Michael J Shattock

Summary

Affiliation: King's College London
Country: UK

Publications

  1. pmc 'Autonomic conflict': a different way to die during cold water immersion?
    Michael J Shattock
    Cardiovascular Division, King s College London, The Rayne Institute, Lambeth Wing, St Thomas Hospital, London SE1 7EH, UK
    J Physiol 590:3219-30. 2012
  2. doi request reprint Phospholemman: its role in normal cardiac physiology and potential as a druggable target in disease
    Michael J Shattock
    Cardiovascular Division, King s College London, London SE1 7EH, UK
    Curr Opin Pharmacol 9:160-6. 2009
  3. doi request reprint Phospholemman-dependent regulation of the cardiac Na/K-ATPase activity is modulated by inhibitor-1 sensitive type-1 phosphatase
    Ali El-Armouche
    Department of Pharmacology, Heart Center, University Medical Center Gottingen, Gottingen, Germany
    FASEB J 25:4467-75. 2011
  4. pmc Nitric oxide regulates cardiac intracellular Na⁺ and Ca²⁺ by modulating Na/K ATPase via PKCε and phospholemman-dependent mechanism
    Davor Pavlovic
    Cardiovascular Division, King s College London, The Rayne Institute, St Thomas Hospital, London, UK
    J Mol Cell Cardiol 61:164-71. 2013
  5. ncbi request reprint Pivotal role of NOX-2-containing NADPH oxidase in early ischemic preconditioning
    Robert M Bell
    King s College London, Cardiac Physiology, Cardiovascular Division, The Rayne Institute, St Thomas Hospital, London SE1 7EH, UK
    FASEB J 19:2037-9. 2005
  6. ncbi request reprint Role of p38-mitogen-activated protein kinase in ischaemic preconditioning in rat heart
    James R Bell
    Cardiac Physiology, Cardiovascular Division, King s College London, The Rayne Institute, St Thomas Hospital, London, UK
    Clin Exp Pharmacol Physiol 35:126-34. 2008
  7. ncbi request reprint Cardioprotection initiated by reactive oxygen species is dependent on activation of PKCepsilon
    Alamgir M N Kabir
    Dept of Cardiology, The Rayne Institute, St Thomas Hospital, London SE1 7EH, UK
    Am J Physiol Heart Circ Physiol 291:H1893-9. 2006
  8. ncbi request reprint Characterization of the phospholemman knockout mouse heart: depressed left ventricular function with increased Na-K-ATPase activity
    James R Bell
    Cardiovascular Division, King s College London, Rayne Institute, St Thomas Hospital, London, UK
    Am J Physiol Heart Circ Physiol 294:H613-21. 2008
  9. ncbi request reprint Reperfusion kinase phosphorylation is essential but not sufficient in the mediation of pharmacological preconditioning: Characterisation in the bi-phasic profile of early and late protection
    Robert M Bell
    Cardiac Physiology, King s College London, Cardiovascular Division, The Rayne Institute, St Thomas Hospital, London, SE1 7EH, UK
    Cardiovasc Res 73:153-63. 2007
  10. doi request reprint Esmolol cardioplegia: the cellular mechanism of diastolic arrest
    Hazem B Fallouh
    Cardiac Surgical Research, The Rayne Institute King s College London, St Thomas Hospital, London, UK
    Cardiovasc Res 87:552-60. 2010

Collaborators

Detail Information

Publications34

  1. pmc 'Autonomic conflict': a different way to die during cold water immersion?
    Michael J Shattock
    Cardiovascular Division, King s College London, The Rayne Institute, Lambeth Wing, St Thomas Hospital, London SE1 7EH, UK
    J Physiol 590:3219-30. 2012
    ....
  2. doi request reprint Phospholemman: its role in normal cardiac physiology and potential as a druggable target in disease
    Michael J Shattock
    Cardiovascular Division, King s College London, London SE1 7EH, UK
    Curr Opin Pharmacol 9:160-6. 2009
    ....
  3. doi request reprint Phospholemman-dependent regulation of the cardiac Na/K-ATPase activity is modulated by inhibitor-1 sensitive type-1 phosphatase
    Ali El-Armouche
    Department of Pharmacology, Heart Center, University Medical Center Gottingen, Gottingen, Germany
    FASEB J 25:4467-75. 2011
    ....
  4. pmc Nitric oxide regulates cardiac intracellular Na⁺ and Ca²⁺ by modulating Na/K ATPase via PKCε and phospholemman-dependent mechanism
    Davor Pavlovic
    Cardiovascular Division, King s College London, The Rayne Institute, St Thomas Hospital, London, UK
    J Mol Cell Cardiol 61:164-71. 2013
    ..This article is part of a Special Issue entitled "Na(+) Regulation in Cardiac Myocytes"...
  5. ncbi request reprint Pivotal role of NOX-2-containing NADPH oxidase in early ischemic preconditioning
    Robert M Bell
    King s College London, Cardiac Physiology, Cardiovascular Division, The Rayne Institute, St Thomas Hospital, London SE1 7EH, UK
    FASEB J 19:2037-9. 2005
    ..PKC-dependent activation of a NOX-2-containing NADPH oxidase is pivotally involved in early ischemic PC. However, adenosine receptor activation can trigger a ROS and NOX-2 independent PC pathway...
  6. ncbi request reprint Role of p38-mitogen-activated protein kinase in ischaemic preconditioning in rat heart
    James R Bell
    Cardiac Physiology, Cardiovascular Division, King s College London, The Rayne Institute, St Thomas Hospital, London, UK
    Clin Exp Pharmacol Physiol 35:126-34. 2008
    ..Previous studies using SB203580 may have been complicated by failure to account for the activation of p38-MAPK by the protocol itself and the anti-oxidant properties of the most commonly used vehicle DMSO...
  7. ncbi request reprint Cardioprotection initiated by reactive oxygen species is dependent on activation of PKCepsilon
    Alamgir M N Kabir
    Dept of Cardiology, The Rayne Institute, St Thomas Hospital, London SE1 7EH, UK
    Am J Physiol Heart Circ Physiol 291:H1893-9. 2006
    ..In addition, protection is absent in PKCepsilon null hearts. Our results imply that, in common with ischemic preconditioning, PKCepsilon is crucial to ROS-mediated protection...
  8. ncbi request reprint Characterization of the phospholemman knockout mouse heart: depressed left ventricular function with increased Na-K-ATPase activity
    James R Bell
    Cardiovascular Division, King s College London, Rayne Institute, St Thomas Hospital, London, UK
    Am J Physiol Heart Circ Physiol 294:H613-21. 2008
    ..Data are consistent with the hypothesis that PLM modulates Na-K-ATPase activity, indirectly affecting intracellular Ca and hence contractile function...
  9. ncbi request reprint Reperfusion kinase phosphorylation is essential but not sufficient in the mediation of pharmacological preconditioning: Characterisation in the bi-phasic profile of early and late protection
    Robert M Bell
    Cardiac Physiology, King s College London, Cardiovascular Division, The Rayne Institute, St Thomas Hospital, London, SE1 7EH, UK
    Cardiovasc Res 73:153-63. 2007
    ....
  10. doi request reprint Esmolol cardioplegia: the cellular mechanism of diastolic arrest
    Hazem B Fallouh
    Cardiac Surgical Research, The Rayne Institute King s College London, St Thomas Hospital, London, UK
    Cardiovasc Res 87:552-60. 2010
    ..Esmolol, an ultra-short-acting beta-blocker, acts as a cardioplegic agent at millimolar concentrations. We investigated the mechanism by which esmolol induces diastolic ventricular arrest...
  11. doi request reprint Novel regulation of cardiac Na pump via phospholemman
    Davor Pavlovic
    Cardiovascular Division, King s College London, The Rayne Institute, St Thomas Hospital, London, UK
    J Mol Cell Cardiol 61:83-93. 2013
    ..The corrected Fig. 4 is reproduced below. The publisher would like to apologize for any inconvenience caused. [corrected]...
  12. ncbi request reprint FCCP is cardioprotective at concentrations that cause mitochondrial oxidation without detectable depolarisation
    Jonathan P Brennan
    Cardiac Physiology Cardiovascular Division, King s College London, SE1 7EH, UK
    Cardiovasc Res 72:322-30. 2006
    ..Here we define the mitochondrial responses to increasing concentrations of FCCP and also to explore the equivalence of the cardioprotective doses of diazoxide...
  13. ncbi request reprint Differential distribution and regulation of mouse cardiac Na+/K+-ATPase alpha1 and alpha2 subunits in T-tubule and surface sarcolemmal membranes
    Roger G Berry
    Cardiac Physiology, King s College London, The Rayne Institute, St Thomas Hospital, London SE1 7EH, UK
    Cardiovasc Res 73:92-100. 2007
    ..The subcellular distribution of these isoforms in T-tubule and surface sarcolemmal (SSL) membranes and their regulation by cAMP-dependent protein kinase (PKA) is unclear...
  14. ncbi request reprint Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activation
    Jonathan P Brennan
    Cardiac Physiology Cardiovascular Division, The Rayne Institute, St Thomas Hospital, King s College London, SE1 7EH, UK
    Cardiovasc Res 72:313-21. 2006
    ....
  15. ncbi request reprint Serine 68 phosphorylation of phospholemman: acute isoform-specific activation of cardiac Na/K ATPase
    Benjamin d Z Silverman
    Cardiovascular Division, King s College London, The Rayne Institute, St Thomas Hospital, London SE1 7EH, UK
    Cardiovasc Res 65:93-103. 2005
    ..The mechanism by which the cardiac Na/K ATPase (NKA) is regulated by phosphorylation is controversial. We have used the perforated-patch technique to limit cell dialysis and maintain conditions as near physiological as possible...
  16. ncbi request reprint The intracellular region of FXYD1 is sufficient to regulate cardiac Na/K ATPase
    Davor Pavlovic
    Cardiovascular Division, The Rayne Institute, King s College London, St Thomas Hospital, London, SE1 7EH, UK
    FASEB J 21:1539-46. 2007
    ..We conclude that unphosphorylated FXYD1 inhibits Na/K ATPase, whereas S68 phosphorylated FXYD1 stimulates Na/K ATPase to a level above that seen in the absence of FXYD1...
  17. pmc Anti-proliferative actions of T-type calcium channel inhibition in Thy1 nephritis
    Andrea Cove-Smith
    Department of Renal Medicine, King s College London, London, United Kingdom
    Am J Pathol 183:391-401. 2013
    ..These results demonstrate that TH1177 inhibits MC proliferation in vitro and in vivo, supporting the hypothesis that TCC inhibition may be a useful strategy for studying and modifying MC proliferative responses to injury. ..
  18. ncbi request reprint Cell volume control in phospholemman (PLM) knockout mice: do cardiac myocytes demonstrate a regulatory volume decrease and is this influenced by deletion of PLM?
    James R Bell
    Cardiac Physiology, Cardiovascular Division, King s College London, The Rayne Institute, St Thomas Hospital, London SE17EH, UK
    Exp Physiol 94:330-43. 2009
    ..A proposed perturbation of the RVD response as a result of the cell isolation process was not restored, however, with short-term culture in either adult or neonatal cardiomyocytes...
  19. ncbi request reprint Cardiac ischemia causes inhibition of the Na/K ATPase by a labile cytosolic compound whose production is linked to oxidant stress
    William Fuller
    Cardiac Physiology, Centre for Cardiovascular Biology and Medicine, King s College London, The Rayne Institute, St Thomas Hospital, SE1 7EH, London, UK
    Cardiovasc Res 57:1044-51. 2003
    ..The aim of these studies was to investigate the effects of ischemia on Na/K ATPase function in Langendorff-perfused rat hearts...
  20. ncbi request reprint Reversible cysteine-targeted oxidation of proteins during renal oxidative stress
    Philip Eaton
    The Centre for Cardiovascular Biology and Medicine, The Rayne Institute, St Thomas Hospital, King s College London, London, United Kingdom
    J Am Soc Nephrol 14:S290-6. 2003
    ..These represent proteins that may be functionally regulated by S-thiolation and thus could undergo a change in activity or function after renal ischemia and reperfusion...
  21. doi request reprint The rate of loss of T-tubules in cultured adult ventricular myocytes is species dependent
    Davor Pavlovic
    Cardiovascular Division, King s College London, The Rayne Institute, St Thomas Hospital, London SE1 7EH, UK
    Exp Physiol 95:518-27. 2010
    ..These results suggest that detubulation in quiescent culture is slower in the mouse than the rat and that this loss of T-tubules profoundly affects excitation-contraction coupling in rat myocytes...
  22. pmc Increased cardiovascular reactivity to acute stress and salt-loading in adult male offspring of fat fed non-obese rats
    Olena Rudyk
    Division of Women s Health, School of Medicine, King s College London, London, United Kingdom
    PLoS ONE 6:e25250. 2011
    ..Fat feeding in the absence of maternal obesity in pregnant rats leads to altered sympathetic control of cardiovascular function in adult male offspring, and hypertension in response to stressor stimuli...
  23. ncbi request reprint Responses to ischaemia and reperfusion in the mouse isolated perfused heart and the phenomenon of 'contractile cycling'
    Fiona J Sutherland
    Cardiovascular Research, The Rayne Institute, St Thomas Hospital, London, UK
    Clin Exp Pharmacol Physiol 30:879-84. 2003
    ....
  24. ncbi request reprint Is there a transient rise in sub-sarcolemmal Na and activation of Na/K pump current following activation of I(Na) in ventricular myocardium?
    Benjamin d Z Silverman
    Centre for Cardiovascular Biology and Medicine, The Rayne Institute, St Thomas Hospital, King s College London, SE1 7EH, London, UK
    Cardiovasc Res 57:1025-34. 2003
    ..The primary aim of this study was to investigate whether activation of Na influx via voltage-gated Na channels can elevate sub-sarcolemmal ('fuzzy-space') [Na] and transiently activate Na/K pump current (I(p))...
  25. ncbi request reprint Antimycin A induced cardioprotection is dependent on pre-ischemic p38-MAPK activation but independent of MKK3
    Alamgir M N Kabir
    Department of Cardiology, The Cardiovascular Division, King s College London, The Rayne Institute, St Thomas Hospital, London SE1 7EH, UK
    J Mol Cell Cardiol 39:709-17. 2005
    ..The mechanism of this protective form of p38-MAPK activation is independent of the upstream kinase MKK3 and does not involve autophosphorylation...
  26. ncbi request reprint S-thiolation of HSP27 regulates its multimeric aggregate size independently of phosphorylation
    Philip Eaton
    Centre for Cardiovascular Biology and Medicine, The Rayne Institute, St Thomas Hospital, London SE1 7EH, United Kingdom
    J Biol Chem 277:21189-96. 2002
    ..This is consistent with the lack of an S-thiolation site on alphaB crystallin. Thus, we have demonstrated a novel mechanism of HSP27 multimeric size regulation. S-thiolation must occur at Cys-141, the only cysteine in rat HSP27...
  27. ncbi request reprint Purification of proteins susceptible to oxidation at cysteine residues: identification of malate dehydrogenase as a target for S-glutathiolation
    Philip Eaton
    The Centre for Cardiovascular Biology and Medicine, The Rayne Institute, King s College London, London, SE1 7EH, UK
    Ann N Y Acad Sci 973:529-32. 2002
    ..Here we present a study in which we used glutathione-agarose to purify cardiac proteins that undergo S-glutathiolation during oxidative stress. We then identified one of the oxidized proteins as malate dehydrogenase...
  28. ncbi request reprint Ischemic preconditioning: a potential role for protein S-thiolation?
    Philip Eaton
    Department of Cardiology, King s College London, London, UK
    Antioxid Redox Signal 7:882-8. 2005
    ..Additional studies testing the role of a Nox2-containing NAD(P)H oxidase as the source of the oxidant stress essential to the triggering IPC showed that protein S-thiolation was the same in wild-type and Nox2 knockout mice...
  29. ncbi request reprint Mouse isolated perfused heart: characteristics and cautions
    Fiona J Sutherland
    Cardiovascular Research, The Rayne Institute, St Thomas Hospital, London, UK
    Clin Exp Pharmacol Physiol 30:867-78. 2003
    ....
  30. ncbi request reprint Ischemia-induced phosphorylation of phospholemman directly activates rat cardiac Na/K-ATPase
    William Fuller
    Cardiac Physiology, The Centre for Cardiovascular Biology and Medicine, The Rayne Institute, St Thomas Hospital, London SE1 7EH, UK
    FASEB J 18:197-9. 2004
    ..The role of PLM is analogous to phospholamban in regulating the sarcoplasmic reticulum calcium ATPase...
  31. ncbi request reprint Influence of isoprostane F2alpha-III on reflow after myocardial infarction
    Kim Greaves
    Department of Cardiology, The Cardiovascular Division, King s College London, St Thomas Hospital, London, UK
    Eur Heart J 25:847-53. 2004
    ..To investigate whether the vasoconstrictor isoprostane F2alpha-III (iPF2alpha-III), released during myocardial reperfusion, contributes to the low/no reflow phenomenon observed following acute myocardial infarction (AMI)...
  32. doi request reprint Experimental hyperleptinemia in neonatal rats leads to selective leptin responsiveness, hypertension, and altered myocardial function
    Anne Maj Samuelsson
    Division of Women s Health, Women s Health Academic Centre, London SE1 7EH, United Kingdom
    Hypertension 62:627-33. 2013
    ..In isolated hearts, contractile function was impaired at 5 months in male leptin-treated rats. Exogenously imposed hyperleptinemia in neonatal rats permanently influences blood pressure and cardiac structure and function...
  33. doi request reprint Inhibition of human mesangial cell proliferation by targeting T-type calcium channels
    Christopher J Mulgrew
    Department of Renal Medicine, King s College London, London, UK
    Nephron Exp Nephrol 113:e77-88. 2009
    ..T-type calcium channels (T-CaCN) play an important role in the proliferation of a number of cell types, including vascular smooth muscle cells. The hypothesis that T-CaCN may play a role in the proliferation of human MC was investigated...
  34. pmc Maternal dietary supplementation with saturated, but not monounsaturated or polyunsaturated fatty acids, leads to tissue-specific inhibition of offspring Na+,K+-ATPase
    James A Armitage
    Division of Reproduction and Endocrinology, King s College London, London, UK
    J Physiol 586:5013-22. 2008
    ..In utero and neonatal exposure to a maternal diet rich in saturated fatty acids is associated with altered activity and expression of Na(+),K(+)-ATPase in adulthood, but mechanisms appear tissue specific...