Research Topics
| Geraint B RogersSummaryAffiliation: King's College London Country: UK Publications
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Detail Information
Publications
Studying bacterial infections through culture-independent approachesGeraint B Rogers
Molecular Microbiology Research Laboratory, Pharmaceutical Science Division, Franklin Wilkins Building, King s College London, 150 Stamford Street, London SE1 9NH, UK
J Med Microbiol 58:1401-18. 2009..The impact that the use of culture-independent, molecular analyses will have on the way we approach the treatment of infections is also considered...
Determining cystic fibrosis-affected lung microbiology: comparison of spontaneous and serially induced sputum samples by use of terminal restriction fragment length polymorphism profilingGeraint B Rogers
King s College London, Molecular Microbiology Research Laboratory, Pharmaceutical Science Division, 150 Stamford Street, Franklin Wilkins Building, London SE1 9NH, United Kingdom
J Clin Microbiol 48:78-86. 2010..Close correlation between T-RFLP and microbiological data in the detection of key species indicates the importance of these findings in routine diagnostics for the detection of recognized and novel CF pathogens...- Novel concepts in evaluating antimicrobial therapy for bacterial lung infections in patients with cystic fibrosisGeraint B Rogers
Molecular Microbiology Research Laboratory, King s College London, United Kingdom
J Cyst Fibros 10:387-400. 2011..Moreover, the degree to which the inherent complexity of CF respiratory infections complicates the process of determining treatment impact and the need to identify more robust microbiological outcome measures will also be reviewed... - Enhancing the utility of existing antibiotics by targeting bacterial behaviour?Geraint B Rogers
Molecular Microbiology Research Laboratory, Institute of Pharmaceutical Sciences, King s College London, London, UK
Br J Pharmacol 165:845-57. 2012..Here, advances in our ability to disrupt these systems that confer reduced susceptibility, and in turn increase the efficacy of antibiotic therapy, are discussed... - Bacterial activity in cystic fibrosis lung infectionsGeraint B Rogers
Department of Life Sciences, King s College London, London, UK
Respir Res 6:49. 2005..The aim of this study was to determine whether the species present were active and, as such, worthy of further investigation as potential pathogens... - Next-generation sequencing in the analysis of human microbiota: essential considerations for clinical applicationGeraint B Rogers
Pharmaceutical Science Division, King s College London, London, UK
Mol Diagn Ther 14:343-50. 2010..Further, ways in which the impact of these factors can be minimized are discussed... - Characterisation of bacteria in ascites--reporting the potential of culture-independent, molecular analysisG B Rogers
Molecular Microbiology Research Group, PSD, King s College London, London, UK
Eur J Clin Microbiol Infect Dis 29:533-41. 2010.... - Lung infections in cystic fibrosis: deriving clinical insight from microbial complexityGeraint B Rogers
Molecular Microbiology Research Laboratory, Pharmaceutical Science Division, 150 Stamford Street, Franklin Wilkins Building, King s College London, London, SE1 9NH, UK
Expert Rev Mol Diagn 10:187-96. 2010..The rapid advance in sequencing technology, along with protocols that limit analysis to viable bacterial cells, are for the first time providing an opportunity to gain such insight... - The exclusion of dead bacterial cells is essential for accurate molecular analysis of clinical samplesG B Rogers
King s College London, UK
Clin Microbiol Infect 16:1656-8. 2010..Here, the increased ability to resolve the impact of antibiotic therapy on Pseudomonas aeruginosa load in cystic fibrosis respiratory samples reveals statistically significant changes that would otherwise go undetected... - Does bacterial density in cystic fibrosis sputum increase prior to pulmonary exacerbation?Franziska A Stressmann
Molecular Microbiology Research Laboratory, Institute of Pharmaceutical Sciences, 150 Stamford Street, Franklin Wilkins Building, King s College London, London, SE1 9NH, UK
J Cyst Fibros 10:357-65. 2011..Despite their clinical significance, the cause of CFPE remains undetermined. It has been suggested that an increase in bacterial density may be a trigger, although this has not been shown empirically... - Revealing the dynamics of polymicrobial infections: implications for antibiotic therapyGeraint B Rogers
King s College London, Molecular Microbiology Research Laboratory, Pharmaceutical Science Division, 150 Stamford Street, Franklin Wilkins Building, King s College London, London, SE1 9NH, UK
Trends Microbiol 18:357-64. 2010..identified that predict a change in infection dynamics and clinical outcomes? Secondly, can these new strategies directly characterize the impact of antimicrobial therapies, allowing treatment efficacy to be both assessed and optimized?.. - Long-term cultivation-independent microbial diversity analysis demonstrates that bacterial communities infecting the adult cystic fibrosis lung show stability and resilienceFranziska Anne Stressmann
Molecular Microbiology Research Laboratory, Institute of Pharmaceutical Science, King s College London, 150 Stamford Street, Franklin Wilkins Building, London SE1 9NH, UK
Thorax 67:867-73. 2012..However, little is known about their clinical significance or persistence in CF airways... - Assessing the diagnostic importance of nonviable bacterial cells in respiratory infectionsGeraint B Rogers
Pharmaceutical Science Division, Molecular Microbiology Research Laboratory, King s College London, London SE1 9NH, UK
Diagn Microbiol Infect Dis 62:133-41. 2008..These findings highlight the significant contribution that nonviable bacteria can make to DNA-based diagnostic analysis of clinical samples while providing a simple and effective means of avoiding such bias... - The use of culture-independent tools to characterize bacteria in endo-tracheal aspirates from pre-term infants at risk of bronchopulmonary dysplasiaFranziska A Stressmann
Molecular Microbiology Research Laboratory, Pharmaceutical Science Division, 150 Stamford Street, Franklin Wilkins Building, King s College London, London, SE1 9NH, UK
J Perinat Med 38:333-7. 2010..Further, we suggest that culture-independent techniques, such as T-RFLP, hold important potential for the characterization of neonatal conditions, such as BPD... - Analysis of the bacterial communities present in lungs of patients with cystic fibrosis from American and British centersFranziska A Stressmann
Molecular Microbiology Research Laboratory, Pharmaceutical Science Research Division, King s College London, 150 Stamford Street, Franklin Wilkins Building, London, SE1 9NH, United Kingdom
J Clin Microbiol 49:281-91. 2011..S. sample group. The impact of cross-infection and biogeography is considered, and the implications for treating CF lung infections also are discussed... - Using bacterial biomarkers to identify early indicators of cystic fibrosis pulmonary exacerbation onsetGeraint B Rogers
Molecular Microbiology Research Laboratory, Pharmaceutical Science Division, 150 Stamford Street, Franklin Wilkins Building, King s College London, London, SE1 9NH, UK
Expert Rev Mol Diagn 11:197-206. 2011..In this article, we discuss key considerations in the design and testing of assays that could predict pulmonary exacerbations... - Studying bacteria in respiratory specimens by using conventional and molecular microbiological approachesGeraint B Rogers
King s College London, Molecular Microbiology Research Laboratory, Pharmaceutical Science Division, 150 Stamford Street, Franklin Wilkins Building, King s College London, London, SE1 9NH, UK
BMC Pulm Med 9:14. 2009..Here, the aim was to determine the extent to which routine diagnostic microbiology gave a different assessment of the species present in sputa when analysed by using culture-independent assessment... - Exploring the parallel development of microbial systems in neonates with cystic fibrosisGeraint B Rogers
Institute of Pharmaceutical Science, Molecular Microbiology Research Laboratory, King s College London, London, United Kingdom
MBio 3:e00408-12. 2012..mBio 3(4):e00251-12, 2012) monitored the development over time of microbiota in the oropharynges and feces of neonates with cystic fibrosis and explored the potential for interactions between these complex microbial systems... - Reducing bias in bacterial community analysis of lower respiratory infectionsGeraint B Rogers
Molecular Microbiology Research Laboratory, Institute of Pharmaceutical Science, King s College London, London, UK
ISME J 7:697-706. 2013..Our findings suggest failure to implement NVCE may result in skewed bacterial community analyses... - Characterization of bacterial community diversity in chronic rhinosinusitis infections using novel culture-independent techniquesFranziska A Stressmann
Molecular Microbiology Research Laboratory, Pharmaceutical Science Division, Franklin Wilkins Building, King s College London, London, United Kingdom, UK
Am J Rhinol Allergy 25:e133-40. 2011..We aimed to characterize the bacterial diversity present in tissue and mucus samples taken from the CRS setting using molecular nonculture-dependent techniques...