A M Shah

Summary

Affiliation: King's College London
Country: UK

Publications

  1. pmc Design and rationale of the MR-INFORM study: stress perfusion cardiovascular magnetic resonance imaging to guide the management of patients with stable coronary artery disease
    Shazia T Hussain
    King s College London, British Heart Foundation BHF Centre of Research Excellence, National Institute for Health Research NIHR Biomedical Research Centre at Guy s and St, Thomas NHS Trust Foundation, Joint Imaging Division, Kings Health Partners, 4th Floor Lambeth Wing, St, Thomas Hospital, London, SE1 7EH, UK
    J Cardiovasc Magn Reson 14:65. 2012
  2. doi request reprint A 28-kDa splice variant of NADPH oxidase-4 is nuclear-localized and involved in redox signaling in vascular cells
    Narayana Anilkumar
    King s College London British Heart Foundation Center of Excellence, 125 Coldharbour Lane, London SE5 9NU, United Kingdom
    Arterioscler Thromb Vasc Biol 33:e104-12. 2013
  3. pmc Neuronal nitric oxide synthase and human vascular regulation
    Narbeh Melikian
    King s College London British Heart Foundation Centre of Excellence, Cardiovascular Division, London, United Kingdom
    Trends Cardiovasc Med 19:256-62. 2009
  4. pmc Involvement of NADPH oxidase in age-associated cardiac remodeling
    Mingyi Wang
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute of Aging, Baltimore, MD, USA
    J Mol Cell Cardiol 48:765-72. 2010
  5. pmc Redox signaling in cardiac myocytes
    Celio X C Santos
    Cardiovascular Division, King s College London British Heart Foundation Centre, London SE5 9PJ, UK
    Free Radic Biol Med 50:777-93. 2011
  6. pmc NADPH oxidases in cardiovascular disease: insights from in vivo models and clinical studies
    Alexander Sirker
    Cardiovascular Division, King s College London British Heart Foundation Centre, London SE5 9PJ, UK
    Basic Res Cardiol 106:735-47. 2011
  7. pmc Role of endothelial Nox2 NADPH oxidase in angiotensin II-induced hypertension and vasomotor dysfunction
    Colin E Murdoch
    Cardiovascular Division, King s College London British Heart Foundation Centre, London, UK
    Basic Res Cardiol 106:527-38. 2011
  8. pmc Functional Genomics Assistant (FUGA): a toolbox for the analysis of complex biological networks
    Ignat Drozdov
    Cardiovascular Division King s College London KCL BHF Centre of Research Excellence School of Medicine James Black Centre 125 Coldharbour Lane, London SE5 9NU UK
    BMC Res Notes 4:462. 2011
  9. pmc Genome-wide expression patterns in physiological cardiac hypertrophy
    Ignat Drozdov
    King s College London KCL BHF Centre of Research Excellence Cardiovascular Division School of Medicine James Black Centre 125 Coldharbour Lane, London, UK
    BMC Genomics 11:557. 2010
  10. ncbi request reprint Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology
    Jian Mei Li
    Department of Cardiology, GKT School of Medicine, King s College of London, SE5 9PJ, UK
    Am J Physiol Regul Integr Comp Physiol 287:R1014-30. 2004

Detail Information

Publications109 found, 100 shown here

  1. pmc Design and rationale of the MR-INFORM study: stress perfusion cardiovascular magnetic resonance imaging to guide the management of patients with stable coronary artery disease
    Shazia T Hussain
    King s College London, British Heart Foundation BHF Centre of Research Excellence, National Institute for Health Research NIHR Biomedical Research Centre at Guy s and St, Thomas NHS Trust Foundation, Joint Imaging Division, Kings Health Partners, 4th Floor Lambeth Wing, St, Thomas Hospital, London, SE1 7EH, UK
    J Cardiovasc Magn Reson 14:65. 2012
    ..In addition, it is similar to invasively determined FFR and therefore has the potential to become the non-invasive test of choice to determine need for revascularisation...
  2. doi request reprint A 28-kDa splice variant of NADPH oxidase-4 is nuclear-localized and involved in redox signaling in vascular cells
    Narayana Anilkumar
    King s College London British Heart Foundation Center of Excellence, 125 Coldharbour Lane, London SE5 9NU, United Kingdom
    Arterioscler Thromb Vasc Biol 33:e104-12. 2013
    ..In this study, we identified and characterized a novel nuclear-localized 28-kDa splice variant of Nox4 in vascular cells...
  3. pmc Neuronal nitric oxide synthase and human vascular regulation
    Narbeh Melikian
    King s College London British Heart Foundation Centre of Excellence, Cardiovascular Division, London, United Kingdom
    Trends Cardiovasc Med 19:256-62. 2009
    ....
  4. pmc Involvement of NADPH oxidase in age-associated cardiac remodeling
    Mingyi Wang
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute of Aging, Baltimore, MD, USA
    J Mol Cell Cardiol 48:765-72. 2010
    ..Increased RAAS activation may drive age-related cardiac remodeling through the activation of Nox2 NADPH oxidase and subsequent increases in MMP activation, fibrosis and cardiomyocyte hypertrophy...
  5. pmc Redox signaling in cardiac myocytes
    Celio X C Santos
    Cardiovascular Division, King s College London British Heart Foundation Centre, London SE5 9PJ, UK
    Free Radic Biol Med 50:777-93. 2011
    ..A better understanding of this complex regulatory system may allow the development of more specific therapeutic strategies for heart diseases...
  6. pmc NADPH oxidases in cardiovascular disease: insights from in vivo models and clinical studies
    Alexander Sirker
    Cardiovascular Division, King s College London British Heart Foundation Centre, London SE5 9PJ, UK
    Basic Res Cardiol 106:735-47. 2011
    ..In this article, we review our current understanding of the roles of NOX enzymes in several common cardiovascular disease states, with a focus on data from genetic studies and clinical data where available...
  7. pmc Role of endothelial Nox2 NADPH oxidase in angiotensin II-induced hypertension and vasomotor dysfunction
    Colin E Murdoch
    Cardiovascular Division, King s College London British Heart Foundation Centre, London, UK
    Basic Res Cardiol 106:527-38. 2011
    ..These results indicate that an increase in endothelial Nox2 levels contributes to angiotensin II-induced endothelial dysfunction, vascular remodeling and hypertension...
  8. pmc Functional Genomics Assistant (FUGA): a toolbox for the analysis of complex biological networks
    Ignat Drozdov
    Cardiovascular Division King s College London KCL BHF Centre of Research Excellence School of Medicine James Black Centre 125 Coldharbour Lane, London SE5 9NU UK
    BMC Res Notes 4:462. 2011
    ..abstract:..
  9. pmc Genome-wide expression patterns in physiological cardiac hypertrophy
    Ignat Drozdov
    King s College London KCL BHF Centre of Research Excellence Cardiovascular Division School of Medicine James Black Centre 125 Coldharbour Lane, London, UK
    BMC Genomics 11:557. 2010
    ..Genome-wide expression patterns in physiological cardiac hypertrophy. Co-expression patterns in physiological cardiac hypertrophy..
  10. ncbi request reprint Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology
    Jian Mei Li
    Department of Cardiology, GKT School of Medicine, King s College of London, SE5 9PJ, UK
    Am J Physiol Regul Integr Comp Physiol 287:R1014-30. 2004
    ....
  11. pmc In search of new therapeutic targets and strategies for heart failure: recent advances in basic science
    Ajay M Shah
    King s College London British Heart Foundation Centre of Excellence, London, UK
    Lancet 378:704-12. 2011
    ....
  12. pmc Free radicals and redox signalling in cardiovascular disease
    A M Shah
    Department of Cardiology, Guy s King s and St Thomas s School of Medicine, King s College London, UK
    Heart 90:486-7. 2004
  13. ncbi request reprint Paracrine and autocrine effects of nitric oxide on myocardial function
    A M Shah
    Department of Cardiology, GKT School of Medicine, Denmark Hill Campus, King s College London, Bessemer Road, London, UK
    Pharmacol Ther 86:49-86. 2000
    ..The balance between beneficial and deleterious effects of NO is of key importance with respect to its pathophysiological role...
  14. ncbi request reprint Hydrodynamic gene delivery to the pig liver via an isolated segment of the inferior vena cava
    J W Fabre
    Department of Hepatology and Transplantation, King s College London School of Medicine, James Black Centre, London, UK
    Gene Ther 15:452-62. 2008
    ..The IVC segment approach is a clinically acceptable approach to liver gene therapy. However, it is less effective in pigs than in rodents, possibly because of larger liver size or a less compliant connective tissue framework...
  15. ncbi request reprint Divergent biological actions of coronary endothelial nitric oxide during progression of cardiac hypertrophy
    D J Grieve
    Department of Cardiology, Guy's, King's and St Thomas' School of Medicine, King's College London (Denmark Hill Campus, London, United Kingdom
    Hypertension 38:267-73. 2001
    ....
  16. ncbi request reprint NADPH oxidases in cardiovascular health and disease
    Alison C Cave
    King s College London, Department of Cardiology, Cardiovascular Division, London, United Kingdom
    Antioxid Redox Signal 8:691-728. 2006
    ..The complexity of regulation of NADPH oxidases in these conditions may provide the possibility of targeted therapeutic manipulation in a cell-, tissue- and/or pathway-specific manner at appropriate points in the disease process...
  17. ncbi request reprint Role of nitric oxide in posthypoxic contractile dysfunction of diabetic cardiomyopathy
    Magdi M El-Omar
    Department of Cardiology, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, Wales, UK
    Eur J Heart Fail 5:229-39. 2003
    ..In conclusion, diabetic hearts exhibit markedly abnormal post-hypoxic relaxation, which is attributable to both ROS and NO derived from iNOS...
  18. ncbi request reprint Protection against endotoxemia-induced contractile dysfunction in mice with cardiac-specific expression of slow skeletal troponin I
    Joanne Layland
    Cardiovascular Division, King s College London, London, UK
    FASEB J 19:1137-9. 2005
    ....
  19. ncbi request reprint Contrasting roles of NADPH oxidase isoforms in pressure-overload versus angiotensin II-induced cardiac hypertrophy
    Jonathan A Byrne
    Department of Cardiology, King s College London, London, UK
    Circ Res 93:802-5. 2003
    ..These data suggest a differential response of the cardiac Nox isoforms, gp91phox and Nox4, to Ang II versus pressure overload...
  20. doi request reprint Nox4 and nox2 NADPH oxidases mediate distinct cellular redox signaling responses to agonist stimulation
    Narayana Anilkumar
    Department of Cardiology, The James Black Centre, King s College London, 125 Coldharbour Lane, London SE59NU, UK
    Arterioscler Thromb Vasc Biol 28:1347-54. 2008
    ..We compared the involvement of Nox2 versus Nox4 in redox-sensitive protein kinase activation after agonist stimulation...
  21. ncbi request reprint Effects of nitric oxide synthase inhibition on Basal function and the force-frequency relationship in the normal and failing human heart in vivo
    J M Cotton
    Department of Cardiology, GKT School of Medicine, King's College London and King's College Hospital, London, UK
    Circulation 104:2318-23. 2001
    ..Because this study was performed in patients with moderate heart failure, whether the findings apply to subjects with more severe heart failure requires further investigation...
  22. ncbi request reprint Impaired endothelial regulation of ventricular relaxation in cardiac hypertrophy: role of reactive oxygen species and NADPH oxidase
    P A MacCarthy
    Department of Cardiology, Guy's King's and St Thomas' Schools of Medicine and Biomedical Sciences, King's College London, UK
    Circulation 104:2967-74. 2001
    ..These are the first data to potentially link increased NADPH oxidase-derived ROS with a defect in cardiac contractile function in a pathological setting...
  23. ncbi request reprint Pathophysiological implications of insulin resistance on vascular endothelial function
    S B Wheatcroft
    Department of Cardiology, Guy s, King s and St Thomas School of Medicine, King s College, London, UK
    Diabet Med 20:255-68. 2003
    ..Abstracts of all references were screened before selecting those relevant to this review...
  24. ncbi request reprint Paracrine modulation of heart cell function by endothelial cells
    A M Shah
    Department of Cardiology, University of Wales College of Medicine, Health Park, Cardiff, UK
    Cardiovasc Res 31:847-67. 1996
    ..g., the Frank-Starling mechanism, neurohumoral influences, the effects of heart rate, coronary perfusion and load. A better understanding of its physiological and pathophysiological roles may lead to novel therapeutic strategies...
  25. ncbi request reprint Differential NADPH- versus NADH-dependent superoxide production by phagocyte-type endothelial cell NADPH oxidase
    J M Li
    Department of Cardiology, Guy's, King's and St Thomas' School of Medicine, King's College London (Denmark Hill Campus, London, UK
    Cardiovasc Res 52:477-86. 2001
    ..Like the neutrophil enzyme, the endothelial oxidase is preferentially NADPH- rather than NADH-dependent. NADH-dependent O(2)(-) production appears to be an artefact related to the use of lucigenin doses > or =50 micromol/l...
  26. doi request reprint A reactive oxygen species-mediated component in neurogenic vasodilatation
    Anna Starr
    Cardiovascular Division, King s College London, Franklin Wilkins Building, Waterloo Campus, London SE1 9NH, UK
    Cardiovasc Res 78:139-47. 2008
    ..This study was designed to investigate in vivo mechanisms involved in TRPV1-mediated peripheral vasodilatation...
  27. pmc Essential role of troponin I in the positive inotropic response to isoprenaline in mouse hearts contracting auxotonically
    Joanne Layland
    Department of Cardiology, King s College London, SE5 9PJ, UK
    J Physiol 556:835-47. 2004
    ....
  28. ncbi request reprint Pivotal role of a gp91(phox)-containing NADPH oxidase in angiotensin II-induced cardiac hypertrophy in mice
    Jennifer K Bendall
    Department of Cardiology, Guy s, King s and St Thomas School of Medicine, King s College London, London, UK
    Circulation 105:293-6. 2002
    ..Angiotensin II treatment increased myocardial NADPH oxidase activity in wild-type but not gp91(phox-/-) mice...
  29. ncbi request reprint Inhibition of myocardial crossbridge cycling by hypoxic endothelial cells: a potential mechanism for matching oxygen supply and demand?
    A M Shah
    Department of Cardiology, University of Wales College of Medicine, Cardiff, UK
    Circ Res 80:688-98. 1997
    ..Such a mechanism could have important implications for the regulation of oxygen supply-demand balance in the heart and be relevant to conditions such as myocardial hibernation...
  30. ncbi request reprint Redox signalling involving NADPH oxidase-derived reactive oxygen species
    R Dworakowski
    Cardiovascular Division, Department of Cardiology, King s College London School of Medicine, Bessemer Road, London SE5 9PJ, UK
    Biochem Soc Trans 34:960-4. 2006
    ..In the present paper, we review the structure and mechanisms of activation of NADPH oxidases and consider their involvement in redox signalling, focusing mainly on the cardiovascular system...
  31. ncbi request reprint Activation of p38 mitogen-activated protein kinase contributes to the early cardiodepressant action of tumor necrosis factor
    Mohamed Bellahcene
    Cardiovascular Division, King s College London, The Rayne Institute, St Thomas Hospital, London, United Kingdom
    J Am Coll Cardiol 48:545-55. 2006
    ..The purpose of this study was to determine whether p38 mitogen-activated protein kinase (p38-MAPK) contributes to tumor necrosis factor-alpha (TNFalpha)-induced contractile depression...
  32. ncbi request reprint NADPH oxidase-dependent redox signalling in cardiac hypertrophy, remodelling and failure
    Colin E Murdoch
    Department of Cardiology, Cardiovascular Division, King s College London School of Medicine, Bessemer Road, London SE5 9PJ, United Kingdom
    Cardiovasc Res 71:208-15. 2006
    ....
  33. ncbi request reprint Activation of NADPH oxidase during progression of cardiac hypertrophy to failure
    Jian Mei Li
    Department of Cardiology, Guy s King s and St Thomas School of Medicine Denmark Hill Campus, King s College London, London, United Kingdom
    Hypertension 40:477-84. 2002
    ....
  34. ncbi request reprint Involvement of the nicotinamide adenosine dinucleotide phosphate oxidase isoform Nox2 in cardiac contractile dysfunction occurring in response to pressure overload
    David J Grieve
    King s College London, Cardiovascular Division, Guy s, King s, and St Thomas School of Medicine, London, England
    J Am Coll Cardiol 47:817-26. 2006
    ..This study sought to examine the role of Nox2 in the contractile dysfunction associated with pressure-overload left ventricular hypertrophy (LVH)...
  35. ncbi request reprint Cardiovascular function following acute volume overload for hydrodynamic gene delivery to the liver
    G J Sawyer
    Department of Hepatology and Transplantation, King s College London School of Medicine, The Rayne Institute, and Department of Clinical Perfusion Sciences, King s College Hospital, London, UK
    Gene Ther 14:1208-17. 2007
    ..Vagal blockade with atropine, and the use of Ringer's solution to prevent electrolyte disturbances, did not ameliorate this picture...
  36. ncbi request reprint Effect of fat distribution on endothelial-dependent and endothelial-independent vasodilatation in healthy humans
    I L Williams
    Cardiovascular Division, King s College, London, UK
    Diabetes Obes Metab 8:296-301. 2006
    ....
  37. ncbi request reprint Phenotypic properties and characteristics of superoxide production by mouse coronary microvascular endothelial cells
    J M Li
    Department of Cardiology, Guy's King's and St Thomas' School of Medicine, King's College London, SE5 9PJ, UK
    J Mol Cell Cardiol 33:1119-31. 2001
    ..Thus, mouse coronary microvascular endothelial cells express both eNOS and NADPH oxidase, interactions between which may play a role in endothelial cell pathophysiology...
  38. pmc Predicting sudden death in patients with mild to moderate chronic heart failure
    M T Kearney
    Department of Cardiology, King s College, Bessemer Road, London SE5 9PJ, UK
    Heart 90:1137-43. 2004
    ..To explore the relation between non-invasive measures of cardiac function and sudden cardiac death, as well as the development and utility of an index integrating these variables to identify patients at increased risk of this mode of death...
  39. pmc Moderate mitral stenosis in pregnancy: the haemodynamic impact of diuresis
    A Siva
    Department of Cardiology, Kings College Hospital, London SE5 9PJ, UK
    Heart 91:e3. 2005
    ..Mitral stenosis in pregnancy and its management in pregnancy are briefly discussed...
  40. ncbi request reprint Transcriptional regulation of the NADPH oxidase isoform, Nox1, in colon epithelial cells: role of GATA-binding factor(s)
    Alison C Brewer
    King s College London, Department of Cardiology, GKT School of Medicine and Dentistry, New Medical School Building, Bessemer Road, London SE5 9PJ, UK
    Free Radic Biol Med 40:260-74. 2006
    ..We also identified more distal, upstream regions which act to repress significantly expression from the Nox1 promoter...
  41. ncbi request reprint NADPH oxidase and endothelial cell function
    Robin Ray
    Cardiovascular Division, Guy s, King s and St Thomas s School of Medicine, King s College London, Bessemer Road, London SE5 9PJ, UK
    Clin Sci (Lond) 109:217-26. 2005
    ....
  42. ncbi request reprint NADPH oxidase and heart failure
    Colin E Murdoch
    King s College London, Department of Cardiology, Cardiovascular Division, London SE5 9PJ, UK
    Curr Opin Pharmacol 6:148-53. 2006
    ..Understanding NADPH oxidase activation and regulation, and their downstream effectors, could help to develop novel therapeutic targets...
  43. ncbi request reprint Pivotal role of NOX-2-containing NADPH oxidase in early ischemic preconditioning
    Robert M Bell
    King s College London, Cardiac Physiology, Cardiovascular Division, The Rayne Institute, St Thomas Hospital, London SE1 7EH, UK
    FASEB J 19:2037-9. 2005
    ..PKC-dependent activation of a NOX-2-containing NADPH oxidase is pivotally involved in early ischemic PC. However, adenosine receptor activation can trigger a ROS and NOX-2 independent PC pathway...
  44. doi request reprint Late gadolinium enhancement of acute myocardial infarction in mice at 7T: cine-FLASH versus inversion recovery
    Andrea Protti
    Cardiovascular Division, King s College London British Heart Foundation Centre, London, United Kingdom
    J Magn Reson Imaging 32:878-86. 2010
    ..We therefore compared the IR technique against cine fast low shot angle (cine-FLASH) for the quantification of MI size in mice at 7T in vivo...
  45. pmc NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis
    Min Zhang
    Cardiovascular Division, King s College London British Heart Foundation Centre, London SE5 9PJ, United Kingdom
    Proc Natl Acad Sci U S A 107:18121-6. 2010
    ..Our results also have wider relevance to the use of nonspecific antioxidant approaches in cardiac disease and may provide an explanation for the failure of such strategies in many settings...
  46. ncbi request reprint Predicting death due to progressive heart failure in patients with mild-to-moderate chronic heart failure
    Mark T Kearney
    Department of Cardiology, GKT School of Medicine, King s College London, Bessemer Road, Denmark Hill, London SE5 9PJ, United Kingdom
    J Am Coll Cardiol 40:1801-8. 2002
    ..The aim of this study was to explore the value of noninvasive predictors of death/mode of death in ambulant outpatients with chronic heart failure (HF)...
  47. ncbi request reprint ROS generation by nonphagocytic NADPH oxidase: potential relevance in diabetic nephropathy
    Jian Mei Li
    Department of Cardiology, Guy s King s and St Thomas s School of Medicine, King s College London, London, United Kingdom
    J Am Soc Nephrol 14:S221-6. 2003
    ..This article reviews current knowledge of the nonphagocyte-NADPH oxidases at both structural and biochemical levels and discusses the possible role of these enzymes in the pathophysiology of diabetic nephropathy...
  48. ncbi request reprint A prognostic index to predict long-term mortality in patients with mild to moderate chronic heart failure stabilised on angiotensin converting enzyme inhibitors
    Mark T Kearney
    Department of Cardiology, GKT School of Medicine, King s College, Bessemer Road, Denmark Hill, SE5 9PJ, London, UK
    Eur J Heart Fail 5:489-97. 2003
    ..Mortality in patients with mild to moderate chronic heart failure remains high. At present there is no easy way of identifying patients within this population at increased risk of death in the medium to long term...
  49. ncbi request reprint Acute haemodynamic effects of lipolysis-induced increase of free fatty acids in healthy men
    Mark T Kearney
    Department of Cardiology, GKT School of Medicine, Denmark Hill, Bessemer Road, London SE5 9PJ, UK
    Clin Sci (Lond) 102:495-500. 2002
    ..1+/-5.4 to 31.3+/-3.9 arbitrary units, P<0.01). In conclusion, acute elevation of FFA in healthy men increases arterial blood pressure and reduces vascular resistance. These haemodynamic changes could be clinically relevant...
  50. ncbi request reprint Analysis of ex vivo left ventricular pressure-volume relations in the isolated murine ejecting heart
    David J Grieve
    Department of Cardiology, GKT School of Medicine, Bessemer Road, London SE5 9PJ, UK
    Exp Physiol 89:573-82. 2004
    ....
  51. pmc Protein phosphatase 2A contributes to the cardiac dysfunction induced by endotoxemia
    Melanie Marshall
    Cardiovascular Division, Department of Cardiology, King s College London, James Black Centre, London SE5 9NU, UK
    Cardiovasc Res 82:67-76. 2009
    ..The aim of this study was to determine whether modulation of PP2A and thus cTnI phosphorylation could improve sepsis-induced contractile dysfunction...
  52. ncbi request reprint Opposing roles of p47phox in basal versus angiotensin II-stimulated alterations in vascular O2- production, vascular tone, and mitogen-activated protein kinase activation
    Jian Mei Li
    Department of Cardiology, Guy s, King s, and St Thomas School of Medicine, King s College London, London, UK
    Circulation 109:1307-13. 2004
    ..The p47phox subunit plays an important role in Ang II-induced oxidase activation, but its role in basal oxidase activity and vascular function is unclear...
  53. pmc Role of cyclic GMP-dependent protein kinase in the contractile response to exogenous nitric oxide in rat cardiac myocytes
    Joanne Layland
    Department of Cardiology, GKT School of Medicine, King s College London Denmark Hill Campus, Bessemer Road, London SE5 9PJ, UK
    J Physiol 540:457-67. 2002
    ..4-fold; P < 0.01) in troponin I phosphorylation compared to control, untreated hearts. These results suggest that the reduction in myofilament Ca(2+) responsiveness produced by DEA/NO results from phosphorylation of troponin I by PKG...
  54. ncbi request reprint The physiological role of endogenous endothelin in the regulation of human coronary vasomotor tone
    P A MacCarthy
    Department of Cardiology, University Hospital of Wales, Cardiff, United Kingdom
    J Am Coll Cardiol 37:137-43. 2001
    ..CONCLUSIONS: These data uncover a role of endogenous endothelin-1 in the maintenance of basal vasomotor tone in patients with angiographically normal coronary arteries...
  55. ncbi request reprint Oxidative stress and heart failure
    J A Byrne
    Department of Cardiology, Guy s King s and St Thomas s School of Medicine, King s College London, London, U K
    Arch Mal Coeur Vaiss 96:214-21. 2003
    ....
  56. ncbi request reprint Obesity, atherosclerosis and the vascular endothelium: mechanisms of reduced nitric oxide bioavailability in obese humans
    I L Williams
    Department of Cardiology, Guy s, King s and St Thomas School of Medicine, King s College London, London, UK
    Int J Obes Relat Metab Disord 26:754-64. 2002
    ..We then focus on the potential factors responsible for endothelial dysfunction in obesity and possible therapeutic interventions targetted at these abnormalities...
  57. pmc Inspiratory muscle load and capacity in chronic heart failure
    N Hart
    Respiratory Muscle Laboratory, Royal Brompton Hospital, London, UK
    Thorax 59:477-82. 2004
    ..We hypothesised that inspiratory muscle endurance, expressed as a function of endurance time (Tlim) adjusted for inspiratory muscle load and inspiratory muscle capacity, would be reduced in CHF...
  58. ncbi request reprint Involvement of NADPH oxidases in cardiac remodelling and heart failure
    Alexander Sirker
    Cardiovascular Division, Department of Cardiology, King s College London School of Medicine, London, UK
    Am J Nephrol 27:649-60. 2007
    ..A better understanding of the roles of this complex enzyme family may define novel therapeutic targets for the prevention of heart failure...
  59. ncbi request reprint Vascular dysfunction and reduced circulating endothelial progenitor cells in young healthy UK South Asian men
    Cliona Murphy
    Cardiovascular Division, Kings College London, London, UK
    Arterioscler Thromb Vasc Biol 27:936-42. 2007
    ....
  60. ncbi request reprint Role of reactive oxygen species in myocardial remodeling
    Min Zhang
    Department of Cardiology, King s College London School of Medicine, Bessemer Road, London SE5 9PJ, United Kingdom
    Curr Heart Fail Rep 4:26-30. 2007
    ..These data could suggest new ways of targeting redox pathways for the prevention and treatment of adverse cardiac remodeling...
  61. ncbi request reprint Cardiomyocytes as effectors of nitric oxide signalling
    Mike Seddon
    Department of Cardiology, Cardiovascular Division, King s College London, London, United Kingdom
    Cardiovasc Res 75:315-26. 2007
    ..In this article, we review the current understanding of this important but complex field, focussing particularly on contractile function and on recent advances in knowledge regarding the autocrine functions of nNOS-derived NO...
  62. doi request reprint Effects of neuronal nitric oxide synthase on human coronary artery diameter and blood flow in vivo
    Michael Seddon
    King s College London British Heart Foundation Centre, Cardiovascular Division, Department of Cardiology, London, UK
    Circulation 119:2656-62. 2009
    ..Here, we investigated the in vivo effects of an nNOS-selective inhibitor, S-methyl-L-thiocitrulline (SMTC), on the human coronary circulation and on flow-mediated dilatation in the forearm...
  63. ncbi request reprint Accelerated endothelial dysfunction in mild prediabetic insulin resistance: the early role of reactive oxygen species
    Edward R Duncan
    The Cardiovascular Division, King s College London School of Medicine, King s College London, London, UK
    Am J Physiol Endocrinol Metab 293:E1311-9. 2007
    ....
  64. ncbi request reprint NADPH oxidase-derived reactive oxygen species in the regulation of endothelial phenotype
    Rafał Dworakowski
    King s College London School of Medicine, The James Black Centre, Cardiovascular Division, London, UK
    Pharmacol Rep 60:21-8. 2008
    ..This review provides an overview of NADPH oxidase structure and regulation in endothelial cells and their role in pathophysiology, focussing particularly on endothelial activation...
  65. ncbi request reprint Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase
    Sofian Johar
    King s College London, Cardiovascular Division, London, UK
    FASEB J 20:1546-8. 2006
    ..These results suggest that aldosterone-dependent activation of a Nox2-containing NADPH oxidase contributes to the profibrotic effect of AngII in the heart as well as the fibrosis seen in mineralocorticoid-dependent hypertension...
  66. pmc Oxidative stress and redox signalling in cardiac hypertrophy and heart failure
    Mike Seddon
    Department of Cardiology, King s College, Cardiovascular Division, London, UK
    Heart 93:903-7. 2007
    ..A better understanding of redox signalling mechanisms may enable the development of new targeted therapeutic strategies rather than the non-specific antioxidant approaches that have to date been disappointing in clinical trials...
  67. pmc Acute tumor necrosis factor alpha signaling via NADPH oxidase in microvascular endothelial cells: role of p47phox phosphorylation and binding to TRAF4
    Jian Mei Li
    Department of Cardiology, Guy s King s and St Thomas School of Medicine, King s College London, London, United Kingdom
    Mol Cell Biol 25:2320-30. 2005
    ..The increased binding between p47phox and TRAF4 that occurs after p47phox phosphorylation could serve to spatially confine ROS generation from NADPH oxidase and subsequent MAPK activation and cell surface ICAM-1 expression in EC...
  68. ncbi request reprint Cardiac dysfunction in the Goto-Kakizaki rat. A model of type II diabetes mellitus
    Magdi M El-Omar
    Department of Cardiology, University of Wales, College of Medicine, Cardiff, UK
    Basic Res Cardiol 99:133-41. 2004
    ....
  69. ncbi request reprint Vascular endothelial function and blood pressure homeostasis in mice overexpressing IGF binding protein-1
    Stephen B Wheatcroft
    Department of Cardiology, Guy s, King s and St Thomas School of Medicine, London, UK
    Diabetes 52:2075-82. 2003
    ..Our data suggest that IGFBP-1 plays an important and potentially beneficial role in regulating metabolic and vascular homeostasis...
  70. ncbi request reprint Strain-dependent variation in vascular responses to nitric oxide in the isolated murine heart
    Jennifer K Bendall
    Department of Cardiology, Guy s King s and St Thomas School of Medicine, King s College London, Denmark Hill Campus, Bessemer Road, London SE5 9PJ, UK
    J Mol Cell Cardiol 34:1325-33. 2002
    ..There is significant strain-dependent variation in coronary and aortic vascular responsiveness in mice, which may reflect differences in the balance between NO and superoxide generation...
  71. ncbi request reprint NOX-2S is a new member of the NOX family of NADPH oxidases
    Yasin Heidari
    Department of Cardiology, GKT School of Medicine, King s College London, Denmark Hill Campus, Bessemer Road, London SE5 9PJ, UK
    Gene 335:133-40. 2004
    ..The sequence identity between mouse and human NOX-2S strongly implies conservation in function and possibly a role for NOX-2S in the regulation of NADPH oxidase activity...
  72. ncbi request reprint Glycated proteins stimulate reactive oxygen species production in cardiac myocytes: involvement of Nox2 (gp91phox)-containing NADPH oxidase
    Min Zhang
    Cardiovascular Division, King s College London, London, United Kingdom
    Circulation 113:1235-43. 2006
    ..However, the effects of early-glycated proteins, such as glycated serum albumin (Gly-BSA), are poorly defined. In this study, we investigated the effects of Gly-BSA on reactive oxygen species (ROS) production by cardiomyocytes...
  73. ncbi request reprint Essential role of the NADPH oxidase subunit p47(phox) in endothelial cell superoxide production in response to phorbol ester and tumor necrosis factor-alpha
    Jian Mei Li
    Department of Cardiology, Guy s King s and St Thomas School of Medicine Denmark Hill Campus, King s College London, London, UK
    Circ Res 90:143-50. 2002
    ..These data show that endothelial cell p47(phox) is critical in the upregulation of NADPH oxidase activity by PMA and TNFalpha...
  74. pmc Nitric oxide and myocardial function in heart failure: friend or foe?
    J M Cotton
    Department of Cardiology, Guy s King s and St Thomas s School of Medicine, King s College London Denmark Hill Campus, London, UK
    Heart 88:564-6. 2002
    ..There is good evidence that nitric oxide has important autocrine/paracrine effects in the myocardium, serving to optimise and fine tune cardiac function..
  75. ncbi request reprint Molecular characterization and localization of the NAD(P)H oxidase components gp91-phox and p22-phox in endothelial cells
    U Bayraktutan
    Department of Cardiology, GKT School of Medicine, King s College, London, UK
    Arterioscler Thromb Vasc Biol 20:1903-11. 2000
    ....
  76. pmc Coronary artery perforation during percutaneous intervention: incidence and outcome
    M G Gunning
    Department of Cardiology, Kings College Hospital, London, UK
    Heart 88:495-8. 2002
    ..To examine the clinical outcome of percutaneous coronary intervention where the procedure was complicated by vessel perforation...
  77. ncbi request reprint Inducible nitric oxide synthase has divergent effects on vascular and metabolic function in obesity
    Brian T Noronha
    Cardiovascular Division, King s College London, UK
    Diabetes 54:1082-9. 2005
    ....
  78. doi request reprint NADPH oxidase signaling and cardiac myocyte function
    Ashwin Akki
    Department of Cardiology, King s College London British Heart Foundation Centre of Excellence, The James Black Centre, 125 Coldharbour Lane, London, SE5 9NU, UK
    J Mol Cell Cardiol 47:15-22. 2009
    ..This article reviews current knowledge regarding the role of NADPH oxidases in cardiomyocyte function in health and disease...
  79. ncbi request reprint Divergent effects of angiotensin-converting enzyme inhibition on blood pressure and endothelial function in obese humans
    Ian L Williams
    GKT School of Medicine, King s College, London, SE5 9PJ, UK
    Diab Vasc Dis Res 3:34-8. 2006
    ..2 (1.2)% versus 8.3 (1.5)%, p=0.9. ACE inhibition had no effect on insulin, lipids or circulating cytokines. In healthy obese humans, despite a significant reduction in blood pressure, ACE inhibition had no effect on FMD...
  80. ncbi request reprint Increased myocardial NADPH oxidase activity in human heart failure
    Christophe Heymes
    Department of Cardiology, Guy s King s and St Thomas s School of Medicine, King s College, London, United Kingdom
    J Am Coll Cardiol 41:2164-71. 2003
    ....
  81. ncbi request reprint Mechanism of endothelial cell NADPH oxidase activation by angiotensin II. Role of the p47phox subunit
    Jian Mei Li
    Department of Cardiology, Guy s, King s, and St Thomas s School of Medicine, King s College London, Bessemer Road, London SE5 9PJ, United Kingdom
    J Biol Chem 278:12094-100. 2003
    ..These data indicate that angiotensin II-stimulated endothelial NADPH oxidase activity is regulated through serine phosphorylation of p47(phox) and its enhanced binding to p22(phox)...
  82. ncbi request reprint Intracellular localization and preassembly of the NADPH oxidase complex in cultured endothelial cells
    Jian Mei Li
    Department of Cardiology, Guy s King s and St Thomas s School of Medicine, King s College London, London SE5 9PJ, United Kingdom
    J Biol Chem 277:19952-60. 2002
    ..These results indicate that, in contrast to the neutrophil enzyme, a substantial proportion of the NADPH oxidase in unstimulated endothelial cells exists as a preassembled intracellular complex associated with the cytoskeleton...
  83. ncbi request reprint Oxidative stress and heart failure
    Philip A MacCarthy
    Department of Cardiology, King s College London, UK
    Coron Artery Dis 14:109-13. 2003
  84. pmc Effect of endothelium-specific insulin resistance on endothelial function in vivo
    Edward R Duncan
    Cardiovascular Division, Department of Cardiology, King s College, London, UK
    Diabetes 57:3307-14. 2008
    ..Insulin resistance is associated with endothelial dysfunction; however, the mechanistic relationship between these abnormalities and the role of impaired endothelial insulin signaling versus global insulin resistance remains unclear...
  85. ncbi request reprint GATA factors lie upstream of Nkx 2.5 in the transcriptional regulatory cascade that effects cardiogenesis
    Alison C Brewer
    Department of Cardiology, King s College Hospital, London SE5 9RS, UK
    Stem Cells Dev 14:425-39. 2005
    ....
  86. ncbi request reprint Wnt2 is a direct downstream target of GATA6 during early cardiogenesis
    Alexander Alexandrovich
    Cardiovascular Division, King s College London, London SE5 9PJ, UK
    Mech Dev 123:297-311. 2006
    ....
  87. ncbi request reprint Preserved glucoregulation but attenuation of the vascular actions of insulin in mice heterozygous for knockout of the insulin receptor
    Stephen B Wheatcroft
    Department of Cardiology, Guy s King s and St Thomas School of Medicine, King s College London, Bessemer Road, London SE5 9PJ, UK
    Diabetes 53:2645-52. 2004
    ..These findings underscore the importance of early intervention in insulin-resistant states, where glucose homeostasis may be normal but substantial abnormalities of the vascular effects of insulin may already be present...
  88. ncbi request reprint Leptin is an endothelial-independent vasodilator in humans with coronary artery disease: Evidence for tissue specificity of leptin resistance
    Aziz U Momin
    Cardiovascular Division, King s College School of Medicine at Guy s, King s College, and St Thomas Hospitals, King s College London, Bessemer Road, London SE5 9PJ, UK
    Eur Heart J 27:2294-9. 2006
    ..We sought to define the mechanisms and correlates of leptin's vascular actions in humans with coronary artery disease...
  89. ncbi request reprint Cardiac size, autonomic function, and 5-year follow-up of chronic heart failure patients with severe prolongation of ventricular activation
    Mark T Kearney
    Department of Cardiology, King s College, London, United Kingdom
    J Card Fail 9:93-9. 2003
    ..We tested the hypotheses that in patients with chronic heart failure, QRS > 150 ms is a risk factor for additional abnormalities of ventricular morphology, heart rate variability, and increased mortality...
  90. doi request reprint Endothelial Nox4 NADPH oxidase enhances vasodilatation and reduces blood pressure in vivo
    Robin Ray
    Cardiovascular Division, King s College London British Heart Foundation Centre, London, United Kingdom
    Arterioscler Thromb Vasc Biol 31:1368-76. 2011
    ..Recent studies indicate that it generates predominantly hydrogen peroxide (H(2)O(2)), but its role in vivo remains unclear...
  91. ncbi request reprint A simple thermodilution technique to assess coronary endothelium-dependent microvascular function in humans: validation and comparison with coronary flow reserve
    Narbeh Melikian
    Cardiovascular Division, King s College London School of Medicine at Guy s, King s College and St Thomas Hospitals, London, UK
    Eur Heart J 28:2188-94. 2007
    ..To validate a novel method for assessment of coronary endothelium-dependent microvascular function and compare this index with the adenosine-derived coronary flow reserve (CFR)...
  92. ncbi request reprint The clinical relevance of raised cardiac troponin I in the absence of significant angiographic coronary artery disease
    Thuraia Nageh
    Department of Cardiology, King s College Hospital, Denmark Hill, London, UK
    Int J Cardiol 100:325-30. 2005
    ..Cardiac troponins are highly sensitive and specific markers of myocardial cell injury. We wished to determine the clinical relevance of raised troponins in the absence of significant angiographic coronary artery disease...
  93. ncbi request reprint Asymmetric dimethylarginine and reduced nitric oxide bioavailability in young Black African men
    Narbeh Melikian
    Cardiovascular Division, King s College London School of Medicine at Guy s, King s College and St Thomas Hospitals, London, United Kingdom
    Hypertension 49:873-7. 2007
    ..This may contribute to the lower NO bioavailability and higher incidence of cardiovascular disease seen in black Africans...
  94. pmc NADPH oxidase-derived reactive oxygen species in cardiac pathophysiology
    Alison Cave
    King s College London Cardiovascular Division London SE5 9PJ, UK
    Philos Trans R Soc Lond B Biol Sci 360:2327-34. 2005
    ..If confirmed, these data would suggest that independently targeting different members of the NOX family may hold the potential for therapeutic intervention in the treatment of cardiac disease...
  95. pmc NADPH oxidase-derived overproduction of reactive oxygen species impairs postischemic neovascularization in mice with type 1 diabetes
    Teni G Ebrahimian
    Cardiovascular Research Center, U689 INSERM, Hopital Lariboisiere, 41 Blvd de la Chapelle, 75475 Paris Cedex 10, France
    Am J Pathol 169:719-28. 2006
    ..05). Thus, inhibition of NADPH oxidase-derived ROS overproduction improves the angiogenic and vasculogenic processes and restores postischemic neovascularization in type 1 diabetic mice...
  96. ncbi request reprint Transmitting biological information using oxygen: reactive oxygen species as signalling molecules in cardiovascular pathophysiology
    Ajay M Shah
    Cardiovasc Res 71:191-4. 2006
  97. ncbi request reprint Increased neuronal nitric oxide synthase-derived NO production in the failing human heart
    Thibaud Damy
    INSERM U572 Hôpital Lariboisière, IFR J Marrey Paris 7, 41 Boulevard de la Chapelle, 75475 Paris Cedex 10, Université D Diderot, Paris, France
    Lancet 363:1365-7. 2004
    ..Our results provide evidence of increased nNOS-derived NO in the failing human heart. Such altered regulation may be important in the pathophysiology of cardiac dysfunction in human congestive heart failure...
  98. ncbi request reprint Divergent roles of endothelial nitric oxide synthase in cardiac hypertrophy and chamber dilatation?
    Ajay M Shah
    Cardiovasc Res 66:421-2. 2005
  99. pmc Prognosis in heart failure with preserved left ventricular systolic function: prospective cohort study
    Philip A MacCarthy
    Department of Cardiology, Guy s, King s, and St Thomas s School of Medicine, London SE5 9PJ
    BMJ 327:78-9. 2003
  100. doi request reprint Reactive oxygen species and endothelial activation
    Sara P Alom-Ruiz
    King s College London School of Medicine, The James Black Centre, Cardiovascular Division, London, United Kingdom
    Antioxid Redox Signal 10:1089-100. 2008
    ....
  101. doi request reprint Reduced nicotinamide adenine dinucleotide phosphate oxidase-derived superoxide and vascular endothelial dysfunction in human heart failure
    Rafał Dworakowski
    Cardiovascular Division, King s College London School of Medicine, London, United Kingdom
    J Am Coll Cardiol 51:1349-56. 2008
    ..We investigated the role of reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase in endothelial dysfunction in human heart failure...