Rudolf Uher

Summary

Affiliation: King's College London
Country: UK

Publications

  1. doi request reprint The role of genetic variation in the causation of mental illness: an evolution-informed framework
    R Uher
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, 16 De Crespigny Park, London, SE5 8AF, UK
    Mol Psychiatry 14:1072-82. 2009
  2. pmc Suicidal ideation during treatment of depression with escitalopram and nortriptyline in genome-based therapeutic drugs for depression (GENDEP): a clinical trial
    Nader Perroud
    MRC SGDP Centre, Institute of Psychiatry at King s College London, UK
    BMC Med 7:60. 2009
  3. doi request reprint Genome-wide pharmacogenetics of antidepressant response in the GENDEP project
    Rudolf Uher
    Medical Research Council Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, SE5 8AF, London, United Kingdom
    Am J Psychiatry 167:555-64. 2010
  4. doi request reprint Trajectories of change in depression severity during treatment with antidepressants
    R Uher
    Medical Research Council Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, UK
    Psychol Med 40:1367-77. 2010
  5. doi request reprint Body weight as a predictor of antidepressant efficacy in the GENDEP project
    Rudolf Uher
    Institute of Psychiatry, King s College London, United Kingdom
    J Affect Disord 118:147-54. 2009
  6. ncbi request reprint Genetic predictors of increase in suicidal ideation during antidepressant treatment in the GENDEP project
    Nader Perroud
    MRC Social Genetic and Developmental Psychiatry Center, Institute of Psychiatry, King s College Lodon, London, UK
    Neuropsychopharmacology 34:2517-28. 2009
  7. doi request reprint History of suicide attempts among patients with depression in the GENDEP project
    Nader Perroud
    MRC SGDP Centre, Institute of Psychiatry at King s College London, SE5 8AF, London, United Kingdom
    J Affect Disord 123:131-7. 2010
  8. doi request reprint Changes in body weight during pharmacological treatment of depression
    Rudolf Uher
    Institute of Psychiatry, King s College London, London, UK
    Int J Neuropsychopharmacol 14:367-75. 2011
  9. ncbi request reprint Moderation of antidepressant response by the serotonin transporter gene
    Patricia Huezo-Diaz
    Institute of Psychiatry, King s College London, UK
    Br J Psychiatry 195:30-8. 2009
  10. pmc Interaction between specific forms of childhood maltreatment and the serotonin transporter gene (5-HTT) in recurrent depressive disorder
    Helen L Fisher
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, Box P080, De Crespigny Park, London SE5 8AF, UK
    J Affect Disord 145:136-41. 2013

Collaborators

Detail Information

Publications74

  1. doi request reprint The role of genetic variation in the causation of mental illness: an evolution-informed framework
    R Uher
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, 16 De Crespigny Park, London, SE5 8AF, UK
    Mol Psychiatry 14:1072-82. 2009
    ..This framework points to a need for a paradigm change in genetic research to enable major progress in elucidating the aetiology of mental illness...
  2. pmc Suicidal ideation during treatment of depression with escitalopram and nortriptyline in genome-based therapeutic drugs for depression (GENDEP): a clinical trial
    Nader Perroud
    MRC SGDP Centre, Institute of Psychiatry at King s College London, UK
    BMC Med 7:60. 2009
    ..The aim of the present study is to investigate the course and predictors of emergence and worsening of suicidal ideation during tricyclic antidepressant and serotonin reuptake inhibitor treatment...
  3. doi request reprint Genome-wide pharmacogenetics of antidepressant response in the GENDEP project
    Rudolf Uher
    Medical Research Council Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, SE5 8AF, London, United Kingdom
    Am J Psychiatry 167:555-64. 2010
    ..The authors performed a genome-wide association analysis of improvement of depression severity with two antidepressant drugs...
  4. doi request reprint Trajectories of change in depression severity during treatment with antidepressants
    R Uher
    Medical Research Council Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, UK
    Psychol Med 40:1367-77. 2010
    ..We explore alternative categorization of outcome by naturally occurring trajectories of symptom change...
  5. doi request reprint Body weight as a predictor of antidepressant efficacy in the GENDEP project
    Rudolf Uher
    Institute of Psychiatry, King s College London, United Kingdom
    J Affect Disord 118:147-54. 2009
    ..The present report explores the moderation of antidepressant response by body weight to establish the specificity to antidepressant mode of action, type of depressive symptoms and gender...
  6. ncbi request reprint Genetic predictors of increase in suicidal ideation during antidepressant treatment in the GENDEP project
    Nader Perroud
    MRC Social Genetic and Developmental Psychiatry Center, Institute of Psychiatry, King s College Lodon, London, UK
    Neuropsychopharmacology 34:2517-28. 2009
    ..Among men, genetic variation in noradrenergic signaling may interact with norepinephrine reuptake-inhibiting antidepressants, thereby contributing to suicidality...
  7. doi request reprint History of suicide attempts among patients with depression in the GENDEP project
    Nader Perroud
    MRC SGDP Centre, Institute of Psychiatry at King s College London, SE5 8AF, London, United Kingdom
    J Affect Disord 123:131-7. 2010
    ..We investigated clinical and demographic characteristics associated with SA and tested the hypothesis that a history of suicide attempts predicts poor response to antidepressants...
  8. doi request reprint Changes in body weight during pharmacological treatment of depression
    Rudolf Uher
    Institute of Psychiatry, King s College London, London, UK
    Int J Neuropsychopharmacol 14:367-75. 2011
    ..While treatment with nortriptyline may be recommended in underweight subjects with typical neurovegetative symptoms, escitalopram is a suitable alternative for subjects at risk of weight gain...
  9. ncbi request reprint Moderation of antidepressant response by the serotonin transporter gene
    Patricia Huezo-Diaz
    Institute of Psychiatry, King s College London, UK
    Br J Psychiatry 195:30-8. 2009
    ..We hypothesised that the pharmacogenetic effect of 5-HTTLPR is modulated by gender, age and other variants in the serotonin transporter gene...
  10. pmc Interaction between specific forms of childhood maltreatment and the serotonin transporter gene (5-HTT) in recurrent depressive disorder
    Helen L Fisher
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, Box P080, De Crespigny Park, London SE5 8AF, UK
    J Affect Disord 145:136-41. 2013
    ....
  11. doi request reprint Variation in GNB3 predicts response and adverse reactions to antidepressants
    Robert Keers
    MRC SGDP Centre, Institute of Psychiatry, King s College London, UK
    J Psychopharmacol 25:867-74. 2011
    ..Our results are consistent with previous associations with GNB3 and emphasize the importance of signalling genes in antidepressant response...
  12. doi request reprint Adverse reactions to antidepressants
    Rudolf Uher
    P080 SGDP, Institute of Psychiatry, King s College London, London SE5 8AF, UK
    Br J Psychiatry 195:202-10. 2009
    ..Adverse drug reactions are important determinants of non-adherence to antidepressant treatment, but their assessment is complicated by overlap with depressive symptoms and lack of reliable self-report measures...
  13. doi request reprint The interaction between child maltreatment, adult stressful life events and the 5-HTTLPR in major depression
    Robert A Power
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    J Psychiatr Res 47:1032-5. 2013
    ....
  14. ncbi request reprint Differential efficacy of escitalopram and nortriptyline on dimensional measures of depression
    Rudolf Uher
    Institute of Psychiatry, King s College London, 16 De Crespigny Park, SE5 8AF, London, UK
    Br J Psychiatry 194:252-9. 2009
    ..Tricyclic antidepressants and serotonin reuptake inhibitors are considered to be equally effective, but differences may have been obscured by internally inconsistent measurement scales and inefficient statistical analyses...
  15. doi request reprint Melancholic, atypical and anxious depression subtypes and outcome of treatment with escitalopram and nortriptyline
    Rudolf Uher
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, United Kingdom
    J Affect Disord 132:112-20. 2011
    ..To investigate whether subtypes of depression predict differential outcomes of treatment with selective serotonin-reuptake inhibitor (SSRI) and a tricyclic antidepressant in major depression...
  16. doi request reprint Neural correlates of body dissatisfaction in anorexia nervosa
    Hans Christoph Friederich
    Eating Disorders Unit, Institute of Psychiatry, King s College London, DeCrespigny Park, SE5 8AF London, UK
    Neuropsychologia 48:2878-85. 2010
    ..Insula hyperactivation along with ACC hypoactivation may be critical for altered interoceptive awareness to body self-comparison and/or for altered implicit motivation to thin-idealized body images in AN patients...
  17. doi request reprint Dissecting the genetic heterogeneity of depression through age at onset
    Robert A Power
    MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 159:859-68. 2012
    ..04). This study provides the first focussed analysis of the genetic contribution to AAO in depression, and establishes a statistical framework that can be applied to a quantitative trait underlying any disorder...
  18. doi request reprint Antidepressant-dependent mRNA changes in mouse associated with hippocampal neurogenesis in a mouse model of depression
    Karim Malki
    MRC Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, London, UK
    Pharmacogenet Genomics 22:765-76. 2012
    ....
  19. ncbi request reprint Genetic predictors of response to antidepressants in the GENDEP project
    Rudolf Uher
    MRC Social Genetic and Developmental Psychiatry Center, Institute of Psychiatry, King s College London, London, UK
    Pharmacogenomics J 9:225-33. 2009
    ..The single marker associations explained only a small proportion of variance in response to antidepressants, indicating a need for a multivariate approach to prediction...
  20. doi request reprint Tumor necrosis factor and its targets in the inflammatory cytokine pathway are identified as putative transcriptomic biomarkers for escitalopram response
    Timothy R Powell
    King s College London, Institute of Psychiatry, MRC Social, Genetic and Developmental Psychiatry Centre, London, UK Electronic address
    Eur Neuropsychopharmacol 23:1105-14. 2013
    ....
  21. ncbi request reprint Non-random dropout and the relative efficacy of escitalopram and nortriptyline in treating major depressive disorder
    Robert A Power
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, United Kingdom
    J Psychiatr Res 46:1333-8. 2012
    ..These findings review the primary analysis of GENDEP and suggest that, when non-random dropout is accounted for, escitalopram is more effective than nortriptyline in reducing symptoms of major depression...
  22. doi request reprint Stressful life events, cognitive symptoms of depression and response to antidepressants in GENDEP
    Robert Keers
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    J Affect Disord 127:337-42. 2010
    ..There is some evidence to suggest that SLEs prior to treatment are associated with greater cognitive symptoms at baseline and may therefore predict changes in these symptoms specifically...
  23. ncbi request reprint Contribution of common genetic variants to antidepressant response
    Katherine E Tansey
    Institute of Psychiatry, King s College London, London, United Kingdom
    Biol Psychiatry 73:679-82. 2013
    ..Pharmacogenetic studies aiming to personalize the treatment of depression are based on the assumption that response to antidepressants is a heritable trait, but there is no compelling evidence to support this...
  24. doi request reprint Genome-wide association analysis accounting for environmental factors through propensity-score matching: application to stressful live events in major depressive disorder
    Robert A Power
    MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 162:521-9. 2013
    ....
  25. pmc Genomewide association scan of suicidal thoughts and behaviour in major depression
    Alexandra Schosser
    MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    PLoS ONE 6:e20690. 2011
    ..Suicidal behaviour can be conceptualised as a continuum from suicidal ideation, to suicidal attempts to completed suicide. In this study we identify genes contributing to suicidal behaviour in the depression study RADIANT...
  26. doi request reprint An examination of decision making in bulimia nervosa
    Pei Chi Liao
    Section of Eating Disorders, Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
    J Clin Exp Neuropsychol 31:455-61. 2009
    ..Patients with eating disorders favor immediate gratification and ignore long-term negative consequences. This study investigated decision making in bulimia nervosa using the Iowa Gambling Task (IGT) and skin conductance responses (SCR)...
  27. doi request reprint Early and delayed onset of response to antidepressants in individual trajectories of change during treatment of major depression: a secondary analysis of data from the Genome-Based Therapeutic Drugs for Depression (GENDEP) study
    Rudolf Uher
    MRC Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, United Kingdom, London, UK
    J Clin Psychiatry 72:1478-84. 2011
    ..We explore the individual trajectories of relative change in depression severity to establish what proportion of individuals experience early and late onset of improvement...
  28. doi request reprint Genetic differences in cytochrome P450 enzymes and antidepressant treatment response
    Karen Hodgson
    1MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    J Psychopharmacol 28:133-41. 2014
    ..Drug metabolism rates are influenced by common variants in the genes encoding these enzymes. However, it remains unclear whether treatment outcomes can be predicted by either CYP450 genotype or antidepressant serum concentration...
  29. ncbi request reprint Fecundity of patients with schizophrenia, autism, bipolar disorder, depression, anorexia nervosa, or substance abuse vs their unaffected siblings
    Robert A Power
    Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, England
    JAMA Psychiatry 70:22-30. 2013
    ..However, this is key to understanding their etiology and designing studies to identify risk variants...
  30. doi request reprint Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants
    Karim Malki
    Institute of Psychiatry, King s College London, United Kingdom
    Biol Psychiatry 69:360-5. 2011
    ..We report on an integrative analysis from the Genome-Based Therapeutic Drugs for Depression (GENDEP) study using gene expression from mice to inform prioritization in a human pharmacogenetic study...
  31. ncbi request reprint Integrative mouse and human mRNA studies using WGCNA nominates novel candidate genes involved in the pathogenesis of major depressive disorder
    Karim Malki
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Pharmacogenomics 14:1979-90. 2013
    ..This study aims to identify novel genes associated with major depressive disorder and pharmacological treatment response using animal and human mRNA studies...
  32. ncbi request reprint Brain responses to body image stimuli but not food are altered in women with bulimia nervosa
    Frederique van den Eynde
    Department of Psychological Medicine, Section of Eating Disorders Institute of Psychiatry, King s College London, London, UK
    BMC Psychiatry 13:302. 2013
    ..Research into the neural correlates of bulimia nervosa (BN) psychopathology remains limited...
  33. doi request reprint Functional neuroanatomy of body checking in people with anorexia nervosa
    Masashi Suda
    Department of Academic Psychiatry, Section of Eating Disorders, Institute of Psychiatry, King s College London, London, United Kingdom
    Int J Eat Disord 46:653-62. 2013
    ..This functional Magnetic Resonance Imaging study examined the neuroanatomy involved in altered perception and identification with body checking in female with anorexia nervosa (AN)...
  34. doi request reprint Genetic susceptibility for bipolar disorder and response to antidepressants in major depressive disorder
    Katherine E Tansey
    Institute of Psychiatry, King s College London, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 165:77-83. 2014
    ..Our data indicate that molecular measure of genetic susceptibility to bipolar disorder does not aid in understanding non-response to antidepressants...
  35. doi request reprint Serotonin transporter length polymorphism, childhood maltreatment, and chronic depression: a specific gene-environment interaction
    George W Brown
    Department of Health Service and Population Research, Institute of Psychiatry, King s College London, UK
    Depress Anxiety 30:5-13. 2013
    ....
  36. doi request reprint Pharmacoproteomic investigation into antidepressant response in two mouse inbred strains
    Karim Malki
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    Proteomics 12:2355-65. 2012
    ....
  37. pmc Self-report and clinician-rated measures of depression severity: can one replace the other?
    Rudolf Uher
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    Depress Anxiety 29:1043-9. 2012
    ..The aim of this study is to test whether self-report provides information relevant to short-term treatment outcomes that is not captured by clinician-rating and vice versa...
  38. doi request reprint Poor decision making in male patients with anorexia nervosa
    Kate Tchanturia
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
    Eur Eat Disord Rev 20:169-73. 2012
    ..Decision making is impaired in female patients with anorexia nervosa (AN), but it is unclear if the same impairment is present in male patients with AN...
  39. pmc Stressful life events and the serotonin transporter gene (5-HTT) in recurrent clinical depression
    Helen L Fisher
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    J Affect Disord 136:189-93. 2012
    ....
  40. pmc The endogenous and reactive depression subtypes revisited: integrative animal and human studies implicate multiple distinct molecular mechanisms underlying major depressive disorder
    Karim Malki
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, at Institute of Psychiatry, SGDP Research Centre PO80, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    BMC Med 12:73. 2014
    ..We investigated this hypothesis by comparing the gene-expression profiles of three animal models of 'reactive' and 'endogenous' depression. We then translated these findings to clinical samples using a human post-mortem mRNA study...
  41. doi request reprint ATP-binding cassette sub-family F member 1 (ABCF1) is identified as a putative therapeutic target of escitalopram in the inflammatory cytokine pathway
    Timothy R Powell
    MRC Social, Genetic and Developmental Psychiatry Centre, King s College London, London, UK
    J Psychopharmacol 27:609-15. 2013
    ....
  42. pmc Provocation of symmetry/ordering symptoms in Anorexia nervosa: a functional neuroimaging study
    Masashi Suda
    Section of Eating Disorders, Institute of Psychiatry, King s College London, London, United Kingdom
    PLoS ONE 9:e97998. 2014
    ..Furthermore, our data also suggest that symptom provocation can progressively overload attempts by the rPFC to exert cognitive control. These findings are discussed in the context of the current neurobiological models of AN. ..
  43. ncbi request reprint Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: A genome-wide association and polygenic scoring study
    Niamh Mullins
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 165:428-37. 2014
    ..Polygenic score analysis suggests pleiotropy between psychiatric disorders and suicidal ideation whereas the tendency to act on such thoughts may have a partially independent genetic diathesis. © 2014 Wiley Periodicals, Inc. ..
  44. doi request reprint Genome-wide association study of co-occurring anxiety in major depression
    Alexandra Schosser
    MRC SGDP Centre, Institute of Psychiatry, King s College London, London, UK
    World J Biol Psychiatry 14:611-21. 2013
    ..In this study we define a quantitative measure of anxiety by summating four anxiety items from the SCAN interview in a large collection of major depression (MDD) cases to identify genes contributing to this complex phenotype...
  45. doi request reprint CYP2C19 genotype predicts steady state escitalopram concentration in GENDEP
    Patricia Huezo-Diaz
    MRC SGDP Centre, Institute of Psychiatry at King s College London, London, UK
    J Psychopharmacol 26:398-407. 2012
    ..0003; p = 0.0012 Bonferroni corrected). In conclusion, we have demonstrated an association between CYP2C19 genotype, including the CYP2C19*17 allele, and steady state escitalopram concentration...
  46. doi request reprint Genome-wide association study of major recurrent depression in the U.K. population
    Cathryn M Lewis
    Medical Research Council s Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, United Kingdom
    Am J Psychiatry 167:949-57. 2010
    ..K. and 1,594 comparison subjects screened negative for psychiatric disorders...
  47. doi request reprint Stressful life events and the brain-derived neurotrophic factor gene in bipolar disorder
    Georgina M Hosang
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    J Affect Disord 125:345-9. 2010
    ..The aim of the present study was to examine the interplay between the BDNF Val(66)Met polymorphism and stressful life events (SLEs) in bipolar disorder...
  48. ncbi request reprint Functional polymorphism in the brain-derived neurotrophic factor gene interacts with stressful life events but not childhood maltreatment in the etiology of depression
    George W Brown
    Department of Health Service and Population Research, Institute of Psychiatry, King s College, London, United Kingdom
    Depress Anxiety 31:326-34. 2014
    ..We also explore the possibility that the Met allele of this polymorphism interacts with childhood maltreatment to increase the risk of chronic depression...
  49. doi request reprint Genetic predictors of antidepressant side effects: a grouped candidate gene approach in the Genome-Based Therapeutic Drugs for Depression (GENDEP) study
    Karen Hodgson
    1Social, Genetic and Developmental Psychiatry Centre, King s College London, London, UK
    J Psychopharmacol 28:142-50. 2014
    ..However, previous work attempting to ascertain the genetic variants involved has had limited success, in part due to the range of ADRs reported with antidepressants...
  50. ncbi request reprint I'm not as slim as that girl: neural bases of body shape self-comparison to media images
    Hans Christoph Friederich
    Eating Disorders Unit, Institute of Psychiatry, King s College London, De Crespigny Park, SE5 8AF, London, UK
    Neuroimage 37:674-81. 2007
    ..Brain networks associated with anxiety induced by self-comparison to slim images may be involved in the genesis of body dissatisfaction and hence with vulnerability to eating disorders...
  51. doi request reprint The role of loss and danger events in symptom exacerbation in bipolar disorder
    Georgina M Hosang
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    J Psychiatr Res 46:1584-9. 2012
    ..No significant associations were observed for manic symptoms. Specific relationships with different types of SLEs may explain previous discrepant findings concerning the relationship between SLEs and BD...
  52. pmc Genetic predictors of response to serotonergic and noradrenergic antidepressants in major depressive disorder: a genome-wide analysis of individual-level data and a meta-analysis
    Katherine E Tansey
    Institute of Psychiatry, King s College London, London, UK
    PLoS Med 9:e1001326. 2012
    ..This study aims to test the hypothesis that common genetic variants can predict response to antidepressants in a clinically meaningful way...
  53. pmc Serotonin transporter gene moderates childhood maltreatment's effects on persistent but not single-episode depression: replications and implications for resolving inconsistent results
    Rudolf Uher
    Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, UK
    J Affect Disord 135:56-65. 2011
    ....
  54. ncbi request reprint Childhood maltreatment predicts unfavorable course of illness and treatment outcome in depression: a meta-analysis
    Valentina Nanni
    King s College London, Institute of Psychiatry, MRC Social, Genetic, and Developmental Psychiatry Research Centre, UK
    Am J Psychiatry 169:141-51. 2012
    ..The authors conducted the first meta-analysis to examine the relationship between childhood maltreatment and these clinically relevant measures of depression...
  55. ncbi request reprint Self-, parent-report and interview measures of obsessive-compulsive disorder in children and adolescents
    Rudolf Uher
    King s College London, Institute of Psychiatry, London, UK
    J Anxiety Disord 22:979-90. 2008
    ..The time-efficient self- and parent-report alternatives will enable routine measurement of OCD severity in clinical practice. Estimates of equivalent summed scores are provided to facilitate comparison...
  56. doi request reprint Genes, environment, and individual differences in responding to treatment for depression
    Rudolf Uher
    MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London
    Harv Rev Psychiatry 19:109-24. 2011
    ..Gaps in evidence are identified that need to be bridged before knowledge about cause can inform cure in personalized psychiatry...
  57. doi request reprint Classification issues and challenges in child and adolescent psychopathology
    Michael Rutter
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Int Rev Psychiatry 24:514-29. 2012
    ..Specific recommendations for changes in ICD-11 are presented and an online supplement provides specific details with respect to diagnostic categories that are in need of further testing...
  58. pmc Biomarkers predicting treatment outcome in depression: what is clinically significant?
    Rudolf Uher
    Institute of Psychiatry, King s College London, 16 De Crespigny Park, SE5 8AF, London, UK
    Pharmacogenomics 13:233-40. 2012
    ..To extend to biomarker studies the consensus clinical significance criterion of a three-point difference in Hamilton Rating Scale for Depression...
  59. doi request reprint Eating disorders, gene-environment interactions and epigenetics
    Iain C Campbell
    Section of Eating Disorders, King s College London, Institute of Psychiatry, London SE5 8AF, UK
    Neurosci Biobehav Rev 35:784-93. 2011
    ..For example, epigenetic changes associated with diet and weight may be reversible and those associated with cognitive processes may be accessible to pharmacological interventions...
  60. doi request reprint Antidepressants, social adversity and outcome of depression in general practice
    George W Brown
    Institute of Psychiatry, Kings College London, Road, London SE1 7EH, United Kingdom
    J Affect Disord 121:239-46. 2010
    ..The role of current social risk factors in moderating the impact of antidepressant medication has not previously been explored...
  61. doi request reprint Reactivity of affect and self-esteem during remission in bipolar affective disorder: an experimental investigation
    Barbara Pavlova
    Institute of Psychiatry, King s College London, London, UK
    J Affect Disord 134:102-11. 2011
    ..We hypothesised that this latent vulnerability can manifest as reactivity of affect and self-esteem to experimentally induced experiences of success and failure and is shaped by history of childhood adversity...
  62. doi request reprint Repetitive transcranial magnetic stimulation reduces cue-induced food craving in bulimic disorders
    Frederique van den Eynde
    Institute of Psychiatry, King s College London, London, United Kingdom
    Biol Psychiatry 67:793-5. 2010
    ..Dysfunction of the dorsolateral prefrontal cortex (DLPFC) is associated with craving. We investigated whether stimulation of the DLPFC reduces food craving in people with a bulimic-type eating disorder...
  63. doi request reprint Gene-environment interaction in major depression and antidepressant treatment response
    Robert Keers
    MRC SGDP Centre, Institute of Psychiatry at King s College London, 16 De Crespigny Park, Denmark Hill, London, SE5 8AF, England, UK
    Curr Psychiatry Rep 14:129-37. 2012
    ..These findings suggest that the dissection of etiological pathways to depression may provide the key to understanding and predicting response to antidepressants...
  64. doi request reprint Forum: The case for gene-environment interactions in psychiatry
    Rudolf Uher
    Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Curr Opin Psychiatry 21:318-21. 2008
  65. ncbi request reprint Personality pathology among individuals with a lifetime history of anorexia nervosa
    Joanna Holliday
    Institute of Psychiatry, King s College London, London, UK
    J Pers Disord 20:417-30. 2006
    ..These results indicate that pathological personality features in AN are persistent traits, although some features may become exaggerated in the acute phase...
  66. ncbi request reprint An investigation of decision making in anorexia nervosa using the Iowa Gambling Task and skin conductance measurements
    Kate Tchanturia
    Institute of Psychiatry, Kings College, London, United Kingdom
    J Int Neuropsychol Soc 13:635-41. 2007
    ..Neither of these features are found in recovered AN. The association between impaired decision making ability and a decreased autonomic response is consistent with the predictions of the Somatic Marker Hypothesis...
  67. doi request reprint The Everyday Feeling Questionnaire: the structure and validation of a measure of general psychological well-being and distress
    Rudolf Uher
    King s College London Institute of Psychiatry, London, SE5 8AF, UK
    Soc Psychiatry Psychiatr Epidemiol 45:413-23. 2010
    ....
  68. ncbi request reprint Gene-environment interaction: overcoming methodological challenges
    Rudolf Uher
    MRC Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, UK
    Novartis Found Symp 293:13-26; discussion 26-30, 68-70. 2008
    ..Consistencies and discrepancies among studies can be exploited for methodological analysis and model specification...
  69. doi request reprint Trends in hospital admissions for eating disorders in a country undergoing a socio-cultural transition, the Czech Republic 1981-2005
    Barbara Pavlova
    Department of Psychology, Institute of Psychiatry, PO78, 4 Windsor Walk, London, SE5 8AF, UK
    Soc Psychiatry Psychiatr Epidemiol 45:541-50. 2010
    ..To test the hypothesis that the socio-cultural transition in the 1990s in Eastern Europe was associated with an increase in admissions for eating disorders (ED)...
  70. pmc Role for the kinase SGK1 in stress, depression, and glucocorticoid effects on hippocampal neurogenesis
    Christoph Anacker
    Stress, Psychiatry and Immunology Laboratory, Department of Psychological Medicine, Institute of Psychiatry, King s College London, London SE5 9NU, United Kingdom
    Proc Natl Acad Sci U S A 110:8708-13. 2013
    ..Our findings identify SGK1 as a mediator for the effects of cortisol on neurogenesis and GR function, with particular relevance to stress and depression...
  71. pmc Genome-wide approaches to antidepressant treatment: working towards understanding and predicting response
    Karen Hodgson
    MRC SGDP Centre, Institute of Psychiatry, King s College London, London, SE5 A8F, UK
    Genome Med 4:52. 2012
    ....
  72. ncbi request reprint The truth about genetic variation in the serotonin transporter gene and response to stress and medication
    Peter McGuffin
    MRC SGDP Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Br J Psychiatry 198:424-7. 2011
    ..When these confounders are accounted for, there probably is a real, if small, effect of 5-HTTLPR on response to both serotonin reuptake inhibitors and environmental adversity...
  73. ncbi request reprint Differential motivational responses to food and pleasurable cues in anorexia and bulimia nervosa: a startle reflex paradigm
    Hans Christoph Friederich
    Eating Disorders Unit, Institute of Psychiatry, King s College London, London, UK
    Psychol Med 36:1327-35. 2006
    ..SEM was used because it is sensitive to motivational states of approach (appetitive response) and withdrawal (aversive response), which are independent of conscious intentional control...
  74. ncbi request reprint Screening young people for obsessive compulsive disorder
    Rudolf Uher
    South London and Maudsley NHS Trust, Institute of Psychiatry, King s College London, UK
    Br J Psychiatry 191:353-4. 2007
    ..97 (95% CI 0.91-0.98) to detect OCD cases. Its specificity is good in children without psychiatric diagnoses, but low in a psychiatric sample. The SOCS is a screening tool suitable for community but not specialist settings...