Andrew Simmons

Summary

Affiliation: King's College London
Country: UK

Publications

  1. doi request reprint The AddNeuroMed framework for multi-centre MRI assessment of Alzheimer's disease: experience from the first 24 months
    Andrew Simmons
    NIHR Specialist Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King s College London, London, UK
    Int J Geriatr Psychiatry 26:75-82. 2011
  2. ncbi request reprint Quality control for functional magnetic resonance imaging using automated data analysis and Shewhart charting
    A Simmons
    Department of Clinical Neurosciences, Institute of Psychiatry, Maudsley Hospital, London, United Kingdom
    Magn Reson Med 41:1274-8. 1999
  3. doi request reprint Hippocampal proton MR spectroscopy in early Alzheimer's disease and mild cognitive impairment
    Catherine M L Foy
    Institute of Psychiatry, MRC Centre for Neurodegeneration Research, King s College London, London, UK
    Brain Topogr 24:316-22. 2011
  4. pmc Inflammatory proteins in plasma are associated with severity of Alzheimer's disease
    Rufina Leung
    King s College London and National Institute for Health Research NIHR, Biomedical Research Centres at South London and Maudsley NHS Foundation Trust and Guy s and St Thomas NHS Foundation Trust, London, United Kingdom
    PLoS ONE 8:e64971. 2013
  5. doi request reprint Entorhinal cortex thickness predicts cognitive decline in Alzheimer's disease
    Latha Velayudhan
    King s College London, Institute of Psychiatry, London and NIHR Biomedical Research Centre for Mental Health, London, UK
    J Alzheimers Dis 33:755-66. 2013
  6. ncbi request reprint A blood gene expression marker of early Alzheimer's disease
    Katie Lunnon
    King s College London, Institute of Psychiatry, King s Health Partners Centre for Neurodegeneration Research, London, UK
    J Alzheimers Dis 33:737-53. 2013
  7. ncbi request reprint Frontal lobe N-acetylaspartate correlates with psychopathology in schizophrenia: a proton magnetic resonance spectroscopy study
    Thordur Sigmundsson
    Department of Psychological Medicine, Institute of Psychiatry, King s College, De Crespigny Park, London SE5 8AF, UK
    Schizophr Res 64:63-71. 2003
  8. doi request reprint Magnetic resonance imaging and magnetic resonance spectroscopy for detection of early Alzheimer's disease
    Eric Westman
    NIHR Specialist Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust, Kings College London, Institute of Psychiatry, London, UK
    J Alzheimers Dis 26:307-19. 2011
  9. doi request reprint MRI measures of Alzheimer's disease and the AddNeuroMed study
    Andrew Simmons
    NIHR Specialist Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King s College London and the MRC Centre for Neurodegeneration, King s College London, Institute of Psychiatry, London SE5 8AF, United Kingdom
    Ann N Y Acad Sci 1180:47-55. 2009
  10. pmc Cortical grey matter volume and sensorimotor gating in schizophrenia
    Veena Kumari
    Department of Psychology, Institute of Psychiatry, King s College London, London, UK
    Cortex 44:1206-14. 2008

Collaborators

Detail Information

Publications107 found, 100 shown here

  1. doi request reprint The AddNeuroMed framework for multi-centre MRI assessment of Alzheimer's disease: experience from the first 24 months
    Andrew Simmons
    NIHR Specialist Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King s College London, London, UK
    Int J Geriatr Psychiatry 26:75-82. 2011
    ..To describe the AddNeuroMed imaging framework for multi-centre magnetic resonance imaging (MRI) assessment of longitudinal changes in Alzheimer's disease and report on early results from the first 24 months of the project...
  2. ncbi request reprint Quality control for functional magnetic resonance imaging using automated data analysis and Shewhart charting
    A Simmons
    Department of Clinical Neurosciences, Institute of Psychiatry, Maudsley Hospital, London, United Kingdom
    Magn Reson Med 41:1274-8. 1999
    ..The use of automated Shewhart charting is proposed to identify significant changes in each parameter over the long term. The protocol has successfully identified system faults and deteriorations undetected by conventional QC...
  3. doi request reprint Hippocampal proton MR spectroscopy in early Alzheimer's disease and mild cognitive impairment
    Catherine M L Foy
    Institute of Psychiatry, MRC Centre for Neurodegeneration Research, King s College London, London, UK
    Brain Topogr 24:316-22. 2011
    ..Reductions in [NAA] can be detected in the hippocampi of subjects with MCI and hippocampal [NAA] and [Cr + PCr] can distinguish between mild AD and normal elderly controls...
  4. pmc Inflammatory proteins in plasma are associated with severity of Alzheimer's disease
    Rufina Leung
    King s College London and National Institute for Health Research NIHR, Biomedical Research Centres at South London and Maudsley NHS Foundation Trust and Guy s and St Thomas NHS Foundation Trust, London, United Kingdom
    PLoS ONE 8:e64971. 2013
    ..In conclusion, IL-10 was associated with both clinical and imaging evidence of severity of disease and might therefore have potential to act as biomarker of disease progression...
  5. doi request reprint Entorhinal cortex thickness predicts cognitive decline in Alzheimer's disease
    Latha Velayudhan
    King s College London, Institute of Psychiatry, London and NIHR Biomedical Research Centre for Mental Health, London, UK
    J Alzheimers Dis 33:755-66. 2013
    ..Focusing on structural analyses that predict decline can identify those individuals at greatest risk for future cognitive loss. This may have potential for increasing the efficacy of early intervention...
  6. ncbi request reprint A blood gene expression marker of early Alzheimer's disease
    Katie Lunnon
    King s College London, Institute of Psychiatry, King s Health Partners Centre for Neurodegeneration Research, London, UK
    J Alzheimers Dis 33:737-53. 2013
    ..However, we accept these results could also represent a marker of diseases sharing common etiology...
  7. ncbi request reprint Frontal lobe N-acetylaspartate correlates with psychopathology in schizophrenia: a proton magnetic resonance spectroscopy study
    Thordur Sigmundsson
    Department of Psychological Medicine, Institute of Psychiatry, King s College, De Crespigny Park, London SE5 8AF, UK
    Schizophr Res 64:63-71. 2003
    ....
  8. doi request reprint Magnetic resonance imaging and magnetic resonance spectroscopy for detection of early Alzheimer's disease
    Eric Westman
    NIHR Specialist Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust, Kings College London, Institute of Psychiatry, London, UK
    J Alzheimers Dis 26:307-19. 2011
    ..Adding MRS measures to a multivariate analysis of MRI measures resulted in significantly better classification than using MRI measures alone. The method shows strong potential for discriminating between Alzheimer's disease and controls...
  9. doi request reprint MRI measures of Alzheimer's disease and the AddNeuroMed study
    Andrew Simmons
    NIHR Specialist Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King s College London and the MRC Centre for Neurodegeneration, King s College London, Institute of Psychiatry, London SE5 8AF, United Kingdom
    Ann N Y Acad Sci 1180:47-55. 2009
    ..Measurements of normalized whole brain volume, whole brain cortical thickness, and point-by-point group-based cortical thickness measurements, demonstrating the power of the automated image analysis techniques employed, are reported...
  10. pmc Cortical grey matter volume and sensorimotor gating in schizophrenia
    Veena Kumari
    Department of Psychology, Institute of Psychiatry, King s College London, London, UK
    Cortex 44:1206-14. 2008
    ....
  11. doi request reprint Association between a longer duration of illness, age and lower frontal lobe grey matter volume in schizophrenia
    Preethi Premkumar
    Department of Psychology, Institute of Psychiatry, De Crespigny Park, King s College London, London SE5 8AF, United Kingdom
    Behav Brain Res 193:132-9. 2008
    ..The effect of illness chronicity on GM volume in the left dorsomedial PFC may be extended to brain structure-neuropsychological function relationships...
  12. doi request reprint AddNeuroMed--the European collaboration for the discovery of novel biomarkers for Alzheimer's disease
    Simon Lovestone
    NIHR Specialist Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King s College London, Institute of Psychiatry, London SE5 8AF, United Kingdom
    Ann N Y Acad Sci 1180:36-46. 2009
    ..Second, design is paramount and combining modalities, such as imaging and proteomics, may be informative. Third, animal models are valuable in biomarker research. Most importantly, we have learned that plasma markers are feasible...
  13. pmc Structural magnetic resonance imaging predictors of responsiveness to cognitive behaviour therapy in psychosis
    Preethi Premkumar
    Department of Psychology, Institute of Psychiatry, King s College London, London, UK
    Schizophr Res 115:146-55. 2009
    ..This study aimed to determine whether improvement in symptoms following CBT for psychosis (CBTp) in people with schizophrenia is positively associated with pre-therapy grey matter volume in brain regions involved in cognitive processing...
  14. ncbi request reprint Brain anatomy and sensorimotor gating in Asperger's syndrome
    Grainne M McAlonan
    Department of Psychological Medicine, Institute of Psychiatry, London, UK
    Brain 125:1594-606. 2002
    ....
  15. pmc Evaluation of enhanced attention to local detail in anorexia nervosa using the embedded figures test; an FMRI study
    Leon Fonville
    King s College London, Institute of Psychiatry, Department of Psychological Medicine, London, United Kingdom
    PLoS ONE 8:e63964. 2013
    ..This is in accordance with previous findings in autism spectrum disorder using a similar methodology and has implications for therapies addressing the appropriate adjustment of cognitive strategies in anorexia nervosa...
  16. ncbi request reprint The antisocial brain: psychopathy matters
    Sarah Gregory
    Forensic and Neurodevelopmental Sciences Department, Institute of Psychiatry, King s College London, England, UK
    Arch Gen Psychiatry 69:962-72. 2012
    ..The population of men who display persistent antisocial and violent behavior is heterogeneous. Callous-unemotional traits in childhood and psychopathic traits in adulthood characterize a distinct subgroup...
  17. pmc Automated hippocampal shape analysis predicts the onset of dementia in mild cognitive impairment
    Sergi G Costafreda
    King s College London, London, UK
    Neuroimage 56:212-9. 2011
    ..We conclude that automated shape analysis generates sensitive measurements of early neurodegeneration which predates the onset of dementia and thus provides a prognostic biomarker for conversion of MCI to AD...
  18. doi request reprint Down syndrome with and without dementia: an in vivo proton Magnetic Resonance Spectroscopy study with implications for Alzheimer's disease
    Melissa Lamar
    Department of Psychological Medicine, Section of Brain Maturation, Institute of Psychiatry, King s College London, London, England, UK
    Neuroimage 57:63-8. 2011
    ..mI] may modify risk for dementia in this vulnerable population...
  19. doi request reprint A lateralized brain network for visuospatial attention
    Michel Thiebaut de Schotten
    Natbrainlab, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King s College London, London, UK
    Nat Neurosci 14:1245-6. 2011
    ..Our results suggest that hemispheric specialization is associated with an unbalanced speed of visuospatial processing...
  20. doi request reprint Can spherical deconvolution provide more information than fiber orientations? Hindrance modulated orientational anisotropy, a true-tract specific index to characterize white matter diffusion
    Flavio Dell'Acqua
    Department of Neuroimaging, King s College London, Institute of Psychiatry, United Kingdom NIHR Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, King s College London, United Kingdom
    Hum Brain Mapp 34:2464-83. 2013
    ..In conclusion, the HMOA represents a true tract-specific and sensitive index and provides a compact characterization of white matter diffusion properties with potential for widespread application in normal and clinical populations...
  21. ncbi request reprint Effects of age and gender on neural networks of motor response inhibition: from adolescence to mid-adulthood
    Katya Rubia
    Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King s College London, London, UK Electronic address
    Neuroimage 83:690-703. 2013
    ....
  22. pmc Regional magnetic resonance imaging measures for multivariate analysis in Alzheimer's disease and mild cognitive impairment
    Eric Westman
    Department of Neuroimaging, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Brain Topogr 26:9-23. 2013
    ..The appropriate choice of input for multivariate analysis in AD and MCI is of great importance. The results support the use of un-normalised cortical thickness measures and volumes normalised by ICV...
  23. pmc Plasma based markers of [11C] PiB-PET brain amyloid burden
    Steven John Kiddle
    National Institute of Health Research Biomedical Research Centre for Mental Health, South London and Maudsley National Health Service Foundation Trust, London, United Kingdom
    PLoS ONE 7:e44260. 2012
    ..545. The number of APOE [Symbol: see text] 4 alleles and plasma apolipoprotein E level were found to contribute most to this model, and the relationship between these variables and brain amyloid burden was explored...
  24. pmc Alzheimer's disease biomarker discovery using in silico literature mining and clinical validation
    Ines Greco
    King s College London, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    J Transl Med 10:217. 2012
    ..The aim of this study was to use a novel in silico approach to discover a set of candidate biomarkers for AD...
  25. doi request reprint Scopolamine disrupts hippocampal activity during allocentric spatial memory in humans: an fMRI study using a virtual reality analogue of the Morris Water Maze
    Elena Antonova
    Department of Psychology, King s College London, Institute of Psychiatry, London, UK
    J Psychopharmacol 25:1256-65. 2011
    ..Furthermore, the results call for further investigation of the dissociation between the hippocampal and neostriatal memory systems during allocentric spatial processing under cholinergic blockade in humans...
  26. ncbi request reprint Cortical activation during motor imagery is reduced in Amyotrophic Lateral Sclerosis
    Biba R Stanton
    MRC Centre for Neurodegeneration Research and Department of Clinical Neuroscience, King s College London, Institute of Psychiatry PO41, De Crespigny Park, London, UK
    Brain Res 1172:145-51. 2007
    ..This reduction in cortical activation during motor imagery contrasts with the pattern seen during motor execution. This may represent the disruption of normal motor imagery networks by ALS pathology outside the primary motor cortex...
  27. ncbi request reprint Selective deficit of hippocampal N-acetylaspartate in antipsychotic-naive patients with schizophrenia
    Dominic Fannon
    Section of General Psychiatry, Institute of Psychiatry, London, UK
    Biol Psychiatry 54:587-98. 2003
    ..There is mounting evidence that antipsychotic medication influences N-acetylaspartate...
  28. doi request reprint Beyond cortical localization in clinico-anatomical correlation
    Marco Catani
    Natbrainlab, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King s College London, UK
    Cortex 48:1262-87. 2012
    ....
  29. doi request reprint Combinatorial markers of mild cognitive impairment conversion to Alzheimer's disease--cytokines and MRI measures together predict disease progression
    Simon J Furney
    King s College London, Institute of Psychiatry and National Institute of Health Research NIHR Biomedical Research Centre for Mental Health, London, UK
    J Alzheimers Dis 26:395-405. 2011
    ....
  30. ncbi request reprint A computational morphometric MRI study of schizophrenia: effects of hallucinations
    Jane Shapleske
    Department of Psychological Medicine, Institute of Psychiatry, London SE5 8AF, UK
    Cereb Cortex 12:1331-41. 2002
    ....
  31. ncbi request reprint Alzheimer's disease and Down's syndrome: an in vivo MRI study
    F Beacher
    Institute of Psychiatry, King s College, London, UK
    Psychol Med 39:675-84. 2009
    ..Individuals with Down's syndrome (DS) are at high risk of developing Alzheimer's disease (AD). However, few studies have investigated brain anatomy in DS individuals with AD...
  32. ncbi request reprint Investigation of facial recognition memory and happy and sad facial expression perception: an fMRI study
    M L Phillips
    Department of Psychological Medicine, Institute of Psychiatry, London, UK
    Psychiatry Res 83:127-38. 1998
    ....
  33. pmc White matter integrity as a predictor of response to treatment in first episode psychosis
    Tiago Reis Marques
    1 Department of Psychosis Studies, Institute of Psychiatry, King s College London, UK
    Brain 137:172-82. 2014
    ..These findings can inform patient stratification to anticipate care needs, and raise the possibility that antipsychotics may restore white matter integrity as part of the therapeutic response. ..
  34. doi request reprint Mitochondrial dysfunction and immune activation are detectable in early Alzheimer's disease blood
    Katie Lunnon
    Institute of Psychiatry, King s Health Partners Centre for Neurodegeneration Research, King s College London, London, UK
    J Alzheimers Dis 30:685-710. 2012
    ....
  35. doi request reprint Proteome-based identification of plasma proteins associated with hippocampal metabolism in early Alzheimer's disease
    Madhav Thambisetty
    King s College London, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    J Neurol 255:1712-20. 2008
    ..We also undertook a proteomic analysis of plasma in these individuals using two-dimensional gel electrophoresis (2DGE)...
  36. ncbi request reprint Brain responses to body image stimuli but not food are altered in women with bulimia nervosa
    Frederique van den Eynde
    Department of Psychological Medicine, Section of Eating Disorders Institute of Psychiatry, King s College London, London, UK
    BMC Psychiatry 13:302. 2013
    ..Research into the neural correlates of bulimia nervosa (BN) psychopathology remains limited...
  37. ncbi request reprint Pattern classification of response inhibition in ADHD: Toward the development of neurobiological markers for ADHD
    Heledd Hart
    Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King s College London, De Crespigny Park, London, SE5 8AF, United Kingdom
    Hum Brain Mapp 35:3083-94. 2014
    ..Hum Brain Mapp 35:3083-3094, 2014. © 2013 Wiley Periodicals, Inc. ..
  38. pmc Disorder-specific predictive classification of adolescents with attention deficit hyperactivity disorder (ADHD) relative to autism using structural magnetic resonance imaging
    Lena Lim
    Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King s College London, London, United Kingdom
    PLoS ONE 8:e63660. 2013
    ....
  39. ncbi request reprint Candidate blood proteome markers of Alzheimer's disease onset and progression: a systematic review and replication study
    Steven J Kiddle
    King s College London, Institute of Psychiatry, London, UK NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation, London, UK
    J Alzheimers Dis 38:515-31. 2014
    ..This suggests that AD pathology does affect the blood proteome with some consistency...
  40. ncbi request reprint Effects of acute ovarian hormone suppression on the human brain: an in vivo 1H MRS study
    Michael C Craig
    Department of Psychological Medicine, Institute of Psychiatry, Section of Brain Maturation, London, UK
    Psychoneuroendocrinology 32:1128-32. 2007
    ..They also showed a trend to a significant increase in Cho concentration in the hippocampus. This supports our previous findings and adds to the evidence that neuronal/glial membrane metabolism is affected by sex hormones in women...
  41. doi request reprint Early specialization for voice and emotion processing in the infant brain
    Anna Blasi
    Department of Forensic and Neurodevelopmental Science, Institute of Psychiatry, King s College London, London SE5 8AF, UK
    Curr Biol 21:1220-4. 2011
    ..These results suggest remarkably early functional specialization for processing human voice and negative emotions...
  42. pmc A comprehensive testing protocol for MRI neuroanatomical segmentation techniques: Evaluation of a novel lateral ventricle segmentation method
    Matthew J Kempton
    King s College London, Institute of Psychiatry, Department of Neuroimaging, UK
    Neuroimage 58:1051-9. 2011
    ..We also demonstrate that the novel segmentation algorithm and FreeSurfer are both effective in determining lateral ventricular volume and are well suited for multicentre and longitudinal MRI studies...
  43. doi request reprint A modified damped Richardson-Lucy algorithm to reduce isotropic background effects in spherical deconvolution
    Flavio Dell'Acqua
    CERMAC, San Raffaele Scientific Institute, Milan, Italy
    Neuroimage 49:1446-58. 2010
    ..Considering both the speed of processing and the scan time required, this new method has the potential for better characterizing white matter anatomy and the integrity of pathological tissue...
  44. doi request reprint Structural neuroimaging studies in major depressive disorder. Meta-analysis and comparison with bipolar disorder
    Matthew J Kempton
    Department of Neuroimaging, PO89, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, England
    Arch Gen Psychiatry 68:675-90. 2011
    ..Although differences in clinical characteristics exist between major depressive disorder (MDD) and bipolar disorder (BD), consistent structural brain abnormalities that distinguish the disorders have not been identified...
  45. ncbi request reprint Preliminary in vivo evidence of increased N-acetyl-aspartate following eicosapentanoic acid treatment in patients with bipolar disorder
    Sophia Frangou
    Section of Neurobiology of Psychosis, Institute of Psychiatry, Kings College London, London, UK
    J Psychopharmacol 21:435-9. 2007
    ..027). These results provide the first evidence for a probable neurotrophic role of ethyl-EPA treatment in BD underlining the need for more detailed investigation of its mechanism of action and therapeutic potential...
  46. ncbi request reprint Influence of X chromosome and hormones on human brain development: a magnetic resonance imaging and proton magnetic resonance spectroscopy study of Turner syndrome
    William J Cutter
    Section of Brain Maturation, Department of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Biol Psychiatry 59:273-83. 2006
    ..Hence, they allow us an opportunity to investigate genetic and endocrine influences on brain development...
  47. ncbi request reprint Procedural learning in schizophrenia: a functional magnetic resonance imaging investigation
    Veena Kumari
    Section of Cognitive Psychopharmacology, Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, UK
    Schizophr Res 57:97-107. 2002
    ....
  48. ncbi request reprint Asperger syndrome: a proton magnetic resonance spectroscopy study of brain
    Declan G M Murphy
    Department of Psychological Medicine, St George s Hospital Medical School, London, England
    Arch Gen Psychiatry 59:885-91. 2002
    ..Nobody has examined the relationship between abnormalities in the frontal and parietal lobes and clinical symptoms in people with AS...
  49. doi request reprint Diffusion tensor imaging in sporadic and familial (D90A SOD1) forms of amyotrophic lateral sclerosis
    Biba R Stanton
    Medical Research Council Centre for Neurodegeneration Research and Department of Clinical Neuroscience, Institute of Psychiatry, King s College London, London SE5 8AF, England
    Arch Neurol 66:109-15. 2009
    ..The basis of heterogeneity in the clinical presentation and rate of progression of amyotrophic lateral sclerosis (ALS) is poorly understood...
  50. ncbi request reprint The cerebellum and decision making under uncertainty
    Nigel Blackwood
    Division of Psychological Medicine, Institute of Psychiatry, PO Box 70, De Crespigny Park, London SE5 8AZ, UK
    Brain Res Cogn Brain Res 20:46-53. 2004
    ..We hypothesise that the neo-cerebellum constructs internal working models of uncertain events in the external world, and that such probabilistic models subserve the predictive capacity central to induction...
  51. ncbi request reprint Neural correlates of tactile prepulse inhibition: a functional MRI study in normal and schizophrenic subjects
    Veena Kumari
    Section of Cognitive Psychopharmacology, Institute of Psychiatry, King s College, De Crespigny Park, London SE5 8AF, UK
    Psychiatry Res 122:99-113. 2003
    ..The findings demonstrate involvement of the striatum, hippocampus, thalamus, and frontal and parietal cortical regions in PPI. Dysfunctions in any of these regions may underlie observations of reduced PPI in schizophrenia...
  52. ncbi request reprint Cognitive effects of nicotine in humans: an fMRI study
    Veena Kumari
    Department of Psychology, Institute of Psychiatry, King s College, London, UK
    Neuroimage 19:1002-13. 2003
    ....
  53. doi request reprint Magnetic resonance safety
    Andrew Simmons
    King s College London, Institute of Psychiatry, Centre for Neuroimaging Sciences, London, UK
    Methods Mol Biol 711:17-28. 2011
    ..Finally, contrast agents, auditory effects and medical implants and devices are discussed, as well as the less thought about issue of biological safety of clinical and pre-clinical MR systems...
  54. doi request reprint Effects of estrogen therapy on age-related differences in gray matter concentration
    D Robertson
    Department of Psychological Medicine, Institute of Psychiatry, King s College, London, UK
    Climacteric 12:301-9. 2009
    ..The inconsistency in the findings of previous studies is likely to be due to a variety of methodological factors. In this study, we attempted to overcome many of these factors...
  55. ncbi request reprint The functional neuroanatomy of implicit-motion perception or representational momentum
    C Senior
    Department of Psychological Medicine, Institute of Psychiatry and GKT School of Medicine, London, UK
    Curr Biol 10:16-22. 2000
    ..We used functional magnetic resonance imaging (fMRI) to explore the neural substrate for representational momentum...
  56. ncbi request reprint Functional frontalisation with age: mapping neurodevelopmental trajectories with fMRI
    K Rubia
    Institute of Psychiatry King s College, University of London, UK
    Neurosci Biobehav Rev 24:13-9. 2000
    ..A significant age effect was found for the prefrontal activation in both task, confirming the hypothesis of a dysmaturational pathogenesis for the hypofrontality in ADHD...
  57. ncbi request reprint Volumetric analysis reveals corticospinal tract degeneration and extramotor involvement in ALS
    C M Ellis
    Department of Neurology, Guy s, Kings and St Thomas School of Medicine and Dentistry, London, UK
    Neurology 57:1571-8. 2001
    ..Pathologic changes in the motor cortex and corticospinal tracts in ALS may be reflected by abnormal signal intensities on conventional MRI. The sensitivity of these changes in detecting underlying pathology remains unclear...
  58. ncbi request reprint An fMRI study of reduced left prefrontal activation in schizophrenia during normal inhibitory function
    K Rubia
    Department of Child Psychiatry, Psychological Medicine, and Neurology, Institute of Psychiatry, King s College, De Crespigny Park, SE5 8AF, London, UK
    Schizophr Res 52:47-55. 2001
    ..Despite good task performance, patients with schizophrenia thus showed abnormal neural network patterns of reduced left prefrontal activation and increased subcortical activation when challenged with motor response inhibition...
  59. ncbi request reprint Attenuated frontal activation in schizophrenia may be task dependent
    V A Curtis
    Department of Psychological Medicine, Institute of Psychiatry King s College, London, UK
    Schizophr Res 37:35-44. 1999
    ..Functional magnetic resonance imaging was used to examine the neural correlates of two linguistic tasks in schizophrenia...
  60. ncbi request reprint Serial precision of metabolite peak area ratios and water referenced metabolite peak areas in proton MR spectroscopy of the human brain
    A Simmons
    Department of Clinical Neurosciences, Institute of Psychiatry, London, UK
    Magn Reson Imaging 16:319-30. 1998
    ..These results allow us to repudiate Marshall's assertion regarding disappointing repeatability of in vivo MRS...
  61. ncbi request reprint Sources of error in comparing functional magnetic resonance imaging and invasive electrophysiological recordings
    D L Hill
    Radiological Sciences, Guy s Hospital, King s College London, United Kingdom
    J Neurosurg 93:214-23. 2000
    ..The authors have conducted a similar study, and in this paper they identify and quantify two characteristics of these data that can make such a comparison problematic...
  62. ncbi request reprint Cortical activity during rotational and linear transformations
    J Barnes
    Centre for Brain and Cognitive Development, School of Psychology, Birkbeck College, University of London, Malet Street, WC1E 7HX, London, UK
    Neuropsychologia 38:1148-56. 2000
    ..The findings demonstrate the extent to which neural substrates for image transformation and perception overlap and are distinct as well as revealing functional specialisation within perception and transformation processing systems...
  63. ncbi request reprint Persecutory delusions and the determination of self-relevance: an fMRI investigation
    N J Blackwood
    Department of Psychological Medicine, Institute of Psychiatry, London
    Psychol Med 34:591-6. 2004
    ..This study aimed to characterize these social cognitive biases in functional neuroanatomical terms...
  64. ncbi request reprint Word retrieval in amyotrophic lateral sclerosis: a functional magnetic resonance imaging study
    S Abrahams
    Department of Psychology, Institute of Psychiatry, King s College, London, UK
    Brain 127:1507-17. 2004
    ..This study provides evidence of cerebral abnormalities in ALS in the network of regions involved in language and executive functions. Moreover, the findings further illustrate the heterogeneity of cognitive and cerebral change in ALS...
  65. ncbi request reprint Self-responsibility and the self-serving bias: an fMRI investigation of causal attributions
    N J Blackwood
    Division of Psychological Medicine, Institute of Psychiatry, London, UK
    Neuroimage 20:1076-85. 2003
    ..The dorsal striatum, previously implicated in motivated behavior, mediates the self-serving bias...
  66. ncbi request reprint Exploring the social brain in schizophrenia: left prefrontal underactivation during mental state attribution
    T A Russell
    Institute of Psychiatry, King s College, London, UK
    Am J Psychiatry 157:2040-2. 2000
    ..The authors used functional magnetic resonance imaging (MRI) to investigate the hypothesis that patients with schizophrenia have a dysfunction in brain regions responsible for mental state attribution...
  67. ncbi request reprint Mapping motor inhibition: conjunctive brain activations across different versions of go/no-go and stop tasks
    K Rubia
    Institute of Psychiatry, King s College, London, UK
    Neuroimage 13:250-61. 2001
    ....
  68. ncbi request reprint Functional anatomy of auditory verbal imagery in schizophrenic patients with auditory hallucinations
    S S Shergill
    Department of Biostatistics, Institute for Psychiatry, London, UK
    Am J Psychiatry 157:1691-3. 2000
    ..This study investigated the functional neuroanatomy of inner speech and auditory verbal imagery in schizophrenic patients predisposed to auditory hallucinations...
  69. ncbi request reprint Development of educational image databases and e-books for medical physics training
    S Tabakov
    Med Eng Phys 27:591-8. 2005
    ..Both the e-books and IDB are engraved on five separate CD-ROMs. Demo of these materials can be taken from www.emerald2.net...
  70. ncbi request reprint Hypofrontality in attention deficit hyperactivity disorder during higher-order motor control: a study with functional MRI
    K Rubia
    Medical Research Council Child and Adolescent Psychiatry Unit, Kings College, London, U K
    Am J Psychiatry 156:891-6. 1999
    ....
  71. ncbi request reprint The effect of acute hypoglycemia on brain function and activation: a functional magnetic resonance imaging study
    J M Rosenthal
    Department of Diabetes, Endocrinology, and Internal Medicine, Guy s, King s and St Thomas School of Medicine, Denmark Hill Campus, Bessemer Road, London SE5 9PJ, U K
    Diabetes 50:1618-26. 2001
    ..Further investigation of these mechanisms may help devise rational treatment strategies to limit cortical dysfunction during acute iatrogenic hypoglycemia...
  72. ncbi request reprint Effects of estrogen replacement therapy on human brain aging: an in vivo 1H MRS study
    D M Robertson
    Department of Psychological Medicine, Institute of Psychiatry, London, UK
    Neurology 57:2114-7. 2001
    ..Cho reflects increased neuronal/glial membrane turnover. Thus, ERT's "neuroprotective" effect may include modulating the effects of age on neural integrity in brain regions involved in cognitive function...
  73. pmc Group analysis of self-organizing maps based on functional MRI using restricted Frechet means
    Arnaud P Fournel
    Department of Neuroimaging, Institute of Psychiatry, King s College London, UK
    Neuroimage 76:373-85. 2013
    ..Taken together, these results indicate that our proposed methods can cast new light on existing data by adopting a global analytical perspective on functional MRI paradigms...
  74. doi request reprint Combining MRI and CSF measures for classification of Alzheimer's disease and prediction of mild cognitive impairment conversion
    Eric Westman
    Department of Neuroimaging, Institute of Psychiatry, King s College London, London, UK
    Neuroimage 62:229-38. 2012
    ....
  75. doi request reprint Structural magnetic resonance imaging in eating disorders: a systematic review of voxel-based morphometry studies
    Frederique van den Eynde
    King s College London, Institute of Psychiatry, Department of Psychological Medicine, Section of Eating Disorders, London, UK
    Eur Eat Disord Rev 20:94-105. 2012
    ..Overall, as the available data are inconclusive, further efforts in this field are warranted...
  76. ncbi request reprint Altered cortical activation during a motor task in ALS. Evidence for involvement of central pathways
    Biba R Stanton
    Dept of Clinical Neuroscience, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    J Neurol 254:1260-7. 2007
    ..To test the hypothesis that patients with amyotrophic lateral sclerosis (ALS) show increased cortical activation during a motor task compared to both healthy controls and patients with muscle weakness due to peripheral lesions...
  77. pmc Brain network analysis: separating cost from topology using cost-integration
    Cedric E Ginestet
    Department of Neuroimaging, Institute of Psychiatry, King s College London, London, United Kingdom
    PLoS ONE 6:e21570. 2011
    ....
  78. ncbi request reprint Superior temporal gyrus abnormalities in early-onset schizophrenia: similarities and differences with adult-onset schizophrenia
    H Matsumoto
    Institute of Psychiatry, Division of Psychological Medicine, Section of Neurobiology of Psychosis, De Crespigny Park, London, SE5 8AF, UK
    Am J Psychiatry 158:1299-304. 2001
    ..The relationship between language-related symptoms and superior temporal gyrus volume is similar to that seen in adult-onset cases but not as lateralized...
  79. ncbi request reprint No differences in hippocampal volume between carriers and non-carriers of the ApoE ε4 and ε2 alleles in young healthy adolescents
    Wasim Khan
    King s College London, Institute of Psychiatry, London, UK NIHR Biomedical Research Centre for Mental Health, King s College London, London, UK NIHR Biomedical Research Unit for Dementia, King s College London, London, UK
    J Alzheimers Dis 40:37-43. 2014
    ....
  80. pmc Emotional decision-making and its dissociable components in schizophrenia and schizoaffective disorder: a behavioural and MRI investigation
    Preethi Premkumar
    Department of Psychology, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, United Kingdom
    Neuropsychologia 46:2002-12. 2008
    ....
  81. doi request reprint Statistical parametric network analysis of functional connectivity dynamics during a working memory task
    Cedric E Ginestet
    King s College London, Institute of Psychiatry, Centre for Neuroimaging Sciences CNS, London, UK
    Neuroimage 55:688-704. 2011
    ..These findings are discussed in relation to the integration/specialization functional dichotomy. The pruning of functional networks under increasing cognitive load may permit greater modular specialization, thereby enhancing performance...
  82. pmc Functional development of fronto-striato-parietal networks associated with time perception
    Anna B Smith
    Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Kings College London London, UK
    Front Hum Neurosci 5:136. 2011
    ....
  83. ncbi request reprint Neural response to pleasant stimuli in anhedonia: an fMRI study
    Martina T Mitterschiffthaler
    Neuroimaging Research, Department of Neurology, King s College, London, UK
    Neuroreport 14:177-82. 2003
    ..Increases in neural activation in putamen and thalamus, previously found in transient sadness, and anterior cingulate could point to an involvement of these structures in anhedonia...
  84. pmc Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease
    Madhav Thambisetty
    King s College London, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, England
    Arch Gen Psychiatry 67:739-48. 2010
    ..Blood-based analytes may be indicators of pathological processes in Alzheimer disease (AD)...
  85. ncbi request reprint Structural magnetic imaging of the hippocampus in early onset schizophrenia
    H Matsumoto
    Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
    Biol Psychiatry 49:824-31. 2001
    ....
  86. ncbi request reprint Towards a functional neuroanatomy of self processing: effects of faces and words
    T T Kircher
    Department of Psychological Medicine, Institute of Psychiatry and GKT School of Medicine, De Crespigny Park, SE5 8AF, London, UK
    Brain Res Cogn Brain Res 10:133-44. 2000
    ..The self-relevant stimuli engaged to a differential extent long term and working memory, semantic and emotional processes. We suggest that regions activated by these stimuli are engaged in self-processing...
  87. ncbi request reprint Dynamic multi-planar EPI of the urinary bladder during voiding with simultaneous detrusor pressure measurement
    A Simmons
    Department of Clinical Neurosciences, Institute of Psychiatry, London, UK
    Magn Reson Imaging 15:295-300. 1997
    ....
  88. doi request reprint White matter abnormalities and illness severity in major depressive disorder
    James Cole
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Br J Psychiatry 201:33-9. 2012
    ..White matter abnormalities have been implicated in the aetiology of major depressive disorder; however, the relationship between the severity of symptoms and white matter integrity is currently unclear...
  89. ncbi request reprint Human attachment security is mediated by the amygdala: evidence from combined fMRI and psychophysiological measures
    Erwin Lemche
    Division of Psychological Medicine, Section of Neuroscience and Emotion, Institute of Psychiatry, London, United Kingdom
    Hum Brain Mapp 27:623-35. 2006
    ..We thereby demonstrate a key role of the amygdala in mediating autonomic activity associated with human attachment insecurity...
  90. ncbi request reprint In vivo 1H-magnetic resonance spectroscopy study of amygdala-hippocampal and parietal regions in autism
    Lisa A Page
    Section of Brain Maturation, Institute of Psychiatry, London
    Am J Psychiatry 163:2189-92. 2006
    ..However, the concentration of glutamate/glutamine in brain regions implicated in autistic spectrum disorders has not yet been examined in vivo...
  91. ncbi request reprint Allocentric spatial memory activation of the hippocampal formation measured with fMRI
    David M Parslow
    King s College London, London, United Kingdom
    Neuropsychology 18:450-61. 2004
    ..These results suggest differential activation of the hippocampal formation during allocentric encoding, in partial support of the spatial mapping hypothesis as applied to humans...
  92. ncbi request reprint A functional MRI study of working memory task in euthymic bipolar disorder: evidence for task-specific dysfunction
    Paul J Monks
    Division of Psychological Medicine, Institute of Psychiatry, London, UK
    Bipolar Disord 6:550-64. 2004
    ..We hypothesized that neuronal dysfunction would be specific to the network underlying the executive rather than the phonological loop component of working memory...
  93. ncbi request reprint Heterozygous PAX6 mutation, adult brain structure and fronto-striato-thalamic function in a human family
    Zoë Ellison-Wright
    Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Eur J Neurosci 19:1505-12. 2004
    ..Highly conserved homeobox genes may be critical for normal ontogenesis of large-scale neurocognitive networks supporting phylogenetically advanced mental functions...
  94. doi request reprint Brain anatomy and ageing in non-demented adults with Down's syndrome: an in vivo MRI study
    F Beacher
    Institute of Psychiatry, Kings College, London SE5 8AF, UK
    Psychol Med 40:611-9. 2010
    ..People with Down's syndrome (DS) are at high risk for developing dementia in middle age. The biological basis for this is unknown. It has been proposed that non-demented adults with DS may undergo accelerated brain ageing...
  95. ncbi request reprint Cortical processing of human somatic and visceral sensation
    Q Aziz
    Department of Clinical Neurosciences, Institute of Psychiatry, London SE5 8AF, United Kingdom
    J Neurosci 20:2657-63. 2000
    ..These findings suggest that cortical specialization in the sensory-discriminative, affective, and cognitive areas of the cortex accounts for the perceptual differences observed between the two sensory modalities...
  96. ncbi request reprint Generic brain activation mapping in functional magnetic resonance imaging: a nonparametric approach
    M J Brammer
    Department of Biostatistics, Institute of Psychiatry, London
    Magn Reson Imaging 15:763-70. 1997
    ....
  97. ncbi request reprint Application of the extremum stack to neurological MRI
    A Simmons
    Department of Clinical Neurosciences, Institute of Psychiatry, London, UK
    IEEE Trans Med Imaging 17:371-82. 1998
    ....
  98. ncbi request reprint Measuring brain stem and cerebellar damage in parkinsonian syndromes using diffusion tensor MRI
    C R V Blain
    King s College London, Institute of Psychiatry, MRC Centre for Neurodegeneration, Department of Clinical Neuroscience, London, UK
    Neurology 67:2199-205. 2006
    ....
  99. ncbi request reprint Corpus callosum may be similar in children with ADHD and siblings of children with ADHD
    S Overmeyer
    Department of Child Psychiatry, Institute of Psychiatry, London, UK
    Dev Med Child Neurol 42:8-13. 2000
    ..Clinicians should not base their pathophysiological diagnosis of this disorder on an abnormality of callosal development...
  100. pmc Magnetic resonance markers of ischaemia: their correlation with vasodilatory reserve in patients with carotid artery stenosis and occlusion
    D Lythgoe
    Neuroimaging, Guy's, King's, and St Thomas' School of Medicine and the Institute of Psychiatry, London, UK
    J Neurol Neurosurg Psychiatry 71:58-62. 2001
    ..Magnetic resonance spectroscopy is unlikely to help in the selection of patients with asymptomatic carotid stenosis for endarterectomy...
  101. ncbi request reprint Neuroimaging correlates of negative priming
    C Steel
    Department of Psychology, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Neuroreport 12:3619-24. 2001
    ..Areas of cortical activation are discussed with reference to theoretical accounts of the negative priming effect...