Leonie S Taams

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint Modulation of monocyte/macrophage function by human CD4+CD25+ regulatory T cells
    Leonie S Taams
    Infection and Immunity Research Group, Franklin Wilkins Building, King s College London, UK
    Hum Immunol 66:222-30. 2005
  2. ncbi request reprint The generation and antigen-specificity of CD4+CD25+ regulatory T cells
    Leonie S Taams
    Dept Immunobiology, King s College London, St Thomas Street, London SE1 9RT, UK
    Inflamm Allergy Drug Targets 5:149-56. 2006
  3. pmc Regulatory T cells in human disease and their potential for therapeutic manipulation
    Leonie S Taams
    Division of Infection, Immunity and Inflammatory Diseases, Guy s Hospital, King s College London, London, UK
    Immunology 118:1-9. 2006
  4. ncbi request reprint Peripheral generation and function of CD4+CD25+ regulatory T cells
    L S Taams
    Infection and Immunity Research Group, King s College London, Franklin Wilkins Building, 150 Stamford Street, London SE1 9NN, UK
    Curr Top Microbiol Immunol 293:115-31. 2005
  5. doi request reprint Interaction with activated monocytes enhances cytokine expression and suppressive activity of human CD4+CD45ro+CD25+CD127(low) regulatory T cells
    Gina J Walter
    King s College London, London, UK
    Arthritis Rheum 65:627-38. 2013
  6. ncbi request reprint Secretory leukocyte protease inhibitor: a pivotal mediator of anti-inflammatory responses in acetaminophen-induced acute liver failure
    Charalambos Gustav Antoniades
    Section of Hepatology, St Mary s Hospital, Imperial College, London, UK Institute of Liver Sciences, King s College London, London, UK
    Hepatology 59:1564-76. 2014
  7. ncbi request reprint Interleukin-17+CD8+ T cells are enriched in the joints of patients with psoriatic arthritis and correlate with disease activity and joint damage progression
    Bina Menon
    King s College London and Guy s and St Thomas Hospitals Foundation NHS Trust, London, UK
    Arthritis Rheumatol 66:1272-81. 2014
  8. doi request reprint FAS/FAS-L dependent killing of activated human monocytes and macrophages by CD4+CD25- responder T cells, but not CD4+CD25+ regulatory T cells
    Ann L Jagger
    Centre for Molecular and Cellular Biology of Inflammation, Division of Immunology, Infection and Inflammatory Disease, King s College London, London SE1 1UL, UK
    J Autoimmun 38:29-38. 2012
  9. pmc The peripheral generation of CD4+ CD25+ regulatory T cells
    Arne N Akbar
    Department of Immunology and Molecular Pathology, Windeyer Institute for Medical Sciences, Royal Free and University College Medical School, London, UK
    Immunology 109:319-25. 2003
  10. pmc Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+ T cells during aging
    Elaine Agius
    Department of Immunology, Division of Infection and Immunity, University College London, London, W1T 4JF, England, UK
    J Exp Med 206:1929-40. 2009

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Modulation of monocyte/macrophage function by human CD4+CD25+ regulatory T cells
    Leonie S Taams
    Infection and Immunity Research Group, Franklin Wilkins Building, King s College London, UK
    Hum Immunol 66:222-30. 2005
    ..Together, these data demonstrate that CD4+CD25+ Tregs can exert direct suppressive effects on monocytes/macrophages, thereby affecting subsequent innate and adaptive immune responses...
  2. ncbi request reprint The generation and antigen-specificity of CD4+CD25+ regulatory T cells
    Leonie S Taams
    Dept Immunobiology, King s College London, St Thomas Street, London SE1 9RT, UK
    Inflamm Allergy Drug Targets 5:149-56. 2006
    ..The aim of this review is to summarize the evidence supporting these opposing viewpoints and to combine them into a general model for the origin, function and antigen-specificity of CD4+CD25+ regulatory T cells...
  3. pmc Regulatory T cells in human disease and their potential for therapeutic manipulation
    Leonie S Taams
    Division of Infection, Immunity and Inflammatory Diseases, Guy s Hospital, King s College London, London, UK
    Immunology 118:1-9. 2006
    ..The purpose of this review was to summarize current knowledge on regulatory T-cell function in human disease, and to assess critically how this can be tailored to suit the therapeutic manipulation of immunity...
  4. ncbi request reprint Peripheral generation and function of CD4+CD25+ regulatory T cells
    L S Taams
    Infection and Immunity Research Group, King s College London, Franklin Wilkins Building, 150 Stamford Street, London SE1 9NN, UK
    Curr Top Microbiol Immunol 293:115-31. 2005
    ..These features make the CD4+CD25+ regulatory T cell subset an interesting target for immunotherapy of chronic inflammatory or autoimmune diseases...
  5. doi request reprint Interaction with activated monocytes enhances cytokine expression and suppressive activity of human CD4+CD45ro+CD25+CD127(low) regulatory T cells
    Gina J Walter
    King s College London, London, UK
    Arthritis Rheum 65:627-38. 2013
    ....
  6. ncbi request reprint Secretory leukocyte protease inhibitor: a pivotal mediator of anti-inflammatory responses in acetaminophen-induced acute liver failure
    Charalambos Gustav Antoniades
    Section of Hepatology, St Mary s Hospital, Imperial College, London, UK Institute of Liver Sciences, King s College London, London, UK
    Hepatology 59:1564-76. 2014
    ..Conclusion: SLPI is a pivotal mediator of anti-inflammatory responses in AALF through modulation of monocyte/macrophage function, which may account for the susceptibility to sepsis in AALF...
  7. ncbi request reprint Interleukin-17+CD8+ T cells are enriched in the joints of patients with psoriatic arthritis and correlate with disease activity and joint damage progression
    Bina Menon
    King s College London and Guy s and St Thomas Hospitals Foundation NHS Trust, London, UK
    Arthritis Rheumatol 66:1272-81. 2014
    ....
  8. doi request reprint FAS/FAS-L dependent killing of activated human monocytes and macrophages by CD4+CD25- responder T cells, but not CD4+CD25+ regulatory T cells
    Ann L Jagger
    Centre for Molecular and Cellular Biology of Inflammation, Division of Immunology, Infection and Inflammatory Disease, King s College London, London SE1 1UL, UK
    J Autoimmun 38:29-38. 2012
    ....
  9. pmc The peripheral generation of CD4+ CD25+ regulatory T cells
    Arne N Akbar
    Department of Immunology and Molecular Pathology, Windeyer Institute for Medical Sciences, Royal Free and University College Medical School, London, UK
    Immunology 109:319-25. 2003
  10. pmc Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+ T cells during aging
    Elaine Agius
    Department of Immunology, Division of Infection and Immunity, University College London, London, W1T 4JF, England, UK
    J Exp Med 206:1929-40. 2009
    ..This may be a predisposing factor for the development of malignancy and infection in the skin during aging...
  11. doi request reprint Source and characterization of hepatic macrophages in acetaminophen-induced acute liver failure in humans
    Charalambos Gustav Antoniades
    Institute of Liver Studies and Cellular Biology of Inflammation, King s College London, London, United Kingdom
    Hepatology 56:735-46. 2012
    ..Levels of CCL2, CCL3, interleukin (IL)-6, IL-10, and transforming growth factor-β1 were significantly elevated in AALF liver tissue relative to chronic liver disease controls...
  12. pmc Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes
    Hayley G Evans
    Departments of Immunobiology and Nephrology and Transplantation, King s College London, London, United Kingdom
    Proc Natl Acad Sci U S A 104:17034-9. 2007
    ....
  13. pmc CD161 expression characterizes a subpopulation of human regulatory T cells that produces IL-17 in a STAT3-dependent manner
    Behdad Afzali
    Medical Research Council Centre for Transplantation, King s College London, King s Health Partners, Guy s Hospital, London, UK
    Eur J Immunol 43:2043-54. 2013
    ..As IL-17 production from this Treg-cell subpopulation is not accompanied by a loss of regulatory function, in the context of cell therapy, exclusion of these cells from the cell product may not be necessary. ..
  14. pmc Lack of suppressive CD4+CD25+FOXP3+ T cells in advanced stages of primary cutaneous T-cell lymphoma
    Machteld M Tiemessen
    Immunobiology Department, Division of Immunology, Infection and Inflammatory Disease, King s College London School of Medicine at Guy s, King s College and St Thomas Hospitals, London, UK
    J Invest Dermatol 126:2217-23. 2006
    ..Our findings thus indicate a dysfunction of peripheral Tregs in certain CTCL patients, which correlates with tumor burden...
  15. pmc CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages
    Machteld M Tiemessen
    Department of Immunobiology, Division of Immunology, Infection and Inflammatory Disease, King s College London School of Medicine at Guy s, King s College, and St Thomas Hospitals, London SE1 9RT, United Kingdom
    Proc Natl Acad Sci U S A 104:19446-51. 2007
    ..Moreover, the data suggest that the Treg-mediated induction of AAM partly involves a novel, cytokine-independent pathway...
  16. ncbi request reprint Proinflammatory mediator-induced reversal of CD4+,CD25+ regulatory T cell-mediated suppression in rheumatoid arthritis
    Jocea M R van Amelsfort
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 56:732-42. 2007
    ..The purpose of the present study was to investigate whether particular proinflammatory mediators that are associated with RA could abrogate CD4+,CD25+ Treg-mediated suppression...
  17. ncbi request reprint Antigen-specific T cell suppression by human CD4+CD25+ regulatory T cells
    Leonie S Taams
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Immunol 32:1621-30. 2002
    ..This would provide a mechanism for the generation of regulatory cells that induce tolerance to a wide array of antigens that may not be encountered in the thymus...
  18. ncbi request reprint CD4(+)CD25(+) regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluid
    Jocea M R van Amelsfort
    University Medical Centre Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 50:2775-85. 2004
    ..We investigated the presence, phenotype, and function of CD4(+)CD25(+) regulatory T cells in peripheral blood (PB) and synovial fluid (SF) from patients with rheumatoid arthritis (RA)...
  19. ncbi request reprint Identification of a CD4+CD25+ T cell subset committed in vivo to suppress antigen-specific T cell responses without additional stimulation
    Esther N M Nolte-'t Hoen
    Department of Infectious Diseases and Immunology, Division of Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Eur J Immunol 34:3016-27. 2004
    ..This suggests that the presence of CD4+CD25+CD134+ T cells indicates sites of active immune suppression...
  20. ncbi request reprint Modulation of T cell responses after cross-talk between antigen presenting cells and T cells: a give-and-take relationship
    Marca H M Wauben
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, P O Box 80 165, 3508 TD Utrecht, The Netherlands
    Novartis Found Symp 252:211-20; discussion 220-5, 257-67. 2003
    ..We speculate that the quantity and quality of molecule reshuffling during cross-talk between T cells and APCs play a role in the regulation of the T cell response...
  21. ncbi request reprint CD4+CD25bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis
    Ismé M de Kleer
    University Medical Center Utrecht, Wilhelmina Children s Hospital, Department of Pediatric Immunology and Immunology Advanced Center on Preclinical Immuno genomics Institute for Translational Medicine, Utrecht, The Netherlands
    J Immunol 172:6435-43. 2004
    ..These data suggest that CD4(+)CD25(bright) Treg cells play a role in determining the patient's fate toward either a favorable or unfavorable clinical course of disease...
  22. ncbi request reprint CD4 CD25 regulatory T cells are not functionally impaired in adult patients with IgE-mediated cow's milk allergy
    Machteld M Tiemessen
    J Allergy Clin Immunol 110:934-6. 2002
  23. pmc Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo
    Milica Vukmanovic-Stejic
    Department of Immunology and Molecular Pathology, Division of Infection and Immunity, Windeyer Institute of Medical Sciences, University College London, London, United Kingdom
    J Clin Invest 116:2423-33. 2006
    ....