Research Topics
| James M StoneSummaryAffiliation: King's College London Country: UK Publications
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Detail Information
Publications
Review: The biological basis of antipsychotic response in schizophreniaJames M Stone
Institute of Psychiatry, King s College London, London SE5 8AF, UK
J Psychopharmacol 24:953-64. 2010..In this selective review we summarise research findings investigating the biological differences between patients with schizophrenia who show a good or a poor response to treatment with antipsychotic drugs...
Non-uniform blockade of intrastriatal D2/D3 receptors by risperidone and amisulprideJames M Stone
Section of Neurochemical Imaging, Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
Psychopharmacology (Berl) 180:664-9. 2005..The striatum does not contain exclusively nigrostriatal dopamine tracts, however. The caudate nucleus and ventral parts of the striatum primarily contain limbic and associative dopamine pathways more relevant to psychosis...
Cortical dopamine D2/D3 receptors are a common site of action for antipsychotic drugs--an original patient data meta-analysis of the SPECT and PET in vivo receptor imaging literatureJames M Stone
King s College London Institute of Psychiatry, DeCrespigny Park, London SE5 8AF, UK
Schizophr Bull 35:789-97. 2009..We found no evidence for 5HT(2A) blockade involvement in antipsychotic action, although we cannot exclude this possibility...- Relationship between ketamine-induced psychotic symptoms and NMDA receptor occupancy: a [(123)I]CNS-1261 SPET studyJames M Stone
Institute of Psychiatry, King s College London, London, UK
Psychopharmacology (Berl) 197:401-8. 2008..Ketamine induces effects resembling both positive and negative psychotic symptoms of schizophrenia. These are thought to arise through its action as an uncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor... - Novel targets for drugs in schizophreniaJ M Stone
Section of Neurochemical Imaging, Kings College London Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
CNS Neurol Disord Drug Targets 6:265-72. 2007..This review summarises the main neurochemical theories of schizophrenia, and, in the light of these, examines possible therapeutic targets for new antipsychotic drugs... - Glutamate and dopamine dysregulation in schizophrenia--a synthesis and selective reviewJames M Stone
King s College London Institute of Psychiatry, London, UK
J Psychopharmacol 21:440-52. 2007..We consider the case for glutamatergic excitotoxicity as a key process in the development and progression of schizophrenia, and suggest ways in which glutamate and dopamine dysregulation may interact in the condition... - [123I]TPCNE--a novel SPET tracer for the sigma-1 receptor: first human studies and in vivo haloperidol challengeJames M Stone
Institute of Psychiatry, King s College London, London, UK
Synapse 60:109-17. 2006..A region in which binding was unaffected by haloperidol pretreatment could not be identified, and the time-activity data were best described by an irreversible model... - Ketamine displaces the novel NMDA receptor SPET probe [(123)I]CNS-1261 in humans in vivoJames M Stone
Institute of Psychiatry, King s College London, De Crespigny Park London, SE5 8AF UK
Nucl Med Biol 33:239-43. 2006..05). [(123)I]CNS-1261 appears to be a specific ligand in vivo for the intra-channel PCP/ketamine/MK-801 NMDA binding site... - Antipsychotic drug action: targets for drug discovery with neurochemical imagingJames M Stone
Section of Neurochemical Imaging, Psychological Medicine, King s College London Institute of Psychiatry, London SE5 8AF, UK
Expert Rev Neurother 6:57-64. 2006.... - Anterior cingulate glutamate levels related to clinical status following treatment in first-episode schizophreniaAlice Egerton
Department of Psychosis Studies, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
Neuropsychopharmacology 37:2515-21. 2012..Treatment with compounds acting on the glutamatergic system might therefore be beneficial in patients who respond poorly to dopaminergic antipsychotics... - Altered relationship between hippocampal glutamate levels and striatal dopamine function in subjects at ultra high risk of psychosisJames M Stone
Department of Psychosis Studies, Institute of Psychiatry, King s College London, United Kingdom
Biol Psychiatry 68:599-602. 2010..Animal models of psychosis propose that striatal hyperdopaminergia is driven by abnormalities in hippocampal glutamatergic neurotransmission, but this has never been tested in humans... - Impact of schizophrenia and chronic antipsychotic treatment on [123I]CNS-1261 binding to N-methyl-D-aspartate receptors in vivoRodrigo A Bressan
Institute of Psychiatry, King's College, London, United Kingdom
Biol Psychiatry 58:41-6. 2005..This supports an effect of the drug on glutamatergic systems that could be exploited for future antipsychotic drug discovery... - Thalamic neurochemical abnormalities in individuals with prodromal symptoms of schizophrenia - relationship to auditory event-related potentialsJames M Stone
Division of Experimental Medicine, Imperial College London, Burlington Danes Building, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
Psychiatry Res 183:174-6. 2010..Reduced thalamic glutamate plus glutamine and N-acetyl aspartate levels were associated with abnormal frontal ERPs, supporting a thalamic basis for filtering impairments... - Proton magnetic resonance spectroscopy and illness stage in schizophrenia--a systematic review and meta-analysisStefan Brugger
Institute of Psychiatry, King s College London, London, United Kingdom
Biol Psychiatry 69:495-503. 2011.... - Substance use and regional gray matter volume in individuals at high risk of psychosisJames M Stone
Department of Psychosis Studies, Institute of Psychiatry, King s College London, United Kingdom
Eur Neuropsychopharmacol 22:114-22. 2012..However, alcohol, tobacco and cannabis at low to moderate intake may be associated with lower gray matter in both ARMS subjects and healthy volunteers-possibly representing low-level cortical damage or change in neural plasticity... - Disruption of frontal θ coherence by Δ9-tetrahydrocannabinol is associated with positive psychotic symptomsPaul D Morrison
The Biomedical Research Centre, Institute of Psychiatry, King s College London, Denmark Hill, UK
Neuropsychopharmacology 36:827-36. 2011..The results reveal that the pro-psychotic effects of THC might be related to impaired network dynamics with impaired communication between the right and left frontal lobes... - The glutamate hypothesis of schizophrenia: neuroimaging and drug developmentAlice Egerton
Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, UK
Curr Pharm Biotechnol 13:1500-12. 2012..Here, we review the contribution of imaging studies to date in understanding glutamatergic abnormalities in psychosis, and discuss the potential of new glutamatergic compounds for treatment of the disorder... - Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairmentAmir Englund
The Biomedical Research Centre, Institute of Psychiatry, King s College London, UK
J Psychopharmacol 27:19-27. 2013..6 ± 18.9%) compared with the CBD group (-0.4% ± 9.7 %) (t=2.39, p<0.05). These findings support the idea that high-THC/low-CBD cannabis products are associated with increased risks for mental health... - Glutamate and psychosis riskAlice Egerton
Department of Psychosis Studies, Institute of Psychiatry, King s Health Partners, King s College London, De Crespigny Park, Denmark Hill, London, UK
Curr Pharm Des 18:466-78. 2012..If glutamatergic abnormalities are present early in the disorder, this suggests that glutamatergic therapies may be useful in psychosis prevention... - Imaging the glutamate system in humans: relevance to drug discovery for schizophreniaJames M Stone
King s College Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
Curr Pharm Des 15:2594-602. 2009..The possibility of developing new drugs for schizophrenia in light of these findings will then be considered... - Neuroanatomical abnormalities that predate the onset of psychosis: a multicenter studyAndrea Mechelli
Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, United Kingdom
Arch Gen Psychiatry 68:489-95. 2011..However, the samples examined to date have been small, and the findings have been inconsistent... - Cannabis in the arm: what can we learn from intravenous cannabinoid studies?Amir Englund
King s College London, Institute of Psychiatry, Denmark Hill, London SE5 8AF
Curr Pharm Des 18:4906-14. 2012..Here in a critical review, we appraise the major findings from recent intravenous cannabinoid studies in humans and trace the historical roots of this work back to the 1970's... - Glutamate dysfunction in people with prodromal symptoms of psychosis: relationship to gray matter volumeJames M Stone
Institute of Psychiatry, King s College London, University College London, United Kingdom
Biol Psychiatry 66:533-9. 2009..Here we determine whether changes in brain glutamate are present in subjects at ultra high risk of developing psychosis and whether these changes are related to reductions in cortical gray matter volume... - Associative blocking to reward-predicting cues is attenuated in ketamine users but can be modulated by images associated with drug useTom P Freeman
Clinical Psychopharmacology Unit, University College London, London, UK
Psychopharmacology (Berl) 225:41-50. 2013..Repeated exposure to ketamine can model aspects of schizophrenia, and frequent users selectively attend to images of the drug... - Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathologySagnik Bhattacharyya
Section of Neuroimaging, Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, London, UK
Neuropsychopharmacology 35:764-74. 2010..Delta-9-THC and CBD can have opposite effects on regional brain function, which may underlie their different symptomatic and behavioral effects, and CBD's ability to block the psychotogenic effects of Delta-9-THC... - The contribution of brain imaging to understanding the mechanism of second generation antipsychotic drugsLyn S Pilowsky
Eur Psychiatry 21:347. 2006 - Internet-enabled high-resolution brain mapping and virtual microscopyShawn Mikula
Center for Neuroscience University of California, Davis, CA, USA
Neuroimage 35:9-15. 2007..Online tools offer the possibility of visualizing and exploring completely digitized sections of brains at a sub-neuronal level and can facilitate large-scale connectional tracing, histochemical, and stereological analyses...