K J Smith

Summary

Affiliation: King's College London
Country: UK

Publications

  1. pmc Lesion genesis in a subset of patients with multiple sclerosis: a role for innate immunity?
    Christina Marik
    Centre for Brain Research, Medical University of Vienna, Austria
    Brain 130:2800-15. 2007
  2. ncbi request reprint The role of nitric oxide in multiple sclerosis
    Kenneth J Smith
    Neuroinflammation Research Group, Guy s, King s, and St Thomas School of Medicine, King s College, London SE1 1UL, UK
    Lancet Neurol 1:232-41. 2002
  3. ncbi request reprint Axonal protection in multiple sclerosis--a particular need during remyelination?
    Kenneth J Smith
    Department of Clinical Neurosciences, Institute of Psychiatry, King s College London, 19 Newcomen Street, London, SE1 1UL, UK
    Brain 129:3147-9. 2006
  4. ncbi request reprint Sodium channels and multiple sclerosis: roles in symptom production, damage and therapy
    Kenneth J Smith
    Department of Clinical Neurosciences, Institute of Psychiatry, King s College London, London, UK
    Brain Pathol 17:230-42. 2007
  5. ncbi request reprint Factors directly affecting impulse transmission in inflammatory demyelinating disease: recent advances in our understanding
    K J Smith
    Department of Neuroimmunology, Neuroinflammation Research Group, Guy s, King s and St Thomas School of Medicine, Dentistry and Biomedical Sciences, Guy s Campus, London SE1 9RT, UK
    Curr Opin Neurol 14:289-98. 2001
  6. ncbi request reprint Electrically active axons degenerate when exposed to nitric oxide
    K J Smith
    Department of Neuroimmunology, Guy s, King s and St Thomas School of Medicine, London, United Kingdom
    Ann Neurol 49:470-6. 2001
  7. ncbi request reprint Effects of 4-aminopyridine on demyelinated axons, synapses and muscle tension
    K J Smith
    Neuroinflammation Research Group, Department of Neuroimmunology, Guy s, King s and St Thomas School of Medicine, Guy s Campus, London SE1 9RT, UK
    Brain 123:171-84. 2000
  8. pmc The pathophysiology of multiple sclerosis: the mechanisms underlying the production of symptoms and the natural history of the disease
    K J Smith
    Department of Clinical Neurosciences, Guy s, King s and St Thomas School of Medicine, King s College, London, UK
    Philos Trans R Soc Lond B Biol Sci 354:1649-73. 1999
  9. doi request reprint Longitudinal changes in magnetisation transfer ratio in secondary progressive multiple sclerosis: data from a randomised placebo controlled trial of lamotrigine
    T Hayton
    Department of Neuroinflammation, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    J Neurol 259:505-14. 2012
  10. doi request reprint Clinical and imaging correlates of the multiple sclerosis impact scale in secondary progressive multiple sclerosis
    T Hayton
    Department of Neuroinflammation, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    J Neurol 259:237-45. 2012

Detail Information

Publications28

  1. pmc Lesion genesis in a subset of patients with multiple sclerosis: a role for innate immunity?
    Christina Marik
    Centre for Brain Research, Medical University of Vienna, Austria
    Brain 130:2800-15. 2007
    ..The findings indicate that mechanisms associated with innate immunity may play a role in the formation of hypoxia-like demyelinating lesions in MS...
  2. ncbi request reprint The role of nitric oxide in multiple sclerosis
    Kenneth J Smith
    Neuroinflammation Research Group, Guy s, King s, and St Thomas School of Medicine, King s College, London SE1 1UL, UK
    Lancet Neurol 1:232-41. 2002
    ....
  3. ncbi request reprint Axonal protection in multiple sclerosis--a particular need during remyelination?
    Kenneth J Smith
    Department of Clinical Neurosciences, Institute of Psychiatry, King s College London, 19 Newcomen Street, London, SE1 1UL, UK
    Brain 129:3147-9. 2006
  4. ncbi request reprint Sodium channels and multiple sclerosis: roles in symptom production, damage and therapy
    Kenneth J Smith
    Department of Clinical Neurosciences, Institute of Psychiatry, King s College London, London, UK
    Brain Pathol 17:230-42. 2007
    ..Some recent findings suggest that such systemic inhibition of sodium channels may also promote axonal protection by suppressing inflammation within the brain...
  5. ncbi request reprint Factors directly affecting impulse transmission in inflammatory demyelinating disease: recent advances in our understanding
    K J Smith
    Department of Neuroimmunology, Neuroinflammation Research Group, Guy s, King s and St Thomas School of Medicine, Dentistry and Biomedical Sciences, Guy s Campus, London SE1 9RT, UK
    Curr Opin Neurol 14:289-98. 2001
    ..Other factors impairing impulse transmission include nodal widening, glutamate toxicity, and disturbances of both the blood-brain barrier and synaptic transmission...
  6. ncbi request reprint Electrically active axons degenerate when exposed to nitric oxide
    K J Smith
    Department of Neuroimmunology, Guy s, King s and St Thomas School of Medicine, London, United Kingdom
    Ann Neurol 49:470-6. 2001
    ....
  7. ncbi request reprint Effects of 4-aminopyridine on demyelinated axons, synapses and muscle tension
    K J Smith
    Neuroinflammation Research Group, Department of Neuroimmunology, Guy s, King s and St Thomas School of Medicine, Guy s Campus, London SE1 9RT, UK
    Brain 123:171-84. 2000
    ..If so, the dominant effects of 4-AP in multiple sclerosis patients are independent of demyelination, and it follows that 4-AP may be beneficial in other neurological disorders in which function is diminished...
  8. pmc The pathophysiology of multiple sclerosis: the mechanisms underlying the production of symptoms and the natural history of the disease
    K J Smith
    Department of Clinical Neurosciences, Guy s, King s and St Thomas School of Medicine, King s College, London, UK
    Philos Trans R Soc Lond B Biol Sci 354:1649-73. 1999
    ..An important mechanism determining persistent neurological deficit is axonal degeneration, although persistent conduction block arising from the failure of repair mechanisms probably also contributes...
  9. doi request reprint Longitudinal changes in magnetisation transfer ratio in secondary progressive multiple sclerosis: data from a randomised placebo controlled trial of lamotrigine
    T Hayton
    Department of Neuroinflammation, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    J Neurol 259:505-14. 2012
    ..11) and mean (p < 0.0001) changing significantly from baseline. These data did not show that lamotrigine was neuroprotective. The clinical correlation of MTR measures was consistent, but the responsiveness to change was limited...
  10. doi request reprint Clinical and imaging correlates of the multiple sclerosis impact scale in secondary progressive multiple sclerosis
    T Hayton
    Department of Neuroinflammation, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    J Neurol 259:237-45. 2012
    ..007), mean NAWM MTR (p = 0.003) and NAGM peak height (p = 0.048) (R (2) = 0.32). These data show that MRI measures and clinical measures do impact on quality of life, but the association is limited...
  11. ncbi request reprint Characterisation of matrix metalloproteinases and the effects of a broad-spectrum inhibitor (BB-1101) in peripheral nerve regeneration
    M Demestre
    Department of Clinical Neurosciences, Guy s, King s and St Thomas School of Medicine, Guy s Campus, London SE1 1UL, UK
    Neuroscience 124:767-79. 2004
    ....
  12. ncbi request reprint Effects on axonal conduction of anti-ganglioside sera and sera from patients with Guillain-Barré syndrome
    A Dilley
    Neuroinflammation Research Group, Guy s, King s and St Thomas School of Medicine, King s College, SE1 1UL, London, UK
    J Neuroimmunol 139:133-40. 2003
    ..Potential explanations are advanced...
  13. doi request reprint A longitudinal study of MRI-detected atrophy in secondary progressive multiple sclerosis
    J Furby
    Department of Neuroinflammation, Institute of Neurology, Queen Square, London, UK
    J Neurol 257:1508-16. 2010
    ..Measures of WB, GM and SC atrophy all have attributes for use as surrogate markers in secondary progressive MS trials and improvement in the reliability of the GM and SC volume measurements may enhance these further...
  14. ncbi request reprint Demyelination: the role of reactive oxygen and nitrogen species
    K J Smith
    Department of Clinical Neurological Sciences, Guy s, King s and St Thomas School of Medicine, London
    Brain Pathol 9:69-92. 1999
    ..However, therapies aimed at diminishing reactive nitrogen species have had a more variable outcome, sometimes exacerbating disease...
  15. ncbi request reprint Axonal protection in experimental autoimmune neuritis by the sodium channel blocking agent flecainide
    David A Bechtold
    Department of Neuroimmunology, King s College, London, SE1 1UL, UK
    Brain 128:18-28. 2005
    ..8% in vehicle-treated rats (P < 0.01). These findings may indicate a novel avenue for axonal protection in GBS and other inflammatory demyelinating neuropathies...
  16. ncbi request reprint Sodium-mediated axonal degeneration in inflammatory demyelinating disease
    David A Bechtold
    Department of Neuroimmunology, Guy s Campus, King s College, London SE1 1UL, UK
    J Neurol Sci 233:27-35. 2005
    ....
  17. ncbi request reprint Pathogenesis of Guillain-Barré syndrome
    R A Hughes
    Department of Neuroimmunology, Guy s, King s and St Thomas School of Medicine, Guy s Hospital, London, UK
    J Neuroimmunol 100:74-97. 1999
    ..The different patterns of GBS are probably due to the diverse interplay between antibodies and T cells of differing specificities...
  18. ncbi request reprint Brain-derived neurotrophic factor in experimental autoimmune neuritis
    Paul A Felts
    Department of Neuroimmunology and the Neuroinflammation Research Group, Guy s, King s and St Thomas School of Medicine, King s College London, Guy s Campus, London SE1 1UL, UK
    J Neuroimmunol 124:62-9. 2002
    ..With the exception of a possibly protective effect indicated by bladder weight, this study suggests that BDNF may not provide an effective therapy for GBS, at least in the acute phase of the disease...
  19. ncbi request reprint Inflammation and primary demyelination induced by the intraspinal injection of lipopolysaccharide
    Paul A Felts
    Department of Neuroimmunology and Neuroinflammation Research Group, Guy s, King s and St Thomas School of Medicine, King s College London, London, UK
    Brain 128:1649-66. 2005
    ..2000), and we therefore suggest that LPS-induced demyelination may serve as the first experimental model available for the study of this type of multiple sclerosis lesion...
  20. ncbi request reprint Accumulation of immunoglobulin across the 'blood-nerve barrier' in spinal roots in adoptive transfer experimental autoimmune neuritis
    R D M Hadden
    Department of Neuroimmunology, Guy s, King s and St Thomas School of Medicine, Guy s Hospital, London, UK
    Neuropathol Appl Neurobiol 28:489-97. 2002
    ..Accumulation of immunoglobulin was maximal during the worsening of neurological deficit, and declined rapidly before the onset of neurological recovery...
  21. ncbi request reprint Blockers of sodium and calcium entry protect axons from nitric oxide-mediated degeneration
    Raju Kapoor
    The Neuroinflammation Research Group, Guy s, King s St Thomas School of Medicine, London, United Kingdom
    Ann Neurol 53:174-80. 2003
    ..Our findings suggest a new strategy for axonal protection in an inflammatory environment, which may be effective in preventing the accumulation of permanent disability in patients with neuroinflammatory disorders...
  22. doi request reprint Grey matter magnetization transfer ratio independently correlates with neurological deficit in secondary progressive multiple sclerosis
    T Hayton
    Dept of Neuroinflammation, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    J Neurol 256:427-35. 2009
    ..The apparent paucity of correlation between MRI measures and EDSS is likely to represent the relative insensitivity of the latter measure in this study group...
  23. ncbi request reprint Axonal protection achieved in a model of multiple sclerosis using lamotrigine
    David A Bechtold
    Department of Clinical Neuroscience, King s College London, Guy s Campus, National Hospital for Neurology and Neurosurgery, London, UK
    J Neurol 253:1542-51. 2006
    ..5 %+/-38.5; lamotrigine: 10.4 %+/-12.5, P<0.01). The findings suggest that lamotrigine may provide a novel avenue for axonal protection in MS...
  24. ncbi request reprint [Pathophysiology of multiple sclerosis]
    Kenneth J Smith
    Department of Clinical Neuroscience, King s College London, Guy s Campus, 19 Newcomen Street, London SE1 1UL, UK
    Rev Prat 56:1299-303. 2006
    ..Lastly, some symptoms in MS are so-called "positive" arising from an acquired hyperexcitability of demyelinated axons and occur either spontaneously (e.g. paresthesias) or mechanically (e.g. Lhermitte's sign)...
  25. doi request reprint Lamotrigine for neuroprotection in secondary progressive multiple sclerosis: a randomised, double-blind, placebo-controlled, parallel-group trial
    Raju Kapoor
    Department of Neuroinflammation, National Hospital for Neurology and Neurosurgery and the Institute of Neurology, Queen Square, London, UK
    Lancet Neurol 9:681-8. 2010
    ..In this phase 2 trial, we aimed to assess whether the sodium-channel blocker lamotrigine is also neuroprotective in patients with secondary progressive multiple sclerosis...
  26. ncbi request reprint Axonal protection using flecainide in experimental autoimmune encephalomyelitis
    David A Bechtold
    Department of Neuroimmunology, King s College, London, United Kingdom
    Ann Neurol 55:607-16. 2004
    ..These findings indicate that flecainide and similar agents may provide a novel therapy aimed at axonal protection in MS and other neuroinflammatory disorders...
  27. ncbi request reprint Remyelination of dorsal column axons by endogenous Schwann cells restores the normal pattern of Nav1.6 and Kv1.2 at nodes of Ranvier
    Joel A Black
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale School of Medicine, New Haven, 2 Rehabilitation Research Center, VA Connecticut Healthcare System, West Haven, CT 06518, USA
    Brain 129:1319-29. 2006
    ..6 the predominant subtype of sodium channel present at such nodes at all stages of their development...
  28. doi request reprint Alternative strategies for adult pneumococcal polysaccharide vaccination: a cost-effectiveness analysis
    Kenneth J Smith
    Section of Decision Sciences and Clinical Systems Modeling, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States
    Vaccine 26:1420-31. 2008
    ..PPV at ages 50/65 may be clinically and, depending on cost-effectiveness criterion used, economically favored over present vaccination recommendations...