L C Schalkwyk

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint Home-cage activity in heterogeneous stock (HS) mice as a model of baseline activity
    J Mill
    Social, Genetic, and Developmental Psychiatric Research Centre, Institute of Psychiatry, King s College London, UK
    Genes Brain Behav 1:166-73. 2002
  2. ncbi request reprint Association analysis of mild mental impairment using DNA pooling to screen 432 brain-expressed single-nucleotide polymorphisms
    L M Butcher
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Mol Psychiatry 10:384-92. 2005
  3. ncbi request reprint Quantitative trait locus association scan of early reading disability and ability using pooled DNA and 100K SNP microarrays in a sample of 5760 children
    E L Meaburn
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London, UK
    Mol Psychiatry 13:729-40. 2008
  4. pmc Using hippocampal microRNA expression differences between mouse inbred strains to characterise miRNA function
    Michael J Parsons
    Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, KCL, PO82, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Mamm Genome 19:552-60. 2008
  5. pmc Applicability of DNA pools on 500 K SNP microarrays for cost-effective initial screens in genomewide association studies
    Sophia J Docherty
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, DeCrispigny Park, London, UK
    BMC Genomics 8:214. 2007
  6. pmc Genotyping DNA pools on microarrays: tackling the QTL problem of large samples and large numbers of SNPs
    Emma Meaburn
    Social, Genetic and Developmental Psychiatry Centre, Box Number P082, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
    BMC Genomics 6:52. 2005
  7. pmc Advanced integrated mouse YAC map including BAC framework
    L C Schalkwyk
    Max Planck Institute of Molecular Genetics, Ihnestrasse 73, D 14195 Berlin, Germany
    Genome Res 11:2142-50. 2001
  8. pmc Interpretation of knockout experiments: the congenic footprint
    L C Schalkwyk
    Social, Genetic and Developmental Psychiatry Centre PO82, Institute of Psychiatry, King s College London, London, United Kingdom
    Genes Brain Behav 6:299-303. 2007
  9. pmc Interspersed repetitive sequence (IRS)-PCR for typing of whole genome radiation hybrid panels
    H Himmelbauer
    Max Planck Institute of Molecular Genetics, Ihnestrasse 73, D 14195 Berlin Dahlem, Germany
    Nucleic Acids Res 28:e7. 2000
  10. pmc A genome-wide association study identifies multiple loci associated with mathematics ability and disability
    S J Docherty
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Genes Brain Behav 9:234-47. 2010

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Home-cage activity in heterogeneous stock (HS) mice as a model of baseline activity
    J Mill
    Social, Genetic, and Developmental Psychiatric Research Centre, Institute of Psychiatry, King s College London, UK
    Genes Brain Behav 1:166-73. 2002
    ....
  2. ncbi request reprint Association analysis of mild mental impairment using DNA pooling to screen 432 brain-expressed single-nucleotide polymorphisms
    L M Butcher
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Mol Psychiatry 10:384-92. 2005
    ..The present SNP strategy combined with DNA pooling and large samples represents a step towards identifying QTLs of small effect size associated with complex traits in the postgenomic era when all functional polymorphisms will be known...
  3. ncbi request reprint Quantitative trait locus association scan of early reading disability and ability using pooled DNA and 100K SNP microarrays in a sample of 5760 children
    E L Meaburn
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London, UK
    Mol Psychiatry 13:729-40. 2008
    ..We conclude that QTL effect sizes, even for highly heritable common disorders and quantitative traits such as early reading disability and ability, might be much smaller than previously considered...
  4. pmc Using hippocampal microRNA expression differences between mouse inbred strains to characterise miRNA function
    Michael J Parsons
    Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, KCL, PO82, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Mamm Genome 19:552-60. 2008
    ..This approach has allowed us to nominate miRNAs that have potential roles in anxiety, exploration, and learning and memory...
  5. pmc Applicability of DNA pools on 500 K SNP microarrays for cost-effective initial screens in genomewide association studies
    Sophia J Docherty
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, DeCrispigny Park, London, UK
    BMC Genomics 8:214. 2007
    ..We demonstrate that this approach can be effectively applied to the truly genomewide Affymetrix GeneChip Mapping 500 K Array...
  6. pmc Genotyping DNA pools on microarrays: tackling the QTL problem of large samples and large numbers of SNPs
    Emma Meaburn
    Social, Genetic and Developmental Psychiatry Centre, Box Number P082, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
    BMC Genomics 6:52. 2005
    ..An efficient solution is to genotype case and control DNA pools using SNP microarrays. We demonstrate that this is practical using DNA pools of 100 individuals...
  7. pmc Advanced integrated mouse YAC map including BAC framework
    L C Schalkwyk
    Max Planck Institute of Molecular Genetics, Ihnestrasse 73, D 14195 Berlin, Germany
    Genome Res 11:2142-50. 2001
    ..and Nusbaum et al. There is a total of 20,205 markers on the final map, 12,033 from our own data, and a total of 56,093 YACs, of which 44,401 are positive for more than one marker...
  8. pmc Interpretation of knockout experiments: the congenic footprint
    L C Schalkwyk
    Social, Genetic and Developmental Psychiatry Centre PO82, Institute of Psychiatry, King s College London, London, United Kingdom
    Genes Brain Behav 6:299-303. 2007
    ..However, the impact of genetic background should not be simply viewed as a potential confound, but as a unique opportunity to study the broader responses of a system to a specific (genetic) perturbation...
  9. pmc Interspersed repetitive sequence (IRS)-PCR for typing of whole genome radiation hybrid panels
    H Himmelbauer
    Max Planck Institute of Molecular Genetics, Ihnestrasse 73, D 14195 Berlin Dahlem, Germany
    Nucleic Acids Res 28:e7. 2000
    ..To test the technique, we have mapped 48 BAC clones derived from mouse chromosome 12 which we mostly identified using complex probes. As mammalian genomes are repeat-rich, the technology can easily be adapted to species other than mouse...
  10. pmc A genome-wide association study identifies multiple loci associated with mathematics ability and disability
    S J Docherty
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Genes Brain Behav 9:234-47. 2010
    ....
  11. ncbi request reprint Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory
    C Fernandes
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Genes Brain Behav 5:433-40. 2006
    ..This suggests a role for the alpha7 subunit in working/episodic memory and a potential role for the alpha7 neural nicotinic receptor gene (CHRNA7) in schizophrenia and its endophenotypes...
  12. pmc A B2 SINE insertion in the Comt1 gene (Comt1(B2i)) results in an overexpressing, behavior modifying allele present in classical inbred mouse strains
    R L Kember
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Genes Brain Behav 9:925-32. 2010
    ....
  13. ncbi request reprint Genetics of behavioural domains across the neuropsychiatric spectrum; of mice and men
    M J H Kas
    Department of Pharmacology and Anatomy, Behavioural Genomics Section, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Mol Psychiatry 12:324-30. 2007
    ....
  14. ncbi request reprint IRS-PCR-based genetic mapping of the huntingtin interacting protein gene (HIP1) on mouse chromosome 5
    H Himmelbauer
    Max Planck Institute for Molecular Genetics, Berlin Dahlem, Germany
    Mamm Genome 9:26-31. 1998
    ....
  15. ncbi request reprint ETn insertion in the mouse Adcy1 gene: transcriptional and phylogenetic analyses
    W L Leong
    Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada
    Mamm Genome 11:97-103. 2000
    ..Further, of the four known solitary (solo) LTRs, we have identified two that show evidence of recombination between LTRs from different ETn families...
  16. ncbi request reprint Technology development at the interface of proteome research and genomics: mapping nonpolymorphic proteins on the physical map of mouse chromosomes
    C Nock
    Max Planck Institute for Molecular Genetics, Berlin Dahlem, Germany
    Electrophoresis 20:1027-32. 1999
    ..This technology therefore is able to draw links between proteins detected by 2-D gel electrophoresis and the corresponding gene loci in the mouse genome...
  17. ncbi request reprint Loss of adenylyl cyclase I activity disrupts patterning of mouse somatosensory cortex
    R M Abdel-Majid
    Department of Anatomy and Neurobiology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Nat Genet 19:289-91. 1998
    ..These results provide the first evidence for involvement of cAMP signalling pathways in pattern formation of the brain...