Geraint B Rogers

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint Studying bacterial infections through culture-independent approaches
    Geraint B Rogers
    Molecular Microbiology Research Laboratory, Pharmaceutical Science Division, Franklin Wilkins Building, King s College London, 150 Stamford Street, London SE1 9NH, UK
    J Med Microbiol 58:1401-18. 2009
  2. pmc Determining cystic fibrosis-affected lung microbiology: comparison of spontaneous and serially induced sputum samples by use of terminal restriction fragment length polymorphism profiling
    Geraint B Rogers
    King s College London, Molecular Microbiology Research Laboratory, Pharmaceutical Science Division, 150 Stamford Street, Franklin Wilkins Building, London SE1 9NH, United Kingdom
    J Clin Microbiol 48:78-86. 2010
  3. pmc Interpreting infective microbiota: the importance of an ecological perspective
    Geraint B Rogers
    Institute of Pharmaceutical Science, Molecular Microbiology Research Laboratory, King s College London, London, UK
    Trends Microbiol 21:271-6. 2013
  4. doi request reprint Novel concepts in evaluating antimicrobial therapy for bacterial lung infections in patients with cystic fibrosis
    Geraint B Rogers
    Molecular Microbiology Research Laboratory, King s College London, United Kingdom
    J Cyst Fibros 10:387-400. 2011
  5. pmc Enhancing the utility of existing antibiotics by targeting bacterial behaviour?
    Geraint B Rogers
    Molecular Microbiology Research Laboratory, Institute of Pharmaceutical Sciences, King s College London, London, UK
    Br J Pharmacol 165:845-57. 2012
  6. doi request reprint Next-generation sequencing in the analysis of human microbiota: essential considerations for clinical application
    Geraint B Rogers
    Pharmaceutical Science Division, King s College London, London, UK
    Mol Diagn Ther 14:343-50. 2010
  7. doi request reprint Characterisation of bacteria in ascites--reporting the potential of culture-independent, molecular analysis
    G B Rogers
    Molecular Microbiology Research Group, PSD, King s College London, London, UK
    Eur J Clin Microbiol Infect Dis 29:533-41. 2010
  8. doi request reprint Lung infections in cystic fibrosis: deriving clinical insight from microbial complexity
    Geraint B Rogers
    Molecular Microbiology Research Laboratory, Pharmaceutical Science Division, 150 Stamford Street, Franklin Wilkins Building, King s College London, London, SE1 9NH, UK
    Expert Rev Mol Diagn 10:187-96. 2010
  9. doi request reprint The exclusion of dead bacterial cells is essential for accurate molecular analysis of clinical samples
    G B Rogers
    King s College London, UK
    Clin Microbiol Infect 16:1656-8. 2010
  10. pmc Bacterial activity in cystic fibrosis lung infections
    Geraint B Rogers
    Department of Life Sciences, King s College London, London, UK
    Respir Res 6:49. 2005

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Studying bacterial infections through culture-independent approaches
    Geraint B Rogers
    Molecular Microbiology Research Laboratory, Pharmaceutical Science Division, Franklin Wilkins Building, King s College London, 150 Stamford Street, London SE1 9NH, UK
    J Med Microbiol 58:1401-18. 2009
    ..The impact that the use of culture-independent, molecular analyses will have on the way we approach the treatment of infections is also considered...
  2. pmc Determining cystic fibrosis-affected lung microbiology: comparison of spontaneous and serially induced sputum samples by use of terminal restriction fragment length polymorphism profiling
    Geraint B Rogers
    King s College London, Molecular Microbiology Research Laboratory, Pharmaceutical Science Division, 150 Stamford Street, Franklin Wilkins Building, London SE1 9NH, United Kingdom
    J Clin Microbiol 48:78-86. 2010
    ..Close correlation between T-RFLP and microbiological data in the detection of key species indicates the importance of these findings in routine diagnostics for the detection of recognized and novel CF pathogens...
  3. pmc Interpreting infective microbiota: the importance of an ecological perspective
    Geraint B Rogers
    Institute of Pharmaceutical Science, Molecular Microbiology Research Laboratory, King s College London, London, UK
    Trends Microbiol 21:271-6. 2013
    ..Here, we suggest that ecological theory can inform clinical understanding...
  4. doi request reprint Novel concepts in evaluating antimicrobial therapy for bacterial lung infections in patients with cystic fibrosis
    Geraint B Rogers
    Molecular Microbiology Research Laboratory, King s College London, United Kingdom
    J Cyst Fibros 10:387-400. 2011
    ..Moreover, the degree to which the inherent complexity of CF respiratory infections complicates the process of determining treatment impact and the need to identify more robust microbiological outcome measures will also be reviewed...
  5. pmc Enhancing the utility of existing antibiotics by targeting bacterial behaviour?
    Geraint B Rogers
    Molecular Microbiology Research Laboratory, Institute of Pharmaceutical Sciences, King s College London, London, UK
    Br J Pharmacol 165:845-57. 2012
    ..Here, advances in our ability to disrupt these systems that confer reduced susceptibility, and in turn increase the efficacy of antibiotic therapy, are discussed...
  6. doi request reprint Next-generation sequencing in the analysis of human microbiota: essential considerations for clinical application
    Geraint B Rogers
    Pharmaceutical Science Division, King s College London, London, UK
    Mol Diagn Ther 14:343-50. 2010
    ..Further, ways in which the impact of these factors can be minimized are discussed...
  7. doi request reprint Characterisation of bacteria in ascites--reporting the potential of culture-independent, molecular analysis
    G B Rogers
    Molecular Microbiology Research Group, PSD, King s College London, London, UK
    Eur J Clin Microbiol Infect Dis 29:533-41. 2010
    ....
  8. doi request reprint Lung infections in cystic fibrosis: deriving clinical insight from microbial complexity
    Geraint B Rogers
    Molecular Microbiology Research Laboratory, Pharmaceutical Science Division, 150 Stamford Street, Franklin Wilkins Building, King s College London, London, SE1 9NH, UK
    Expert Rev Mol Diagn 10:187-96. 2010
    ..The rapid advance in sequencing technology, along with protocols that limit analysis to viable bacterial cells, are for the first time providing an opportunity to gain such insight...
  9. doi request reprint The exclusion of dead bacterial cells is essential for accurate molecular analysis of clinical samples
    G B Rogers
    King s College London, UK
    Clin Microbiol Infect 16:1656-8. 2010
    ..Here, the increased ability to resolve the impact of antibiotic therapy on Pseudomonas aeruginosa load in cystic fibrosis respiratory samples reveals statistically significant changes that would otherwise go undetected...
  10. pmc Bacterial activity in cystic fibrosis lung infections
    Geraint B Rogers
    Department of Life Sciences, King s College London, London, UK
    Respir Res 6:49. 2005
    ..The aim of this study was to determine whether the species present were active and, as such, worthy of further investigation as potential pathogens...
  11. doi request reprint Does bacterial density in cystic fibrosis sputum increase prior to pulmonary exacerbation?
    Franziska A Stressmann
    Molecular Microbiology Research Laboratory, Institute of Pharmaceutical Sciences, 150 Stamford Street, Franklin Wilkins Building, King s College London, London, SE1 9NH, UK
    J Cyst Fibros 10:357-65. 2011
    ..Despite their clinical significance, the cause of CFPE remains undetermined. It has been suggested that an increase in bacterial density may be a trigger, although this has not been shown empirically...
  12. pmc Reducing bias in bacterial community analysis of lower respiratory infections
    Geraint B Rogers
    Molecular Microbiology Research Laboratory, Institute of Pharmaceutical Science, King s College London, London, UK
    ISME J 7:697-706. 2013
    ..Our findings suggest failure to implement NVCE may result in skewed bacterial community analyses...
  13. pmc Revealing the dynamics of polymicrobial infections: implications for antibiotic therapy
    Geraint B Rogers
    King s College London, Molecular Microbiology Research Laboratory, Pharmaceutical Science Division, 150 Stamford Street, Franklin Wilkins Building, King s College London, London, SE1 9NH, UK
    Trends Microbiol 18:357-64. 2010
    ..identified that predict a change in infection dynamics and clinical outcomes? Secondly, can these new strategies directly characterize the impact of antimicrobial therapies, allowing treatment efficacy to be both assessed and optimized?..
  14. ncbi request reprint Long-term cultivation-independent microbial diversity analysis demonstrates that bacterial communities infecting the adult cystic fibrosis lung show stability and resilience
    Franziska Anne Stressmann
    Molecular Microbiology Research Laboratory, Institute of Pharmaceutical Science, King s College London, 150 Stamford Street, Franklin Wilkins Building, London SE1 9NH, UK
    Thorax 67:867-73. 2012
    ..However, little is known about their clinical significance or persistence in CF airways...
  15. doi request reprint Assessing the diagnostic importance of nonviable bacterial cells in respiratory infections
    Geraint B Rogers
    Pharmaceutical Science Division, Molecular Microbiology Research Laboratory, King s College London, London SE1 9NH, UK
    Diagn Microbiol Infect Dis 62:133-41. 2008
    ..These findings highlight the significant contribution that nonviable bacteria can make to DNA-based diagnostic analysis of clinical samples while providing a simple and effective means of avoiding such bias...
  16. pmc Ascitic microbiota composition is correlated with clinical severity in cirrhosis with portal hypertension
    Geraint B Rogers
    Institute of Pharmaceutical Science, King s College London, London, United Kingdom
    PLoS ONE 8:e74884. 2013
    ..Entry of bacteria into ascites is unlikely to be limited to translocation from the gut, raising fundamental questions about the processes that underlie the development of spontaneous bacterial peritonitis. ..
  17. doi request reprint The use of culture-independent tools to characterize bacteria in endo-tracheal aspirates from pre-term infants at risk of bronchopulmonary dysplasia
    Franziska A Stressmann
    Molecular Microbiology Research Laboratory, Pharmaceutical Science Division, 150 Stamford Street, Franklin Wilkins Building, King s College London, London, SE1 9NH, UK
    J Perinat Med 38:333-7. 2010
    ..Further, we suggest that culture-independent techniques, such as T-RFLP, hold important potential for the characterization of neonatal conditions, such as BPD...
  18. ncbi request reprint Time between Collection and Storage Significantly Influences Bacterial Sequence Composition in Sputum Samples from Cystic Fibrosis Respiratory Infections
    Leah Cuthbertson
    NERC Centre for Ecology and Hydrology, Wallingford, United Kingdom Institute of Pharmaceutical Science, Molecular Microbiology Research Laboratory, King s College London, London, United Kingdom
    J Clin Microbiol 52:3011-6. 2014
    ..008). Failure to stabilize samples at -80°C within 12 h of collection results in significant changes in the detected community composition. ..
  19. ncbi request reprint Clinical measures of disease in adult non-CF bronchiectasis correlate with airway microbiota composition
    Geraint B Rogers
    Molecular Microbiology Research Laboratory, Institute of Pharmaceutical Science, King s College London, London, UK
    Thorax 68:731-7. 2013
    ..Despite the potentially important roles for infection in adult non-cystic fibrosis (CF) bronchiectasis disease progression, the bacterial species present in the lower airways of these patients is poorly characterised...
  20. pmc Analysis of the bacterial communities present in lungs of patients with cystic fibrosis from American and British centers
    Franziska A Stressmann
    Molecular Microbiology Research Laboratory, Pharmaceutical Science Research Division, King s College London, 150 Stamford Street, Franklin Wilkins Building, London, SE1 9NH, United Kingdom
    J Clin Microbiol 49:281-91. 2011
    ..S. sample group. The impact of cross-infection and biogeography is considered, and the implications for treating CF lung infections also are discussed...
  21. pmc Using bacterial biomarkers to identify early indicators of cystic fibrosis pulmonary exacerbation onset
    Geraint B Rogers
    Molecular Microbiology Research Laboratory, Pharmaceutical Science Division, 150 Stamford Street, Franklin Wilkins Building, King s College London, London, SE1 9NH, UK
    Expert Rev Mol Diagn 11:197-206. 2011
    ..In this article, we discuss key considerations in the design and testing of assays that could predict pulmonary exacerbations...
  22. pmc Studying bacteria in respiratory specimens by using conventional and molecular microbiological approaches
    Geraint B Rogers
    King s College London, Molecular Microbiology Research Laboratory, Pharmaceutical Science Division, 150 Stamford Street, Franklin Wilkins Building, King s College London, London, SE1 9NH, UK
    BMC Pulm Med 9:14. 2009
    ..Here, the aim was to determine the extent to which routine diagnostic microbiology gave a different assessment of the species present in sputa when analysed by using culture-independent assessment...
  23. pmc Exploring the parallel development of microbial systems in neonates with cystic fibrosis
    Geraint B Rogers
    Institute of Pharmaceutical Science, Molecular Microbiology Research Laboratory, King s College London, London, United Kingdom
    MBio 3:e00408-12. 2012
    ..mBio 3(4):e00251-12, 2012) monitored the development over time of microbiota in the oropharynges and feces of neonates with cystic fibrosis and explored the potential for interactions between these complex microbial systems...
  24. ncbi request reprint Characterization of bacterial community diversity in chronic rhinosinusitis infections using novel culture-independent techniques
    Franziska A Stressmann
    Molecular Microbiology Research Laboratory, Pharmaceutical Science Division, Franklin Wilkins Building, King s College London, London, United Kingdom, UK
    Am J Rhinol Allergy 25:e133-40. 2011
    ..We aimed to characterize the bacterial diversity present in tissue and mucus samples taken from the CRS setting using molecular nonculture-dependent techniques...
  25. pmc Combined Systems Approaches Reveal Highly Plastic Responses to Antimicrobial Peptide Challenge in Escherichia coli
    Justyna Kozlowska
    King s College London, Institute of Pharmaceutical Science, London, United Kingdom
    PLoS Pathog 10:e1004104. 2014
    ....