T Toulopoulou

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint Substantial genetic overlap between neurocognition and schizophrenia: genetic modeling in twin samples
    Timothea Toulopoulou
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Arch Gen Psychiatry 64:1348-55. 2007
  2. ncbi request reprint The Maudsley Family Study: premorbid and current general intellectual function levels in familial bipolar I disorder and schizophrenia
    Timothea Toulopoulou
    Division of Psychological Medicine, Institute of Psychiatry, De Crespingy Park, London, UK
    J Clin Exp Neuropsychol 28:243-59. 2006
  3. ncbi request reprint Cognitive performance in presumed obligate carriers for psychosis
    Timothea Toulopoulou
    Division of Psychological Medicine, Institute of Psychiatry, London, UK
    Br J Psychiatry 187:284-5. 2005
  4. ncbi request reprint Verbal memory deficit in patients with schizophrenia: an important future target for treatment
    Timothea Toulopoulouand
    Division of Psychological Medicine, Institute of Psychiatry, Box 63, De Crespigny Park, London, SE5 8AF, UK
    Expert Rev Neurother 4:43-52. 2004
  5. ncbi request reprint The relationship between volumetric brain changes and cognitive function: a family study on schizophrenia
    Timothea Toulopoulou
    Division of Psychological Medicine, Section of General Psychiatry, Institute of Psychiatry, London, United Kingdom
    Biol Psychiatry 56:447-53. 2004
  6. ncbi request reprint Episodic memory in schizophrenic patients and their relatives
    T Toulopoulou
    Division of Psychological Medicine Box 63, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Schizophr Res 63:261-71. 2003
  7. ncbi request reprint Selectivity of verbal memory deficit in schizophrenic patients and their relatives
    Timothea Toulopoulou
    Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 116:1-7. 2003
  8. doi request reprint Theory of Mind as a potential trait marker of schizophrenia: a family study
    A D Pentaraki
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
    Cogn Neuropsychiatry 17:64-89. 2012
  9. doi request reprint No association of Disrupted-in-Schizophrenia-1 variation with prefrontal function in patients with schizophrenia and bipolar disorder
    D P Prata
    Division of Psychosis Studies, Institute of Psychiatry, King s Health Partners, King s College London, London, UK
    Genes Brain Behav 10:276-85. 2011
  10. doi request reprint Genetic overlap between episodic memory deficits and schizophrenia: results from the Maudsley Twin Study
    S F Owens
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, King s Health Partners, UK
    Psychol Med 41:521-32. 2011

Detail Information

Publications48

  1. ncbi request reprint Substantial genetic overlap between neurocognition and schizophrenia: genetic modeling in twin samples
    Timothea Toulopoulou
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Arch Gen Psychiatry 64:1348-55. 2007
    ..Neurocognitive deficits are among the most promising indicators of increased risk for schizophrenia; however, it is not clear to what extent these deficits are genetically linked to the disorder...
  2. ncbi request reprint The Maudsley Family Study: premorbid and current general intellectual function levels in familial bipolar I disorder and schizophrenia
    Timothea Toulopoulou
    Division of Psychological Medicine, Institute of Psychiatry, De Crespingy Park, London, UK
    J Clin Exp Neuropsychol 28:243-59. 2006
    ..The two groups of relatives showed distinct differences in intellectual function but we cannot exclude the possibility that these were a function of our sampling methods...
  3. ncbi request reprint Cognitive performance in presumed obligate carriers for psychosis
    Timothea Toulopoulou
    Division of Psychological Medicine, Institute of Psychiatry, London, UK
    Br J Psychiatry 187:284-5. 2005
    ....
  4. ncbi request reprint Verbal memory deficit in patients with schizophrenia: an important future target for treatment
    Timothea Toulopoulouand
    Division of Psychological Medicine, Institute of Psychiatry, Box 63, De Crespigny Park, London, SE5 8AF, UK
    Expert Rev Neurother 4:43-52. 2004
    ..Therefore, a better understanding of the nature of this deficit could lead to treatments that not only improve the specific systems mediating the impairment, but could also have wider implications for clinical and social outcome...
  5. ncbi request reprint The relationship between volumetric brain changes and cognitive function: a family study on schizophrenia
    Timothea Toulopoulou
    Division of Psychological Medicine, Section of General Psychiatry, Institute of Psychiatry, London, United Kingdom
    Biol Psychiatry 56:447-53. 2004
    ....
  6. ncbi request reprint Episodic memory in schizophrenic patients and their relatives
    T Toulopoulou
    Division of Psychological Medicine Box 63, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Schizophr Res 63:261-71. 2003
    ..This study was designed to further elucidate the nature of the memory dysfunction being transmitted...
  7. ncbi request reprint Selectivity of verbal memory deficit in schizophrenic patients and their relatives
    Timothea Toulopoulou
    Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 116:1-7. 2003
    ..Our finding of a selective deficit in verbal memory among relatives suggests that such impairment constitutes a familial, probably genetic, risk factor for schizophrenia...
  8. doi request reprint Theory of Mind as a potential trait marker of schizophrenia: a family study
    A D Pentaraki
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
    Cogn Neuropsychiatry 17:64-89. 2012
    ....
  9. doi request reprint No association of Disrupted-in-Schizophrenia-1 variation with prefrontal function in patients with schizophrenia and bipolar disorder
    D P Prata
    Division of Psychosis Studies, Institute of Psychiatry, King s Health Partners, King s College London, London, UK
    Genes Brain Behav 10:276-85. 2011
    ..The absence of an effect in patients may reflect interactions of the effects of DISC1 genotype with the effects of other genes associated with these disorders, and/or with the effects of the disorders on brain function...
  10. doi request reprint Genetic overlap between episodic memory deficits and schizophrenia: results from the Maudsley Twin Study
    S F Owens
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, King s Health Partners, UK
    Psychol Med 41:521-32. 2011
    ..In this study, we set out to quantify the genetic and environmental contributions to variance in visual and verbal memory performance, and to quantify their genetic relationship with schizophrenia...
  11. doi request reprint Memory functioning in familial bipolar I disorder patients and their relatives
    Seema Quraishi
    NIHR Biomedical Research Centre for Mental Health, South London and Maudsley Foundation NHS Trust and Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Bipolar Disord 11:209-14. 2009
    ..The aim of this study was to compare the memory function of patients with familial bipolar I disorder (BD I) who had shown psychotic features, their non-psychotic, non-bipolar first-degree relatives, and normal controls...
  12. doi request reprint Genetic modelling of childhood social development and personality in twins and siblings with schizophrenia
    M M Picchioni
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
    Psychol Med 40:1305-16. 2010
    ..This study aimed to establish the degree to which these childhood and adolescent developmental abnormalities are genetically determined...
  13. ncbi request reprint Substantial shared genetic influences on schizophrenia and event-related potentials
    Mei Hua Hall
    Social, Genetic, and Developmental Psychiatry Research Centre, Division of Psychological Medicine, Institute of Psychiatry, King s College London, UK, and the Psychology Research Laboratory, McLean Hospital, Belmont, MA, USA
    Am J Psychiatry 164:804-12. 2007
    ..The present study used a twin design to estimate the extent of genetic overlap between these indices and the liability to schizophrenia...
  14. doi request reprint Striatal dopamine synthesis capacity in twins discordant for schizophrenia
    P Shotbolt
    Psychiatric Imaging, MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College London, London, UK
    Psychol Med 41:2331-8. 2011
    ..Relatives of patients with schizophrenia are themselves at increased risk of developing the condition. In this study we examined striatal dopamine synthesis capacity in both members of twin pairs discordant for schizophrenia...
  15. doi request reprint Twins discordant for schizophrenia: psychopathology of the non-schizophrenic co-twins
    S V Argyropoulos
    Division of General Psychiatry and Psychological Medicine, Institute of Psychiatry, London, UK
    Acta Psychiatr Scand 118:214-9. 2008
    ..Patients with schizophrenia are more likely to suffer from mood and anxiety disorders compared with the general population. We explored the aetiology of this comorbidity using a twin study design...
  16. pmc Abnormal cortisol awakening response predicts worse cognitive function in patients with first-episode psychosis
    M Aas
    Department of Psychological Medicine, Institute of Psychiatry, King s College London, UK
    Psychol Med 41:463-76. 2011
    ....
  17. pmc White matter microstructure in schizophrenia: effects of disorder, duration and medication
    Richard Kanaan
    Institute of Psychiatry, Department of Psychological Medicine, King s College London, PO 62, Denmark Hill, London SE5 9RJ, UK
    Br J Psychiatry 194:236-42. 2009
    ..Diffusion tensor magnetic resonance imaging studies in schizophrenia to date have been largely inconsistent. This may reflect variation in methodology, and the use of small samples with differing illness duration and medication exposure...
  18. doi request reprint The effects of neuregulin1 on brain function in controls and patients with schizophrenia and bipolar disorder
    Andrea Mechelli
    Department of Psychology, Institute of Psychiatry, King s College London, 103 Denmark Hill, London, SE5 8AF, UK
    Neuroimage 42:817-26. 2008
    ..Our results suggest that genetic variation in neuregulin1 has a measurable impact on brain function and provide preliminary evidence for a disease-specific pattern of gene action in different regions of the prefrontal cortex...
  19. doi request reprint Increased inferior frontal activation during word generation: a marker of genetic risk for schizophrenia but not bipolar disorder?
    Sergi G Costafreda
    Institute of Psychiatry, King s College London, London, United Kingdom
    Hum Brain Mapp 30:3287-98. 2009
    ..Increased engagement of the inferior frontal cortex during verbal-fluency may thus be a marker of genetic vulnerability to schizophrenia...
  20. doi request reprint Neuropsychological correlates of eye movement abnormalities in schizophrenic patients and their unaffected relatives
    Jolanta Zanelli
    Institute of Psychiatry, Psychological Medicine and Psychiatry, Denmark Hill, DeCrespigny Park, London SE5 8AF, United Kingdom
    Psychiatry Res 168:193-7. 2009
    ..Smooth pursuit performance was unrelated to any neuropsychological measure. Our study suggests that antisaccade errors are likely to represent part of a generalized neuropsychological deficit in schizophrenia...
  21. doi request reprint Altered effect of dopamine transporter 3'UTR VNTR genotype on prefrontal and striatal function in schizophrenia
    Diana P Prata
    Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, PO67, De Crespigny Park, London SE5 8AF, England
    Arch Gen Psychiatry 66:1162-72. 2009
    ..The dopamine transporter plays a key role in the regulation of central dopaminergic transmission, which modulates cognitive processing. Disrupted dopamine function and impaired executive processing are robust features of schizophrenia...
  22. doi request reprint Regional gray matter volume in monozygotic twins concordant and discordant for schizophrenia
    Stefan J Borgwardt
    Section of Neuroimaging, Institute of Psychiatry, King s College London, London, United Kingdom
    Biol Psychiatry 67:956-64. 2010
    ..We investigated the influence of genetic and environmental risk on GMV in monozygotic (MZ) twin pairs concordant and discordant for schizophrenia...
  23. doi request reprint Evidence of association of KIBRA genotype with episodic memory in families of psychotic patients and controls
    Evangelos Vassos
    King s College London, Institute of Psychiatry, Department of Psychological Medicine and Psychiatry and NIHR Biomedical Research Centre, London, UK
    J Psychiatr Res 44:795-8. 2010
    ..05). This study replicates the association between the KIBRA gene and episodic memory and suggests a possibly differential effect of the polymorphism in psychotic and non-psychotic individuals...
  24. doi request reprint Impaired intellect and memory: a missing link between genetic risk and schizophrenia?
    Timothea Toulopoulou
    King s College London, United Kingdom
    Arch Gen Psychiatry 67:905-13. 2010
    ..Although a variety of candidate intermediate phenotypes have emerged, few have explicitly quantified the extent of their genetic overlap with schizophrenia...
  25. pmc Pattern of neural responses to verbal fluency shows diagnostic specificity for schizophrenia and bipolar disorder
    Sergi G Costafreda
    Institute of Psychiatry, King s College London, De Crespigny Park, London UK
    BMC Psychiatry 11:18. 2011
    ..Determining the distinct pattern of neural responses in schizophrenia and bipolar disorder may provide biomarkers for their diagnoses...
  26. pmc Epistasis between the DAT 3' UTR VNTR and the COMT Val158Met SNP on cortical function in healthy subjects and patients with schizophrenia
    Diana P Prata
    Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, London WC2R 2LS, United Kingdom
    Proc Natl Acad Sci U S A 106:13600-5. 2009
    ....
  27. doi request reprint PRODH gene is associated with executive function in schizophrenic families
    Tao Li
    Psychiatric Laboratory, Department of Psychiatry, West China Hospital, Sichuan University, Sichuan, China
    Am J Med Genet B Neuropsychiatr Genet 147:654-7. 2008
    ..It fails to confirm previous reports of an association between COMT and cognitive function...
  28. ncbi request reprint Brain volumes in familial and non-familial schizophrenic probands and their unaffected relatives
    Colm McDonald
    Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London, United Kingdom
    Am J Med Genet 114:616-25. 2002
    ..Individuals inheriting the susceptibility to schizophrenia appear particularly prone to develop ventricular enlargement in response to obstetric complications...
  29. ncbi request reprint Dermatoglyphics and Schizophrenia: a meta-analysis and investigation of the impact of obstetric complications upon a-b ridge count
    Elvira Bramon
    Division of Psychological Medicine, Institute of Psychiatry, P O Box 63, De Crespigny Park, London SE5 8AF, UK
    Schizophr Res 75:399-404. 2005
    ..However, the severity or the origin of these ABRC changes has not been established...
  30. ncbi request reprint Intellectual asymmetry and genetic liability in first-degree relatives of probands with schizophrenia
    Eugenia Kravariti
    Institute of Psychiatry, Department of Psychiatry, Division of Psychological Medicine, Box 63, De Crespigny Park, London SE5 8AF, UK
    Br J Psychiatry 188:186-7. 2006
    ..Intellectual asymmetry with a relative superiority of verbal skills to spatial skills represents a putative endophenotype of schizophrenia...
  31. ncbi request reprint Antisaccade performance in monozygotic twins discordant for schizophrenia: the Maudsley twin study
    Ulrich Ettinger
    Centre for Neuroimaging Sciences, Institute of Psychiatry, King s College London, London SE5 8AF, UK
    Am J Psychiatry 163:543-5. 2006
    ..Deficiency in antisaccade performance has been proposed as a schizophrenia endophenotype...
  32. ncbi request reprint Distribution of symptom dimensions across Kraepelinian divisions
    Dimitris G Dikeos
    Institute of Psychiatry, SGDP Building, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Br J Psychiatry 189:346-53. 2006
    ..Dimensional structures are established for many psychiatric diagnoses, but dimensions have not been compared between diagnostic groups...
  33. doi request reprint Opposite effects of catechol-O-methyltransferase Val158Met on cortical function in healthy subjects and patients with schizophrenia
    Diana P Prata
    Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College, London, United Kingdom
    Biol Psychiatry 65:473-80. 2009
    ..We addressed this by comparing the effects of COMT Val158Met genotype on cortical activation during a task of executive functions in healthy and schizophrenic subjects...
  34. ncbi request reprint Magnetic resonance imaging of the thalamus and adhesio interthalamica in twins with schizophrenia
    Ulrich Ettinger
    Centre for Neuroimaging Sciences, Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, England
    Arch Gen Psychiatry 64:401-9. 2007
    ..However, it is not clear to what extent these abnormalities are determined by the genetic liability for schizophrenia...
  35. ncbi request reprint Differential methylation of the X-chromosome is a possible source of discordance for bipolar disorder female monozygotic twins
    Araceli Rosa
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
    Am J Med Genet B Neuropsychiatr Genet 147:459-62. 2008
    ....
  36. ncbi request reprint Neurological abnormalities in schizophrenic twins
    Marco M Picchioni
    Division of Psychological Medicine, Institute of Psychiatry, Kings College London, London, United Kingdom
    Biol Psychiatry 59:341-8. 2006
    ..Neurological abnormalities (NAs) are well recognized in schizophrenia, though their genetic and environmental determinants, and pathophysiological significance, are poorly understood...
  37. doi request reprint Do COMT, BDNF and NRG1 polymorphisms influence P50 sensory gating in psychosis?
    M Shaikh
    NIHR Biomedical Research Centre, Institute of Psychiatry, King s College London South London and Maudsley NHS Foundation Trust, London, UK
    Psychol Med 41:263-76. 2011
    ....
  38. doi request reprint Selective attention deficits reflect increased genetic vulnerability to schizophrenia
    Francesca M Filbey
    Department of Psychiatry, Institute of Psychiatry, King s College, De Crespigny Park, SE5 8AF London, UK
    Schizophr Res 101:169-75. 2008
    ..Impairment in attention is prominent in schizophrenia and may be a valuable genetic indicator for vulnerability to this disease...
  39. ncbi request reprint Association between BDNF val66 met genotype and episodic memory
    Emma Dempster
    Section of Molecular Genetics, Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 134:73-5. 2005
    ..When cases and unaffected relatives were analyzed separately, met66 was associated with a lower score on the WMS delayed measure in the relatives only (R2 = 0.077 P = 0.01), which is consistent with previous findings...
  40. ncbi request reprint Brain MRI abnormalities in schizophrenia: same genes or same environment?
    F V Rijsdijk
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UK
    Psychol Med 35:1399-409. 2005
    ..Bivariate genetic model fitting (adjusted to account for selection) was used to quantify the genetic relationship between schizophrenia and brain volumes and to estimate the heritability of these volumes...
  41. ncbi request reprint Evidence of normal hearing laterality in familial schizophrenic patients and their relatives
    Timothea Toulopoulou
    Department of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
    Am J Med Genet B Neuropsychiatr Genet 147:73-6. 2008
    ..Adjusting for age, accuracy, and obligate status made no difference. In conclusion, familial schizophrenic patients and their relatives have normal REA and hearing laterality on the fused DL test...
  42. ncbi request reprint Hippocampal volume in familial and nonfamilial schizophrenic probands and their unaffected relatives
    Katja Schulze
    Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
    Biol Psychiatry 53:562-70. 2003
    ..The aim of our study was to assess the contribution of familial liability and obstetric complications to hippocampal volume reduction in schizophrenia...
  43. ncbi request reprint Normal cerebral asymmetry in familial and non-familial schizophrenic probands and their unaffected relatives
    Ben Chapple
    Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Schizophr Res 67:33-40. 2004
    ....
  44. ncbi request reprint Increased rate of birth complications and small head size at birth in winter-born male patients with schizophrenia
    Shu Takagai
    Schizophr Res 83:303-5. 2006
  45. ncbi request reprint Effective adjunctive use of pergolide with quetiapine for cognitive impairment and negative symptoms in schizophrenia
    Yoshimoto Sekine
    J Clin Psychopharmacol 25:281-3. 2005
  46. ncbi request reprint Episodic memory performance predicted by the 2bp deletion in exon 6 of the "alpha 7-like" nicotinic receptor subunit gene
    Emma L Dempster
    Division of Cellular and Molecular Biology, Toronto Western Research Institute, Toronto Western Hospital, McLaughlin Pavillion, 6th Floor Room 415, 399 Bathurst St, Toronto, Ont M5T 2S8, Canada
    Am J Psychiatry 163:1832-4. 2006
    ..CHRNA7 is involved in memory formation, a core dysfunction in schizophrenia. The authors set out to determine if this locus is associated with memory dysfunction in schizophrenia...
  47. ncbi request reprint Poor mental health associated with job dissatisfaction among school teachers in Japan
    Michiko Nagai
    Department of Psychiatric Nursing, Hamamatsu University School of Medicine, Shizuoka, Japan
    J Occup Health 49:515-22. 2007
    ..Poor mental health of Japanese school teachers, female teachers in particular, was found to be associated with job dissatisfaction...
  48. ncbi request reprint Assessment of executive functions: review of instruments and identification of critical issues
    Raymond C K Chan
    Neuropsychology and Applied Cognitive Neuroscience Laboratory and Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, China
    Arch Clin Neuropsychol 23:201-16. 2008
    ..Recently developed measurement models and technology may also facilitate a more ecologically and ethologically valid assessment for the specific needs of different individuals...