Research Topics
Species | Katya RubiaSummaryAffiliation: King's College London Country: UK Publications
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Publications
Methylphenidate normalizes frontocingulate underactivation during error processing in attention-deficit/hyperactivity disorderKatya Rubia
Department of Child Psychiatry, Institute of Psychiatry, King s College London, London, United Kingdom
Biol Psychiatry 70:255-62. 2011..We used functional magnetic resonance imaging to investigate the effects of single-dose MPH on activation of error processing brain areas in medication-naive boys with ADHD during a stop task that elicits 50% error rates...
Disorder-specific dysfunctions in patients with attention-deficit/hyperactivity disorder compared to patients with obsessive-compulsive disorder during interference inhibition and attention allocationKatya Rubia
Department of Child Psychiatry, Institute of Psychiatry, King s College London, London, UK
Hum Brain Mapp 32:601-11. 2011..The aim of this study was to investigate disorder-specific abnormalities in neural networks mediating interference inhibition and selective attention...
Methylphenidate normalizes fronto-striatal underactivation during interference inhibition in medication-naïve boys with attention-deficit hyperactivity disorderKatya Rubia
Department of Child Psychiatry, Institute of Psychiatry, King s College London, London, UK
Neuropsychopharmacology 36:1575-86. 2011..MPH therefore appears to have a region-specific upregulation effect on fronto-striatal activation...
Disorder-specific dissociation of orbitofrontal dysfunction in boys with pure conduct disorder during reward and ventrolateral prefrontal dysfunction in boys with pure ADHD during sustained attentionKatya Rubia
Department of Child Psychiatry MRC Center for Social, Genetic and Developmental Psychiatry SGDP, Institute of Psychiatry, King s College, 16 De Crespigny Park, London, SE5 8AF, UK
Am J Psychiatry 166:83-94. 2009....
A review of fronto-striatal and fronto-cortical brain abnormalities in children and adults with Attention Deficit Hyperactivity Disorder (ADHD) and new evidence for dysfunction in adults with ADHD during motivation and attentionAna Cubillo
Department of Child Psychiatry, Institute of Psychiatry, King s College London, UK
Cortex 48:194-215. 2012..The brain deficits in ADHD therefore appear to be multi-systemic and to persist throughout the lifespan...
Fronto-striato-cerebellar dysregulation in adolescents with depression during motivated attentionKaylita Chantiluke
Child and Adolescent Psychiatry, Institute of Psychiatry, King s College London, Denmark Hill, London, UK
Biol Psychiatry 71:59-67. 2012..In this study, we investigated the neurofunctional correlates of the interplay between attention and motivation in medication-naive pediatric MDD using a rewarded sustained attention task...
Progressive increase of frontostriatal brain activation from childhood to adulthood during event-related tasks of cognitive controlKatya Rubia
Department of Child Psychiatry, Institute of Psychiatry, King s College, London, UK
Hum Brain Mapp 27:973-93. 2006..The findings suggest progressive maturation of task-specific frontostriatal and frontocortical networks for cognitive control functions in the transition from childhood to mid-adulthood...
Task-specific hypoactivation in prefrontal and temporoparietal brain regions during motor inhibition and task switching in medication-naive children and adolescents with attention deficit hyperactivity disorderAnna B Smith
Department of Child Psychiatry, Institute of Psychiatry, King's College, London, SE5 8AF, UK
Am J Psychiatry 163:1044-51. 2006..Furthermore, functional abnormalities are task-specific and extend from frontostriatal to parietal and temporal cortices...
Methylphenidate normalises activation and functional connectivity deficits in attention and motivation networks in medication-naïve children with ADHD during a rewarded continuous performance taskKatya Rubia
Department of Child Psychiatry, Institute of Psychiatry, King s College, London, UK
Neuropharmacology 57:640-52. 2009....
Temporal lobe dysfunction in medication-naïve boys with attention-deficit/hyperactivity disorder during attention allocation and its relation to response variabilityKatya Rubia
Department of Child Psychiatry, Institute of Psychiatry, King s College, London, United Kingdom
Biol Psychiatry 62:999-1006. 2007..Furthermore, we explore the relationship between the neural substrates of attention allocation and response variability, typically increased in patients...
Induction of psychosis by Δ9-tetrahydrocannabinol reflects modulation of prefrontal and striatal function during attentional salience processingSagnik Bhattacharyya
Department of Psychosis Studies, Institute of Psychiatry, King s College London, De Crespigny Park, London, England
Arch Gen Psychiatry 69:27-36. 2012..Cannabis can induce acute psychotic symptoms, and its chronic use may increase the risk of schizophrenia. We investigated whether its psychotic effects are mediated through an influence on attentional salience processing...
Developmental effects of reward on sustained attention networksAnna B Smith
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King s College London, London, UK
Neuroimage 56:1693-704. 2011..These findings may be the neural underpinnings for the progressive maturation of motivational control over risk taking behaviours between adolescence and adulthood...
Fronto-striatal underactivation during interference inhibition and attention allocation in grown up children with attention deficit/hyperactivity disorder and persistent symptomsAna Cubillo
Department of Child Psychiatry, Institute of Psychiatry, King s College London, London, SE5 8AF, UK
Psychiatry Res 193:17-27. 2011..Furthermore, they show that functional deficits in adult ADHD are not related to chronic stimulant medication given that this sample was medication-naive...
Disorder-specific dysfunction in right inferior prefrontal cortex during two inhibition tasks in boys with attention-deficit hyperactivity disorder compared to boys with obsessive-compulsive disorderKatya Rubia
Department of Child Psychiatry, Institute of Psychiatry, King s College, London, United Kingdom
Hum Brain Mapp 31:287-99. 2010....
Reduced activation and inter-regional functional connectivity of fronto-striatal networks in adults with childhood Attention-Deficit Hyperactivity Disorder (ADHD) and persisting symptoms during tasks of motor inhibition and cognitive switchingAna Cubillo
Department of Child Psychiatry, Institute of Psychiatry, King s College, London SE5 8AF, UK
J Psychiatr Res 44:629-39. 2010..This suggests that neuro-functional abnormalities in ADHD patients are likely to continue between childhood and early adulthood...
Sex-dependent age modulation of frontostriatal and temporo-parietal activation during cognitive controlAnastasia Christakou
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King s College London, Box P046, De Crespigny Park SE5 8AF, UK
Neuroimage 48:223-36. 2009..Gender differences in frontal and parietal recruitment may thus be related to gender differences in the neurofunctional maturation of these brain regions...
Linear age-correlated functional development of right inferior fronto-striato-cerebellar networks during response inhibition and anterior cingulate during error-related processesKatya Rubia
Department of Child Psychiatry, Institute of Psychiatry, London SE5 8AF, United Kingdom
Hum Brain Mapp 28:1163-77. 2007..This study shows developmental specialization of the integrated function of right inferior prefrontal cortex, basal ganglia, thalamus, and cerebellum for inhibitory control and of anterior cingulate gyrus for error-related processes...
A functional magnetic resonance imaging study of inhibitory control in obsessive-compulsive disorderLisa A Page
King s College London, Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, Room 3 14, Weston Education Centre, 10 Cutcombe Road, London, SE5 9RJ, UK
Psychiatry Res 174:202-9. 2009..OCD is associated with task-relevant fronto-striatal dysfunction during motor inhibition and cognitive switching. In addition, parieto-temporal dysfunction was observed during tasks with a higher attentional load...
Disorder-specific inferior prefrontal hypofunction in boys with pure attention-deficit/hyperactivity disorder compared to boys with pure conduct disorder during cognitive flexibilityKatya Rubia
Department of Child Psychiatry, MRC Center for Social, Genetic and Developmental Psychiatry, Institute of Psychiatry, King s College, London, United Kingdom
Hum Brain Mapp 31:1823-33. 2010..This study investigates disorder-specific functional abnormalities during cognitive flexibility between medication-naïve children and adolescents with noncomorbid CD and those with noncomorbid ADHD compared to healthy controls...
Abnormal brain activation during inhibition and error detection in medication-naive adolescents with ADHDKatya Rubia
Department of Psychiatry, Institute of Psychiatry, 16 De Crespigny Park, London SE5 8AF, UK
Am J Psychiatry 162:1067-75. 2005....
Effects of age and sex on developmental neural networks of visual-spatial attention allocationKatya Rubia
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King s College London, UK
Neuroimage 51:817-27. 2010....
Abnormal centroparietal ERP response in predominantly medication-naive adolescent boys with ADHD during both response inhibition and executionRachel V Gow
Department of Adolescent and Child Psychiatry, Institute of Psychiatry, King s College, London, United Kingdom
J Clin Neurophysiol 29:181-9. 2012..The findings demonstrate that adolescents with ADHD have abnormal ERP responses not only during inhibitory, but also execution-related processes and, furthermore, that these deficits are independent from medication history...
Shared and disorder-specific prefrontal abnormalities in boys with pure attention-deficit/hyperactivity disorder compared to boys with pure CD during interference inhibition and attention allocationKatya Rubia
Department of Child Psychiatry, Institute of Psychiatry, King s College, London, UK
J Child Psychol Psychiatry 50:669-78. 2009..This study investigates differences and commonalities in functional neural networks mediating interference inhibition and attention allocation between medication-naïve children and adolescents with pure CD and those with pure ADHD...
5-HT, prefrontal function and aging: fMRI of inhibition and acute tryptophan depletionMelissa Lamar
Department of Psychology, Institute of Psychiatry, King s College London, London, UK
Neurobiol Aging 30:1135-46. 2009..Maintaining successful Simon performance during ATD is achieved by increasing cerebellar and parietal contributions to compensate for decreased fronto-cingulo-striatal involvement...
Brain activation in paediatric obsessive compulsive disorder during tasks of inhibitory controlJames Woolley
Child and Adolescent Psychiatry PO 46, Institute of Psychiatry, Denmark Hill, London SE5 8AF, UK
Br J Psychiatry 192:25-31. 2008..Obsessive-compulsive disorder (OCD) may be related to a dysfunction in frontostriatal pathways mediating inhibitory control. However, no functional magnetic resonance imaging (fMRI) study has tested this in children...
Methylphenidate effects on prefrontal functioning during attentional-capture and response inhibitionAstrid M Pauls
Department of Neuroimaging, Institute of Psychiatry, King s College London, United Kingdom
Biol Psychiatry 72:142-9. 2012..In the current study, we assessed the effects of methylphenidate on neural networks of inhibitory control and attentional-capture within the context of two inhibitory control tasks...
Impulsiveness as a timing disturbance: neurocognitive abnormalities in attention-deficit hyperactivity disorder during temporal processes and normalization with methylphenidateKatya Rubia
Department of Child Psychiatry MRC Center for Social, Genetic and Developmental Psychiatry SGDP, Institute of Psychiatry, 16 De Crespigny Park, London, UK
Philos Trans R Soc Lond B Biol Sci 364:1919-31. 2009....
The neural basis of response inhibition and attention allocation as mediated by gestational ageEmma J Lawrence
Department of Psychological Medicine, Institute of Psychiatry, King s College London, United Kingdom
Hum Brain Mapp 30:1038-50. 2009....
Dissociated functional brain abnormalities of inhibition in boys with pure conduct disorder and in boys with pure attention deficit hyperactivity disorderKatya Rubia
Department of Child Psychiatry MRC Center for Social, Genetic, and Developmental Psychiatry, Institute of Psychiatry, King s College, London SE5 8AF, UK
Am J Psychiatry 165:889-97. 2008....
Reduced activation in lateral prefrontal cortex and anterior cingulate during attention and cognitive control functions in medication-naïve adolescents with depression compared to controlsRozmin Halari
Child and Adolescent Psychiatry, Institute of Psychiatry, London, UK
J Child Psychol Psychiatry 50:307-16. 2009..This study investigated whether medication-naïve adolescents with MDD show abnormal brain activation of fronto-striatal and fronto-cingulate networks when performing tasks of attentional and cognitive control...
"Cool" inferior frontostriatal dysfunction in attention-deficit/hyperactivity disorder versus "hot" ventromedial orbitofrontal-limbic dysfunction in conduct disorder: a reviewKatya Rubia
Department of Child Psychiatry Medical Research Council Center for Social, Genetic and Developmental Psychiatry, Institute of Psychiatry, London, United Kingdom
Biol Psychiatry 69:e69-87. 2011..There is, hence, evidence for dissociated underlying pathophysiologies for these two disorders that may have implications for future anatomy-based differential diagnosis and prevention and intervention...
Tryptophan depletion reduces right inferior prefrontal activation during response inhibition in fast, event-related fMRIKatya Rubia
Institute of Psychiatry, King s College London, De Crespigny Park, SE5 8AF, London, UK
Psychopharmacology (Berl) 179:791-803. 2005....
Right inferior prefrontal cortex mediates response inhibition while mesial prefrontal cortex is responsible for error detectionKatya Rubia
Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
Neuroimage 20:351-8. 2003..Failure to inhibit was associated with activation in mesial frontopolar and bilateral inferior parietal cortices, presumably reflecting an attention network for error detection...
Reduced activation in right lateral prefrontal cortex and anterior cingulate gyrus in medication-naïve adolescents with attention deficit hyperactivity disorder during time discriminationAnna B Smith
Centre for Social Genetic and Developmental Psychiatry, Institute of Psychiatry, King s College, London, UK
J Child Psychol Psychiatry 49:977-85. 2008..We investigated the neuro-anatomical substrates mediating fine temporal discrimination in adolescents with ADHD compared with controls, using functional magnetic resonance imaging (fMRI)...
Neural basis of Delta-9-tetrahydrocannabinol and cannabidiol: effects during response inhibitionStefan J Borgwardt
Section of Neuroimaging, Institute of Psychiatry, King s College London, United Kingdom
Biol Psychiatry 64:966-73. 2008..This study examined the effect of Delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on brain activation during a motor inhibition task...
Maturation of limbic corticostriatal activation and connectivity associated with developmental changes in temporal discountingAnastasia Christakou
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King s College London, London, UK
Neuroimage 54:1344-54. 2011....
Dissociable functional connectivity changes during the Stroop task relating to risk, resilience and disease expression in bipolar disorderFrancesco Pompei
Section of Neurobiology of Psychosis, Institute of Psychiatry, King s College London, UK
Neuroimage 57:576-82. 2011....
Response inhibition and reward response bias mediate the predictive relationships between impulsivity and sensation seeking and common and unique variance in conduct disorder and substance misuseNatalie Castellanos-Ryan
Department of Psychological Medicine, Institute of Psychiatry, King s College London, UK
Alcohol Clin Exp Res 35:140-55. 2011....
Motor timing deficits in community and clinical boys with hyperactive behavior: the effect of methylphenidate on motor timingKatya Rubia
Institute of Psychiatry, King s College London, London, United Kingdom
J Abnorm Child Psychol 31:301-13. 2003....
Right ventromedial and dorsolateral prefrontal cortices mediate adaptive decisions under ambiguity by integrating choice utility and outcome evaluationAnastasia Christakou
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, United Kingdom
J Neurosci 29:11020-8. 2009..These findings provide functional evidence of the underlying processes by which these prefrontal subregions drive adaptive choice in the task, namely through contingency-sensitive outcome evaluation...
Familial and disease specific abnormalities in the neural correlates of the Stroop Task in Bipolar DisorderFrancesco Pompei
Section of Neurobiology of Psychosis, Institute of Psychiatry, Kings College, London, UK
Neuroimage 56:1677-84. 2011..Our findings suggest that while reduced parietal engagement relates to genetic risk, fronto-striatal dysfunction reflects processes underpinning disease expression for mood disorders...
Performance of children with attention deficit hyperactivity disorder (ADHD) on a test battery of impulsivenessKatya Rubia
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Kings College, London, UK
Child Neuropsychol 13:276-304. 2007..The task battery as a whole showed 76% correct discrimination of cases and controls...
Investigation of cool and hot executive function in ODD/CD independently of ADHDChristopher W Hobson
Institute of Psychiatry, Kings College, London
J Child Psychol Psychiatry 52:1035-43. 2011..However, it is currently unclear to what extent ODD/CD is associated with neuropsychological deficits, independently of attention deficit hyperactivity disorder (ADHD)...
Functional development of fronto-striato-parietal networks associated with time perceptionAnna B Smith
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Kings College London London, UK
Front Hum Neurosci 5:136. 2011....
The neural correlates of cognitive time management: a reviewKatya Rubia
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, London, United Kingdom
Acta Neurobiol Exp (Wars) 64:329-40. 2004..The review shows that the same brain regions are involved in both motor timing and time estimation, suggesting that both functions are probably inseparable and mediated by common neural networks...
Neural correlates of switching set as measured in fast, event-related functional magnetic resonance imagingAnna B Smith
Department of Child Psychiatry, Institute of Psychiatry, King's College London, London, United Kingdom
Hum Brain Mapp 21:247-56. 2004..We conclude that left DLPFC activation is involved directly in cognitive switching, in conjunction with parietal and temporal brain regions. Pre- and postcentral gyrus activation may be related to motor components of switching set...
Neural correlates of executive function in autistic spectrum disordersNicole Schmitz
Department of Psychological Medicine, Section of Brain Maturation, Institute of Psychiatry, King College London, UK
Biol Psychiatry 59:7-16. 2006..However, to date, no functional imaging study on ASD has investigated inhibition and cognitive flexibility and no one has related EF brain activation to brain structure...
Striatal dopamine transporter alterations in ADHD: pathophysiology or adaptation to psychostimulants? A meta-analysisPaolo Fusar-Poli
Department of Psychosis Studies, Institute of Psychiatry, King s College London, USA
Am J Psychiatry 169:264-72. 2012..However, individual studies using single photon emission tomography (SPECT) or positron emission tomography (PET) have yielded inconsistent results, i.e., both high and low striatal dopamine transporter levels...
A right hemispheric frontocerebellar network for time discrimination of several hundreds of millisecondsAnna Smith
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, London, UK
Neuroimage 20:344-50. 2003..We conclude that right DLPFC, rather than having a purely working memory function, might be more centrally involved in time perception than previously thought...
Gray matter volume abnormalities in ADHD: voxel-based meta-analysis exploring the effects of age and stimulant medicationTomohiro Nakao
Institute of Psychiatry, King s College London, UK
Am J Psychiatry 168:1154-63. 2011..The authors conducted a meta-analysis of voxel-based morphometry studies in children and adults with ADHD and examined the potential effects of age and stimulant medication on regional gray matter volumes...
The neurobiology of Meditation and its clinical effectiveness in psychiatric disordersKatya Rubia
Institute of Psychiatry, Department of Child and Adolescent Psychiatry, King s College University London, UK
Biol Psychol 82:1-11. 2009....
The dynamic approach to neurodevelopmental psychiatric disorders: use of fMRI combined with neuropsychology to elucidate the dynamics of psychiatric disorders, exemplified in ADHD and schizophreniaKatya Rubia
Department of Child and Adolescent Psychiatry Unit, Institute of Psychiatry Kings College, De Crespigny Park, London SE 8AF, UK
Behav Brain Res 130:47-56. 2002..Comparisons between patient groups will be essential to address the specificity of neurocognitive mechanisms corresponding to specific neurodevelopmental psychiatric disorders...
Evidence for a pure time perception deficit in children with ADHDAnna Smith
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, London, UK
J Child Psychol Psychiatry 43:529-42. 2002..The aim of this study was to explore further the abilities of hyperactive children in skills of time estimation, using a range of time perception tasks in different temporal domains...
Structural and functional brain imaging in adult attention-deficit/hyperactivity disorderAna Cubillo
Department of Child Psychiatry SGDP, P046, Institute of Psychiatry, 16 De Crespigny Park, London, SE5 8AF, UK
Expert Rev Neurother 10:603-20. 2010....
Meta-analysis of fMRI studies of timing in attention-deficit hyperactivity disorder (ADHD)Heledd Hart
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King s College London, London, UK
Neurosci Biobehav Rev 36:2248-56. 2012....
Altered functional neuroanatomy of response inhibition in adolescent males who were born very pretermChiara Nosarti
Division of Psychological Medicine, Institute of Psychiatry, London, UK
Dev Med Child Neurol 48:265-71. 2006....
Total red blood cell concentrations of omega-3 fatty acids are associated with emotion-elicited neural activity in adolescent boys with attention-deficit hyperactivity disorderRachel V Gow
Department of Child and Adolescent Psychiatry, PO Box 85, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE58AF, UK
Prostaglandins Leukot Essent Fatty Acids 80:151-6. 2009....
Heterozygous PAX6 mutation, adult brain structure and fronto-striato-thalamic function in a human familyZoë Ellison-Wright
Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
Eur J Neurosci 19:1505-12. 2004..Highly conserved homeobox genes may be critical for normal ontogenesis of large-scale neurocognitive networks supporting phylogenetically advanced mental functions...
Neuro-anatomic evidence for the maturational delay hypothesis of ADHDKatya Rubia
Department of Child Psychiatry/Medical Research Council Social, Genetic, and Developmental Psychiatry Research Center (SGDP, Institute of Psychiatry, 16 De Crespigny Park, SG DP PO46, London SE5 8AF, United Kingdom
Proc Natl Acad Sci U S A 104:19663-4. 2007
