P C Sham

Summary

Affiliation: King's College London
Country: UK

Publications

  1. doi request reprint The functional MMP-9 microsatellite marker is not associated with episodic memory in humans
    Evangelos Vassos
    Psychiatr Genet 18:252. 2008
  2. pmc Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait
    Jo Knight
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London, United Kingdom
    BMC Genet 4:S74. 2003
  3. ncbi request reprint The effect of marker characteristics on the power to detect linkage disequilibrium due to single or multiple ancestral mutations
    P C Sham
    Department of Psychiatry, Institute of Psychiatry, London, UK
    Ann Hum Genet 64:161-9. 2000
  4. pmc Equivalence between Haseman-Elston and variance-components linkage analyses for sib pairs
    P C Sham
    Social, Genetic and Developmental Research Centre, Institute of Psychiatry, London, SE5 8AF, England
    Am J Hum Genet 68:1527-32. 2001
  5. ncbi request reprint GENESiS: creating a composite index of the vulnerability to anxiety and depression in a community-based sample of siblings
    P C Sham
    Social, Genetic and Developmental Psychiatry Research Centre, London, UK
    Twin Res 3:316-22. 2000
  6. ncbi request reprint Shifting paradigms in gene-mapping methodology for complex traits
    P Sham
    Division of Psychological Medicine and Social, Genetic, Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London, UK
    Pharmacogenomics 2:195-202. 2001
  7. ncbi request reprint DNA Pooling: a tool for large-scale association studies
    Pak Sham
    P080, Institute of Psychiatry, King s College, Denmark Hill, London SE5 8AF, UK
    Nat Rev Genet 3:862-71. 2002
  8. pmc Powerful regression-based quantitative-trait linkage analysis of general pedigrees
    Pak C Sham
    SGDP Research Centre, Institute of Psychiatry, King s College, Denmark Hill, London SE5 8AF, United Kingdom
    Am J Hum Genet 71:238-53. 2002
  9. pmc Power comparison of parametric and nonparametric linkage tests in small pedigrees
    P C Sham
    Departments of Psychiatry and Biostatistics and Computing, Institute of Psychiatry, London SE5 8AF, United Kingdom
    Am J Hum Genet 66:1661-8. 2000
  10. ncbi request reprint Variance-Components QTL linkage analysis of selected and non-normal samples: conditioning on trait values
    P C Sham
    Social, Genetic and Developmental Psychiatry Research Center and Department of Psychiatry, Institute of Psychiatry, Denmark Hill, London, United Kingdom
    Genet Epidemiol 19:S22-8. 2000

Collaborators

Detail Information

Publications94

  1. doi request reprint The functional MMP-9 microsatellite marker is not associated with episodic memory in humans
    Evangelos Vassos
    Psychiatr Genet 18:252. 2008
  2. pmc Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait
    Jo Knight
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London, United Kingdom
    BMC Genet 4:S74. 2003
    ....
  3. ncbi request reprint The effect of marker characteristics on the power to detect linkage disequilibrium due to single or multiple ancestral mutations
    P C Sham
    Department of Psychiatry, Institute of Psychiatry, London, UK
    Ann Hum Genet 64:161-9. 2000
    ..They also show that multiple ancestral disease mutations do not necessarily preclude linkage disequilibrium mapping, if highly polymorphic markers or multi-locus haplotypes are used...
  4. pmc Equivalence between Haseman-Elston and variance-components linkage analyses for sib pairs
    P C Sham
    Social, Genetic and Developmental Research Centre, Institute of Psychiatry, London, SE5 8AF, England
    Am J Hum Genet 68:1527-32. 2001
    ..We show how this method can be used for both the selection of maximally informative sib pairs for genotyping and the subsequent analysis of such selected samples...
  5. ncbi request reprint GENESiS: creating a composite index of the vulnerability to anxiety and depression in a community-based sample of siblings
    P C Sham
    Social, Genetic and Developmental Psychiatry Research Centre, London, UK
    Twin Res 3:316-22. 2000
    ..This index, which has a sib correlation of 0.22, will be used as a quantitative phenotype in the molecular genetic phase of GENESiS...
  6. ncbi request reprint Shifting paradigms in gene-mapping methodology for complex traits
    P Sham
    Division of Psychological Medicine and Social, Genetic, Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London, UK
    Pharmacogenomics 2:195-202. 2001
    ....
  7. ncbi request reprint DNA Pooling: a tool for large-scale association studies
    Pak Sham
    P080, Institute of Psychiatry, King s College, Denmark Hill, London SE5 8AF, UK
    Nat Rev Genet 3:862-71. 2002
    ..Sophisticated pooling designs are being developed that can take account of hidden population stratification, confounders and inter-loci interactions, and that allow the analysis of haplotypes...
  8. pmc Powerful regression-based quantitative-trait linkage analysis of general pedigrees
    Pak C Sham
    SGDP Research Centre, Institute of Psychiatry, King s College, Denmark Hill, London SE5 8AF, United Kingdom
    Am J Hum Genet 71:238-53. 2002
    ..In large sibships, the new method is slightly more powerful than variance-components models. The proposed method provides a practical and powerful tool for the linkage analysis of quantitative traits...
  9. pmc Power comparison of parametric and nonparametric linkage tests in small pedigrees
    P C Sham
    Departments of Psychiatry and Biostatistics and Computing, Institute of Psychiatry, London SE5 8AF, United Kingdom
    Am J Hum Genet 66:1661-8. 2000
    ..The results also suggest that both parametric and nonparametric methods are suitable for linkage analysis of complex disorders in small pedigrees. However, whether these results apply to large pedigrees remains to be answered...
  10. ncbi request reprint Variance-Components QTL linkage analysis of selected and non-normal samples: conditioning on trait values
    P C Sham
    Social, Genetic and Developmental Psychiatry Research Center and Department of Psychiatry, Institute of Psychiatry, Denmark Hill, London, United Kingdom
    Genet Epidemiol 19:S22-8. 2000
    ....
  11. ncbi request reprint Haplotype association analysis of discrete and continuous traits using mixture of regression models
    P C Sham
    Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, P O 080, King s College London, De Crespigny Park, London SE5 8AF, United Kingdom
    Behav Genet 34:207-14. 2004
    ..We have implemented this method using the SNPHAP and Mx programs and illustrated its use on published data on idiopathic generalized epilepsy...
  12. pmc Power of linkage versus association analysis of quantitative traits, by use of variance-components models, for sibship data
    P C Sham
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London SE5 8AF, United Kingdom
    Am J Hum Genet 66:1616-30. 2000
    ..We also describe both how the power of linkage is attenuated by incomplete linkage and incomplete marker information and how the power of association is attenuated by incomplete linkage disequilibrium...
  13. ncbi request reprint Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits
    S Purcell
    Social, Genetics and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, De Crespigny Park, UK
    Bioinformatics 19:149-50. 2003
    ..A website for performing power calculations for the design of linkage and association genetic mapping studies of complex traits...
  14. ncbi request reprint Optimal weighting scheme for affected sib-pair analysis of sibship data
    P C Sham
    Department of Psychological Medicine, Institute of Psychiatry, London, England
    Ann Hum Genet 61:61-9. 1997
    ..A corollary is that, in affected sib-pair analysis, the 'informativeness' of a sibship is more nearly proportional to the number of affected sib-pairs than to the number of affected siblings, up to about five affected siblings...
  15. ncbi request reprint Use of an artificial neural network to detect association between a disease and multiple marker genotypes
    D Curtis
    Joint Academic Department of Psychological Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, London, UK
    Ann Hum Genet 65:95-107. 2001
    ..The application of neural networks to such problems shows considerable promise and further work could usefully be directed towards optimising the design and implementation of such networks...
  16. ncbi request reprint Association analysis between dopamine receptor genes and bipolar affective disorder
    T Li
    Department of Psychological Medicine, The Institute of Psychiatry, London, UK
    Psychiatry Res 86:193-201. 1999
    ..We also report a novel, rare one-repeat variant of the DRD4 exon 3 VNTR repeat in Chinese populations, which appears to be absent in Caucasians and is not associated with disease...
  17. ncbi request reprint Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A receptor gene and response to clozapine
    M J Arranz
    Department of Psychological Medicine, Institute of Psychiatry, Denmark Hill, London, UK
    Mol Psychiatry 3:61-6. 1998
    ..These results provide further evidence suggesting that genetic variation at 5-HT2A receptors may influence clozapine response and strengthen the candidacy of these receptors as important therapeutic targets...
  18. ncbi request reprint Optimal sibship selection for genotyping in quantitative trait locus linkage analysis
    S Purcell
    Social, Genetic and Developmental Research Centre, 111 Denmark Hill, Denmark Hill, London SE5 8AF, UK
    Hum Hered 52:1-13. 2001
    ..In comparison to previous methods of selecting phenotypically extreme sibships for genotyping, the proposed method is considerably more efficient and is robust with regard to the specification of the genetic model...
  19. ncbi request reprint Transmission disequilibrium analysis of HLA class II DRB1, DQA1, DQB1 and DPB1 polymorphisms in schizophrenia using family trios from a Han Chinese population
    T Li
    Department of Psychological Medicine, Institute of Psychiatry, SE5 8AF, London, UK
    Schizophr Res 49:73-8. 2001
    ..However, our results are compatible with the view that this region of HLA might contain a susceptibility gene which is in linkage disequilibrium with DRB1 and DQA1 genes...
  20. ncbi request reprint Model-free analysis and permutation tests for allelic associations
    J H Zhao
    Department of Psychological Medicine, Institute of Psychiatry, St Bartholomew s and Royal London School of Medicine and Dentistry, London, UK
    Hum Hered 50:133-9. 2000
    ..A memory-efficient algorithm is developed which enables several highly polymorphic markers to be analysed...
  21. ncbi request reprint Association analysis of monoamine genes with measures of depression and anxiety in a selected community sample of siblings
    M W Nash
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 135:33-7. 2005
    ..To our knowledge, this is the first study to report an association of the 3' end of TPH1 with continuous measures of depression and anxiety...
  22. ncbi request reprint Life events and depression in a community sample of siblings
    F V Rijsdijk
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London
    Psychol Med 31:401-10. 2001
    ..Appropriate modelling of life events in linkage and association analyses should help to identify QTLs for depression and anxiety...
  23. ncbi request reprint Analytic power calculation for QTL linkage analysis of small pedigrees
    F V Rijsdijk
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London SE5 8AF, UK
    Eur J Hum Genet 9:335-40. 2001
    ..We show that this approximation is sufficiently accurate for practical purposes in small to moderately large pedigrees, and that large sibships are more efficient than other family structures under a range of genetic models...
  24. ncbi request reprint Combining functional and linkage disequilibrium information in the selection of tag SNPs
    P C Sham
    Department of Psychiatry, Institute of Psychiatry, King s College London, UK
    Bioinformatics 23:129-31. 2007
    ..This flexible feature is useful for researchers who wish to prioritize genomic regions or SNPs in an association study. AVAILABILITY: The online WCLUSTAG program is available at http://bioinfo.hku.hk/wclustag/..
  25. ncbi request reprint A quantitative genetic analysis of schizotypal personality traits
    Y M Linney
    Department of Psychological Medicine, Institute of Psychiatry, London
    Psychol Med 33:803-16. 2003
    ..Previous twin studies investigating the heritability of schizotypy have often had limited power and have failed to measure the disorganization/social anxiety component...
  26. ncbi request reprint Scholastic achievement at age 16 and risk of schizophrenia and other psychoses: a national cohort study
    J H MacCabe
    Department of Psychiatry, Institute of Psychiatry, King s College London, London, UK
    Psychol Med 38:1133-40. 2008
    ..We investigated whether school performance at age 16 is associated with risk of adult schizophrenia and other psychoses in a large national cohort, while controlling for multiple confounders...
  27. ncbi request reprint Brain MRI abnormalities in schizophrenia: same genes or same environment?
    F V Rijsdijk
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UK
    Psychol Med 35:1399-409. 2005
    ..Bivariate genetic model fitting (adjusted to account for selection) was used to quantify the genetic relationship between schizophrenia and brain volumes and to estimate the heritability of these volumes...
  28. ncbi request reprint Association analysis of polymorphisms in the DRD4 gene and heroin abuse in Chinese subjects
    T Li
    Section of Molecular Genetics, Department of Psychological Medicine, and Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom
    Am J Med Genet 96:616-21. 2000
    ..The association we observed between inhalers and the DRD4 polymorphism is difficult to interpret, although it is possible that the association is explained by different levels of novelty seeking between the two subgroups...
  29. ncbi request reprint Recessive amyotrophic lateral sclerosis families with the D90A SOD1 mutation share a common founder: evidence for a linked protective factor
    A Al-Chalabi
    Departments of Neuroscience and Clinical Neurosciences, Institute of Psychiatry and King s College School of Medicine and Dentistry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Hum Mol Genet 7:2045-50. 1998
    ..We propose a tightly linked protective factor which modifies the toxic effect of mutant SOD1 in recessive families...
  30. ncbi request reprint Extension of conditional model-free likelihood-based linkage analysis to additive and other models
    D Curtis
    Joint Academic Department of Psychological Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, Royal London Hospital, Whitechapel, London, UK
    Ann Hum Genet 66:157-67. 2002
    ..Nevertheless, the new method allows researchers greater flexibility in analysing linkage data for diseases in which one or more risk polymorphisms have already been identified...
  31. ncbi request reprint Statistical methods in psychiatric genetics
    P C Sham
    Department of Psychological Medicine, Institute of Psychiatry, London, UK
    Stat Methods Med Res 7:279-300. 1998
    ....
  32. ncbi request reprint A novel method of two-locus linkage analysis applied to a genome scan for late onset Alzheimer's disease
    D Curtis
    Joint Academic Department of Psychological Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, London, UK
    Ann Hum Genet 65:473-81. 2001
    ..The results provide support for the existence of additional susceptibility loci linked to D10S1211 and to D12S358...
  33. ncbi request reprint The common genetic liability between schizophrenia and bipolar disorder: a review
    E Bramon
    Division of Psychological Medicine and Social Genetic Developmental Psychiatry Research Centre, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom
    Curr Psychiatry Rep 3:332-7. 2001
    ..Thus, recent evidence increasingly supports a dimensional approach in the understanding of the functional psychoses, and this is expected to have implications for etiologic research and future clinical treatment...
  34. ncbi request reprint A model-fitting implementation of the DeFries-Fulker model for selected twin data
    S Purcell
    Social, Genetic and Developmental Research Centre, Institute of Psychiatry, London SE5 8AF, UK
    Behav Genet 33:271-8. 2003
    ..This more flexible implementation of the DF model allows DZ-O twins to be incorporated in a sex-limitation model. Brief simulation results are presented along with the Mx scripts used...
  35. ncbi request reprint Prenatal exposure to influenza epidemics and risk of mental retardation
    N Takei
    Department of Psychological Medicine, Institute of Psychiatry, London, UK
    Eur Arch Psychiatry Clin Neurosci 245:255-9. 1995
    ..Maternal exposure to influenza at approximately the third to fourth month of gestation may be risk factor for developing mental handicap...
  36. ncbi request reprint Computation of individual latent variable scores from data with multiple missingness patterns
    D D Campbell
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, Box P080, London, SE5 8AF, UK
    Behav Genet 37:408-22. 2007
    ..The program, documentation and a tutorial, containing worked examples and specimen input and output files, is available at http://statgen.iop.kcl.ac.uk/lsc ...
  37. ncbi request reprint Do schizophrenic patients who managed to get to university have a non-developmental form of illness?
    J H MacCabe
    Division of Psychological Medicine, Institute of Psychiatry, London
    Psychol Med 32:535-44. 2002
    ..We hypothesized that the aetiology and form of schizophrenia may differ in such patients. We therefore studied a group of schizophrenic patients who were functioning well enough to enter university prior to illness onset...
  38. ncbi request reprint Is the P300 wave an endophenotype for schizophrenia? A meta-analysis and a family study
    Elvira Bramon
    Institute of Psychiatry, P O Box 63, De Crespigny Park, London SE5 8AF, UK
    Neuroimage 27:960-8. 2005
    ..We assessed the usefulness of the P300 wave as endophenotype for schizophrenia by means of a meta-analysis of the literature as well as our own family study...
  39. ncbi request reprint A new method of linkage analysis using LOD scores for quantitative traits supports linkage of monoamine oxidase activity to D17S250 in the Collaborative Study on the Genetics of Alcoholism pedigrees
    David Curtis
    Academic Department of Psychiatry, Queen Mary s School of Medicine and Dentistry, London E1 1BB, UK
    Psychiatr Genet 15:181-7. 2005
    ..Here, we describe a new method for LOD score analysis of quantitative traits which does not require specification of a mode of inheritance...
  40. ncbi request reprint Reaction time of the Continuous Performance Test is an endophenotypic marker for schizophrenia: a study of first-episode neuroleptic-naive schizophrenia, their non-psychotic first-degree relatives and healthy population controls
    Qiang Wang
    Psychiatric Laboratory and Department of Psychiatry, West China Hospital, Sichuan University, Sichuan Chengdu, PR China
    Schizophr Res 89:293-8. 2007
    ..Our findings supported the use of the hit reaction time measure of the CPT as an endophenotype marker for schizophrenia...
  41. ncbi request reprint The TRP2 allele of COL9A2 is an age-dependent risk factor for the development and severity of intervertebral disc degeneration
    Jeffrey J T Jim
    Department of Biochemistry, University of Hong Kong, Pokfulam, Hong Kong, China
    Spine (Phila Pa 1976) 30:2735-42. 2005
    ..Although they are common, the etiology of these conditions is poorly understood. A large population case-control study in the Southern Chinese was performed to study genetic risk factors to DDD...
  42. ncbi request reprint Regional brain morphometry in patients with schizophrenia or bipolar disorder and their unaffected relatives
    Colm McDonald
    Division of Psychological Medicine, Institute of Psychiatry, London, UK
    Am J Psychiatry 163:478-87. 2006
    ..The authors used region-of-interest morphometry to volumetrically assess brain structures frequently implicated in psychotic illness in families affected with schizophrenia or psychotic bipolar disorder...
  43. ncbi request reprint Episodic memory performance predicted by the 2bp deletion in exon 6 of the "alpha 7-like" nicotinic receptor subunit gene
    Emma L Dempster
    Division of Cellular and Molecular Biology, Toronto Western Research Institute, Toronto Western Hospital, McLaughlin Pavillion, 6th Floor Room 415, 399 Bathurst St, Toronto, Ont M5T 2S8, Canada
    Am J Psychiatry 163:1832-4. 2006
    ..CHRNA7 is involved in memory formation, a core dysfunction in schizophrenia. The authors set out to determine if this locus is associated with memory dysfunction in schizophrenia...
  44. ncbi request reprint Distribution of symptom dimensions across Kraepelinian divisions
    Dimitris G Dikeos
    Institute of Psychiatry, SGDP Building, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Br J Psychiatry 189:346-53. 2006
    ..Dimensional structures are established for many psychiatric diagnoses, but dimensions have not been compared between diagnostic groups...
  45. ncbi request reprint T-1213C polymorphism of estrogen receptor beta is associated with low bone mineral density and osteoporotic fractures
    Annie W C Kung
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Bone 39:1097-106. 2006
    ..26-4.25) even after adjusting for BMD. In conclusion, ESR2 is involved in BMD determination in both sexes. The T-1213C polymorphism influences the risk of fracture in postmenopausal women independent of BMD...
  46. ncbi request reprint Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD)
    Dawei Li
    Bio X Life Science Research Center, Shanghai Jiao Tong University, Hao Ran Building, 1954 Hua Shan Road, Shanghai 200030, China
    Hum Mol Genet 15:2276-84. 2006
    ..In conclusion, there is a statistically significant association between ADHD and dopamine system genes, especially DRD4 and DRD5. These findings strongly implicate the involvement of brain dopamine systems in the pathogenesis of ADHD...
  47. ncbi request reprint Assessment of linkage and association of 13 genetic loci with bone mineral density
    Helen H L Lau
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China
    J Bone Miner Metab 24:226-34. 2006
    ..The effect of each polymorphism on BMD variance ranged from 1% to 4%. In conclusion, ERalpha, ERbeta and LRP5 are important candidate genes determining BMD variation, especially in females...
  48. pmc Estimated haplotype counts from case-control samples cannot be treated as observed counts
    David Curtis
    Am J Hum Genet 78:729-30; author reply 728-9. 2006
  49. ncbi request reprint WHAP: haplotype-based association analysis
    Shaun Purcell
    Center for Human Genetic Research, MGH, Boston, MA, USA
    Bioinformatics 23:255-6. 2007
    ..We illustrate using these tests to dissect a multi-locus association...
  50. doi request reprint CLUMPHAP: a simple tool for performing haplotype-based association analysis
    Jo Knight
    Social Genetic and Developmental Psychiatry MRC Centre, Institute of Psychiatry, Kings College London, De Crespigny Park, London, UK
    Genet Epidemiol 32:539-45. 2008
    ..Our results show that CLUMPHAP tends to have greater power than the omnibus haplotype test and is comparable in power to multiple regression locus-coding approaches...
  51. doi request reprint A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3
    Ian P M Tomlinson
    Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, London WC2A 3PX, UK
    Nat Genet 40:623-30. 2008
    ..3 (P = 3.3 x 10(-18) overall; P = 9.6 x 10(-17) replication), which tags a plausible causative gene, EIF3H. These data provide further evidence for the 'common-disease common-variant' model of CRC predisposition...
  52. doi request reprint Power of transmission/disequilibrium tests in admixed populations
    Miao Xin Li
    Department of Biochemistry, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Genet Epidemiol 32:434-44. 2008
    ..This study clarifies the potential influence of population admixture on the performance of TDTs...
  53. doi request reprint Depression in college: depressive symptoms and personality factors in Beijing and Hong Kong college freshmen
    Yuqing Song
    Institute of Mental Health, Peking University, China
    Compr Psychiatry 49:496-502. 2008
    ..The present study investigated the 2-week prevalence of depressive symptoms in college freshmen from Beijing and Hong Kong. The relationship between depression and 3 personality factors in these college freshmen was analyzed...
  54. pmc Genome-wide detection and characterization of positive selection in human populations
    Pardis C Sabeti
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02139, USA
    Nature 449:913-8. 2007
    ....
  55. pmc A second generation human haplotype map of over 3.1 million SNPs
    Kelly A Frazer
    The Scripps Research Institute, 10550 North Torrey Pines Road MEM275, La Jolla, California 92037, USA
    Nature 449:851-61. 2007
    ..Finally, we demonstrate increased differentiation at non-synonymous, compared to synonymous, SNPs, resulting from systematic differences in the strength or efficacy of natural selection between populations...
  56. ncbi request reprint The Roles of PAX6 and SOX2 in Myopia: lessons from the 1958 British Birth Cohort
    Claire L Simpson
    MRC Centre of Epidemiology for Child Health, Institute of Child Health, University College London, London, United Kingdom
    Invest Ophthalmol Vis Sci 48:4421-5. 2007
    ..The authors investigated the roles of PAX6 and SOX2 in common myopia as part of a broader association study of refractive error...
  57. ncbi request reprint Population differences in the International Multi-Centre ADHD Gene Project
    Benjamin M Neale
    MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Genet Epidemiol 32:98-107. 2008
    ..Any case-control sample employing an Israeli sample with Northern Europeans must consider stratification. A Northern European tag set, however, appears to be appropriate for capturing the variation across populations...
  58. ncbi request reprint An association study of RGS4 polymorphisms with clinical phenotypes of schizophrenia in a Chinese population
    Hon Cheong So
    Department of Psychiatry, University of Hong Kong, Hong Kong, China
    Am J Med Genet B Neuropsychiatr Genet 147:77-85. 2008
    ..The association with information subtest score suggests an effect of RGS4 on premorbid functioning, which may be related to neurodevelopmental processes. Further independent studies are required to verify our findings...
  59. pmc PLINK: a tool set for whole-genome association and population-based linkage analyses
    Shaun Purcell
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Hum Genet 81:559-75. 2007
    ..Analysis of the patterns of segmental sharing has the potential to map disease loci that contain multiple rare variants in a population-based linkage analysis...
  60. ncbi request reprint Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone mass
    John P A Ioannidis
    Department of Hygiene and Epidemology, University of Ioannina School of Medicine, Ioannina, Greece
    J Bone Miner Res 22:173-83. 2007
    ..Evidence was gained to suggest that several chromosomal loci regulate BMD in a site-specific and sex-specific manner...
  61. ncbi request reprint Resistin gene polymorphisms and progression of glycaemia in southern Chinese: a 5-year prospective study
    Jian Yu Xu
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Clin Endocrinol (Oxf) 66:211-7. 2007
    ..We evaluated, in a 5-year prospective study, whether RETN polymorphisms could predict the progression of glycaemia in southern Chinese...
  62. ncbi request reprint Morbid risk for psychiatric disorder among the relatives of methamphetamine users with and without psychosis
    Chih Ken Chen
    Department of Psychiatry, Chang Gung Memorial Hospital, Keelung, Taiwan
    Am J Med Genet B Neuropsychiatr Genet 136:87-91. 2005
    ..8, 95% CI: 1.0-8.0, P = 0.042). The greater his or her familial loading for schizophrenia, the more likely a MAMP user is to develop psychosis, and the longer that psychosis is likely to last...
  63. pmc The future of association studies: gene-based analysis and replication
    Benjamin M Neale
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Am J Hum Genet 75:353-62. 2004
    ....
  64. ncbi request reprint Epistasis in quantitative trait locus linkage analysis: interaction or main effect?
    Shaun Purcell
    Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, P O 080, King s College London, Denmark Hill, London SE5 8AF, United Kingdom
    Behav Genet 34:143-52. 2004
    ..Second, because the nonepistatic variance component estimates in submodels can partially absorb epistatic variance when it is not explicitly modeled, power to formally detect epistasis is low...
  65. ncbi request reprint Mismatch negativity in schizophrenia: a family study
    Elvira Bramon
    Institute of Psychiatry, PO Box 63, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Schizophr Res 67:1-10. 2004
    ..We investigated whether MMN is a potential marker of genetic vulnerability to schizophrenia by comparing MMN in a group of patients with schizophrenia, their unaffected relatives, and controls...
  66. ncbi request reprint Is haplotype tagging the panacea to association mapping studies?
    Ansar Jawaid
    MRC Social Genetic Developmental Psychiatry Research Centre SGDP, Institute of Psychiatry, Kings College London, UK
    Eur J Hum Genet 12:259-62. 2004
  67. ncbi request reprint Linkage disequilibrium analysis of polymorphisms in the gene for myelin oligodendrocyte glycoprotein in Tourette's syndrome patients from a Chinese sample
    Yi Huang
    Department of Psychological Medicine and Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 124:76-80. 2004
    ..000, P = 0.046) which did not survive correction for multiple testing. Our results suggest that there is no association between the MOG gene polymorphisms we tested and GTS...
  68. ncbi request reprint Schizotypal personality traits in nonpsychotic relatives are associated with positive symptoms in psychotic probands
    Ignacio Mata
    Fundacion Argibide, Pamplona Navarra, Spain
    Schizophr Bull 29:273-83. 2003
    ....
  69. ncbi request reprint Regression-based sib pair linkage analysis for binary traits
    Maurice P A Zeegers
    Department of Epidemiology, Faculty of Health Science, Maastricht University, Maastricht, The Netherlands
    Hum Hered 55:125-31. 2003
    ....
  70. pmc Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia
    Ilya Chumakov
    Genset S A, F 91030 Evry, France
    Proc Natl Acad Sci U S A 99:13675-80. 2002
    ....
  71. ncbi request reprint Estimation of sib-pair IBD sharing and multipoint polymorphism information content by linear regression
    Fruhling V Rijsdijk
    Social, Genetic and Developmental Psychiatry Research Centre, IoP, London, UK
    Behav Genet 32:211-20. 2002
    ..We illustrate MPIC by assessing the relative information content of single nucleotide polymorphism (SNP) and microsatellite markers...
  72. ncbi request reprint Analytic approaches to twin data using structural equation models
    Fruhling V Rijsdijk
    SGDP Centre, Institute of Psychiatry, Kings College London, UK
    Brief Bioinform 3:119-33. 2002
    ..The flexibility of Mx allows the modelling of multivariate data to examine the genetic and environmental relations between two or more phenotypes and the modelling to categorical traits under liability-threshold models...
  73. ncbi request reprint Planning genetic studies in human stroke: sample size estimates based on family history data
    Ahamad Hassan
    Department of Clinical Neurosciences, St George s Hospital Medical School, London, United Kingdom
    Neurology 58:1483-8. 2002
    ..Alternative approaches include linkage analysis using affected sibling pairs, transmission disequilibrium testing (TDT), and sibling TDT (S-TDT). Despite theoretical benefits, the feasibility of these methods in stroke remains unknown...
  74. ncbi request reprint A twin study of genetic relationships between psychotic symptoms
    Alastair G Cardno
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
    Am J Psychiatry 159:539-45. 2002
    ..Biometrical model fitting was applied to clinical data from twins to investigate whether operationally defined schizophrenic, schizoaffective, and manic syndromes share genetic risk factors...
  75. ncbi request reprint Allelic association analysis of the dopamine D2, D3, 5-HT2A, and GABA(A)gamma2 receptors and serotonin transporter genes with heroin abuse in Chinese subjects
    Tao Li
    Division of Psychological Medicine, The Institute of Psychiatry, London, United Kingdom
    Am J Med Genet 114:329-35. 2002
    ....
  76. ncbi request reprint Evidence for association between novel polymorphisms in the PRODH gene and schizophrenia in a Chinese population
    Tao Li
    Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 129:13-5. 2004
    ..Overall this finding supports a role for the PRODH locus in schizophrenia...
  77. ncbi request reprint Association analysis of the DRD4 and COMT genes in methamphetamine abuse
    Tao Li
    Division of Psychological Medicine, Institute of Psychiatry, King s College, De Crespigny Park, Denmark Hill, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 129:120-4. 2004
    ..01, OR = 1.10, 95% CI: 1.10-1.18) were significant but the latter was weak. We conclude that genetic variation in the dopamine system may encode an additive effect on risk of becoming a methamphetamine abuser...
  78. ncbi request reprint Dermatoglyphics and Schizophrenia: a meta-analysis and investigation of the impact of obstetric complications upon a-b ridge count
    Elvira Bramon
    Division of Psychological Medicine, Institute of Psychiatry, P O Box 63, De Crespigny Park, London SE5 8AF, UK
    Schizophr Res 75:399-404. 2005
    ..However, the severity or the origin of these ABRC changes has not been established...
  79. ncbi request reprint Application of logistic regression to case-control association studies involving two causative loci
    Bernard V North
    Academic Department of Psychiatry, Queen Mary s School of Medicine and Dentistry, London E1 1BB, UK
    Hum Hered 59:79-87. 2005
    ..Hence we conclude that in general both conditional and unconditional analyses should be performed when searching for additional loci...
  80. ncbi request reprint SNPs, microarrays and pooled DNA: identification of four loci associated with mild mental impairment in a sample of 6000 children
    Lee M Butcher
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    Hum Mol Genet 14:1315-25. 2005
    ..Although each SNP accounts for a small amount of variance, their effects are additive and they can be combined in a 'SNP set' that can be used as a genetic risk index for MMI in behavioral genomic analyses...
  81. ncbi request reprint Association between BDNF val66 met genotype and episodic memory
    Emma Dempster
    Section of Molecular Genetics, Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 134:73-5. 2005
    ..When cases and unaffected relatives were analyzed separately, met66 was associated with a lower score on the WMS delayed measure in the relatives only (R2 = 0.077 P = 0.01), which is consistent with previous findings...
  82. pmc A central resource for accurate allele frequency estimation from pooled DNA genotyped on DNA microarrays
    Claire L Simpson
    Department of Neurology, PO43, Institute of Psychiatry London SE5 8AF, UK
    Nucleic Acids Res 33:e25. 2005
    ....
  83. ncbi request reprint The relationship of fatigue to mental and physical health in a community sample
    Richard J Williamson
    Social, Genetic, Developmental Psychiatry Research, Institute of Psychiatry, PO80, 16 De Crespigny Park, Denmark Hill London SE5 8AF, UK
    Soc Psychiatry Psychiatr Epidemiol 40:126-32. 2005
    ..The present study seeks to differentiate between fatigue and depression/anxiety and to investigate the familiality/heritability of fatigue using sib-pairs...
  84. ncbi request reprint MaGIC: a program to generate targeted marker sets for genome-wide association studies
    Claire L Simpson
    Institute of Psychiatry, Kings College London, London, UK
    Biotechniques 37:996-9. 2004
    ..The program and source code is freely available at http://cogent.iop.kcl.ac.uk/MaGIC.cogx...
  85. ncbi request reprint CLUSTAG: hierarchical clustering and graph methods for selecting tag SNPs
    S I Ao
    Department of Mathematics, The University of Hong Kong, Pokfulam, Hong Kong
    Bioinformatics 21:1735-6. 2005
    ....
  86. ncbi request reprint Association analysis of dopamine D2-like receptor genes and methamphetamine abuse
    Chih Ken Chen
    Division of Psychological Medicine, Institute of Psychiatry, University of London, UK
    Psychiatr Genet 14:223-6. 2004
    ..This study employs an association approach to examine the genetic underpinning of methamphetamine (MAMP) use and MAMP-induced psychosis...
  87. ncbi request reprint Commingling analysis of intraocular pressure and glaucoma in an older Australian population
    Ananth C Viswanathan
    Moorfields Eye Hospital, London, United Kingdom
    Ann Hum Genet 68:489-97. 2004
    ..To test the hypothesis of a major genetic determinant of intraocular pressure (IOP) under the mixed genetic model in a defined population, and to elucidate the relationship between IOP and glaucoma...
  88. ncbi request reprint Association of genetic risks for schizophrenia and bipolar disorder with specific and generic brain structural endophenotypes
    Colm McDonald
    Division of Psychological Medicine, Institute of Psychiatry, London
    Arch Gen Psychiatry 61:974-84. 2004
    ..For more than a century, it has been uncertain whether or not the major diagnostic categories of psychosis--schizophrenia and bipolar disorder--are distinct disease entities with specific genetic causes and neuroanatomical substrates...
  89. ncbi request reprint Genome-wide linkage analysis of a composite index of neuroticism and mood-related scales in extreme selected sibships
    Matthew W Nash
    MRC Social, Genetic and Developmental Psychiatry Research Centre, Section of Epidemiology, Institute of Psychiatry, King s College, London, UK
    Hum Mol Genet 13:2173-82. 2004
    ..2) around 64 cM (43-70 cM) near marker D1S2892 and another on chromosome 6p (LOD 2.7) around 47 cM (34-63 cM) near marker D6S1610. Further exploratory sex-specific analyses suggested that these QTLs might have sex-limited effects...
  90. ncbi request reprint Heritability of Schneider's first-rank symptoms
    Alastair G Cardno
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, Wales, UK
    Br J Psychiatry 180:35-8. 2002
    ..Schneider's first-rank symptoms are given particular weight when making a diagnosis of schizophrenia, but the nuclear syndrome, characterised by one or more first-rank symptoms, has been found previously to have no heritability...
  91. ncbi request reprint Confirmation of linkage to chromosome 1q for spine bone mineral density in southern Chinese
    Ching Lung Cheung
    Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
    Hum Genet 120:354-9. 2006
    ..Further analyses of candidate genes are warranted to identify QTL genes and variants underlying the variations of BMD in this region...
  92. ncbi request reprint Age at onset in sod1-mediated amyotrophic lateral sclerosis shows familiality
    Isabella Fogh
    Neurogenetics 8:235-6. 2007
  93. ncbi request reprint Neurocognitive deficits in first-episode schizophrenic patients and their first-degree relatives
    Xiaohong Ma
    Psychiatric Laboratory and Department of Psychiatry, West China Hospital, Sichuan University, Chengdu, P R China
    Am J Med Genet B Neuropsychiatr Genet 144:407-16. 2007
    ..These patterns of neurocognitive deficits may represent "endophenotypes" denoting varying degrees of vulnerability to schizophrenia and may be of value in future molecular genetic studies...
  94. ncbi request reprint Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study
    Aimin Xu
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Rd, Hong Kong, China
    Circulation 115:1537-43. 2007
    ..In the present study, we further evaluated the prospective association of A-FABP with the metabolic syndrome (MetS) as defined by the updated National Cholesterol Education Program criteria...