Ana M Valdes

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint Telomere length in leukocytes correlates with bone mineral density and is shorter in women with osteoporosis
    A M Valdes
    Twin Research and Genetic Epidemiology Unit, King s College London, St Thomas Hospital Campus, London, SE1 7EH, UK
    Osteoporos Int 18:1203-10. 2007
  2. pmc Improved weight management using genetic information to personalize a calorie controlled diet
    Ioannis Arkadianos
    Sciona Inc, Boulder, 80302, Colorado, USA
    Nutr J 6:29. 2007
  3. ncbi request reprint Large scale meta-analysis of urinary C-terminal telopeptide, serum cartilage oligomeric protein and matrix metalloprotease degraded type II collagen and their role in prevalence, incidence and progression of osteoarthritis
    A M Valdes
    Academic Rheumatology, University of Nottingham, Clinical Sciences Bld, Nottingham City Hospital, Nottingham NG5 1PB, UK Dept of Twin Research, King s College London, London SE1 7EH, UK Electronic address
    Osteoarthritis Cartilage 22:683-9. 2014
  4. pmc A twin study of mitochondrial DNA polymorphisms shows that heteroplasmy at multiple sites is associated with mtDNA variant 16093 but not with zygosity
    Toby Andrew
    Department of Twin Research and Genetic Epidemiology, King s College London, London, United Kingdom
    PLoS ONE 6:e22332. 2011
  5. pmc The genetic contribution to severe post-traumatic osteoarthritis
    Ana M Valdes
    Academic Rheumatology, Nottingham City Hospital, Nottingham, UK
    Ann Rheum Dis 72:1687-90. 2013
  6. pmc Genetic contribution to radiographic severity in osteoarthritis of the knee
    Ana M Valdes
    Correspondence to Dr Ana M Valdes, Kings College London, Twin Research Unit, St Thomas Hospital, Lambeth Palace Rd, London SE1 7EH, UK
    Ann Rheum Dis 71:1537-40. 2012
  7. pmc Use of class I and class II HLA loci for predicting age at onset of type 1 diabetes in multiple populations
    A M Valdes
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London SE1 7EH, UK
    Diabetologia 55:2394-401. 2012
  8. doi request reprint Inverse relationship between preoperative radiographic severity and postoperative pain in patients with osteoarthritis who have undergone total joint arthroplasty
    Ana M Valdes
    Department of Twin Research, King s College London, St Thomas Hospital, London, UK
    Semin Arthritis Rheum 41:568-75. 2012
  9. pmc Conditional genotype analysis: detecting secondary disease loci in linkage disequilibrium with a primary disease locus
    Glenys Thomson
    Department of Integrative Biology, University of California, 3060 VLSB MC 3140, Berkeley, California 94720, USA
    BMC Proc 1:S163. 2007
  10. pmc Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis
    Hanneke J M Kerkhof
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Med Genet 11:164. 2010

Collaborators

Detail Information

Publications71

  1. ncbi request reprint Telomere length in leukocytes correlates with bone mineral density and is shorter in women with osteoporosis
    A M Valdes
    Twin Research and Genetic Epidemiology Unit, King s College London, St Thomas Hospital Campus, London, SE1 7EH, UK
    Osteoporos Int 18:1203-10. 2007
    ..Clinical osteoporosis was associated with shorter telomeres, suggesting that telomere length can be used as a marker of bone aging...
  2. pmc Improved weight management using genetic information to personalize a calorie controlled diet
    Ioannis Arkadianos
    Sciona Inc, Boulder, 80302, Colorado, USA
    Nutr J 6:29. 2007
    ..This study investigated whether the inclusion of genetic information to personalize a patient's diet (nutrigenetics) could improve long term weight management...
  3. ncbi request reprint Large scale meta-analysis of urinary C-terminal telopeptide, serum cartilage oligomeric protein and matrix metalloprotease degraded type II collagen and their role in prevalence, incidence and progression of osteoarthritis
    A M Valdes
    Academic Rheumatology, University of Nottingham, Clinical Sciences Bld, Nottingham City Hospital, Nottingham NG5 1PB, UK Dept of Twin Research, King s College London, London SE1 7EH, UK Electronic address
    Osteoarthritis Cartilage 22:683-9. 2014
    ..To evaluate the role of three cartilage-derived biomarkers on osteoarthritis (OA): urinary C-terminal telopeptide (uCTX-II), serum cartilage oligomeric protein (sCOMP), and serum MMP degraded type II collagen (sC2M)...
  4. pmc A twin study of mitochondrial DNA polymorphisms shows that heteroplasmy at multiple sites is associated with mtDNA variant 16093 but not with zygosity
    Toby Andrew
    Department of Twin Research and Genetic Epidemiology, King s College London, London, United Kingdom
    PLoS ONE 6:e22332. 2011
    ..5×10(-14)) and also at VRII (p = 2×10(-4)) suggesting a possible predisposing role for this site in the accumulation of heteroplasmy. Our data indicate that BMI is potentially associated with control region heteroplasmy...
  5. pmc The genetic contribution to severe post-traumatic osteoarthritis
    Ana M Valdes
    Academic Rheumatology, Nottingham City Hospital, Nottingham, UK
    Ann Rheum Dis 72:1687-90. 2013
    ..to compare the combined role of genetic variants loci associated with risk of knee or hip osteoarthritis (OA) in post-traumatic (PT) and non-traumatic (NT) cases of clinically severe OA leading to total joint replacement...
  6. pmc Genetic contribution to radiographic severity in osteoarthritis of the knee
    Ana M Valdes
    Correspondence to Dr Ana M Valdes, Kings College London, Twin Research Unit, St Thomas Hospital, Lambeth Palace Rd, London SE1 7EH, UK
    Ann Rheum Dis 71:1537-40. 2012
    ..The authors have assessed the role of three variants reported to influence risk of knee OA with p<5×10-8 in determining patellofemoral and tibiofemoral Kellgren Lawrence (K/L) grade in knee OA cases...
  7. pmc Use of class I and class II HLA loci for predicting age at onset of type 1 diabetes in multiple populations
    A M Valdes
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London SE1 7EH, UK
    Diabetologia 55:2394-401. 2012
    ..The study aimed to assess, in multiple populations, the role of HLA alleles on early and late age at onset of type 1 diabetes...
  8. doi request reprint Inverse relationship between preoperative radiographic severity and postoperative pain in patients with osteoarthritis who have undergone total joint arthroplasty
    Ana M Valdes
    Department of Twin Research, King s College London, St Thomas Hospital, London, UK
    Semin Arthritis Rheum 41:568-75. 2012
    ..To determine cross-sectionally the influence of risk factors on chronic pain following total joint replacement (TJR) of the knee (TKR) or the hip (THR)...
  9. pmc Conditional genotype analysis: detecting secondary disease loci in linkage disequilibrium with a primary disease locus
    Glenys Thomson
    Department of Integrative Biology, University of California, 3060 VLSB MC 3140, Berkeley, California 94720, USA
    BMC Proc 1:S163. 2007
    ..12 cM from DR, rare allele increases RA risk five-fold). No false negatives were found. Power calculations were performed...
  10. pmc Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis
    Hanneke J M Kerkhof
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Med Genet 11:164. 2010
    ..The objective of this study was to examine the relationship between common genetic variation of the ESR2 gene and osteoarthritis...
  11. pmc Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1
    A M Valdes
    Twin Research Unit, King s College London, St Thomas Hospital, London, UK
    Diabetes Obes Metab 11:46-52. 2009
    ..The aim of this study was to assess if markers in the class III Major Histocompatibility Complex (MHC) region are associated with T1D after accounting for linkage disequilibrium (LD) with DRB1-DQB1...
  12. doi request reprint The contribution of genes to osteoarthritis
    Ana M Valdes
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital Campus, Kings College, London School of Medicine, London SE1 7EH, UK
    Med Clin North Am 93:45-66, x. 2009
    ..This article discusses the impact that future genome-wide association scans can have on our understanding of the pathogenesis of OA and on identifying individuals at high risk for developing severe OA...
  13. pmc Leukocyte telomere length is associated with cognitive performance in healthy women
    A M Valdes
    Twin Research and Genetic Epidemiology Unit, Kings College London, School of Medicine, St Thomas Hospital, London, UK
    Neurobiol Aging 31:986-92. 2010
    ..Age-related cognitive decline begins in mid-life and continues with advancing age. Leukocyte telomere length (LTL) shortens with age, and inflammation and oxidative stress enhance this process. Shorter LTL is associated with dementia...
  14. doi request reprint The contribution of genes to osteoarthritis
    Ana M Valdes
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital Campus, Kings College London School of Medicine, London SE1 7EH, UK
    Rheum Dis Clin North Am 34:581-603. 2008
    ..The authors discuss the impact that future genome-wide association scans can have on our understanding of the pathogenesis of OA and on identifying individuals at high risk for developing severe OA...
  15. pmc Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis
    Ana M Valdes
    Twin Research Unit, St Thomas Hospital Campus, Kings College London School of Medicine, London SE1 7EH, UK
    Am J Hum Genet 82:1231-40. 2008
    ..Our results and previous studies on the role of the cyclooxygenase 2 enzyme encoded by PTGS2 underscore the importance of this signaling pathway in the pathogenesis of knee OA...
  16. doi request reprint Association of the DVWA and GDF5 polymorphisms with osteoarthritis in UK populations
    A M Valdes
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London SE1 7EH, UK
    Ann Rheum Dis 68:1916-20. 2009
    ..Variants in the growth differentiation factor 5 (GDF5) and in the double von Willebrand factor A (DVWA) have recently been reported to be associated with osteoarthritis (OA) in Asian populations...
  17. pmc Large scale replication study of the association between HLA class II/BTNL2 variants and osteoarthritis of the knee in European-descent populations
    Ana M Valdes
    Department of Twin Research and Genetic Epidemiology, King s College London, London, United Kingdom
    PLoS ONE 6:e23371. 2011
    ..07). The rs10947262 and rs7775228 variants are not associated with risk of knee OA in European descent populations and they do not appear tag the same HLA class II haplotype as they do in Japanese individuals...
  18. pmc Genetic variation within the HLA class III influences T1D susceptibility conferred by high-risk HLA haplotypes
    A M Valdes
    King s College London, Department of Twin Research and Genetic Epidemiology, UK
    Genes Immun 11:209-18. 2010
    ..82) with each other, but a joint analysis showed that the association for each SNP was not solely because of LD. Our data support a role for more than one locus in the class III region contributing to risk of T1D...
  19. pmc The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis
    Ana M Valdes
    Department of Twin Research, King s College London, St Thomas Hospital, London, UK
    Ann Rheum Dis 70:1556-61. 2011
    ..To assess if a coding variant in the gene encoding transient receptor potential cation channel, subfamily V, member 1 (TRPV1) is associated with genetic risk of painful knee osteoarthritis (OA)...
  20. doi request reprint Genetic epidemiology of hip and knee osteoarthritis
    Ana M Valdes
    Department of Twin Research and Genetic Epidemiology, St Thomas Hospital, Kings College London School of Medicine, London SE1 7EH, UK
    Nat Rev Rheumatol 7:23-32. 2011
    ....
  21. doi request reprint Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis
    Ana M Valdes
    Department of Twin Research and Genetic Epidemiology, St Thomas Hospital Campus, King s College London, London SE1 7EH, UK
    Arthritis Rheum 62:2347-52. 2010
    ..We undertook this study to investigate the role of genetic variation in SMAD3 in the risk of large-joint OA in humans...
  22. doi request reprint Involvement of different risk factors in clinically severe large joint osteoarthritis according to the presence of hand interphalangeal nodes
    Ana M Valdes
    Department of Twin Research and Genetic Epidemiology, King s College London and St Thomas Hospital, London, UK
    Arthritis Rheum 62:2688-95. 2010
    ....
  23. doi request reprint Role of the Nav1.7 R1150W amino acid change in susceptibility to symptomatic knee osteoarthritis and multiple regional pain
    Ana M Valdes
    St Thomas Hospital, King s College London, UK
    Arthritis Care Res (Hoboken) 63:440-4. 2011
    ..To assess the genetic association of pain in patients with knee osteoarthritis (OA) and those with multiple regional pain with the R1150W variant in the α-subunit of the voltage-gated sodium channel Na(V)1.7...
  24. doi request reprint A meta-analysis of interleukin-6 promoter polymorphisms on risk of hip and knee osteoarthritis
    A M Valdes
    Department of Twin Research, St Thomas Hospital Campus, Kings College London School of Medicine London, UK
    Osteoarthritis Cartilage 18:699-704. 2010
    ..We investigated the role of two single nucleotide polymorphisms (SNPs) mapping to the promoter of the IL-6 gene on genetic susceptibility to hip and knee OA...
  25. doi request reprint The clinical relevance of genetic susceptibility to osteoarthritis
    Ana M Valdes
    Department of Twin Research, St Thomas Hospital Campus, Kings College London School of Medicine, Westminster Bridge Road, London SE1 7EH, UK
    Best Pract Res Clin Rheumatol 24:3-14. 2010
    ....
  26. doi request reprint The genetic epidemiology of osteoarthritis
    Ana M Valdes
    Department of Twin Research and Genetic Epidemiology, St Thomas Hospital Campus, Kings College London School of Medicine, London, UK
    Curr Opin Rheumatol 22:139-43. 2010
    ..The scope of the present article is to offer an overview of recent developments in the genetic epidemiology of knee and hip osteoarthritis, with particular emphasis on published genomewide association studies (GWAS)...
  27. doi request reprint Variation at the ANP32A gene is associated with risk of hip osteoarthritis in women
    Ana M Valdes
    Kings College London, London, UK
    Arthritis Rheum 60:2046-54. 2009
    ..We undertook this study to test whether genetic variation at ANP32A was associated with osteoarthritis (OA) in women...
  28. ncbi request reprint Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women
    Ana M Valdes
    St Thomas Hospital, London, UK
    Arthritis Rheum 54:533-9. 2006
    ....
  29. ncbi request reprint Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee
    Ana M Valdes
    St Thomas Hospital, and King s College London, London, UK
    Arthritis Rheum 56:137-46. 2007
    ..To assess whether the association of genetic polymorphisms with osteoarthritis (OA) in other populations could be replicated in a large, multicenter, mixed-sex, case-control study of clinical knee OA...
  30. ncbi request reprint Association between a variation in LRCH1 and knee osteoarthritis: a genome-wide single-nucleotide polymorphism association study using DNA pooling
    Tim D Spector
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Arthritis Rheum 54:524-32. 2006
    ..To perform a large-scale association analysis of single-nucleotide polymorphisms (SNPs) in patients with radiographically defined osteoarthritis (OA) of the knee...
  31. pmc Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women
    J Brent Richards
    Twin Research and Genetic Epidemiology, St Thomas Hospital, King s College, London School of Medicine, London, United Kingdom
    Am J Clin Nutr 86:1420-5. 2007
    ..Leukocyte telomere length (LTL) is a predictor of aging-related disease and decreases with each cell cycle and increased inflammation...
  32. ncbi request reprint Nevus size and number are associated with telomere length and represent potential markers of a decreased senescence in vivo
    Veronique Bataille
    Twin Research and Genetic Epidemiology Unit, King s College London, St Thomas Hospital Campus, London SE1 7EH, United Kingdom
    Cancer Epidemiol Biomarkers Prev 16:1499-502. 2007
    ..Understanding mechanisms influencing the induction and involution of nevi will not only help in understanding the pathophysiology of melanoma but should also shed light on the complex relationship between aging and cancer...
  33. ncbi request reprint Radiographic progression of lumbar spine disc degeneration is influenced by variation at inflammatory genes: a candidate SNP association study in the Chingford cohort
    Ana M Valdes
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Spine (Phila Pa 1976) 30:2445-51. 2005
    ..A candidate gene association study in a longitudinal cohort...
  34. pmc Receiver operating characteristic analysis of HLA, CTLA4, and insulin genotypes for type 1 diabetes
    Ana M Valdes
    Academic Rheumatology, University of Nottingham, Nottingham, UK
    Diabetes Care 36:2504-7. 2013
    ..This study assessed the ability to distinguish between type 1 diabetes-affected individuals and their unaffected relatives using HLA and single nucleotide polymorphism (SNP) genotypes...
  35. ncbi request reprint Association study of candidate genes for the prevalence and progression of knee osteoarthritis
    Ana M Valdes
    St Thomas Hospital, London, UK
    Arthritis Rheum 50:2497-507. 2004
    ..We examined the role of 26 single-nucleotide polymorphisms (SNPs) from 24 candidate genes in OA susceptibility and progression...
  36. pmc Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study
    J B Richards
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
    Lancet 371:1505-12. 2008
    ..Osteoporosis is diagnosed by the measurement of bone mineral density, which is a highly heritable and multifactorial trait. We aimed to identify genetic loci that are associated with bone mineral density...
  37. pmc Metabolomic markers reveal novel pathways of ageing and early development in human populations
    Cristina Menni
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK, Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, Neuherberg, Germany, Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany, Institute of Epidemiology I, Helmholtz Zentrum Munchen, Neuherberg, Germany, Pfizer Research Laboratories, Groton, CT, USA, Worldwide R and D, Pfizer Inc, Cambridge, MA, USA, School of Medicine and Pharmacology, University of Western Australia, Crawley, WA, Australia, Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, Australia, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, Metabolon Inc, 617 Davis Drive, Durham, NC 27713, USA Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, Doha, National University of Singapore
    Int J Epidemiol 42:1111-9. 2013
    ..Human ageing is a complex, multifactorial process and early developmental factors affect health outcomes in old age...
  38. ncbi request reprint The interaction of genes and smoking on forced expiratory volume: a classic twin study
    Guangju Zhai
    Twin Research and Genetic Epidemiology Unit, King s College London School of Medicine, St Thomas Hospital Campus, Lambeth Palace Rd, London SE1 7EH, UK
    Chest 132:1772-7. 2007
    ..The aims of this study were to estimate heritability of the ratio of measured FEV1 (mFEV1) to expected FEV(1) (eFEV1) in a white population, and to examine the interaction between genetic factors and smoking on this ratio...
  39. pmc Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs
    Toby Andrew
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London SE1 7EH, United Kingdom
    Am J Hum Genet 78:480-6. 2006
    ..9) at 14q23.2, and suggestive linkage at 10q26.13 (LOD 2.4) and 3p26.1 (LOD 2.7). This is the first report of loci, mapped in a sample of healthy individuals, that influence mean telomere variation in humans...
  40. pmc Cohort Profile: TwinsUK and healthy ageing twin study
    Alireza Moayyeri
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, UK
    Int J Epidemiol 42:76-85. 2013
    ..Several collaborative projects in the field of epidemiology of complex disorders are ongoing in our cohort and interested researchers are encouraged to get in contact for future collaborations...
  41. pmc Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22
    Evangelos Evangelou
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Ann Rheum Dis 70:349-55. 2011
    ..It is characterised by changes in joint structure, including degeneration of the articular cartilage, and its aetiology is multifactorial with a strong postulated genetic component...
  42. doi request reprint Natural history and risk factors for bone loss in postmenopausal Caucasian women: a 15-year follow-up population-based study
    G Zhai
    Twin Research and Genetic Epidemiology Unit, King s College London School of Medicine, St Thomas Hospital Campus, Lambeth Palace Road, London SE1 7EH, UK
    Osteoporos Int 19:1211-7. 2008
    ..67% per year, but quadratic for lumbar spine (LS) at a rate of 3.12% initially, and slowing down with age. We also confirmed the protective role of HRT, increasing weight, and lean mass in long-term bone loss...
  43. pmc GDF5 single-nucleotide polymorphism rs143383 is associated with lumbar disc degeneration in Northern European women
    F M K Williams
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
    Arthritis Rheum 63:708-12. 2011
    ..In vitro, the gene product growth differentiation factor 5 has been shown to promote growth and repair of animal disc. This study was undertaken to investigate whether the GDF5 gene plays a role in LDD...
  44. ncbi request reprint The effects of social status on biological aging as measured by white-blood-cell telomere length
    L F Cherkas
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK, and The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103 2714, USA
    Aging Cell 5:361-5. 2006
    ..Comparison of TRFL in the 17 most discordant SES twin pairs confirmed this difference. Low SES, in addition to the harmful effects of smoking, obesity and lack of exercise, appears to have an impact on telomere length...
  45. ncbi request reprint The additive effect of individual genes in predicting risk of knee osteoarthritis
    A M Valdes
    Twin Research Unit, St Thomas Hospital Campus, Kings College London, Lambeth Palace Road, London SE1 7EH, UK
    Ann Rheum Dis 67:124-7. 2008
    ..We aimed to answer whether carrying several genetic variants associated with knee OA could result in a greater risk of OA...
  46. pmc Reduction of leucocyte telomere length in radiographic hand osteoarthritis: a population-based study
    G Zhai
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Ann Rheum Dis 65:1444-8. 2006
    ..Although age is the strongest predictor of osteoarthritis, the exact mechanism underlying this disorder remains elusive...
  47. pmc A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium
    G Zhai
    Department of Twin Research and Genetic Epidemiology, King s College London, UK
    J Med Genet 46:614-6. 2009
    ..01), suggesting the potential mechanism of the gene in hand OA might be via effects on subchondral bone. The authors' findings provide a potential new insight into genetic mechanisms in the development of hand OA...
  48. pmc Glycosylation of immunoglobulin g: role of genetic and epigenetic influences
    Cristina Menni
    Department of Twins Research and Genetic Epidemiology, Kings College London, London, United Kingdom
    PLoS ONE 8:e82558. 2013
    ..To determine the extent to which genetic and epigenetic factors contribute to variations in glycosylation of immunoglobulin G (IgG) in humans...
  49. doi request reprint Omics technologies and the study of human ageing
    Ana M Valdes
    1 Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK 2 Academic Rheumatology, University of Nottingham, Nottingham NG5 1PB, UK
    Nat Rev Genet 14:601-7. 2013
    ....
  50. pmc Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans
    Massimo Mangino
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
    Hum Mol Genet 21:5385-94. 2012
    ..Overall, our results provide novel insights into the genetic architecture of inter-individual LTL variation in the general population...
  51. pmc A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length
    M Mangino
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
    J Med Genet 46:451-4. 2009
    ..Telomere length is a predictor for a number of common age related diseases and is a heritable trait...
  52. doi request reprint History of knee surgery is associated with higher prevalence of neuropathic pain-like symptoms in patients with severe osteoarthritis of the knee
    Ana M Valdes
    Academic Rheumatology, Clinical Sciences Building, Nottingham City Hospital Hucknall Road, Nottingham NG5 1PB, UK Electronic address
    Semin Arthritis Rheum 43:588-92. 2014
    ..Neuropathic pain (NP) mechanisms contribute to the pain experience in osteoarthritis (OA). We aimed to characterise the factors that contribute to NP-like symptoms in knee OA patients...
  53. doi request reprint Homocysteine levels and leukocyte telomere length
    J B Richards
    Centre for Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, King s College London School of Medicine, London, UK
    Atherosclerosis 200:271-7. 2008
    ..As leukocyte telomere length (LTL) registers the cumulative oxidative stress and inflammation, we examined the relationship between homocysteine and LTL...
  54. ncbi request reprint Obesity, cigarette smoking, and telomere length in women
    A M Valdes
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Lancet 366:662-4. 2005
    ..017), and each pack-year smoked was equivalent to an additional 5 bp of telomere length lost (18%) compared with the rate in the overall cohort. Our results emphasise the pro-ageing effects of obesity and cigarette smoking...
  55. ncbi request reprint Serum adiponectin and bone mineral density in women
    J B Richards
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London SE1 7EH, and University of Cambridge, United Kingdom
    J Clin Endocrinol Metab 92:1517-23. 2007
    ..Bone mineral density (BMD) is positively associated with body weight. This association persists even at non-load bearing sites, suggesting that a nonmechanical factor such as an adipocyte-derived hormone may modulate BMD...
  56. ncbi request reprint Human leukocyte antigen class I B and C loci contribute to Type 1 Diabetes (T1D) susceptibility and age at T1D onset
    Ana M Valdes
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Hum Immunol 66:301-13. 2005
    ..5 years, p < 0.001; and 7.8 years, p < 0.002, respectively). These data support a role for HLA class I alleles in susceptibility to and age at onset of T1D...
  57. ncbi request reprint Gene-gene interactions between CYP2B6 and CYP2A6 in nicotine metabolism
    Huijun Z Ring
    Center for Health Sciences, SRI International, Menlo Park, CA, USA
    Pharmacogenet Genomics 17:1007-15. 2007
    ..We investigated the influence of genetic variation in another potential nicotine-metabolizing enzyme, CYP2B6, and its interaction with CYP2A6, on the metabolism of nicotine...
  58. ncbi request reprint The HLA class I A locus affects susceptibility to type 1 diabetes
    Janelle A Noble
    Children s Hospital, Oakland Research Institute, Oakland, CA 94609, USA
    Hum Immunol 63:657-64. 2002
    ..Our results suggest an important role for class I antigens in modulating susceptibility to type 1 diabetes...
  59. pmc Association and interaction of the IL4R, IL4, and IL13 loci with type 1 diabetes among Filipinos
    Teodorica L Bugawan
    Roche Molecular Systems, Alameda, CA 94501, USA
    Am J Hum Genet 72:1505-14. 2003
    ..Our data suggest that the risk for T1D is determined, in part, by polymorphisms within the IL4R locus, including promoter and coding-sequence variants, and by specific combinations of genotypes at the IL4R and the IL4 and IL13 loci...
  60. ncbi request reprint Miniaturized sealed-tube allele-specific PCR
    J Ross Hawkins
    Incyte Genomics Ltd, Cambridge, UK
    Hum Mutat 19:543-53. 2002
    ..By virtue of its simplicity, the method is versatile and cost-effective with potential for use in industrial-scale genetic studies or in the clinical diagnostic setting...
  61. ncbi request reprint Human telomere biology: pitfalls of moving from the laboratory to epidemiology
    Abraham Aviv
    The Center of Human Development and Aging of New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Int J Epidemiol 35:1424-9. 2006
    ..Here we explain some of the reasons for this variability and propose several principles that should be considered in conducting epidemiological telomere research. Ignoring these principles could lead to misleading conclusions...
  62. pmc Linkage disequilibrium with predisposing DR3 haplotypes accounts for apparent effects of tumor necrosis factor and lymphotoxin-alpha polymorphisms on type 1 diabetes susceptibility
    Janelle A Noble
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Hum Immunol 67:999-1004. 2006
    ..Thus, variation at TNF does not affect the T1D risk for B18-DR3 haplotypes, and the apparent association of TNF(-238)A with T1D may simply reflect its presence on a high-risk haplotype...
  63. doi request reprint Searching for additional disease loci in a genomic region
    Glenys Thomson
    Department of Integrative Biology, University of California, Berkeley, CA 94720, USA
    Adv Genet 60:253-92. 2008
    ..We recommend a multistrategy approach using a variety of complementary methods described below...
  64. pmc Type 1 diabetes risk for human leukocyte antigen (HLA)-DR3 haplotypes depends on genotypic context: association of DPB1 and HLA class I loci among DR3- and DR4-matched Italian patients and controls
    Janelle A Noble
    Childrens Hospital Oakland Research Institute, Oakland, CA, USA
    Hum Immunol 69:291-300. 2008
    ..These data indicate that T1D risk conferred by the 8.1 haplotype is genotype dependent...
  65. ncbi request reprint When is a replication not a replication? Or how to spot a good genetic association study
    Tim D Spector
    Arthritis Rheum 54:1051-4. 2006
  66. doi request reprint Influence of apoA-V gene variants on postprandial triglyceride metabolism: impact of gender
    Estibaliz Olano-Martin
    Hugh Sinclair Human Nutrition Group, School of Chemistry, Food Biosciences, and Pharmacy, University of Reading, Reading RG6 6AP, United Kingdom
    J Lipid Res 49:945-53. 2008
    ..015). However, in linear regression analysis, a significant independent association with TG AUC (P = 0.007) was only evident for the apoA-V -1131 T>C SNP, indicating a greater relative importance of the apoA-V genotype...
  67. ncbi request reprint DPB1 alleles are associated with type 1 diabetes susceptibility in multiple ethnic groups
    Thomas D Cruz
    Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Diabetes 53:2158-63. 2004
    ..This supports the concept that multiple genes in the HLA region can affect type 1 diabetes susceptibility...
  68. ncbi request reprint A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes
    Janelle A Noble
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Diabetes 52:1579-82. 2003
    ..04). These data also suggest that TCF7 C883A may affect age of disease onset. Analysis of genotype data from surrounding SNPs suggests that this TCF7 polymorphism may itself represent a risk factor for type 1 diabetes...
  69. ncbi request reprint Val64Ile polymorphism in the C-C chemokine receptor 2 is associated with reduced coronary artery calcification
    Ana M Valdes
    GlaxoSmithKline, Stevenage, Hertfordshire, UK
    Arterioscler Thromb Vasc Biol 22:1924-8. 2002
    ..A common polymorphism in the human CCR2 gene resulting in a substitution of isoleucine for valine (Val64Ile) has been associated with other disease phenotypes in humans...
  70. ncbi request reprint Association of the single nucleotide polymorphism C1858T of the PTPN22 gene with type 1 diabetes
    Martha B Ladner
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Hum Immunol 66:60-4. 2005
    ..These results are consistent with the hypothesis that individuals lacking the C allele of PTPN22 may have reduced capacity to downregulate T-cell responses and may therefore be more susceptible to autoimmunity...