Tim D Spector

Summary

Affiliation: King's College London
Country: UK

Publications

  1. pmc A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length
    M Mangino
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
    J Med Genet 46:451-4. 2009
  2. pmc A probabilistic model of biological ageing of the lungs for analysing the effects of smoking, asthma and COPD
    Silvia Chiappa
    Microsoft Research Cambridge, 21 Station Road, Cambridge CB1 2FB, UK
    Respir Res 14:60. 2013
  3. ncbi request reprint Understanding coronary artery disease using twin studies
    Massimo Mangino
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
    Heart 99:373-5. 2013
  4. pmc A twin approach to unraveling epigenetics
    Jordana T Bell
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, Westminster Bridge Road, London SE1 7EH, UK
    Trends Genet 27:116-25. 2011
  5. pmc Variance decomposition of protein profiles from antibody arrays using a longitudinal twin model
    Bernet S Kato
    Department of Twin Research and Genetic Epidemiology, King s College London, St, Thomas Hospital, Westminster Bridge Road, London SE1 7EH, UK
    Proteome Sci 9:73. 2011
  6. pmc Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study
    J B Richards
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
    Lancet 371:1505-12. 2008
  7. pmc Novel genes for QTc interval. How much heritability is explained, and how much is left to find?
    Yalda Jamshidi
    Division of Clinical Developmental Sciences, St George s University of London, London, UK
    Genome Med 2:35. 2010
  8. pmc A method for determining skeletal lengths from DXA images
    Usha Chinappen-Horsley
    King s College London, St Thomas Hospital Campus, Twin Research and Genetic Epidemiology Unit, Lambeth Palace Road, London, SE1 7EH, UK
    BMC Musculoskelet Disord 8:113. 2007
  9. pmc Genetic polymorphisms of innate immunity-related inflammatory pathways and their association with factors related to type 2 diabetes
    Paul Arora
    Office for Biotechnology, Genomics and Population Health, Public Health Agency of Canada, 180 Queen Street West, Toronto, M5V 3L7, Canada
    BMC Med Genet 12:95. 2011
  10. pmc Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis
    Hanneke J M Kerkhof
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Med Genet 11:164. 2010

Detail Information

Publications133 found, 100 shown here

  1. pmc A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length
    M Mangino
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
    J Med Genet 46:451-4. 2009
    ..Telomere length is a predictor for a number of common age related diseases and is a heritable trait...
  2. pmc A probabilistic model of biological ageing of the lungs for analysing the effects of smoking, asthma and COPD
    Silvia Chiappa
    Microsoft Research Cambridge, 21 Station Road, Cambridge CB1 2FB, UK
    Respir Res 14:60. 2013
    ..As a consequence, available results are incomplete and often difficult to compare, also due to the ways the effects are expressed. Furthermore, current approaches consider one type of measurement only or several types separately...
  3. ncbi request reprint Understanding coronary artery disease using twin studies
    Massimo Mangino
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
    Heart 99:373-5. 2013
    ....
  4. pmc A twin approach to unraveling epigenetics
    Jordana T Bell
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, Westminster Bridge Road, London SE1 7EH, UK
    Trends Genet 27:116-25. 2011
    ....
  5. pmc Variance decomposition of protein profiles from antibody arrays using a longitudinal twin model
    Bernet S Kato
    Department of Twin Research and Genetic Epidemiology, King s College London, St, Thomas Hospital, Westminster Bridge Road, London SE1 7EH, UK
    Proteome Sci 9:73. 2011
    ..abstract:..
  6. pmc Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study
    J B Richards
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
    Lancet 371:1505-12. 2008
    ..Osteoporosis is diagnosed by the measurement of bone mineral density, which is a highly heritable and multifactorial trait. We aimed to identify genetic loci that are associated with bone mineral density...
  7. pmc Novel genes for QTc interval. How much heritability is explained, and how much is left to find?
    Yalda Jamshidi
    Division of Clinical Developmental Sciences, St George s University of London, London, UK
    Genome Med 2:35. 2010
    ..Additional discovery of both common and rare variants will yield further etiological insight and accelerate clinical applications...
  8. pmc A method for determining skeletal lengths from DXA images
    Usha Chinappen-Horsley
    King s College London, St Thomas Hospital Campus, Twin Research and Genetic Epidemiology Unit, Lambeth Palace Road, London, SE1 7EH, UK
    BMC Musculoskelet Disord 8:113. 2007
    ..The aim of this study was to show that skeletal ratios, such as length of femur to height, could be accurately measured from a DXA (dual energy X-ray absorptiometry) image...
  9. pmc Genetic polymorphisms of innate immunity-related inflammatory pathways and their association with factors related to type 2 diabetes
    Paul Arora
    Office for Biotechnology, Genomics and Population Health, Public Health Agency of Canada, 180 Queen Street West, Toronto, M5V 3L7, Canada
    BMC Med Genet 12:95. 2011
    ..Genetic variation can affect the innate immune response to certain environmental factors, and may, therefore, determine an individual's lifetime risk of disease...
  10. pmc Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis
    Hanneke J M Kerkhof
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Med Genet 11:164. 2010
    ..The objective of this study was to examine the relationship between common genetic variation of the ESR2 gene and osteoarthritis...
  11. pmc Association between a variation in the phosphodiesterase 4D gene and bone mineral density
    Richard H Reneland
    Sequenom, Inc, San Diego, California, USA
    BMC Med Genet 6:9. 2005
    ..Bone mineral density (BMD) is a useful surrogate marker for risk of fracture and is a highly heritable trait. The genetic variants underlying this genetic contribution are largely unknown...
  12. pmc Variations in genome-wide gene expression in identical twins - a study of primary osteoblast-like culture from female twins discordant for osteoporosis
    Ying T Mak
    Twin Research and Genetic Epidemiology Unit, St, Thomas Hospital, London SE1 7EH, United Kingdom
    BMC Genet 5:14. 2004
    ..Such discordant monozygotic twin pairs are rare and very few studies have explored the potential usefulness of this approach...
  13. pmc Development of musculoskeletal toxicity without clear benefit after administration of PG-116800, a matrix metalloproteinase inhibitor, to patients with knee osteoarthritis: a randomized, 12-month, double-blind, placebo-controlled study
    Piotr Krzeski
    Procter and Gamble Pharmaceuticals, Whitehall Lane, Egham TW20 9NW, Surrey, UK
    Arthritis Res Ther 9:R109. 2007
    ..This study adds to the weight of evidence suggesting that side effect profiles of MMP inhibitors in general make them unsuitable for use in osteoarthritis...
  14. pmc Reproducibility and sensitivity to change of various methods to measure joint space width in osteoarthritis of the hip: a double reading of three different radiographic views taken with a three-year interval
    Emmanuel Maheu
    Service de Rhumatologie, Hopital Saint Antoine, Paris, France
    Arthritis Res Ther 7:R1375-85. 2005
    ..6 or greater for assessing JSN over three years. Selecting a single reader was the most accurate method, with 0.3 mm precision. Using this cutoff, 50% of patients were classified as 'progressors'...
  15. ncbi request reprint Association between a variation in LRCH1 and knee osteoarthritis: a genome-wide single-nucleotide polymorphism association study using DNA pooling
    Tim D Spector
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Arthritis Rheum 54:524-32. 2006
    ..To perform a large-scale association analysis of single-nucleotide polymorphisms (SNPs) in patients with radiographically defined osteoarthritis (OA) of the knee...
  16. ncbi request reprint The relation between insulin resistance and hemostasis: pleiotropic genes and common environment
    Marlies de Lange
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, Lambeth Palace Road, London, SE1 7EH, UK
    Twin Res 6:152-61. 2003
    ....
  17. pmc Choline-stabilized orthosilicic acid supplementation as an adjunct to calcium/vitamin D3 stimulates markers of bone formation in osteopenic females: a randomized, placebo-controlled trial
    Tim D Spector
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, Kings College, London, UK
    BMC Musculoskelet Disord 9:85. 2008
    ..The effect of oral choline-stabilized orthosilicic acid (ch-OSA) on markers of bone turnover and bone mineral density (BMD) was investigated in a double-blind placebo-controlled trial...
  18. ncbi request reprint The UK Adult Twin Registry (TwinsUK)
    Tim D Spector
    Twin Research and Genetic Epidemiology Unit, Kings College London, St Thomas Hospital Campus, London, UK
    Twin Res Hum Genet 9:899-906. 2006
    ..The resource has led to many successful and innovative research projects particularly in common age-related diseases, and has led to collaborations with over 80 groups worldwide...
  19. pmc Effect of risedronate on joint structure and symptoms of knee osteoarthritis: results of the BRISK randomized, controlled trial [ISRCTN01928173]
    Tim D Spector
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Arthritis Res Ther 7:R625-33. 2005
    ..Both doses of risedronate were well tolerated. In this study, clear trends towards improvement were observed in both joint structure and symptoms in patients with primary knee OA treated with risedronate...
  20. ncbi request reprint Bisphosphonates: potential therapeutic agents for disease modification in osteoarthritis
    Tim D Spector
    Department of Rheumatology and Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, England, UK
    Aging Clin Exp Res 15:413-8. 2003
    ..Clinical studies are now under way to determine the efficacy and safety of bisphosphonates which may offer new therapeutic options in the treatment of OA...
  21. ncbi request reprint Risk factors for osteoarthritis: genetics
    Tim D Spector
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Osteoarthritis Cartilage 12:S39-44. 2004
    ..OA is a complex disease, and understanding its complexity should help us find the genes and new pathways and drug targets...
  22. ncbi request reprint The St. Thomas' UK Adult Twin Registry
    Tim D Spector
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Twin Res 5:440-3. 2002
    ..The registry has led to many successful innovative research projects, particularly in common diseases previously thought to be predominantly environmental and helped positionally clone some novel genes for common diseases...
  23. pmc The relationship between DXA-based and anthropometric measures of visceral fat and morbidity in women
    Kenan Direk
    Department of Twin Research and Genetic Epidemiology, London, UK
    BMC Cardiovasc Disord 13:25. 2013
    ..Study aims were to a) identify a valid DXA-based measure of visceral adipose tissue (VAT), b) estimate VAT heritability and c) assess visceral fat association with morbidity in relation to body fat distribution...
  24. ncbi request reprint Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee
    Ana M Valdes
    St Thomas Hospital, and King s College London, London, UK
    Arthritis Rheum 56:137-46. 2007
    ..To assess whether the association of genetic polymorphisms with osteoarthritis (OA) in other populations could be replicated in a large, multicenter, mixed-sex, case-control study of clinical knee OA...
  25. pmc Identification of quantitative trait loci for fibrin clot phenotypes: the EuroCLOT study
    Frances M K Williams
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, UK
    Arterioscler Thromb Vasc Biol 29:600-5. 2009
    ..The aims of the current study from the EU consortium EuroCLOT were to (1) determine the heritability of fibrin phenotypes and (2) identify QTLs associated with fibrin phenotypes...
  26. doi request reprint The association between physical activity in leisure time and leukocyte telomere length
    Lynn F Cherkas
    Twin Research and Genetic Epidemiology Unit, King s College London, St Thomas Hospital Campus, London SE1 7EH, England
    Arch Intern Med 168:154-8. 2008
    ..We therefore tested the hypothesis that physical activity level in leisure time (over the past 12 months) is associated with leukocyte telomere length (LTL) in normal healthy volunteers...
  27. pmc The role of heredity in determining central retinal thickness
    S H Melissa Liew
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Br J Ophthalmol 91:1143-7. 2007
    ..To examine the relative roles of genetic and environmental factors in central retinal thickness, by performing a classical twin study...
  28. ncbi request reprint Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women
    Ana M Valdes
    St Thomas Hospital, London, UK
    Arthritis Rheum 54:533-9. 2006
    ....
  29. pmc Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford Study
    Gregory Livshits
    King s College London, London, UK
    Arthritis Rheum 60:2037-45. 2009
    ....
  30. ncbi request reprint Role of the Nav1.7 R1150W amino acid change in susceptibility to symptomatic knee osteoarthritis and multiple regional pain
    Ana M Valdes
    St Thomas Hospital, King s College London, UK
    Arthritis Care Res (Hoboken) 63:440-4. 2011
    ..To assess the genetic association of pain in patients with knee osteoarthritis (OA) and those with multiple regional pain with the R1150W variant in the α-subunit of the voltage-gated sodium channel Na(V)1.7...
  31. pmc The SH2B gene is associated with serum leptin and body fat in normal female twins
    Yalda Jamshidi
    Nutrition Food and Health Research Centre, King s College London, Franklin Wilkins Building, 150 Stamford Street, London SE1 9NH, UK
    Obesity (Silver Spring) 15:5-9. 2007
    ..If SH2-B signaling is attenuated in diet-induced obesity, it could become a target for drug-induced leptin sensitization...
  32. pmc Large scale replication study of the association between HLA class II/BTNL2 variants and osteoarthritis of the knee in European-descent populations
    Ana M Valdes
    Department of Twin Research and Genetic Epidemiology, King s College London, London, United Kingdom
    PLoS ONE 6:e23371. 2011
    ..07). The rs10947262 and rs7775228 variants are not associated with risk of knee OA in European descent populations and they do not appear tag the same HLA class II haplotype as they do in Japanese individuals...
  33. pmc A common genetic factor underlies hypertension and other cardiovascular disorders
    Frances M K Williams
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London SE1 7EH, UK
    BMC Cardiovasc Disord 4:20. 2004
    ..This study used a classical twin design to examine whether these conditions are linked through shared environmental exposures or by a common underlying genetic propensity to vasospasm...
  34. pmc Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women
    J Brent Richards
    Twin Research and Genetic Epidemiology, St Thomas Hospital, King s College, London School of Medicine, London, United Kingdom
    Am J Clin Nutr 86:1420-5. 2007
    ..Leukocyte telomere length (LTL) is a predictor of aging-related disease and decreases with each cell cycle and increased inflammation...
  35. ncbi request reprint Nevus size and number are associated with telomere length and represent potential markers of a decreased senescence in vivo
    Veronique Bataille
    Twin Research and Genetic Epidemiology Unit, King s College London, St Thomas Hospital Campus, London SE1 7EH, United Kingdom
    Cancer Epidemiol Biomarkers Prev 16:1499-502. 2007
    ..Understanding mechanisms influencing the induction and involution of nevi will not only help in understanding the pathophysiology of melanoma but should also shed light on the complex relationship between aging and cancer...
  36. ncbi request reprint Variation at the ANP32A gene is associated with risk of hip osteoarthritis in women
    Ana M Valdes
    Kings College London, London, UK
    Arthritis Rheum 60:2046-54. 2009
    ..We undertook this study to test whether genetic variation at ANP32A was associated with osteoarthritis (OA) in women...
  37. pmc Identification and replication of three novel myopia common susceptibility gene loci on chromosome 3q26 using linkage and linkage disequilibrium mapping
    Toby Andrew
    Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, UK
    PLoS Genet 4:e1000220. 2008
    ..That two mitochondrial regulatory processes in the retina are implicated in the aetiology of myopia is surprising and is likely to provide novel insight into the molecular genetic basis of common myopia...
  38. pmc Quantitative trait loci for bone lengths on chromosome 5 using dual energy X-Ray absorptiometry imaging in the Twins UK cohort
    Usha Chinappen-Horsley
    Twin Research and Genetic Epidemiology Unit, King s College London School of Medicine, St Thomas Hospital, London, United Kingdom
    PLoS ONE 3:e1752. 2008
    ..Replication and further fine mapping of this region is ongoing to determine potential genes influencing bone size and diseases affecting bone...
  39. ncbi request reprint Protein tyrosine phosphatase-1B gene PTPN1: selection of tagging single nucleotide polymorphisms and association with body fat, insulin sensitivity, and the metabolic syndrome in a normal female population
    Nicola J Spencer-Jones
    Department of Clinical Developmental Sciences, St George s, University of London, London, UK
    Diabetes 54:3296-304. 2005
    ..PTPN1 variants appear to contribute to central fat and metabolic syndrome traits, secondary to their effect on insulin sensitivity...
  40. pmc Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis
    Ana M Valdes
    Twin Research Unit, St Thomas Hospital Campus, Kings College London School of Medicine, London SE1 7EH, UK
    Am J Hum Genet 82:1231-40. 2008
    ..Our results and previous studies on the role of the cyclooxygenase 2 enzyme encoded by PTGS2 underscore the importance of this signaling pathway in the pathogenesis of knee OA...
  41. ncbi request reprint Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis
    Ana M Valdes
    Department of Twin Research and Genetic Epidemiology, St Thomas Hospital Campus, King s College London, London SE1 7EH, UK
    Arthritis Rheum 62:2347-52. 2010
    ..We undertook this study to investigate the role of genetic variation in SMAD3 in the risk of large-joint OA in humans...
  42. doi request reprint Estimating heritability and shared environmental effects for refractive error in twin and family studies
    Margarida C Lopes
    Department of Twin Research and Genetic Epidemiology, King s College London School of Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 50:126-31. 2009
    ..This large twin study aimed to explore the role of shared environment in refractive error...
  43. pmc The heritability of macular response to supplemental lutein and zeaxanthin: a classic twin study
    Christopher J Hammond
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital Campus, London, United Kingdom
    Invest Ophthalmol Vis Sci 53:4963-8. 2012
    ..This classic twin study was designed to determine the heritability of macular pigment (MP) augmentation in response to supplemental lutein (L) and zeaxanthin (Z)...
  44. ncbi request reprint The relationship of joint hypermobility, bone mineral density, and osteoarthritis in the general population: the Chingford Study
    A Louise Dolan
    Department of Rheumatology, Queen Elizabeth Hospital, London, UK
    J Rheumatol 30:799-803. 2003
    ..We assessed hypermobility and its relationship to bone mineral density (BMD) and OA in a postmenopausal female community population...
  45. doi request reprint Quantitative linkage analysis for pancreatic B-cell function and insulin resistance in a large twin cohort
    Mario Falchi
    Twin Research and Genetic Epidemiology Unit, St Thomas Campus, King s College London School of Medicine, London, UK
    Diabetes 57:1120-4. 2008
    ..The recent nonlinear computer version of homeostasis model assessment (HOMA)2 provides an appropriate and convenient assessment of glucose metabolism, enabling gene-mapping studies in large population samples...
  46. pmc Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs
    Toby Andrew
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London SE1 7EH, United Kingdom
    Am J Hum Genet 78:480-6. 2006
    ..9) at 14q23.2, and suggestive linkage at 10q26.13 (LOD 2.4) and 3p26.1 (LOD 2.7). This is the first report of loci, mapped in a sample of healthy individuals, that influence mean telomere variation in humans...
  47. pmc Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects
    Frances M K Williams
    Department Twin Research and Genetic Epidemiology, King s College London, London, UK
    Ann Rheum Dis 72:1141-8. 2013
    ..To date, the agnostic search of the genome by genome-wide association (GWA) to identify common variants associated with LDD has not been fruitful. This study is the first GWA meta-analysis of LDD...
  48. pmc Association between DHEAS and bone loss in postmenopausal women: a 15-year longitudinal population-based study
    Michael A Ghebre
    Department of Twin Research and Genetic Epidemiology, King s College London, UK
    Calcif Tissue Int 89:295-302. 2011
    ..The nature of the association is unclear, but such an association implies that, in managing BMD loss, women might benefit from maintaining a high level of DHEAS...
  49. pmc A twin study of mitochondrial DNA polymorphisms shows that heteroplasmy at multiple sites is associated with mtDNA variant 16093 but not with zygosity
    Toby Andrew
    Department of Twin Research and Genetic Epidemiology, King s College London, London, United Kingdom
    PLoS ONE 6:e22332. 2011
    ..5×10(-14)) and also at VRII (p = 2×10(-4)) suggesting a possible predisposing role for this site in the accumulation of heteroplasmy. Our data indicate that BMI is potentially associated with control region heteroplasmy...
  50. pmc Pain reporting at different body sites is explained by a single underlying genetic factor
    Frances M K Williams
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital Campus, London SE1 7EH, UK
    Rheumatology (Oxford) 49:1753-5. 2010
    ....
  51. pmc Adiponectin gene ADIPOQ SNP associations with serum adiponectin in two female populations and effects of SNPs on promoter activity
    Theodosios Kyriakou
    Nutritional Sciences Division, King s College London, Franklin Wilkins Building, London, SE1 9NH, UK
    J Hum Genet 53:718-27. 2008
    ..2 kb of the ADIPOQ promoter region was cloned in a luciferase reporter plasmid, and the four haplotypes were transfected in differentiated 3T3-L1 adipocytes. No significant allelic effects on promoter activity were found...
  52. ncbi request reprint Lack of association between leukocyte telomere length and genetic variants in two ageing-related candidate genes
    Feng Zhang
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, King s College London, United Kingdom
    Mech Ageing Dev 128:415-22. 2007
    ....
  53. ncbi request reprint Genome-wide scan for prospective memory suggests linkage to chromosome 12q22
    Jamie J Singer
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, SE1 7EH, UK
    Behav Genet 36:18-28. 2006
    ..76, empirical p-value 0.0006). Within this QTL lies an obvious candidate-the SCAD gene. These results suggest that large-scale gene discovery studies are possible with self-report memory questionnaires...
  54. ncbi request reprint Central retinal thickness is positively correlated with macular pigment optical density
    S H Melissa Liew
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Exp Eye Res 82:915-20. 2006
    ..This finding has important implications for future studies investigating MPOD, and its response to dietary modification/supplementation...
  55. ncbi request reprint The heritable determinants of cartilage oligomeric matrix protein
    Frances M K Williams
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Arthritis Rheum 54:2147-51. 2006
    ..An association between COMP and OA has been shown, yet the precise factors governing serum levels of COMP remain unclear. The aim of this study was to determine whether genetic factors influence serum levels of COMP...
  56. ncbi request reprint Joint linkage and association of six single-nucleotide polymorphisms in the factor XIII-A subunit gene point to V34L as the main functional locus
    Marlies de Lange
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Arterioscler Thromb Vasc Biol 26:1914-9. 2006
    ..The current study investigated 6 single-nucleotide polymorphisms (SNPs) within the FXIII A-subunit gene to locate functional polymorphism(s) responsible for variation in FXIII activation...
  57. pmc Reduced telomere length in rheumatoid arthritis is independent of disease activity and duration
    Sophia E Steer
    Department of Rheumatology, Twin Research and Genetic Epidemiology Unit, Kings College London School of Medicine at Guy s, King s and St Thomas, London SE1 7EH, UK
    Ann Rheum Dis 66:476-80. 2007
    ..Telomere loss in white blood cells (WBC) is accelerated by oxidative stress and inflammation in vitro. It was postulated that the accelerated WBC telomere shortening in RA occurs as a result of exposure to chronic inflammation...
  58. ncbi request reprint Heritability analyses show visit-to-visit blood pressure variability reflects different pathological phenotypes in younger and older adults: evidence from UK twins
    Cristina Menni
    aDepartment of Twin Research and Genetic Epidemiology, King s College London, London, UK bDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands cBritish Heart Foundation BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
    J Hypertens 31:2356-61. 2013
    ..We hypothesize that BPV should demonstrate the same pattern of additive genetic, shared environmental and unique environmental variance as BP, if both are phenotypic surrogates...
  59. pmc Biomarkers for type 2 diabetes and impaired fasting glucose using a nontargeted metabolomics approach
    Cristina Menni
    Department of Twin Research and Genetic Epidemiology, King s College London, London, U K
    Diabetes 62:4270-6. 2013
    ....
  60. pmc The relationship between retinal arteriolar and venular calibers is genetically mediated, and each is associated with risk of cardiovascular disease
    Samantha J Fahy
    Department of Twin Research and Genetic Epidemiology, King s College London, School of Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 52:975-81. 2011
    ..59) between these two traits and to assess the shared and specific influence of established and novel cardiovascular disease risk factors on them...
  61. doi request reprint Repeated measures of intraocular pressure result in higher heritability and greater power in genetic linkage studies
    Francis Carbonaro
    Department of Twin Research and Genetic Epidemiology, King s College London School of Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 50:5115-9. 2009
    ..This was a cohort study in which 344 pairs of twins, 163 monozygotic (MZ) and 181 dizygotic (DZ), were enrolled...
  62. pmc Progression of lumbar disc degeneration over a decade: a heritability study
    Frances M K Williams
    Department of Twin Research and Genetic Epidemiology, King s College London, UK
    Ann Rheum Dis 70:1203-7. 2011
    ..Cross-sectional LDD as determined by MRI scan is known to be highly heritable. The authors postulated that the rate of progression might also be controlled by genetic factors...
  63. ncbi request reprint Radiographic progression of lumbar spine disc degeneration is influenced by variation at inflammatory genes: a candidate SNP association study in the Chingford cohort
    Ana M Valdes
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Spine (Phila Pa 1976) 30:2445-51. 2005
    ..A candidate gene association study in a longitudinal cohort...
  64. ncbi request reprint The genetic epidemiology of joint hypermobility: a population study of female twins
    Alan J Hakim
    The Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Arthritis Rheum 50:2640-4. 2004
    ..To estimate the genetic influence on joint hypermobility in an unselected population using a classic twin study design...
  65. ncbi request reprint Association study of candidate genes for the prevalence and progression of knee osteoarthritis
    Ana M Valdes
    St Thomas Hospital, London, UK
    Arthritis Rheum 50:2497-507. 2004
    ..We examined the role of 26 single-nucleotide polymorphisms (SNPs) from 24 candidate genes in OA susceptibility and progression...
  66. pmc Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms
    Guangju Zhai
    Department of Twin Research and Genetic Epidemiology, King s College London, London, United Kingdom
    PLoS Genet 7:e1002025. 2011
    ..Several SNPs were associated with changes in gene expression levels, and the related genes are connected to biological pathways linking DHEAS with ageing. This study provides much needed insight into the function of DHEAS...
  67. pmc Metabolomic markers reveal novel pathways of ageing and early development in human populations
    Cristina Menni
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK, Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, Neuherberg, Germany, Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany, Institute of Epidemiology I, Helmholtz Zentrum Munchen, Neuherberg, Germany, Pfizer Research Laboratories, Groton, CT, USA, Worldwide R and D, Pfizer Inc, Cambridge, MA, USA, School of Medicine and Pharmacology, University of Western Australia, Crawley, WA, Australia, Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, Australia, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, Metabolon Inc, 617 Davis Drive, Durham, NC 27713, USA Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, Doha, National University of Singapore
    Int J Epidemiol 42:1111-9. 2013
    ..Human ageing is a complex, multifactorial process and early developmental factors affect health outcomes in old age...
  68. doi request reprint Intervertebral T-score differences in younger and older women
    Glen M Blake
    Osteoporosis Research Unit, King s College London, King s Health Partners, Guy s Hospital, London, UK
    J Clin Densitom 16:329-35. 2013
    ..Clinically significant T-score differences can occur in the absence of osteoarthritis, and visual assessment of spine DXA scans for evidence of degenerative disease is advised before vertebrae are omitted from scan analyses...
  69. doi request reprint Progression of central pulse pressure over 1 decade of aging and its reversal by nitroglycerin a twin study
    Marina Cecelja
    King s College London, British Heart Foundation Centre, Cardiovascular Division, Department of Clinical Pharmacology, St Thomas Hospital, London, United Kingdom
    J Am Coll Cardiol 59:475-83. 2012
    ..The goal of this study was to examine the progression of central arterial pulse pressure (cPP) in women and the degree to which this can be reversed by nitrovasodilation...
  70. pmc The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis
    Ana M Valdes
    Department of Twin Research, King s College London, St Thomas Hospital, London, UK
    Ann Rheum Dis 70:1556-61. 2011
    ..To assess if a coding variant in the gene encoding transient receptor potential cation channel, subfamily V, member 1 (TRPV1) is associated with genetic risk of painful knee osteoarthritis (OA)...
  71. ncbi request reprint Identification of QTLs for serum lipid levels in a female sib-pair cohort: a novel application to improve the power of two-locus linkage analysis
    Mario Falchi
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Hum Mol Genet 14:2971-9. 2005
    ....
  72. ncbi request reprint Risk of wrist fracture in women is heritable and is influenced by genes that are largely independent of those influencing BMD
    Toby Andrew
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, United Kingdom
    J Bone Miner Res 20:67-74. 2005
    ..BMD is highly heritable, but statistical models showed very little overlap of shared genes between the two traits...
  73. ncbi request reprint The interaction of genes and smoking on forced expiratory volume: a classic twin study
    Guangju Zhai
    Twin Research and Genetic Epidemiology Unit, King s College London School of Medicine, St Thomas Hospital Campus, Lambeth Palace Rd, London SE1 7EH, UK
    Chest 132:1772-7. 2007
    ..The aims of this study were to estimate heritability of the ratio of measured FEV1 (mFEV1) to expected FEV(1) (eFEV1) in a white population, and to examine the interaction between genetic factors and smoking on this ratio...
  74. doi request reprint Using epigenome-wide association scans of DNA methylation in age-related complex human traits
    Pei Chien Tsai
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
    Epigenomics 4:511-26. 2012
    ..This article reviews analytical considerations in conducting EWAS and recent applications of this approach to human aging and age-related complex traits...
  75. ncbi request reprint The first "classical" twin study? Analysis of refractive error using monozygotic and dizygotic twins published in 1922
    Shiao Hui M Liew
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London SE1 7EH, United Kingdom
    Twin Res Hum Genet 8:198-200. 2005
    ..Therefore, this is likely to be the first reported classical twin study...
  76. ncbi request reprint Genome-wide search for nevus density shows linkage to two melanoma loci on chromosome 9 and identifies a new QTL on 5q31 in an adult twin cohort
    Mario Falchi
    Twin Research and Genetic Epidemiology Unit, St Thomas Campus, Kings College London, London SE1 7EH, UK
    Hum Mol Genet 15:2975-9. 2006
    ..They provide both novel and replicated QTLs for nevus development, some of which might overlap with those for melanoma and warrant detailed investigation...
  77. pmc Pigmentation and vitamin D metabolism in Caucasians: low vitamin D serum levels in fair skin types in the UK
    Daniel Glass
    Department of Twin Research and Genetic Epidemiology, Kings College London, St Thomas Hospital Campus, London, UK
    PLoS ONE 4:e6477. 2009
    ..Public health messages are advocating sun avoidance to reduce skin cancer risk but the potential deleterious effects of these recommendations for vitamin D metabolism have been poorly investigated...
  78. ncbi request reprint Heritability of the second to fourth digit ratio (2d:4d): A twin study
    Simon N Paul
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, United Kingdom
    Twin Res Hum Genet 9:215-9. 2006
    ..However the current study design does not preclude the possibility of confounding between heritability estimates and unobserved prenatal effects...
  79. ncbi request reprint An investigation of unique and shared gene effects on speed of sound and bone density using axial transmission quantitative ultrasound and DXA in twins
    Karen M Knapp
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, United Kingdom
    J Bone Miner Res 18:1525-30. 2003
    ..Genetic influences were found for all SOS and BMD measurements. A combination of shared and unique genetic influences was found to control BMD and SOS at the radius...
  80. ncbi request reprint Structural, psychological, and genetic influences on low back and neck pain: a study of adult female twins
    Alexander J MacGregor
    St Thomas Hospital, London, UK
    Arthritis Rheum 51:160-7. 2004
    ....
  81. ncbi request reprint Serum branched-chain amino acid to histidine ratio: a novel metabolomic biomarker of knee osteoarthritis
    Guangju Zhai
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, Westminster Bridge Road, London SE1 7EH, UK
    Ann Rheum Dis 69:1227-31. 2010
    ..There is a pressing need to develop reliable molecular biomarkers in osteoarthritis. The aim of the study was to identify novel serum biomarkers for osteoarthritis using a metabolomics approach...
  82. ncbi request reprint Relationship between dry eye symptoms and pain sensitivity
    Jelle Vehof
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, Waterloo, London, England2Department of Ophthalmology and Epidemiology, University Medical Center Groningen, Groningen, The Netherlands
    JAMA Ophthalmol 131:1304-8. 2013
    ..Dry eye disease (DED) is common, but little is known about factors contributing to symptoms of dry eye, given the poor correlation between these symptoms and objective signs at the ocular surface...
  83. pmc Dietary garlic and hip osteoarthritis: evidence of a protective effect and putative mechanism of action
    Frances M K Williams
    Dept Twin Research and Genetic Epidemiology, King s College London, London, UK
    BMC Musculoskelet Disord 11:280. 2010
    ..Patterns of food intake and prevalent osteoarthritis of the hand, hip, and knee were studied using the twin design to limit the effect of confounding factors. Compounds found in associated food groups were further studied in vitro...
  84. ncbi request reprint The genetic epidemiology of osteoarthritis
    Ana M Valdes
    Department of Twin Research and Genetic Epidemiology, St Thomas Hospital Campus, Kings College London School of Medicine, London, UK
    Curr Opin Rheumatol 22:139-43. 2010
    ..The scope of the present article is to offer an overview of recent developments in the genetic epidemiology of knee and hip osteoarthritis, with particular emphasis on published genomewide association studies (GWAS)...
  85. ncbi request reprint Where did I leave my keys? A twin study of self-reported memory ratings using the multifactorial memory questionnaire
    Jamie J Singer
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, United Kingdom
    Twin Res Hum Genet 8:108-12. 2005
    ..g., learning to use a new gadget). Given their clinical significance and ease of administration, these tests could prove to be useful in examining memory functioning in large-scale population studies...
  86. doi request reprint Arterial stiffening relates to arterial calcification but not to noncalcified atheroma in women. A twin study
    Marina Cecelja
    King s College London British Heart Foundation Centre, Cardiovascular Division, Department of Clinical Pharmacology, St Thomas Hospital, Lambeth Palace Road, London, United Kingdom
    J Am Coll Cardiol 57:1480-6. 2011
    ....
  87. ncbi request reprint Genome-wide scan for blood pressure suggests linkage to chromosome 11, and replication of loci on 16, 17, and 22
    Marlies de Lange
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, Lambeth Palace Rd, London SE1 7EH, UK
    Hypertension 44:872-7. 2004
    ..Future studies should focus on the fine mapping of these replicated regions, which include potential candidate genes...
  88. ncbi request reprint The role of bone metabolism in osteoarthritis
    David J Hunter
    Department of Rheumatology and Twin Research, Saint Thomas Hospital, Lambeth Palace Road, London SE 1 7EH, UK
    Curr Rheumatol Rep 5:15-9. 2003
    ..High BMD at non-joint sites is associated with an increased risk of OA; however, low BMD and high bone turnover appears to be associated with more rapid progression. These alterations in bone turnover offer new therapeutic opportunities...
  89. ncbi request reprint Genetic contribution to renal function and electrolyte balance: a twin study
    David J Hunter
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Clin Sci (Lond) 103:259-65. 2002
    ....
  90. ncbi request reprint Genetic and environmental influences on lipids, lipoproteins, and apolipoproteins: effects of menopause
    Rita P S Middelberg
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Arterioscler Thromb Vasc Biol 22:1142-7. 2002
    ....
  91. ncbi request reprint Emotional intelligence and its association with orgasmic frequency in women
    Andrea V Burri
    Twin Research and Genetic Epidemiology Department, King s College London, St Thomas Hospital, Westminster Bridge Road, London, UK
    J Sex Med 6:1930-7. 2009
    ..FOD has been acknowledged to be multifactorial and recent research has implicated the importance of psychosocial risk factors...
  92. doi request reprint The heritability of corneal hysteresis and ocular pulse amplitude: a twin study
    Francis Carbonaro
    Twin Research and Genetic Epidemiology Unit, King s College London School of Medicine, London, United Kingdom
    Ophthalmology 115:1545-9. 2008
    ..To examine the roles of genetic and environmental factors in corneal hysteresis and ocular pulse amplitude by performing a classic twin study...
  93. ncbi request reprint Ethnic differences in F cell levels in Jamaica: a potential tool for identifying new genetic loci controlling fetal haemoglobin
    Lisa E Creary
    Division of Gene and Cell Based Therapy, King s College London School of Medicine, James Black Centre, London, UK
    Br J Haematol 144:954-60. 2009
    ..46) despite substantial differences in average ancestry. The data confirm ethnic differences in FC levels and indicate the potential usefulness of these populations for admixture mapping of genes for FC levels...
  94. pmc A susceptibility locus for myopia in the normal population is linked to the PAX6 gene region on chromosome 11: a genomewide scan of dizygotic twins
    Christopher J Hammond
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, and West Kent Eye Center, Princess Royal University Hospital, Orpington, United Kingdom
    Am J Hum Genet 75:294-304. 2004
    ....
  95. ncbi request reprint Proopiomelanocortin gene variants are associated with serum leptin and body fat in a normal female population
    Yuanneng Chen
    Department of Clinical Developmental Sciences, St George s Hospital Medical School, London, UK
    Eur J Hum Genet 13:772-80. 2005
    ..78 (P<0.0001)). Associations of BMI, weight and total fat with SNPs in regions flanking the POMC gene in this powerful study suggest that regulation of POMC expression may be influential in determining body weight...
  96. ncbi request reprint Heritability of macular pigment: a twin study
    Shiao Hui Melissa Liew
    Twin Research and Genetic Epidemiology Unit, The Rayne Institute, St Thomas Hospital, London, United Kingdom
    Invest Ophthalmol Vis Sci 46:4430-6. 2005
    ..A classic twin study was performed to determine the heritability of MP in the healthy eye...
  97. doi request reprint The genetics and epidemiology of female sexual dysfunction: a review
    Andrea V Burri
    Twin Research and Genetic Epidemiology Department, King s College London St Thomas Hospital, London, UK
    J Sex Med 6:646-57. 2009
    ..In contrast to the successful advances of genetic research in a wide variety of human diseases, genetic exploration in FSD lags far behind...
  98. pmc A survey of UK public interest in internet-based personal genome testing
    Lynn F Cherkas
    Department of Twin Research and Genetic Epidemiology, King s College London, London, United Kingdom
    PLoS ONE 5:e13473. 2010
    ....
  99. ncbi request reprint The relationship of bone density and fracture to incident and progressive radiographic osteoarthritis of the knee: the Chingford Study
    Deborah J Hart
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Arthritis Rheum 46:92-9. 2002
    ..This study was undertaken to examine the association of bone mass with incident and progressive disease and to determine whether prior fractures influence the development of OA...
  100. doi request reprint An epidemiological survey of post-coital psychological symptoms in a UK population sample of female twins
    Andrea V Burri
    Department of Twin Research and Genetic Epidemiology, King s College, United Kingdom
    Twin Res Hum Genet 14:240-8. 2011
    ..It seems that the most important targets for intervention and prevention occur outside of the family, such as relationship quality and satisfaction, and history of abuse...
  101. pmc Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults
    Swee Lay Thein
    King s College London School of Medicine, Division of Gene and Cell Based Therapy, King s College Hospital, London SE5 9PJ, United Kingdom
    Proc Natl Acad Sci U S A 104:11346-51. 2007
    ..The results support a key role for the HBS1L-related genetic variants in HbF control and illustrate the biological complexity of the mechanism of 6q QTL as a modifier of fetal hemoglobin levels in the beta hemoglobinopathies...