S A Surguladze
Affiliation: King's College London
- Interaction of catechol O-methyltransferase and serotonin transporter genes modulates effective connectivity in a facial emotion-processing circuitryS A Surguladze
Institute of Psychiatry, King s College London, London, UK
Transl Psychiatry 2:e70. 2012..We suggest that the epistatic effect of reduced effective connectivity may underlie an inefficient emotion regulation that places these individuals at greater risk for depressive disorders...
- The McCollough effect and facial emotion discrimination in patients with schizophrenia and their unaffected relativesSimon A Surguladze
Department of Psychosis Studies, Institute of Psychiatry, King s College London, PO Box 69, De Crespigny Park, London SE5 9AF, UK
Schizophr Bull 38:599-607. 2012..Our results support the heritability of FA discrimination deficits as a trait and indicate visual adaptation abnormalities in schizophrenia, which are symptom related...
- Depression is associated with increased sensitivity to signals of disgust: a functional magnetic resonance imaging studySimon A Surguladze
Department of Psychosis, King s College London Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
J Psychiatr Res 44:894-902. 2010..Enhanced activation to facial expressions of disgust may reflect an emotion processing bias that suggests high relevance of emotion of disgust to depression...
- Exaggerated neural response to emotional faces in patients with bipolar disorder and their first-degree relativesS A Surguladze
King s College London Institute of Psychiatry, DeCrespigny Park, London SE5 8AF, UK
Neuroimage 53:58-64. 2010..Exaggerated medial prefrontal cortical and subcortical (putamen and amygdala) responses to emotional signals may represent heritable neurobiological abnormalities underlying bipolar disorder...
- Emotion processing in schizophrenia: fMRI study of patients treated with risperidone long-acting injections or conventional depot medicationSimon A Surguladze
Division of Psychological Medicine and Psychiatry, King s College London Institute of Psychiatry, London, UK
J Psychopharmacol 25:722-33. 2011..Our results suggest that networks implicated in the allocation of attentional resources (VMPFC) and emotion processing (amygdala, cerebellum) are differentially affected in patients on CONV versus RLAI...
- Genetic variation in the serotonin transporter modulates neural system-wide response to fearful facesS A Surguladze
Institute of Psychiatry, King s College London, London, United Kingdom
Genes Brain Behav 7:543-51. 2008..These effects may underlie the vulnerability to mood and anxiety disorders potentially triggered by socially salient, emotional cues in individuals with the S allele of 5-HTTLPR...
- Resting-state cerebral blood flow in amygdala is modulated by sex and serotonin transporter genotypeW El-Hage
Inserm U930 ERL, Université François Rabelais and CHRU de Tours, Tours, France Institute of Psychiatry, King s College London, London, UK Electronic address
Neuroimage 76:90-7. 2013..The novelty of our results lies in the demonstration of gene by sex interaction with resting blood flow in the amygdala that elucidates sex-related differences in emotional reactivity...
- Genetic modulation of neural response during working memory in healthy individuals: interaction of glucocorticoid receptor and dopaminergic genesW El-Hage
Inserm U930 ERL CNRS 3106, Universite Francois Rabelais, Department of Psychiatry, CHRU Tours, Tours, France
Mol Psychiatry 18:174-82. 2013..Epistasis of COMT and BclI minor alleles is associated with higher activation, suggesting lower efficiency, of DLPFC during WM...
- Neural response to specific components of fearful faces in healthy and schizophrenic adultsJoaquim Radua
King s College London Institute of Psychiatry, London, UK
Neuroimage 49:939-46. 2010..PCA-based analysis could be useful in isolating brain response to salient facial features in psychiatric populations...
- Cerebral and autonomic responses to emotional facial expressions in depersonalisation disorderErwin Lemche
Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
Br J Psychiatry 193:222-8. 2008..Depersonalisation disorder is characterised by emotion suppression, but the cerebral mechanisms of this symptom are not yet fully understood...
- The effect of long-acting risperidone on working memory in schizophrenia: a functional magnetic resonance imaging studySimon A Surguladze
Department of Psychiatry, King s College London Institute of Psychiatry, De Crespigny Park, London, UK
J Clin Psychopharmacol 27:560-70. 2007..We conclude that RLAI may contribute to normalization of brain activation in regions involved in working memory functioning in people with chronic schizophrenia...
- Limbic and prefrontal responses to facial emotion expressions in depersonalizationErwin Lemche
Section of Neuroscience and Emotion, Brain Image Analysis Unit, Neuroimaging Research Group, Centre for Neuroimaging Sciences, Institute of Psychiatry, London, UK
Neuroreport 18:473-7. 2007....
- Human attachment security is mediated by the amygdala: evidence from combined fMRI and psychophysiological measuresErwin Lemche
Division of Psychological Medicine, Section of Neuroscience and Emotion, Institute of Psychiatry, London, United Kingdom
Hum Brain Mapp 27:623-35. 2006..We thereby demonstrate a key role of the amygdala in mediating autonomic activity associated with human attachment insecurity...
- Recognition accuracy and response bias to happy and sad facial expressions in patients with major depressionSimon A Surguladze
Section of Neuroscience and Emotion, Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, United Kingdom
Neuropsychology 18:212-8. 2004..The authors suggest that, in depressed patients, the inability to accurately identify subtle changes in facial expression displayed by others in social situations may underlie the impaired interpersonal functioning...
- A preferential increase in the extrastriate response to signals of dangerSimon A Surguladze
Section of Neuroscience and Emotion, Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
Neuroimage 19:1317-28. 2003..We suggest that this differential pattern of response to different categories of emotional signals allows the preferential direction of visual attention to signals of imminent danger than to other, less-salient emotional stimuli...
- Insight in eating disorders: clinical and cognitive correlatesG Konstantakopoulos
Section of Cognitive Neuropsychiatry, Institute of Psychiatry, King s College, London, UK
Psychol Med 41:1951-61. 2011..The aim of this study was to explore the extent of lack of insight and its components in eating disorders (EDs) and to investigate the relationship between insight and clinical and cognitive characteristics in this group...