). The rs10947262 and rs7775228 variants are not associated with risk of knee OA in European descent populations and they do not appear tag the same HLA class II haplotype as they do in Japanese individuals... - The clinical relevance of genetic susceptibility to osteoarthritisAna M Valdes
Department of Twin Research, St Thomas Hospital Campus, Kings College London School of Medicine, Westminster Bridge Road, London SE1 7EH, UK
Best Pract Res Clin Rheumatol 24:3-14. 2010.... - A meta-analysis of interleukin-6 promoter polymorphisms on risk of hip and knee osteoarthritisA M Valdes
Department of Twin Research, St Thomas Hospital Campus, Kings College London School of Medicine London, UK
Osteoarthritis Cartilage 18:699-704. 2010..We investigated the role of two single nucleotide polymorphisms (SNPs) mapping to the promoter of the IL-6 gene on genetic susceptibility to hip and knee OA... - Involvement of different risk factors in clinically severe large joint osteoarthritis according to the presence of hand interphalangeal nodesAna M Valdes
Department of Twin Research and Genetic Epidemiology, King s College London and St Thomas Hospital, London, UK
Arthritis Rheum 62:2688-95. 2010.... - Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritisAna M Valdes
Department of Twin Research and Genetic Epidemiology, St Thomas Hospital Campus, King s College London, London SE1 7EH, UK
Arthritis Rheum 62:2347-52. 2010..We undertook this study to investigate the role of genetic variation in SMAD3 in the risk of large-joint OA in humans... - Role of the Nav1.7 R1150W amino acid change in susceptibility to symptomatic knee osteoarthritis and multiple regional painAna M Valdes
St Thomas Hospital, King s College London, UK
Arthritis Care Res (Hoboken) 63:440-4. 2011..To assess the genetic association of pain in patients with knee osteoarthritis (OA) and those with multiple regional pain with the R1150W variant in the α-subunit of the voltage-gated sodium channel Na(V)1.7... - Genetic epidemiology of hip and knee osteoarthritisAna M Valdes
Department of Twin Research and Genetic Epidemiology, St Thomas Hospital, Kings College London School of Medicine, London SE1 7EH, UK
Nat Rev Rheumatol 7:23-32. 2011.... - The genetic epidemiology of osteoarthritisAna M Valdes
Department of Twin Research and Genetic Epidemiology, St Thomas Hospital Campus, Kings College London School of Medicine, London, UK
Curr Opin Rheumatol 22:139-43. 2010..The scope of the present article is to offer an overview of recent developments in the genetic epidemiology of knee and hip osteoarthritis, with particular emphasis on published genomewide association studies (GWAS)... - The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritisAna M Valdes
Department of Twin Research, King s College London, St Thomas Hospital, London, UK
Ann Rheum Dis 70:1556-61. 2011..To assess if a coding variant in the gene encoding transient receptor potential cation channel, subfamily V, member 1 (TRPV1) is associated with genetic risk of painful knee osteoarthritis (OA)... - Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and womenAna M Valdes
St Thomas Hospital, London, UK
Arthritis Rheum 54:533-9. 2006.... - Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the kneeAna M Valdes
St Thomas Hospital, and King s College London, London, UK
Arthritis Rheum 56:137-46. 2007..To assess whether the association of genetic polymorphisms with osteoarthritis (OA) in other populations could be replicated in a large, multicenter, mixed-sex, case-control study of clinical knee OA... - Association between a variation in LRCH1 and knee osteoarthritis: a genome-wide single-nucleotide polymorphism association study using DNA poolingTim D Spector
Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
Arthritis Rheum 54:524-32. 2006..To perform a large-scale association analysis of single-nucleotide polymorphisms (SNPs) in patients with radiographically defined osteoarthritis (OA) of the knee... - Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in womenJ Brent Richards
Twin Research and Genetic Epidemiology, St Thomas Hospital, King s College, London School of Medicine, London, United Kingdom
Am J Clin Nutr 86:1420-5. 2007..Leukocyte telomere length (LTL) is a predictor of aging-related disease and decreases with each cell cycle and increased inflammation... - Nevus size and number are associated with telomere length and represent potential markers of a decreased senescence in vivoVeronique Bataille
Twin Research and Genetic Epidemiology Unit, King s College London, St Thomas Hospital Campus, London SE1 7EH, United Kingdom
Cancer Epidemiol Biomarkers Prev 16:1499-502. 2007..Understanding mechanisms influencing the induction and involution of nevi will not only help in understanding the pathophysiology of melanoma but should also shed light on the complex relationship between aging and cancer... - A twin study of mitochondrial DNA polymorphisms shows that heteroplasmy at multiple sites is associated with mtDNA variant 16093 but not with zygosityToby Andrew
Department of Twin Research and Genetic Epidemiology, King s College London, London, United Kingdom
PLoS ONE 6:e22332. 2011..5×10(-14)) and also at VRII (p = 2×10(-4)) suggesting a possible predisposing role for this site in the accumulation of heteroplasmy. Our data indicate that BMI is potentially associated with control region heteroplasmy... - Radiographic progression of lumbar spine disc degeneration is influenced by variation at inflammatory genes: a candidate SNP association study in the Chingford cohortAna M Valdes
Twin Research and Genetic Epidemiology Unit, St. Thomas Hospital, London, UK
Spine 30:2445-51. 2005..CONCLUSIONS: Our results suggest a role for genes regulating inflammatory pathways in the radiographic progression of spine degeneration. This could prove a fruitful area for future therapeutics for the spine and other joints... - Association study of candidate genes for the prevalence and progression of knee osteoarthritisAna M Valdes
St Thomas Hospital, London, UK
Arthritis Rheum 50:2497-507. 2004..We examined the role of 26 single-nucleotide polymorphisms (SNPs) from 24 candidate genes in OA susceptibility and progression... - Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association studyJ B Richards
Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
Lancet 371:1505-12. 2008..Osteoporosis is diagnosed by the measurement of bone mineral density, which is a highly heritable and multifactorial trait. We aimed to identify genetic loci that are associated with bone mineral density... - Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22Evangelos Evangelou
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
Ann Rheum Dis 70:349-55. 2011..It is characterised by changes in joint structure, including degeneration of the articular cartilage, and its aetiology is multifactorial with a strong postulated genetic component... - GDF5 single-nucleotide polymorphism rs143383 is associated with lumbar disc degeneration in Northern European womenF M K Williams
Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
Arthritis Rheum 63:708-12. 2011..In vitro, the gene product growth differentiation factor 5 has been shown to promote growth and repair of animal disc. This study was undertaken to investigate whether the GDF5 gene plays a role in LDD... - The additive effect of individual genes in predicting risk of knee osteoarthritisA M Valdes
Twin Research Unit, St Thomas Hospital Campus, Kings College London, Lambeth Palace Road, London SE1 7EH, UK
Ann Rheum Dis 67:124-7. 2008..We aimed to answer whether carrying several genetic variants associated with knee OA could result in a greater risk of OA... - The effects of social status on biological aging as measured by white-blood-cell telomere lengthL F Cherkas
Twin Research and Genetic Epidemiology Unit, St Thomas' Hospital, London, UK, and The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103-2714, USA
Aging Cell 5:361-5. 2006..Comparison of TRFL in the 17 most discordant SES twin pairs confirmed this difference. Low SES, in addition to the harmful effects of smoking, obesity and lack of exercise, appears to have an impact on telomere length... - A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortiumG Zhai
Department of Twin Research and Genetic Epidemiology, King s College London, UK
J Med Genet 46:614-6. 2009..01), suggesting the potential mechanism of the gene in hand OA might be via effects on subchondral bone. The authors' findings provide a potential new insight into genetic mechanisms in the development of hand OA... - Natural history and risk factors for bone loss in postmenopausal Caucasian women: a 15-year follow-up population-based studyG Zhai
Twin Research and Genetic Epidemiology Unit, King s College London School of Medicine, St Thomas Hospital Campus, Lambeth Palace Road, London SE1 7EH, UK
Osteoporos Int 19:1211-7. 2008..67% per year, but quadratic for lumbar spine (LS) at a rate of 3.12% initially, and slowing down with age. We also confirmed the protective role of HRT, increasing weight, and lean mass in long-term bone loss... - Reduction of leucocyte telomere length in radiographic hand osteoarthritis: a population-based studyG Zhai
Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
Ann Rheum Dis 65:1444-8. 2006..Although age is the strongest predictor of osteoarthritis, the exact mechanism underlying this disorder remains elusive... - Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairsToby Andrew
Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London SE1 7EH, United Kingdom
Am J Hum Genet 78:480-6. 2006..9) at 14q23.2, and suggestive linkage at 10q26.13 (LOD 2.4) and 3p26.1 (LOD 2.7). This is the first report of loci, mapped in a sample of healthy individuals, that influence mean telomere variation in humans... - The interaction of genes and smoking on forced expiratory volume: a classic twin studyGuangju Zhai
Twin Research and Genetic Epidemiology Unit, King s College London School of Medicine, St Thomas Hospital Campus, Lambeth Palace Rd, London SE1 7EH, UK
Chest 132:1772-7. 2007..The aims of this study were to estimate heritability of the ratio of measured FEV1 (mFEV1) to expected FEV(1) (eFEV1) in a white population, and to examine the interaction between genetic factors and smoking on this ratio... - A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere lengthM Mangino
Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
J Med Genet 46:451-4. 2009..Telomere length is a predictor for a number of common age related diseases and is a heritable trait... - Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humansMassimo Mangino
Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
Hum Mol Genet 21:5385-94. 2012..Overall, our results provide novel insights into the genetic architecture of inter-individual LTL variation in the general population... - Homocysteine levels and leukocyte telomere lengthJ B Richards
Centre for Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, King s College London School of Medicine, London, UK
Atherosclerosis 200:271-7. 2008..As leukocyte telomere length (LTL) registers the cumulative oxidative stress and inflammation, we examined the relationship between homocysteine and LTL... - Cohort Profile: TwinsUK and healthy ageing twin studyAlireza Moayyeri
Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, UK
Int J Epidemiol 42:76-85. 2013..Several collaborative projects in the field of epidemiology of complex disorders are ongoing in our cohort and interested researchers are encouraged to get in contact for future collaborations... - Serum adiponectin and bone mineral density in womenJ B Richards
Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London SE1 7EH, and University of Cambridge, United Kingdom
J Clin Endocrinol Metab 92:1517-23. 2007..Bone mineral density (BMD) is positively associated with body weight. This association persists even at non-load bearing sites, suggesting that a nonmechanical factor such as an adipocyte-derived hormone may modulate BMD... - Obesity, cigarette smoking, and telomere length in womenA M Valdes
Twin Research and Genetic Epidemiology Unit, St Thomas' Hospital, London, UK
Lancet 366:662-4. 2005..017), and each pack-year smoked was equivalent to an additional 5 bp of telomere length lost (18%) compared with the rate in the overall cohort. Our results emphasise the pro-ageing effects of obesity and cigarette smoking... - Human leukocyte antigen class I B and C loci contribute to Type 1 Diabetes (T1D) susceptibility and age at T1D onsetAna M Valdes
Children's Hospital Oakland Research Institute, Oakland, CA 94609, USA
Hum Immunol 66:301-13. 2005..5 years, p < 0.001; and 7.8 years, p < 0.002, respectively). These data support a role for HLA class I alleles in susceptibility to and age at onset of T1D... - Association and interaction of the IL4R, IL4, and IL13 loci with type 1 diabetes among FilipinosTeodorica L Bugawan
Roche Molecular Systems, Alameda, CA 94501, USA
Am J Hum Genet 72:1505-14. 2003..Our data suggest that the risk for T1D is determined, in part, by polymorphisms within the IL4R locus, including promoter and coding-sequence variants, and by specific combinations of genotypes at the IL4R and the IL4 and IL13 loci... - Miniaturized sealed-tube allele-specific PCRJ Ross Hawkins
Incyte Genomics Ltd, Cambridge, UK
Hum Mutat 19:543-53. 2002..By virtue of its simplicity, the method is versatile and cost-effective with potential for use in industrial-scale genetic studies or in the clinical diagnostic setting... - The HLA class I A locus affects susceptibility to type 1 diabetesJanelle A Noble
Children s Hospital, Oakland Research Institute, Oakland, CA 94609, USA
Hum Immunol 63:657-64. 2002..Our results suggest an important role for class I antigens in modulating susceptibility to type 1 diabetes... - Searching for additional disease loci in a genomic regionGlenys Thomson
Department of Integrative Biology, University of California, Berkeley, CA 94720, USA
Adv Genet 60:253-92. 2008..We recommend a multistrategy approach using a variety of complementary methods described below... - Type 1 diabetes risk for human leukocyte antigen (HLA)-DR3 haplotypes depends on genotypic context: association of DPB1 and HLA class I loci among DR3- and DR4-matched Italian patients and controlsJanelle A Noble
Childrens Hospital Oakland Research Institute, Oakland, CA, USA
Hum Immunol 69:291-300. 2008..These data indicate that T1D risk conferred by the 8.1 haplotype is genotype dependent... - Human telomere biology: pitfalls of moving from the laboratory to epidemiologyAbraham Aviv
The Center of Human Development and Aging of New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
Int J Epidemiol 35:1424-9. 2006..Here we explain some of the reasons for this variability and propose several principles that should be considered in conducting epidemiological telomere research. Ignoring these principles could lead to misleading conclusions... - Linkage disequilibrium with predisposing DR3 haplotypes accounts for apparent effects of tumor necrosis factor and lymphotoxin-alpha polymorphisms on type 1 diabetes susceptibilityJanelle A Noble
Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
Hum Immunol 67:999-1004. 2006..Thus, variation at TNF does not affect the T1D risk for B18-DR3 haplotypes, and the apparent association of TNF(-238)A with T1D may simply reflect its presence on a high-risk haplotype... - Gene-gene interactions between CYP2B6 and CYP2A6 in nicotine metabolismHuijun Z Ring
Center for Health Sciences, SRI International, Menlo Park, CA, USA
Pharmacogenet Genomics 17:1007-15. 2007..We investigated the influence of genetic variation in another potential nicotine-metabolizing enzyme, CYP2B6, and its interaction with CYP2A6, on the metabolism of nicotine... - Val64Ile polymorphism in the C-C chemokine receptor 2 is associated with reduced coronary artery calcificationAna M Valdes
GlaxoSmithKline, Stevenage, Hertfordshire, UK
Arterioscler Thromb Vasc Biol 22:1924-8. 2002..A common polymorphism in the human CCR2 gene resulting in a substitution of isoleucine for valine (Val64Ile) has been associated with other disease phenotypes in humans... - Association of the single nucleotide polymorphism C1858T of the PTPN22 gene with type 1 diabetesMartha B Ladner
Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
Hum Immunol 66:60-4. 2005..These results are consistent with the hypothesis that individuals lacking the C allele of PTPN22 may have reduced capacity to downregulate T-cell responses and may therefore be more susceptible to autoimmunity... - Influence of apoA-V gene variants on postprandial triglyceride metabolism: impact of genderEstibaliz Olano-Martin
Hugh Sinclair Human Nutrition Group, School of Chemistry, Food Biosciences, and Pharmacy, University of Reading, Reading RG6 6AP, United Kingdom
J Lipid Res 49:945-53. 2008..015). However, in linear regression analysis, a significant independent association with TG AUC (P = 0.007) was only evident for the apoA-V -1131 T>C SNP, indicating a greater relative importance of the apoA-V genotype... - A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetesJanelle A Noble
Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
Diabetes 52:1579-82. 2003..04). These data also suggest that TCF7 C883A may affect age of disease onset. Analysis of genotype data from surrounding SNPs suggests that this TCF7 polymorphism may itself represent a risk factor for type 1 diabetes... - When is a replication not a replication? Or how to spot a good genetic association studyTim D Spector
Arthritis Rheum 54:1051-4. 2006 - DPB1 alleles are associated with type 1 diabetes susceptibility in multiple ethnic groupsThomas D Cruz
Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
Diabetes 53:2158-63. 2004..This supports the concept that multiple genes in the HLA region can affect type 1 diabetes susceptibility...