Swee L Thein

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint Impact of acute chest syndrome on lung function of children with sickle cell disease
    Karl P Sylvester
    Departments of Child Health, Health and Life Sciences, and Haematological Medicine, King s College London School of Medicine at Guy s, King s College, and St Thomas Hospitals, London, United Kingdom
    J Pediatr 149:17-22. 2006
  2. ncbi request reprint Airway hyperresponsiveness and acute chest syndrome in children with sickle cell anemia
    Karl P Sylvester
    Division of Asthma, Allergy and Lung Biology, MRC Asthma Centre, King s College London, UK
    Pediatr Pulmonol 42:272-6. 2007
  3. ncbi request reprint Lung gas transfer in children with sickle cell anaemia
    Karl P Sylvester
    King s College London, MRC Asthma Centre, Division of Asthma, Allergy and Lung Biology, King s College Hospital, Denmark Hill, London SE5 9RS, UK
    Respir Physiol Neurobiol 158:70-4. 2007
  4. doi request reprint Hydroxyurea therapy lowers circulating DNA levels in sickle cell anemia
    Pinar Ulug
    King s College London School of Medicine, Division of Gene and Cell Based Therapy, Denmark Hill Campus, London SE5 9NU
    Am J Hematol 83:714-6. 2008
  5. doi request reprint The presence of alpha-thalassaemia trait blunts the response to hydroxycarbamide in patients with sickle cell disease
    Nisha Vasavda
    Molecular Haematology, Division of Gene and Cell Based Therapy, King s College London School of Medicine, London, UK
    Br J Haematol 143:589-92. 2008
  6. pmc Genetic variation on chromosome 6 influences F cell levels in healthy individuals of African descent and HbF levels in sickle cell patients
    Lisa E Creary
    King s College London School of Medicine, Division of Gene and Cell, Based Therapy, James Black Centre, Denmark Hill Campus, London, United Kingdom
    PLoS ONE 4:e4218. 2009
  7. pmc The molecular basis of β-thalassemia
    Swee Lay Thein
    Department of Haematological Medicine, King s College London School of Medicine King s College Hospital NHS Foundation Trust, London SE5 9NU, United Kingdom
    Cold Spring Harb Perspect Med 3:a011700. 2013
  8. doi request reprint The emerging role of fetal hemoglobin induction in non-transfusion-dependent thalassemia
    Swee Lay Thein
    King s College Hospital King s College London School of Medicine, London, UK
    Blood Rev 26:S35-9. 2012
  9. doi request reprint Genetic modifiers of sickle cell disease
    Swee Lay Thein
    Department of Molecular Haematology, King s College London, London, UK
    Hemoglobin 35:589-606. 2011
  10. doi request reprint Milestones in the history of hemoglobin research (in memory of professor Titus H.J. Huisman)
    Swee Lay Thein
    Department of Molecular Haematology, King s College London, London, UK
    Hemoglobin 35:450-62. 2011

Research Grants

Collaborators

Detail Information

Publications55

  1. ncbi request reprint Impact of acute chest syndrome on lung function of children with sickle cell disease
    Karl P Sylvester
    Departments of Child Health, Health and Life Sciences, and Haematological Medicine, King s College London School of Medicine at Guy s, King s College, and St Thomas Hospitals, London, United Kingdom
    J Pediatr 149:17-22. 2006
    ..To test the hypothesis that children with sickle cell disease (SCD) who experienced an acute chest syndrome (ACS) hospitalization episode would have worse lung function than children with SCD without ACS episodes...
  2. ncbi request reprint Airway hyperresponsiveness and acute chest syndrome in children with sickle cell anemia
    Karl P Sylvester
    Division of Asthma, Allergy and Lung Biology, MRC Asthma Centre, King s College London, UK
    Pediatr Pulmonol 42:272-6. 2007
    ..Importantly, if AHR is to be correctly diagnosed, some SCA children will require to undergo both cold air and exercise challenge testing...
  3. ncbi request reprint Lung gas transfer in children with sickle cell anaemia
    Karl P Sylvester
    King s College London, MRC Asthma Centre, Division of Asthma, Allergy and Lung Biology, King s College Hospital, Denmark Hill, London SE5 9RS, UK
    Respir Physiol Neurobiol 158:70-4. 2007
    ..Our results suggest this abnormality is independent of other lung function abnormalities...
  4. doi request reprint Hydroxyurea therapy lowers circulating DNA levels in sickle cell anemia
    Pinar Ulug
    King s College London School of Medicine, Division of Gene and Cell Based Therapy, Denmark Hill Campus, London SE5 9NU
    Am J Hematol 83:714-6. 2008
    ..02). cfDNA levels may be useful in monitoring response to hydroxyurea therapy in SCD...
  5. doi request reprint The presence of alpha-thalassaemia trait blunts the response to hydroxycarbamide in patients with sickle cell disease
    Nisha Vasavda
    Molecular Haematology, Division of Gene and Cell Based Therapy, King s College London School of Medicine, London, UK
    Br J Haematol 143:589-92. 2008
    ..We provide data from 30 SCD patients (10 with alpha-thalassaemia) demonstrating that co-existing alpha-thalassaemia significantly affects several standard measures of HC efficacy in SCD...
  6. pmc Genetic variation on chromosome 6 influences F cell levels in healthy individuals of African descent and HbF levels in sickle cell patients
    Lisa E Creary
    King s College London School of Medicine, Division of Gene and Cell, Based Therapy, James Black Centre, Denmark Hill Campus, London, United Kingdom
    PLoS ONE 4:e4218. 2009
    ..We have started to distinguish effects originating from European and African ancestral populations in our admixed study populations...
  7. pmc The molecular basis of β-thalassemia
    Swee Lay Thein
    Department of Haematological Medicine, King s College London School of Medicine King s College Hospital NHS Foundation Trust, London SE5 9NU, United Kingdom
    Cold Spring Harb Perspect Med 3:a011700. 2013
    ..Unraveling the molecular basis of β-thalassemia has provided a paradigm for understanding of much of human genetics...
  8. doi request reprint The emerging role of fetal hemoglobin induction in non-transfusion-dependent thalassemia
    Swee Lay Thein
    King s College Hospital King s College London School of Medicine, London, UK
    Blood Rev 26:S35-9. 2012
    ..Recent findings have provided new insights regarding HbF regulatory pathways, providing new opportunities for derepression of fetal globin gene expression and HbF induction...
  9. doi request reprint Genetic modifiers of sickle cell disease
    Swee Lay Thein
    Department of Molecular Haematology, King s College London, London, UK
    Hemoglobin 35:589-606. 2011
    ..Illumination of such modifying factors may guide future therapeutic interventions and improve prediction of disease severity, with implications for genetic counseling, prenatal diagnosis and implementation of high risk therapy...
  10. doi request reprint Milestones in the history of hemoglobin research (in memory of professor Titus H.J. Huisman)
    Swee Lay Thein
    Department of Molecular Haematology, King s College London, London, UK
    Hemoglobin 35:450-62. 2011
    ..This review highlights the milestones and key developments in Hb research most relevant to hematologists, and that have impacted our understanding and management of the thalassemias and sickle cell disease...
  11. pmc Association between hemolysis and albuminuria in adults with sickle cell anemia
    Thomas G Day
    King s College London School of Medicine, Molecular Haematology, London, UK
    Haematologica 97:201-5. 2012
    ..Altogether, the incidence of hyperfiltration was 71% and microalbuminuria 37%, making nephropathy a common complication of sickle cell anemia...
  12. pmc Selection of housekeeping genes for gene expression studies in human reticulocytes using real-time PCR
    Nicholas Silver
    Molecular Haematology, Division of Gene and Cell Based Therapy, King s College London School of Medicine at King s College Hospital, Denmark Hill, London, SE5 9PJ, UK
    BMC Mol Biol 7:33. 2006
    ..On this basis, stability of the candidate housekeeping genes was ranked according to repeatability of the gene expression differences among 31 samples...
  13. pmc Genome annotation of a 1.5 Mb region of human chromosome 6q23 encompassing a quantitative trait locus for fetal hemoglobin expression in adults
    James Close
    Department of Haematological Medicine, GKT School of Medicine, London, SE5 9PJ, UK
    BMC Genomics 5:33. 2004
    ....
  14. pmc Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults
    Swee Lay Thein
    King s College London School of Medicine, Division of Gene and Cell Based Therapy, King s College Hospital, London SE5 9PJ, United Kingdom
    Proc Natl Acad Sci U S A 104:11346-51. 2007
    ..The results support a key role for the HBS1L-related genetic variants in HbF control and illustrate the biological complexity of the mechanism of 6q QTL as a modifier of fetal hemoglobin levels in the beta hemoglobinopathies...
  15. pmc Control of fetal hemoglobin: new insights emerging from genomics and clinical implications
    Swee Lay Thein
    Division of Gene and Cell Based Therapy, King s College London School of Medicine, Molecular Haematology, Denmark Hill Campus, London SE5 9NU, UK
    Hum Mol Genet 18:R216-23. 2009
    ..These genetic results have already provided remarkable insights into molecular mechanisms that underlie the hemoglobin 'switch'...
  16. doi request reprint Discovering the genetics underlying foetal haemoglobin production in adults
    Swee Lay Thein
    King s College London School of Medicine, Molecular Haematology, Division of Gene and Cell Based Therapy, Denmark Hill Campus, London, UK
    Br J Haematol 145:455-67. 2009
    ....
  17. ncbi request reprint Genetic modifiers of beta-thalassemia
    Swee Lay Thein
    Department of Haematological Medicine, Guy s, King s and St Thomas School of Medicine King s College London, Denmark Hill Campus, Bessemer Road, London SE5 9PJ, UK
    Haematologica 90:649-60. 2005
    ..This article reviews the clinical and hematologic diversity encountered in beta thalassemia with an overview of the modifier genes that moderate their disease expression...
  18. ncbi request reprint A novel deletion causing (epsilon gamma delta beta) degrees thalassaemia in a Chilean family
    Laurence Game
    Department of Haematological Medicine, King s College Hospital, Guy s, Kings and St Thomas School of Medicine, King s College London, London, UK
    Br J Haematol 123:154-9. 2003
    ....
  19. doi request reprint Genetic modifiers of the beta-haemoglobinopathies
    Swee Lay Thein
    King s College London School of Medicine, Department of Haematological Medicine, King s College Hospital, London, UK
    Br J Haematol 141:357-66. 2008
    ..Integrating multiplex genetic testing with clinical and laboratory data to generate predictive models shows potential, but such genetic approaches also require large datasets...
  20. ncbi request reprint Genetic insights into the clinical diversity of beta thalassaemia
    Swee Lay Thein
    Department of Haematological Medicine, Guy s, King s and St Thomas School of Medicine, Denmark Hill Campus, Bessemer Road, London SE5 9PJ, UK
    Br J Haematol 124:264-74. 2004
  21. ncbi request reprint Alpha-haemoglobin stabilising protein is a quantitative trait gene that modifies the phenotype of beta-thalassaemia
    Mei I Lai
    Molecular Haematology, Division of Gene and Cell Based Therapy, King s College London School of Medicine, London, UK
    Br J Haematol 133:675-82. 2006
    ..In some families, the subtle altered levels in AHSP related to the AHSP genotype appears to be a relevant contributory factor in the haematological phenotype...
  22. doi request reprint Outcome of adults with sickle cell disease admitted to critical care - experience of a single institution in the UK
    Kate Gardner
    Department of Haematological Medicine, King s College Hospital NHS Foundation Trust, Denmark Hill, London, UK
    Br J Haematol 150:610-3. 2010
    ..CCU mortality for SCD patients was 19.6%, comparable to a CCU-wide mortality of 17.6% during the study period in the same institution. Re-admission to CCU was high (16% over the 8-year period) but did not increase mortality risk...
  23. ncbi request reprint A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15
    Stephan Menzel
    King s College London School of Medicine, Division of Gene and Cell Based Therapy, King s Denmark Hill Campus, London SE5 9PJ, UK
    Nat Genet 39:1197-9. 2007
    ..The 2p15 BCL11A quantitative trait locus accounts for 15.1% of the trait variance...
  24. doi request reprint Quantification of hepcidin using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
    Sukhvinder S Bansal
    King s College London, Pharmaceutical Sciences Division 150 Stamford Street, Waterloo, London SE1 9NH, UK
    Rapid Commun Mass Spectrom 23:1531-42. 2009
    ..000005) and elevated levels in inflammation (P < 0.0007). In summary a validated method has been developed for the determination of hepcidin concentrations in clinical samples...
  25. ncbi request reprint Circulating DNA: a potential marker of sickle cell crisis
    Nisha Vasavda
    King s College London, King s College Hospital, Division of Gene and Cell Based Therapy, Denmark Hill, London, UK
    Br J Haematol 139:331-6. 2007
    ..005) and total white cell counts (P < 0.05) in steady state. The study shows that plasma DNA concentration may have potential as a biomarker in sickle cell patients...
  26. doi request reprint Ethnic differences in F cell levels in Jamaica: a potential tool for identifying new genetic loci controlling fetal haemoglobin
    Lisa E Creary
    Division of Gene and Cell Based Therapy, King s College London School of Medicine, James Black Centre, London, UK
    Br J Haematol 144:954-60. 2009
    ..46) despite substantial differences in average ancestry. The data confirm ethnic differences in FC levels and indicate the potential usefulness of these populations for admixture mapping of genes for FC levels...
  27. ncbi request reprint Free fetal DNA in maternal circulation: a potential prognostic marker for chromosomal abnormalities?
    Ageliki Gerovassili
    Division of Gene and Cell Based Therapy, King s College London School of Medicine, London, UK
    Prenat Diagn 27:104-10. 2007
    ..We aimed to quantify the levels of fetal and total cfDNA on prospectively collected samples, to understand their correlation with other variables and to clarify their diagnostic value...
  28. pmc Experimental generation of SNP haplotype signatures in patients with sickle cell anaemia
    Stephan Menzel
    Division of Gene and Cell Based Therapy, King s College London School of Medicine, London, United Kingdom
    PLoS ONE 5:e13004. 2010
    ..With the goal to generate haplotype signatures from patients experimentally, we have investigated the suitability of an existing nanofluidic assay platform to perform phase alignment with single-nucleotide polymorphism alleles...
  29. doi request reprint Quantitation of hepcidin in serum using ultra-high-pressure liquid chromatography and a linear ion trap mass spectrometer
    Sukhvinder S Bansal
    Pharmaceutical Sciences Division, King s College London, 150 Stamford Street, Waterloo, London SE1 9NH, UK
    Rapid Commun Mass Spectrom 24:1251-9. 2010
    ..6 +/- 2.7 nmol/L, in patients with sickle cell disease, 7.0 +/- 8.9 nmol/L; in patients with end-stage renal disease, 30.5 +/- 15.7 nmol/L; and patients with penetrant hereditary hemochromatosis, 1.4 +/- 0.8 nmol/L...
  30. ncbi request reprint Cell-free DNA levels in pregnancies at risk of sickle-cell disease and significant ethnic variation
    Ageliki Gerovassili
    Division of Gene and Cell Based Therapy, King s College London School of Medicine, King s College Hospital, London, UK
    Br J Haematol 135:738-41. 2006
    ..A significant variation in cf-DNA was found between ethnic groups, which should be taken into consideration in future studies measuring cf-DNA...
  31. doi request reprint Quantitation of hepcidin in human urine by liquid chromatography-mass spectrometry
    Sukhvinder S Bansal
    Pharmaceutical Sciences Division, King s College London, 150 Stamford Street, Waterloo, and Institute of Liver Studies, King s College Hospital, London SE1 9NH, UK
    Anal Biochem 384:245-53. 2009
    ....
  32. ncbi request reprint Heterogeneity of the epsilon gamma delta beta-thalassaemias: characterization of three novel English deletions
    Helen Rooks
    Department of Haematological Medicine, Guy s Kings and St Thomas School of Medicine, King s College London, London SE5 9PJ, UK
    Br J Haematol 128:722-9. 2005
    ....
  33. ncbi request reprint The HBS1L-MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans
    Stephan Menzel
    King s College London School of Medicine, Division of Gene and Cell Based Therapy, London, United Kingdom
    Blood 110:3624-6. 2007
    ..These results support the notion that changes of F-cell abundance can be an indicator of more general shifts in hematopoietic patterns in humans...
  34. doi request reprint Renal iron load in sickle cell disease is influenced by severity of haemolysis
    Nisha Vasavda
    King s College London School of Medicine, Molecular Haematology, London, UK
    Br J Haematol 157:599-605. 2012
    ..We postulate that the increased R-R2 is associated with haemolysis rather than transfusional iron load in sickle cell disease...
  35. ncbi request reprint Molecular therapies in beta-thalassaemia
    Lynn Quek
    Department of Haematological Medicine, King s College Hospital, Denmark Hill, London, UK
    Br J Haematol 136:353-65. 2007
    ..Improved understanding of the molecular basis of the disease complications, such as iron overloading, has also provided clues for potential molecular targets at the tertiary level...
  36. doi request reprint The HBS1L-MYB intergenic interval associated with elevated HbF levels shows characteristics of a distal regulatory region in erythroid cells
    Karin Wahlberg
    Division of Gene and Cell Based Therapy, King s College London School of Medicine, London, United Kingdom
    Blood 114:1254-62. 2009
    ..The data suggest that GATA-1 regulates numerous genes of various functions on chromosome 6q...
  37. ncbi request reprint Temporal relationship of asthma to acute chest syndrome in sickle cell disease
    Karl P Sylvester
    Division of Asthma, Allergy and Lung Biology, King s College London, United Kingdom
    Pediatr Pulmonol 42:103-6. 2007
    ..02). The ACS children had been diagnosed as asthmatic at a median of 3.5 (range 0.5-7) years prior to their first ACS episode. In conclusion, these results suggest asthma exacerbations may predispose to ACS episodes...
  38. ncbi request reprint Beta-thalassaemia prototype of a single gene disorder with multiple phenotypes
    Swee Lay Thein
    Department of Haematological Medicine, Guy s, King s and St Thomas School of Medicine, London, UK
    Int J Hematol 76:96-104. 2002
    ..This article reviews the clinical and haematological diversity encountered in beta thalassaemia and their relationship with the underlying genotypes...
  39. ncbi request reprint The linear effects of alpha-thalassaemia, the UGT1A1 and HMOX1 polymorphisms on cholelithiasis in sickle cell disease
    Nisha Vasavda
    King s College London School of Medicine, Division of Gene and Cell Based Therapy, London, UK
    Br J Haematol 138:263-70. 2007
    ..Each additional [TA] repeat is associated with an increase in mean serum bilirubin levels of 21% and cholelithiasis risk of 87% in SCD...
  40. doi request reprint Sickle cell nephropathy - a practical approach
    Claire C Sharpe
    Department of Renal Medicine, King s College London, UK
    Br J Haematol 155:287-97. 2011
    ..We summarize current knowledge of genetic modulation of sickle-related renal dysfunction. We outline the evidence for various treatment options and discuss others for which little evidence currently exists...
  41. doi request reprint Outcome of children with sickle cell disease admitted to intensive care - a single institution experience
    Jack L Bartram
    Department of Paediatric Haematology, King s College London School of Medicine, King s College Hospital, Denmark Hill, London, UK
    Br J Haematol 150:614-7. 2010
    ..The most common reason for admission was acute chest syndrome (43%). 88% of admissions required blood transfusion, of which 74% had exchange blood transfusions. The mortality among children with SCD admitted to PICU is low...
  42. ncbi request reprint Exhaled carbon monoxide levels in children with sickle cell disease
    Karl P Sylvester
    Department of Child Health, King s College Hospital, 4th Floor Golden Jubilee Wing, Bessemer Road, SE5 9RS London, UK
    Eur J Pediatr 164:162-5. 2005
    ..60; 95% C.I. 2.93-4.28; P <0.0001). Conclusion:These results suggest that measurement of end-tidal carbon monoxide levels is a reliable and useful method to monitor haemolysis in children with sickle cell disease...
  43. ncbi request reprint The measurement of urinary hydroxyurea in sickle cell anaemia
    R Neil Dalton
    Paediatrics, Guy s and St Thomas NHS Trust, London, UK
    Br J Haematol 130:138-44. 2005
    ..These assays are potentially useful to study hydroxyurea metabolism further, develop optimal dosing regimes and monitor compliance with treatment...
  44. doi request reprint Acute human parvovirus B19 infection and nephrotic syndrome in patients with sickle cell disease
    Lynn Quek
    Department of Haematological Medicine, King s College Hospital NHS Trust, Denmark Hill, London, UK
    Br J Haematol 149:289-91. 2010
    ..This is consistent with a view that although NS is potentially a rare complication of symptomatic acute HPV B19 infection, exposure to HPV B19 is not associated with an increased risk of renal disease...
  45. ncbi request reprint cMYB is involved in the regulation of fetal hemoglobin production in adults
    Jie Jiang
    Department of Haematological Medicine, King s College London School of Medicine at King s College Hospital, Denmark Hill Campus, London SE5 9PJ, United Kingdom
    Blood 108:1077-83. 2006
    ..These observations suggest that differences in the intrinsic levels of cMYB may account for some of the variation in adult HbF levels. The possible mechanism of cMYB influencing gamma- to beta-globin switching is discussed...
  46. ncbi request reprint Lamin B-receptor mutations in Pelger-Huët anomaly
    Steve Best
    Department of Haematology, King s College Hospital, London, UK, SE5 9RS
    Br J Haematol 123:542-4. 2003
    ..Our results confirm recently published findings that LBR mutations cause Pelger-Huët...
  47. ncbi request reprint Hepatic dysfunction in sickle cell disease: a new system of classification based on global assessment
    Philip A Berry
    Institute of Liver Studies, King s College Hospital, London, United Kingdom
    Clin Gastroenterol Hepatol 5:1469-76; quiz 1369. 2007
    ..Because previous attempts to describe patterns of liver disease have not reflected clinical experience, we aimed to characterize the presentation, clinicopathologic findings, and natural history of such patients...
  48. doi request reprint The effects of air quality on haematological and clinical parameters in children with sickle cell anaemia
    Hrishi Mittal
    King s College London, London, UK
    Ann Hematol 88:529-33. 2009
    ..The lower levels of bilirubin and other markers of haemolysis with increased exposure to air pollutants could be mediated by increased exposure to NO...
  49. doi request reprint Binding patterns of BCL11A in the globin and GATA1 loci and characterization of the BCL11A fetal hemoglobin locus
    Kiran Jawaid
    King s College London, The James Black Centre, UK
    Blood Cells Mol Dis 45:140-6. 2010
    ..We also observed BCL11A and GATA-1 binding in a known auto-regulatory promoter element of the GATA1 locus...
  50. ncbi request reprint Two candidate genes for low platelet count identified in an Asian Indian kindred by genome-wide linkage analysis: glycoprotein IX and thrombopoietin
    Chad Garner
    Epidemiology Division, Department of Medicine, University of California, Irvine, CA 92697 7550, USA
    Eur J Hum Genet 14:101-8. 2006
    ..The results suggest that two QTLs on chromosome 3q influence platelet count variation in the Asian Indian kindred, with the GPIX transmembrane mutation and the 3' UTR SNP in THPO being strong candidates...
  51. pmc Evidence of genetic interaction between the beta-globin complex and chromosome 8q in the expression of fetal hemoglobin
    Chad P Garner
    Department of Integrative Biology, University of California, Berkeley, Berkeley, CA 94720 3140, USA
    Am J Hum Genet 70:793-9. 2002
    ..The results of analysis in a large Indian kindred indicate that there is an interaction between the XmnI-Ggamma site and a QTL on chromosome 8q that is influencing the production of fetal Hb...
  52. ncbi request reprint Quantitative trait locus on chromosome 8q influences the switch from fetal to adult hemoglobin
    Chad Garner
    Epidemiology Division, Department of Medicine, University of California Irvine, Irvine, CA 92697 7550, USA
    Blood 104:2184-6. 2004
    ..This result provides strong evidence that a quantitative trait locus exists on chromosome 8q that influences the developmental switch from fetal to adult hemoglobin...
  53. ncbi request reprint Heterocellular hereditary persistence of fetal haemoglobin affects the haematological parameters of beta-thalassaemia trait
    Chad Garner
    Department of Environmental Analysis and Design, Division of Epidemiology, University of California, Irvine, CA, USA
    Br J Haematol 123:353-8. 2003
    ....
  54. ncbi request reprint Population analysis of the alpha hemoglobin stabilizing protein (AHSP) gene identifies sequence variants that alter expression and function
    Camila O Dos Santos
    The Children s Hospital of Philadelphia, Division of Hematology, Philadelphia, Pennsylvania 19104, USA
    Am J Hematol 83:103-8. 2008
    ....
  55. ncbi request reprint Windy weather and low humidity are associated with an increased number of hospital admissions for acute pain and sickle cell disease in an urban environment with a maritime temperate climate
    Simon Jones
    School of Mathematics, Kingston University, Kingston upon Thames, Surrey, UK
    Br J Haematol 131:530-3. 2005
    ..The effect of high wind and low humidity is likely to be related to skin cooling...

Research Grants3

  1. A QTL for fetal hemoglobin and F cells on chromosome 8q
    Swee Thein; Fiscal Year: 2003
    ..The discovery of these factors may also suggest new approaches for therapeutic augmentation of fetal hemoglobin production in patients with SCD and beta thalassemia. ..